PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTPN18	1	PSTPIP2	2	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
PTPN12	2	SHC1	0	two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Habib T (1994), Charest A (1996), Charest A (1996), Habib T (1994), Habib T (1994), Brehme M (2009), Li J (2013), St-Denis N (2016), St-Denis N (2016), Huttlin EL (2017)	10
PTPN22	3	GRB2	2	affinity chromatography technology	Hill RJ (2002)	1
LPXN	4	PSTPIP2	2	affinity chromatography technology	Huttlin EL (2017)	1
PTPN22	3	PSTPIP2	2	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
GRB2	2	PSTPIP2	2	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Bisson N (2011)	2
CDC5L	2	SHC1	0	affinity chromatography technology	Lleres D (2010)	1
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
PTPN12	2	PSTPIP2	2	affinity chromatography technology, bioid, affinity chromatography technology	St-Denis N (2016), St-Denis N (2016), Huttlin EL (2017)	3
SHC1	0	PSTPIP2	2	affinity chromatography technology	Brehme M (2009)	1
GRB2	2	PTPN18	1	affinity chromatography technology	Bisson N (2011)	1
VAPA	1	PTPN12	2	affinity chromatography technology	Huttlin EL (2017)	1
CDC5L	2	PSTPIP2	2	affinity chromatography technology	Lleres D (2010)	1
TRIM25	5	PSTPIP2	2	affinity chromatography technology	Choudhury NR (2017)	1
LPXN	4	PTPN12	2	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	GRB2	2	affinity chromatography technology	Choudhury NR (2017)	1
VAPA	1	PSTPIP2	2	affinity chromatography technology	Huttlin EL (2017)	1
PTPN12	2	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology	Charest A (1997), Charest A (1997), Bisson N (2011)	3
TRIM25	5	PTPN12	2	affinity chromatography technology	Choudhury NR (2017)	1