PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2D2	0	LRSAM1	2	two hybrid	Markson G (2009)	1
EGFR	5	LRSAM1	2	affinity chromatography technology	Amit I (2004)	1
USP2	0	EGFR	5	affinity chromatography technology	Kim J (2012)	1
AP3B1	3	LRSAM1	2	affinity chromatography technology	Traikov S (2014)	1
LRSAM1	2	RNF111	2	two hybrid	Woodsmith J (2012)	1
HSP90AA1	7	TERF1	1	affinity chromatography technology	Hein MY (2015)	1
UBE2D3	1	MKRN3	2	two hybrid	Markson G (2009)	1
DBNL	2	LRSAM1	2	biochemical	Kristensen AR (2012)	1
TSG101	1	MKRN3	2	two hybrid	Markson G (2009)	1
UBE2W	0	TRIM17	5	two hybrid	Markson G (2009)	1
DBNL	2	ERO1A	0	biochemical	Kristensen AR (2012)	1
LRSAM1	2	MTMR2	2	biochemical	Kristensen AR (2012)	1
HSP90AA1	7	UBE2N	1	pull down	Zhang M (2005)	1
UBE3A	4	HSF1	1	biochemical	Kristensen AR (2012)	1
UBE2D1	0	UBE3A	4	enzymatic study, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, enzymatic study, pull down, pull down	Nuber U (1999), Burch L (2004), Scheffner M (1994), Schwarz SE (1998), Uchiki T (2009), Nuber U (1996), Nuber U (1996), Jacobson AD (2014), Honda R (1997), Wu PY (2003), Kim HT (2007), McClurg UL (2016)	12
UBE2D4	0	LRSAM1	2	two hybrid	Markson G (2009)	1
CTPS2	0	MTMR2	2	biochemical	Kristensen AR (2012)	1
UTP6	2	LRSAM1	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2N	1	CBS	0	affinity chromatography technology	Boldt K (2016)	1
UBE2J1	1	LRSAM1	2	two hybrid	van Wijk SJ (2009)	1
TSG101	1	RNF111	2	two hybrid	Markson G (2009)	1
ANKMY2	3	HSF1	1	biochemical	Kristensen AR (2012)	1
UBE2W	0	RNF111	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
UBE2D1	0	LRSAM1	2	two hybrid, pull down, enzymatic study	Markson G (2009), Chua HH (2016), Hakonen JE (2017)	3
CTPS2	0	LRSAM1	2	biochemical	Kristensen AR (2012)	1
UBE2N	1	MKRN3	2	two hybrid	Markson G (2009)	1
GOPC	5	HSF1	1	biochemical	Kristensen AR (2012)	1
LRSAM1	2	VPS11	3	two hybrid	Woodsmith J (2012)	1
EHD4	1	LRSAM1	2	biochemical	Kristensen AR (2012)	1
PLIN3	3	MTMR2	2	biochemical	Kristensen AR (2012)	1
UBE2E1	1	LRSAM1	2	two hybrid	Markson G (2009)	1
CBS	0	HSF1	1	biochemical	Kristensen AR (2012)	1
UBE2D2	0	RNF111	2	two hybrid, two hybrid, pull down, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Erker Y (2013), Wright JD (2016), Birkou M (2017), Birkou M (2017)	6
HSP90AA1	7	LRSAM1	2	affinity chromatography technology	Taipale M (2012)	1
MAGEA1	0	UBE3A	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM17	5	LRSAM1	2	two hybrid	Woodsmith J (2012)	1
LIPF	0	LRSAM1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2K	0	MKRN3	2	two hybrid	Markson G (2009)	1
LRSAM1	2	FAM178B	0	two hybrid	Stelzl U (2005)	1
P3H1	2	LRSAM1	2	biochemical	Kristensen AR (2012)	1
DBNL	2	P3H1	2	biochemical	Kristensen AR (2012)	1
UBE3A	4	UBE2E1	1	pull down, two hybrid, pull down	Nuber U (1996), Kumar S (1997), Kumar S (1997)	3
DBNL	2	PLIN3	3	biochemical	Kristensen AR (2012)	1
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
EGFR	5	EHD4	1	affinity chromatography technology	Tong J (2014)	1
UBE2D3	1	RNF111	2	two hybrid, two hybrid, pull down, two hybrid	van Wijk SJ (2009), Markson G (2009), Erker Y (2013), Rolland T (2014)	4
UBE2E1	1	RNF111	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
TSG101	1	TRIM74	0	two hybrid	Markson G (2009)	1
UBE2D3	1	LRSAM1	2	two hybrid	Markson G (2009)	1
HSP90AA1	7	TRIM17	5	affinity chromatography technology	Taipale M (2012)	1
HSP90AA1	7	RNF111	2	affinity chromatography technology	Taipale M (2012)	1
ERO1A	0	DDX5	2	biochemical	Kristensen AR (2012)	1
LRSAM1	2	KLC1	5	two hybrid	Stelzl U (2005)	1
UBE2K	0	RNF111	2	two hybrid	Markson G (2009)	1
UBE2D3	1	TRIM17	5	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
MDM4	0	UBE2D1	0	pull down, pull down	Badciong JC (2002), Singh RK (2007)	2
PPME1	0	HSPBP1	0	biochemical	Kristensen AR (2012)	1
UBE2K	0	UBE2N	1	biochemical	Wan C (2015)	1
EGFR	5	YTHDF1	1	affinity chromatography technology	Li J (2013)	1
UBE2W	0	LRSAM1	2	two hybrid	Markson G (2009)	1
UBE2H	3	MKRN3	2	two hybrid	Markson G (2009)	1
LRSAM1	2	HSF1	1	biochemical	Kristensen AR (2012)	1
GOPC	5	LRSAM1	2	biochemical	Kristensen AR (2012)	1
LRSAM1	2	YTHDF1	1	biochemical	Havugimana PC (2012)	1
MTMR2	2	HSF1	1	biochemical	Kristensen AR (2012)	1
UBE2H	3	TRIM17	5	two hybrid	Markson G (2009)	1
MAGEA1	0	MDM4	0	two hybrid	Kozakova L (2015)	1
HSP90AA1	7	MDM4	0	affinity chromatography technology	Taipale M (2012)	1
EGFR	5	DDX5	2	affinity chromatography technology	Yao Z (2017)	1
UBE2D2	0	TRIM17	5	two hybrid, two hybrid, pull down	Markson G (2009), Napolitano LM (2011), Woodsmith J (2012)	3
P3H1	2	UBE3A	4	biochemical	Kristensen AR (2012)	1
P3H1	2	ERO1A	0	biochemical	Kristensen AR (2012)	1
UBE2D2	0	MKRN3	2	two hybrid	Markson G (2009)	1
UEVLD	3	LRSAM1	2	two hybrid	Markson G (2009)	1
TERF1	1	DBNL	2	two hybrid	Lee OH (2011)	1
USP21	2	LRSAM1	2	two hybrid	Hayes SD (2012)	1
MDM4	0	UBE2D3	1	pull down	Zhu Y (2009)	1
UBE2D1	0	RNF111	2	two hybrid, two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009), Rolland T (2014)	3
TRIM17	5	UBE2E1	1	two hybrid	Napolitano LM (2011)	1
CTPS2	0	PLIN3	3	biochemical	Kristensen AR (2012)	1
GOPC	5	DR1	1	biochemical	Kristensen AR (2012)	1
DBNL	2	PPME1	0	biochemical	Kristensen AR (2012)	1
CBS	0	GOPC	5	biochemical	Kristensen AR (2012)	1
CTPS2	0	HSF1	1	biochemical	Kristensen AR (2012)	1
USP2	0	TRIM74	0	two hybrid	Hayes SD (2012)	1
ATXN7	0	LRSAM1	2	two hybrid	Kahle JJ (2011)	1
HSP90AA1	7	HSF1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Hu Y (2003), Nair SC (1996), Guo Y (2001), Bento CF (2010), Wang X (2006), Rao R (2012), Fu Q (2008), Prince TL (2015), Prince TL (2015)	9
UBE2D4	0	TRIM17	5	two hybrid	Markson G (2009)	1
ERO1A	0	LRSAM1	2	biochemical	Kristensen AR (2012)	1
UBE2D1	0	TRIM17	5	two hybrid, two hybrid, pull down	Markson G (2009), Napolitano LM (2011), Woodsmith J (2012)	3
CBS	0	LRSAM1	2	biochemical	Kristensen AR (2012)	1
UBE2D4	0	RNF111	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
LRSAM1	2	GPR108	6	two hybrid	Stelzl U (2005)	1
PLIN3	3	LRSAM1	2	biochemical	Kristensen AR (2012)	1
P3H1	2	PPME1	0	biochemical	Kristensen AR (2012)	1
UBE2D4	0	MKRN3	2	two hybrid	Markson G (2009)	1
DBNL	2	DR1	1	biochemical	Kristensen AR (2012)	1
UBE2K	0	LRSAM1	2	two hybrid	Markson G (2009)	1
DBNL	2	UBE3A	4	biochemical	Kristensen AR (2012)	1
DDX5	2	LRSAM1	2	biochemical	Kristensen AR (2012)	1
LRSAM1	2	HSPBP1	0	biochemical	Kristensen AR (2012)	1
ATXN1	2	UBE2E1	1	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hong S (2008), Hong S (2008), Hong S (2008), Hong S (2008), Hong S (2008), Kang AR (2015)	6
DBNL	2	CBS	0	biochemical	Kristensen AR (2012)	1
TSG101	1	VPS11	3	two hybrid	Markson G (2009)	1
EGFR	5	TSG101	1	affinity chromatography technology	Yao Z (2017)	1
LRSAM1	2	ANKMY2	3	biochemical	Kristensen AR (2012)	1
HSP90AA1	7	TRIM74	0	affinity chromatography technology	Taipale M (2012)	1
UBE2D3	1	UBE3A	4	enzymatic study, pull down, pull down	Anan T (1998), Sionov RV (2001), Jacobson AD (2014)	3
USP2	0	LRSAM1	2	two hybrid	Hayes SD (2012)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
UBE3A	4	DR1	1	biochemical	Kristensen AR (2012)	1
UBE2N	1	RNF111	2	affinity chromatography technology, pull down	Poulsen SL (2013), Wright JD (2016)	2
LRSAM1	2	LRSAM1	2	enzymatic study, two hybrid	Amit I (2004), Hakonen JE (2017)	2
MDM4	0	USP2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Allende-Vega N (2010), Allende-Vega N (2010), Wang CL (2014), Wang CL (2014), Wang CL (2014)	5
CBS	0	ERO1A	0	biochemical	Kristensen AR (2012)	1
MDM4	0	UBE2D2	0	pull down, enzymatic study	Iyappan S (2010), Bista M (2013)	2
LRSAM1	2	PPME1	0	biochemical	Kristensen AR (2012)	1
LRSAM1	2	NINL	1	two hybrid	Stelzl U (2005)	1
EHD4	1	MTMR2	2	biochemical	Kristensen AR (2012)	1
UBE2W	0	MKRN3	2	two hybrid	Markson G (2009)	1
LRSAM1	2	DR1	1	biochemical	Kristensen AR (2012)	1
TRIM17	5	UBE2N	1	pull down	Woodsmith J (2012)	1
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
TERF1	1	LRSAM1	2	two hybrid	Lee OH (2011)	1
PHF23	3	LRSAM1	2	affinity chromatography technology, affinity chromatography technology, pull down	Wang Z (2014), Wang Z (2014), Wang Z (2014)	3
TSG101	1	LRSAM1	2	two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, enzymatic study, two hybrid, imaging technique, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Rual JF (2005), Amit I (2004), Amit I (2004), Amit I (2004), Markson G (2009), McDonald B (2008), Schlundt A (2009), Amit I (2004), Rolland T (2014), Amit I (2004), Chua HH (2016), Chua HH (2016), Chua HH (2016), Hakonen JE (2017)	14
ATXN1	2	LRSAM1	2	two hybrid	Lim J (2006)	1
EGFR	5	P3H1	2	affinity chromatography technology	Yao Z (2017)	1
UBE2H	3	LRSAM1	2	two hybrid	Markson G (2009)	1
UBE2N	1	LRSAM1	2	two hybrid, two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009), Hakonen JE (2017)	3
ANKMY2	3	HSP90AA1	7	affinity chromatography technology	Huttlin EL (2017)	1
UBE2E1	1	MKRN3	2	two hybrid	Markson G (2009)	1
PLIN3	3	ANKMY2	3	biochemical	Kristensen AR (2012)	1
LRSAM1	2	TRIM74	0	two hybrid	Woodsmith J (2012)	1
UBE2D1	0	MKRN3	2	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
DBNL	2	DDX5	2	biochemical	Kristensen AR (2012)	1
USP21	2	USP2	0	enzymatic study	Loch CM (2012)	1
LRSAM1	2	MDM4	0	two hybrid	Woodsmith J (2012)	1
ERO1A	0	PPME1	0	biochemical	Kristensen AR (2012)	1
HSF1	1	HSPBP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Huttlin EL (2017), Boldt K (2016)	4
P3H1	2	HSPBP1	0	biochemical	Kristensen AR (2012)	1
PLIN3	3	CBS	0	biochemical	Kristensen AR (2012)	1
HSF1	1	PLIN3	3	biochemical	Kristensen AR (2012)	1
LRSAM1	2	MKRN3	2	two hybrid	Woodsmith J (2012)	1
MKRN3	2	MDM4	0	two hybrid	Woodsmith J (2012)	1
UBE2D2	0	UBE3A	4	enzymatic study, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down	Anan T (1998), Hatakeyama S (1997), Hatakeyama S (1997), Louria-Hayon I (2009), Jacobson AD (2014), Mortensen F (2015), Rolfe M (1995), Kuslansky Y (2016)	8
ERO1A	0	HSPBP1	0	biochemical	Kristensen AR (2012)	1
EHD4	1	CTPS2	0	biochemical	Kristensen AR (2012)	1
DBNL	2	HSPBP1	0	biochemical	Kristensen AR (2012)	1
LRRC46	1	LRSAM1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LRSAM1	2	UBE3A	4	biochemical	Kristensen AR (2012)	1
HSF1	1	DR1	1	biochemical	Kristensen AR (2012)	1
MAGEA1	0	LRSAM1	2	two hybrid	Kozakova L (2015)	1