PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TBL1Y	0	TUBB8	2	affinity chromatography technology	Huttlin EL (2017)	1
TCP1	0	CCT2	1	affinity chromatography technology, biochemical, biochemical, biochemical, biochemical	Gingras AC (2005), Imai Y (2003), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	5
HDAC3	5	TBL1X	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang J (2002), Zhang J (2002), Zhang J (2002), Guenther MG (2000), Guenther MG (2000), Choi HK (2008), Bantscheff M (2011), Joshi P (2013)	8
HDAC3	5	CCT3	1	affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Huttlin EL (2017)	2
TBL1Y	0	CCT6A	1	affinity chromatography technology	Huttlin EL (2017)	1
CCT2	1	CCT3	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
FOXK2	9	TBL1XR1	23	affinity chromatography technology, pull down	Li X (2015), Shan L (2016)	2
HDAC3	5	CCT4	2	affinity chromatography technology	Joshi P (2013)	1
TBL1Y	0	TBL1XR1	23	affinity chromatography technology	Huttlin EL (2017)	1
TBL1Y	0	WDR36	0	affinity chromatography technology	Huttlin EL (2017)	1
TBL1Y	0	LRIF1	3	affinity chromatography technology	Huttlin EL (2017)	1
CCT2	1	CCT6B	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
FOXK2	9	TBL1Y	0	affinity chromatography technology	Li X (2015)	1
GPS2	0	TBL1X	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Zhang J (2002), Zhang J (2002), Zhang J (2002), Oberoi J (2011), Bi H (2014), Huttlin EL (2015), Huang J (2015), Huang J (2015), Huang J (2015), Huttlin EL (2017)	10
TCP1	0	CCT4	2	affinity chromatography technology, biochemical, biochemical, biochemical	Gingras AC (2005), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
NCOR2	12	GPS2	0	pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Oberoi J (2011), Oberoi J (2011), Bi H (2014), Huttlin EL (2015), Huttlin EL (2017)	5
TBL1Y	0	NCOR2	12	affinity chromatography technology	Huttlin EL (2017)	1
NCOR1	9	GPS2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Zhang J (2002), Zhang J (2002), Zhang J (2002), Zhang J (2002), Zhang J (2002), Huttlin EL (2015), Huttlin EL (2017)	9
TBL1Y	0	TUBA4A	1	affinity chromatography technology	Huttlin EL (2017)	1
SUZ12	0	CCT3	1	affinity chromatography technology	Cao Q (2014)	1
TBL1Y	0	CCT4	2	affinity chromatography technology	Huttlin EL (2017)	1
FOXK2	9	TBL1X	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Li X (2015), Shan L (2016), Shan L (2016), Shan L (2016), Shan L (2016)	5
CCT4	2	CCT3	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
TBL1Y	0	CAPN15	7	affinity chromatography technology	Huttlin EL (2017)	1
TBL1Y	0	CCT2	1	affinity chromatography technology	Huttlin EL (2017)	1
CCT5	1	CCT7	2	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
TBL1Y	0	NCOR1	9	affinity chromatography technology	Huttlin EL (2017)	1
HDAC3	5	TCP1	0	affinity chromatography technology, pull down, affinity chromatography technology	Guenther MG (2002), Guenther MG (2002), Joshi P (2013)	3
DNAJB4	0	DNAJB1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TBL1Y	0	INTS6	4	affinity chromatography technology	Huttlin EL (2017)	1
HDAC3	5	GPS2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang J (2002), Zhang J (2002), Zhang J (2002), Sanyal S (2007), Sanyal S (2007), Bantscheff M (2011), Joshi P (2013), Bi H (2014), Huttlin EL (2015), Huttlin EL (2017)	10
TBL1Y	0	FBXL18	5	affinity chromatography technology	Huttlin EL (2017)	1
CCT2	1	CCT4	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TBL1XR1	23	GPS2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Huttlin EL (2015), Huttlin EL (2017)	3
TUBA4A	1	CCT7	2	affinity chromatography technology	Huttlin EL (2017)	1
CCT5	1	CCT6A	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CCT5	1	CCT6B	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TCP1	0	CCT6B	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CCT3	1	CCT6B	2	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
FOXK2	9	NCOR1	9	affinity chromatography technology, affinity chromatography technology, biochemical	Li X (2015), Shan L (2016), Shan L (2016)	3
TCP1	0	CCT5	1	affinity chromatography technology, biochemical, biochemical	Gingras AC (2005), Havugimana PC (2012), Wan C (2015)	3
CCT7	2	CCT6A	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
TBL1Y	0	CCT6B	2	affinity chromatography technology	Huttlin EL (2017)	1
CCT2	1	CCT7	2	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
CCT4	2	CCT5	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TBL1X	1	NCOR2	12	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Yoon HG (2003), Guenther MG (2002), Li J (2000), Li J (2000), Li J (2000), Guenther MG (2000), Guenther MG (2000), Guenther MG (2000), Oberoi J (2011)	9
TCP1	0	CCT7	2	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Gingras AC (2005), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	5
TCP1	0	CCT6A	1	affinity chromatography technology, biochemical, biochemical	Gingras AC (2005), Havugimana PC (2012), Wan C (2015)	3
CCT3	1	CCT7	2	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
NCOR1	9	TBL1X	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Zhang J (2002), Zhang J (2002), Zhang J (2002), Zhang J (2002), Zhang J (2002), Li J (2000), Li J (2000), Guenther MG (2000), Choi HK (2008), Yoon HG (2005), Li J (2012), Lan X (2016)	17
CCT6B	2	CCT6A	1	biochemical	Wan C (2015)	1
HDAC3	5	CCT5	1	pull down, affinity chromatography technology	Guenther MG (2002), Joshi P (2013)	2
TBL1Y	0	DNAJB1	1	affinity chromatography technology	Huttlin EL (2017)	1
CCT2	1	CCT5	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
CCT4	2	CCT6B	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TBL1Y	0	DNAJB4	0	affinity chromatography technology	Huttlin EL (2017)	1
TBL1Y	0	CCT5	1	affinity chromatography technology	Huttlin EL (2017)	1
CCT4	2	CCT7	2	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
SUZ12	0	TBL1Y	0	affinity chromatography technology	Cao Q (2014)	1
CCT6B	2	CCT7	2	biochemical	Wan C (2015)	1
FOXK2	9	NCOR2	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Li X (2015), Shan L (2016), Shan L (2016), Shan L (2016)	4
CCT3	1	CCT6A	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
CCT5	1	CCT3	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
TBL1Y	0	MAP3K7	2	affinity chromatography technology	Huttlin EL (2017)	1
GPS2	0	FOXK2	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TBL1Y	0	CHD8	44	affinity chromatography technology	Huttlin EL (2017)	1
TBL1X	1	TBL1XR1	23	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Perissi V (2008), Choi HK (2008), Bantscheff M (2011), Lan X (2016)	4
TBL1Y	0	HDAC3	5	affinity chromatography technology	Huttlin EL (2017)	1
TBL1Y	0	TAB1	1	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K7	2	TAB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Channavajhala PL (2003), Ninomiya-Tsuji J (1999), Sakurai H (2000), Liu XY (2008), Li S (2011), Li S (2011), Ear T (2010), Singhirunnusorn P (2005), Prickett TD (2008), Kim SY (2012), Jiang Z (2002), Shibuya H (1996), Shibuya H (1996), Minoda Y (2009), Minoda Y (2009), Scholz R (2010), Scholz R (2010), Scholz R (2010), Kim SI (2009), Ge B (2003), Blonska M (2005), Kishimoto K (2000), Kishimoto K (2000), Zhu Y (2013), Liu R (2014), Chen TC (2014), Moon G (2015), Ninomiya-Tsuji J (2003), Min Y (2016), St-Denis N (2016), Zhang J (2017)	33
NCOR1	9	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, two hybrid, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, imaging technique, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Fischle W (2002), Fischle W (2002), Fischle W (2001), Zhang J (2002), Zhang J (2002), Zhang J (2002), Li J (2000), Li J (2000), Li J (2000), Li J (2000), Underhill C (2000), Alenghat T (2006), Jiang S (2006), Wen YD (2000), Wen YD (2000), Wen YD (2000), Liu XF (2004), Yoon HG (2005), Yoon HG (2005), Zhu P (2006), Bantscheff M (2011), Joshi P (2013)	26
TBL1Y	0	CCT3	1	affinity chromatography technology	Huttlin EL (2017)	1
DNAJB4	0	TBL1X	1	two hybrid	Wang J (2011)	1
HDAC3	5	TBL1XR1	23	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang J (2002), Choi HK (2008), Zhu P (2006), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Jung H (2017)	7
TBL1Y	0	TBL1X	1	affinity chromatography technology	Huttlin EL (2017)	1
HDAC3	5	CCT6A	1	affinity chromatography technology	Joshi P (2013)	1
HDAC3	5	CCT2	1	affinity chromatography technology	Joshi P (2013)	1
NCOR2	12	NCOR1	9	biochemical, two hybrid	Li J (2000), Korutla L (2005)	2
FOXK2	9	HDAC3	5	affinity chromatography technology, affinity chromatography technology, biochemical	Shan L (2016), Shan L (2016), Shan L (2016)	3
NCOR1	9	TBL1XR1	23	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Zhang J (2002), Choi HK (2008), Yoon HG (2005), Bantscheff M (2011), Jung H (2017)	10
TBL1Y	0	CCT7	2	affinity chromatography technology	Huttlin EL (2017)	1
CCT4	2	CCT6A	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
CCT2	1	CCT6A	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
TCP1	0	CCT3	1	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Gingras AC (2005), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	5
NCOR2	12	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Guenther MG (2000), Guenther MG (2000), Guenther MG (2000), Fischle W (2002), Fischle W (2002), Guenther MG (2002), Guenther MG (2002), Guenther MG (2002), Guenther MG (2002), Li J (2000), Li J (2000), Li J (2000), Underhill C (2000), Guenther MG (2000), Guenther MG (2000), Kim MY (2006), Wang L (2006), Torres-Padilla ME (2002), Codina A (2005), Wen YD (2000), Rajendran P (2011), Liu A (2006), Bantscheff M (2011), Joshi P (2013), Xu F (2016)	27
TBL1Y	0	GPS2	0	affinity chromatography technology	Huttlin EL (2017)	1
TBL1Y	0	TCP1	0	affinity chromatography technology	Huttlin EL (2017)	1
HDAC3	5	CCT7	2	affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Huttlin EL (2017)	2