PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TJP2	2	TJP1	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, biochemical	Itoh M (1999), Wittchen ES (1999), Wittchen ES (1999), Wittchen ES (1999), Fanning AS (1998), Couzens AL (2013), Wan C (2015)	7
KRT31	0	CLDN2	0	two hybrid	Rolland T (2014)	1
CLDN2	0	PIAS2	2	two hybrid	Van Itallie CM (2012)	1
CLDN2	0	UBE2I	0	two hybrid	Van Itallie CM (2012)	1
CLDN2	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
CLDN2	0	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
KRTAP4-12	2	LNX1	7	two hybrid	Rual JF (2005)	1
LNX1	7	CLDN2	0	two hybrid	Guo Z (2012)	1
KRTAP10-3	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
UBE2I	0	PIAS2	2	two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down	Rual JF (2005), Lee BH (2003), Bandyopadhyay S (2010), Schmidt D (2002), Wang J (2011), Rolland T (2014), Saul VV (2014), van den Akker E (2005), Schmidt D (2002)	9
LNX1	7	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
KRTAP4-12	2	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
CLDN2	0	TJP1	2	pull down	Itoh M (1999)	1
CLDN2	0	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
CLDN2	0	TJP2	2	two hybrid	Van Itallie CM (2012)	1
KRTAP4-12	2	NOTCH2NL	1	two hybrid	Rolland T (2014)	1