PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HIF1AN	0	CDC37	0	affinity chromatography technology	Rodriguez J (2016)	1
PTGES3	0	NR3C2	4	affinity chromatography technology	Freeman BC (2000)	1
MKS1	3	SUGT1	1	bioid	Gupta GD (2015)	1
EGLN3	0	STIP1	1	affinity chromatography technology	Rodriguez J (2016)	1
HSP90AA1	7	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Hein MY (2015)	2
HSP90AB1	2	PTGES3	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Wang J (2011), Taipale M (2014), Taipale M (2014), Weikl T (1999), Picard D (2006), Chadli A (2008), Karagoez GE (2011)	7
PTGES3	0	CDC37	0	pull down	Sun L (2012)	1
PTPN18	1	STIP1	1	affinity chromatography technology	Li X (2016)	1
HSP90AA1	7	USP19	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Gano JJ (2010), Lee JG (2014), Lee JG (2014), Lee JG (2014), He WT (2016), He WT (2016), He WT (2016)	7
HSP90AA1	7	YES1	1	affinity chromatography technology	Taipale M (2012)	1
EGFR	5	STIP1	1	protein complementation assay	Deribe YL (2009)	1
LAMP1	0	EGFR	5	imaging technique	Kitai Y (2017)	1
NR3C2	4	AIP	1	affinity chromatography technology	Schuelke JP (2010)	1
EGFR	5	YES1	1	affinity chromatography technology	Tong J (2014)	1
SUGT1	1	HSP90AB1	2	affinity chromatography technology	Niikura Y (2006)	1
ARNT	1	IKBKG	0	affinity chromatography technology	Bracken CP (2005)	1
HSP90AA1	7	RET	3	affinity chromatography technology	Taipale M (2012)	1
IKBKG	0	RET	3	pull down	Fenner BJ (2010)	1
EGFR	5	IKBKG	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
YES1	1	AIP	1	affinity chromatography technology	Huttlin EL (2017)	1
GDI2	1	STIP1	1	biochemical	Wan C (2015)	1
AIP	1	PPA1	1	biochemical	Wan C (2015)	1
EGLN3	0	AIP	1	affinity chromatography technology	Rodriguez J (2016)	1
PRAMEF17	0	PRAMEF10	0	affinity chromatography technology	Huttlin EL (2017)	1
OFD1	3	AIP	1	bioid	Gupta GD (2015)	1
AIP	1	CLEC7A	3	two hybrid	Wang J (2011)	1
EGLN3	0	CSNK2A1	15	affinity chromatography technology	Rodriguez J (2016)	1
DNAAF2	2	GNAQ	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARNT	1	AHR	3	two hybrid, pull down, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lindebro MC (1995), Lindebro MC (1995), Whitelaw M (1993), Yamaguchi Y (1995), Mimura J (1999), Mimura J (1999), Nakata A (2009), Elferink CJ (2001), Chen HS (2012), Zhang T (2010), Dougherty EJ (2008), Huttlin EL (2017), Singh SS (1996), Lando D (2000), Sadek CM (2000), Kumar MB (2001), Bacsi SG (1996), Klinge CM (1999), Reisz-Porszasz S (1994), Ohtake F (2007), Wang BJ (2013), Wang BJ (2013), Heid SE (2000)	23
PTPN18	1	AIP	1	affinity chromatography technology	St-Denis N (2016)	1
ARNT	1	AIP	1	pull down	Kazlauskas A (2001)	1
PREP	5	AIP	1	biochemical	Wan C (2015)	1
EGLN3	0	AHR	3	affinity chromatography technology	Rodriguez J (2016)	1
DUSP2	0	PTGES3	0	affinity chromatography technology	Li X (2016)	1
EGLN3	0	ARNT	1	affinity chromatography technology	Rodriguez J (2016)	1
AHR	3	AIP	1	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, pull down	Carver LA (1997), Carver LA (1997), Carver LA (1998), Petrulis JR (2000), Ma Q (1997), Ma Q (1997), Ma Q (1997), Dunham EE (2006), Berg P (2002), Kazlauskas A (2000)	10
PPARA	1	AIP	1	affinity chromatography technology, pull down	Sumanasekera WK (2003), Sumanasekera WK (2003)	2
EGFR	5	AIP	1	protein complementation assay	Deribe YL (2009)	1
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
HSP90AA1	7	NR3C2	4	affinity chromatography technology	Taipale M (2012)	1
SUGT1	1	AIP	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
DUSP2	0	AIP	1	affinity chromatography technology	Li X (2016)	1
IKBKG	0	HSP90AB1	2	affinity chromatography technology	Hein MY (2015)	1
HSP90AA1	7	SUGT1	1	pull down, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Zhang M (2008), Lee YT (2004), Lee YT (2004), Mayor A (2007), Spiechowicz M (2007), Spiechowicz M (2007), Gano JJ (2010), Niikura Y (2006), Niikura Y (2006), Niikura Y (2006), Liu XS (2012), Goral A (2016), Goral A (2016)	13
HIF1AN	0	AIP	1	affinity chromatography technology	Rodriguez J (2016)	1
AGO1	11	HSP90AA1	7	affinity chromatography technology	Fabian MR (2009)	1
CDC37	0	USP19	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
NEK8	3	STIP1	1	bioid	Gupta GD (2015)	1
TNNI3K	0	AIP	1	two hybrid	Zhao Y (2003)	1
EGLN3	0	CDC37	0	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	PPP6R2	3	affinity chromatography technology	Rodriguez J (2016)	1
PHLPP1	4	SUGT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Sowa ME (2009), Gao G (2013), St-Denis N (2016), St-Denis N (2016), Gangula NR (2013)	5
IKBKG	0	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Chen G (2002), Taipale M (2014), Taipale M (2014), Liu D (2014), Hein MY (2015), Hein MY (2015), Li J (2013)	8
CDK9	3	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
PHLPP1	4	AIP	1	bioid	St-Denis N (2016)	1
PRAMEF10	0	AIP	1	affinity chromatography technology	Huttlin EL (2017)	1
NEK8	3	CDC37	0	bioid	Gupta GD (2015)	1
PTPN1	2	AIP	1	affinity chromatography technology	Li X (2016)	1
OFD1	3	CDC37	0	bioid	Gupta GD (2015)	1
PPA1	1	STIP1	1	biochemical	Wan C (2015)	1
CSNK2A1	15	AIP	1	enzymatic study	Zhang M (2011)	1
EGFR	5	NADSYN1	3	affinity chromatography technology	Yao Z (2017)	1
HSP90AA1	7	NEK8	3	affinity chromatography technology	Taipale M (2012)	1
IKBKG	0	AIP	1	two hybrid	Ravasi T (2010)	1
ULK3	1	AIP	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSP90AA1	7	PTGES3	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down	McLaughlin SH (2002), Mollapour M (2010), Kovacs JJ (2005), Giommarelli C (2010), Tsutsumi S (2012), Lee YT (2004), Schuelke JP (2010), Sarkar S (2012), Gano JJ (2010), Zelin E (2012), Obermann WM (1998), Wang J (2011), Weaver AJ (2000), Donze O (2001), Shimamura T (2012), Chan CT (2008), Chan CT (2008), Graumann K (2000), Martinez-Yamout MA (2006), Chadli A (2010), Woo SH (2009), Woo SH (2009), Woo SH (2009), Ni L (2010), Chadli A (2008), Picard D (2006), Wochnik GM (2004), Woodford MR (2016), Scholz GM (2001), McLaughlin SH (2006), Sun L (2012), Woodford MR (2016), Lepvrier E (2015)	33
EGFR	5	PTPN18	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
PTGES3	0	AIP	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Schuelke JP (2010), Taipale M (2014), Taipale M (2014), Kazlauskas A (2000)	4
IRF7	2	AIP	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
PPP6R2	3	AIP	1	bioid	Couzens AL (2013)	1
AIP	1	NADSYN1	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
TDGF1	0	AIP	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGLN3	0	NR3C2	4	affinity chromatography technology	Rodriguez J (2016)	1
AIP	1	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Li J (2011), Schuelke JP (2010), Taipale M (2014), Taipale M (2014), Kazlauskas A (2000)	5
HIF1AN	0	PPP6R2	3	affinity chromatography technology	Rodriguez J (2016)	1
CDK9	3	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mak AB (2010), Varjosalo M (2013), Huttlin EL (2015), Li J (2013), Huttlin EL (2017)	5
HIF1AN	0	ARNT	1	affinity chromatography technology	Rodriguez J (2016)	1
CDK9	3	STIP1	1	affinity chromatography technology	Varjosalo M (2013)	1
AIP	1	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
EGFR	5	PTGES3	0	affinity chromatography technology	Tong J (2014)	1
AIP	1	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
EGFR	5	RET	3	two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Bhinge K (2017), Bhinge K (2017)	4
NPHP4	10	SUGT1	1	bioid	Gupta GD (2015)	1
CCDC120	1	AIP	1	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	TNNI3K	0	affinity chromatography technology	Taipale M (2012)	1
AIP	1	GDI2	1	biochemical	Havugimana PC (2012)	1
HSPA9	2	AIP	1	biochemical	Kristensen AR (2012)	1
MKS1	3	AIP	1	bioid	Gupta GD (2015)	1
EGLN3	0	CDK9	3	affinity chromatography technology	Rodriguez J (2016)	1
AIP	1	USP19	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
NEK8	3	SUGT1	1	bioid	Gupta GD (2015)	1
CSNK2A1	15	HSP90AB1	2	enzymatic study	Zhang M (2011)	1
HSP90AB1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Cheng MB (2010), Gano JJ (2010), Skarra DV (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Wan C (2015), Hein MY (2015)	8
OFD1	3	STIP1	1	bioid	Gupta GD (2015)	1
AIP	1	DNAAF2	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
ARNT	1	PTGES3	0	pull down	Kazlauskas A (2001)	1
AHR	3	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Ma Q (1997), Kazlauskas A (2000), Soshilov A (2008), Soshilov A (2008), Heid SE (2000)	5
AIP	1	GNAQ	1	pull down	Nakata A (2009)	1
EGFR	5	HSPA9	2	affinity chromatography technology, affinity chromatography technology	Li J (2013), Yao Z (2017)	2
PTGES3	0	STIP1	1	biochemical	Wan C (2015)	1
EGLN3	0	PTPN1	2	affinity chromatography technology	Rodriguez J (2016)	1
CDK9	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mak AB (2010), Taipale M (2012), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	5
PTPN1	2	EGFR	5	x-ray crystallography, enzymatic study, two hybrid, protein complementation assay, affinity chromatography technology, pull down, pull down	Sarmiento M (2000), Zhang ZY (1996), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Milarski KL (1993), Milarski KL (1993)	7
OFD1	3	SUGT1	1	bioid	Gupta GD (2015)	1
HSP90AB1	2	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Erazo T (2013), Erazo T (2013), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Hein MY (2015), Li J (2013), Karras GI (2017), Synoradzki K (2015)	10
NPHP4	10	STIP1	1	bioid	Gupta GD (2015)	1
CSNK2A1	15	PTPN1	2	enzymatic study	Jung EJ (1998)	1
AIP	1	PPA2	1	biochemical	Wan C (2015)	1
BIRC5	1	AIP	1	affinity chromatography technology	Vargiolu M (2009)	1
CDK9	3	CSNK2A1	15	affinity chromatography technology	Claudio PP (2006)	1
HSP90AA1	7	BIRC5	1	affinity chromatography technology	Plescia J (2005)	1
NPHP4	10	AIP	1	bioid	Gupta GD (2015)	1
NPHP4	10	HSP90AB1	2	bioid	Gupta GD (2015)	1
NPHP4	10	HSP90AA1	7	bioid	Gupta GD (2015)	1
EGFR	5	NPHP4	10	affinity chromatography technology	Yao Z (2017)	1
EGFR	5	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	6
PTGES3	0	AHR	3	pull down	Kazlauskas A (2000)	1
NEU4	1	AIP	1	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AB1	2	STIP1	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology	Havugimana PC (2012), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Wan C (2015), Chadli A (2008), Huttlin EL (2017)	8
EGFR	5	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavictoire SJ (2003), Foerster S (2013), Li J (2013), Li J (2013)	4
STIP1	1	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Scheufler C (2000), Johnson BD (1998), Mollapour M (2010), Li J (2011), Kundrat L (2010), Tsutsumi S (2012), Sarkar S (2012), Gano JJ (2010), Skarra DV (2011), Horibe T (2011), Brinker A (2002), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Graumann K (2000), Hein MY (2015), Chadli A (2010), Chadli A (2008), Woodford MR (2016), Scholz GM (2001), Sun L (2012), Woodford MR (2016), Huttlin EL (2017)	23
HSP90AA1	7	ARNT	1	affinity chromatography technology	Isaacs JS (2004)	1
AIP	1	EIF2S3	0	biochemical	Kristensen AR (2012)	1
AIP	1	GNA13	0	pull down, two hybrid	Nakata A (2009), Nakata A (2009)	2
RET	3	AIP	1	protein complementation assay, affinity chromatography technology, affinity chromatography technology	Vargiolu M (2009), Vargiolu M (2009), Vargiolu M (2009)	3
DUSP16	0	PTGES3	0	affinity chromatography technology	Li X (2016)	1
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
HSP90AA1	7	HSPA9	2	affinity chromatography technology	Gano JJ (2010)	1
AGO1	11	AIP	1	affinity chromatography technology, affinity chromatography technology	Li S (2014), Li S (2014)	2
AHR	3	GNA13	0	affinity chromatography technology	Nakata A (2009)	1
HSP90AA1	7	CSNK2A1	15	pull down, enzymatic study, enzymatic study, affinity chromatography technology	Miyata Y (1995), Muller P (2012), Zhang M (2011), Woo SH (2009)	4
EGLN3	0	DNAAF2	2	affinity chromatography technology	Rodriguez J (2016)	1
YES1	1	CDC37	0	affinity chromatography technology	Huttlin EL (2017)	1
IKBKG	0	EGLN3	0	affinity chromatography technology, affinity chromatography technology, pull down	Fu J (2013), Fu J (2013), Fu J (2013)	3
GDI2	1	PREP	5	biochemical	Wan C (2015)	1
AIP	1	STIP1	1	pull down	Li J (2011)	1
CSNK2A1	15	SUGT1	1	enzymatic study, enzymatic study	Liu XS (2012), Bansal PK (2009)	2
NEU4	1	SUGT1	1	affinity chromatography technology	Huttlin EL (2017)	1
NEK8	3	AIP	1	bioid	Gupta GD (2015)	1
PRAMEF17	0	AIP	1	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	CSNK2A1	15	affinity chromatography technology	Tong J (2014)	1
CDK9	3	AIP	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
ULK3	1	CDC37	0	affinity chromatography technology	Huttlin EL (2015)	1
AIP	1	LAMP1	0	biochemical	Kristensen AR (2012)	1
PPARA	1	HSP90AA1	7	affinity chromatography technology, pull down, two hybrid	Sumanasekera WK (2003), Sumanasekera WK (2003), Sumanasekera WK (2003)	3
EGFR	5	NEK8	3	affinity chromatography technology	Yao Z (2017)	1
DUSP16	0	AIP	1	affinity chromatography technology	Li X (2016)	1