PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	TP73	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Stindt MH (2015), Puca R (2011), De Laurenzi V (1998), Di Como CJ (1999)	4
PPP2R1A	8	CCNG1	1	affinity chromatography technology	Yadav L (2017)	1
PTPA	0	APP	1	pull down	Olah J (2011)	1
PAK5	0	LZTS2	4	two hybrid	Rual JF (2005)	1
NXF1	0	PTPA	0	affinity chromatography technology	Castello A (2012)	1
NXF1	0	TFIP11	5	affinity chromatography technology	Castello A (2012)	1
CUL4A	2	MDM2	2	affinity chromatography technology, affinity chromatography technology	Banks D (2006), Latini P (2011)	2
CDK2	0	GRN	2	affinity chromatography technology	Neganova I (2011)	1
CUL4B	8	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Jin J (2006), Wang H (2006), Higa LA (2006), Higa LA (2006), Kawajiri K (2009), Bennett EJ (2010), Havugimana PC (2012), Ji Q (2014), Wan C (2015), Hein MY (2015), Mo Y (2017), Mo Y (2017), Yang Y (2015), Yang Y (2015), Yang Y (2015), Higa LA (2006), Higa LA (2006), Ohtake F (2007), Ohtake F (2007), Ohtake F (2007)	23
CUL4A	2	TP53	0	affinity chromatography technology	Banks D (2006)	1
CCNG1	1	PLEKHA4	4	two hybrid	Wang J (2011)	1
TRIM25	5	PPP2R5E	4	affinity chromatography technology	Choudhury NR (2017)	1
PTPA	0	MDM2	2	affinity chromatography technology	Wei S (2012)	1
MOV10	6	UBR4	15	affinity chromatography technology	Castello A (2012)	1
TP53	0	UBR4	15	affinity chromatography technology	Fogeron ML (2013)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
TFIP11	5	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down	Ye M (2015), Ye M (2015), Ye M (2015)	3
CCNG1	1	LZTS2	4	two hybrid	Rolland T (2014)	1
CCNG1	1	LARP1B	0	affinity chromatography technology	Huttlin EL (2015)	1
PPP2R5C	3	APP	1	pull down	Olah J (2011)	1
CCNG1	1	SHKBP1	4	two hybrid	Wang J (2011)	1
CCNG1	1	TFIP11	5	two hybrid	Rolland T (2014)	1
ZZEF1	5	HECTD3	8	biochemical	Kristensen AR (2012)	1
CDKN2A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Zhang Y (2003), Zhang Y (2003), Rizos H (2003), Zhang Y (1998), Zhang Y (1998), Li L (2010), Li L (2010), Kamijo T (1998), Stott FJ (1998), Ivanov AA (2017)	10
NXF1	0	GRN	2	affinity chromatography technology	Castello A (2012)	1
CCNG1	1	CDK2	0	affinity chromatography technology	Piscopo DM (2008)	1
TRIM25	5	CUL4A	2	affinity chromatography technology	Choudhury NR (2017)	1
CCNG1	1	NFATC4	2	two hybrid	Wang J (2011)	1
CDK2	0	LMNA	2	affinity chromatography technology	Neganova I (2011)	1
CCNG1	1	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology	Zhao L (2003), Zhao L (2003), Ohtsuka T (2003)	3
MDM2	2	CUL4B	8	affinity chromatography technology	Latini P (2011)	1
MDM2	2	DDB1	6	affinity chromatography technology, affinity chromatography technology	Latini P (2011), Jacob AG (2014)	2
DDB1	6	NXF1	0	biochemical	Havugimana PC (2012)	1
TFIP11	5	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down	Ye M (2015), Ye M (2015), Ye M (2015)	3
HMBOX1	2	APP	1	pull down	Olah J (2011)	1
MDM2	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, protein complementation assay, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, unspecified method, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, far western blotting, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, biochemical, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, protein complementation assay, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, imaging technique, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, pull down, unspecified method, fluorescent resonance energy transfe, two hybrid, pull down	Li M (2003), Latonen L (2001), Zhang Y (2003), Zhang Y (2003), Kurki S (2003), Kurki S (2003), Freeman DJ (2003), Ito A (2002), Ito A (2002), Grossman SR (1998), Fang S (2000), Liu G (2000), Zhang Y (1998), Zhang Y (1998), Chen J (1993), Thut CJ (1997), Leung KM (2002), Wawrzynow B (2009), Ochocka AM (2009), Chen D (2009), Hedstroem E (2009), Brenkman AB (2008), Qiu W (2008), Qiu W (2008), Zhang Z (2008), Muller P (2008), Colaluca IN (2008), Colaluca IN (2008), Colaluca IN (2008), Tang Y (2008), Tang Y (2008), Lu X (2007), Lukashchuk N (2007), Lukashchuk N (2007), Lee JH (2007), Carter S (2007), Sasaki M (2007), Brooks CL (2007), Li L (2007), Becker K (2007), Zhao BX (2006), Zhao BX (2006), Abida WM (2007), Yang WH (2006), Ma J (2006), Wallace M (2006), Shimizu H (2006), Andrews P (2006), Yang J (2009), Zhu Z (2009), Wang C (2005), Higashitsuji H (2005), Higashitsuji H (2005), Yan C (2005), Vega FM (2004), Dai MS (2004), Dai MS (2004), Groenroos E (2004), Ohkubo S (2006), Sui G (2004), Di Stefano V (2004), Brignone C (2004), Katayama H (2004), Linares LK (2003), OKeefe K (2003), Wang W (2003), Blattner C (2002), Matt T (2004), Matt T (2004), Eyckerman S (2005), Shimizu H (2002), Shimizu H (2002), Migliorini D (2002), Gu J (2001), Sengupta S (2001), Chernov MV (2001), Cross B (2011), Cross B (2011), Cross B (2011), Buschmann T (2001), Nakamura S (2000), Rodriguez MS (2000), Rodriguez MS (2000), Geyer RK (2000), Zaika A (1999), Maki CG (1999), Chen L (2010), Chen L (2010), Lin RK (2010), Fuchs SY (1998), Xirodimas DP (2001), Fuchs SY (1998), Inoue T (2001), Wu L (2011), Du W (2009), Li DQ (2009), Illuzzi JL (2011), Oliver TG (2011), Kim MM (2007), Marchenko ND (2007), Vaseva AV (2009), Vaseva AV (2009), Lai KP (2010), Naderi EH (2011), Zdzalik M (2010), Singh RK (2007), Meng L (2011), Moore L (2007), Kim S (2010), Inoue Y (2011), Fraser JA (2010), Worrall EG (2009), Wu H (2011), Wang KS (2011), Wang KS (2011), Wang KS (2011), Izumi T (2010), Huang YF (2009), Tang J (2006), Tang J (2006), Fu X (2010), Fu X (2010), Shloush J (2011), Yadavilli S (2009), Stevenson LF (2007), Suzuki T (2010), Cheng Q (2009), Kulikov R (2010), Kulikov R (2010), Li L (2010), Li L (2010), Cheng Q (2011), Li D (2011), Nie J (2010), Demma M (2010), Sun XX (2011), Jung CR (2010), Jung CR (2010), Jung CR (2010), Jung CR (2010), Nishida T (2011), Li M (2011), Li M (2011), Amson R (2011), Amson R (2011), Bhatt P (2011), David Y (2011), Zhang Y (2010), Liu J (2010), Liu J (2010), Song MS (2008), Cummins JM (2004), Kim CK (2010), Kim CK (2010), Yan C (2010), Wang X (2011), Phillips A (2010), Phillips A (2010), Kang HN (2011), Kang HN (2011), Wang X (2004), Sionov RV (2001), Wei S (2012), Camus S (2012), Ding B (2012), Yang Z (2012), Yang Z (2012), Tripathi V (2007), Tripathi V (2007), Dai C (2011), Chen S (2012), Honda R (1997), Kinyamu HK (2003), Zhan C (2012), Zhan C (2012), Lee CW (2010), Zhou X (2012), Bouska A (2008), Wade M (2012), Ferreon JC (2009), Domenici F (2011), Uldrijan S (2007), Uldrijan S (2007), Stad R (2000), Stad R (2000), Banks D (2006), Banks D (2006), Bernal F (2010), Bernal F (2010), Jain AK (2012), Kane SA (2000), Tan Z (2000), Yang Z (2012), Wawrzynow B (2007), Wawrzynow B (2007), Wawrzynow B (2007), Hiramatsu K (2006), Bao-Lei T (2006), Kulikov R (2005), Yang Y (2005), Lindstroem MS (2007), Bech-Otschir D (2001), Li Y (2012), Gillotin S (2010), Burch L (2004), Liu WL (2001), OHagan HM (2004), OHagan HM (2004), Funari G (2009), Candeias MM (2008), Brew CT (2006), Wang J (2011), Calabro V (2002), Burch L (2004), Iyappan S (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Kurki S (2004), Tian LF (2006), Wang J (2006), Bae S (2012), Bae S (2012), Frazier DP (2012), Frazier DP (2012), Lew QJ (2012), Lew QJ (2012), Huart AS (2012), Li Z (2004), Balint E (1999), Balint E (1999), Funston G (2012), Dou X (2012), Sadagopan S (2012), Sadagopan S (2012), Dixit D (2012), Roxburgh P (2012), Xu L (2012), Drago-Ferrante R (2008), Li H (2009), Negorev D (2001), Wang X (2012), Wang X (2012), Wang X (2012), Boettger A (1997), Jung H (2008), Oliner JD (1992), Seemann S (2005), Kawai H (2007), Schuster K (2007), Dawson R (2003), DArcy P (2009), Schon O (2004), Schon O (2004), Hogan C (2008), Lottin-Divoux S (2005), Latini P (2011), Latini P (2011), Latini P (2011), McCoy MA (2003), Kussie PH (1996), Shieh SY (1997), Shieh SY (1997), Naski N (2009), Naski N (2009), Schon O (2002), Tamborini E (2001), Wade M (2006), Wade M (2006), Lohrum MA (2003), Garcia JF (2002), Garcia JF (2002), Kallen J (2009), Kulikov R (2006), Kulikov R (2006), Czarna A (2009), Czarna A (2009), Hu B (2007), Chi SW (2005), Yu GW (2006), Yu GW (2006), Saji S (2001), Chen L (1997), Zhang H (1998), Issaeva N (2004), Wade M (2008), Wade M (2008), Chen HF (2007), Chen HF (2007), Li HH (2004), Wang J (2011), Gu L (2009), Gu L (2009), Meng L (2008), Meng L (2008), Okamoto K (2006), Malaguarnera R (2008), Zhou M (2003), Zhou M (2003), Di Conza G (2012), Xirodimas DP (2004), Auger KR (2005), Li J (2011), Li J (2011), Li J (2011), Lee SJ (2007), Chau JF (2012), Lu X (2005), Mazars A (2010), Mazars A (2010), Mazars A (2010), Olson DC (1993), Picksley SM (1994), Issaeva N (2004), Issaeva N (2004), Zhang J (2012), Wen W (2013), Wen W (2013), Bursac S (2012), Yang Y (2013), Yang Y (2013), Landre V (2013), Pettersson S (2012), Thin TH (2007), Thin TH (2007), Piccinin S (2012), Shan B (2012), Caratozzolo MF (2012), Lui K (2013), Kobet E (2000), Lim KH (2010), Ranaweera RS (2013), Cui D (2013), Ebina M (2013), He Y (2013), He Y (2013), Siepe D (2009), Suh HW (2013), Zhan YA (2013), Wang J (2011), Hjerpe R (2010), Murray MF (2007), Jin L (2013), Jin L (2013), Zhang R (2013), Yan S (2013), Sun XX (2011), Heyne K (2014), Heyne K (2014), Bista M (2013), Jin J (2014), Mikawa T (2014), Qi M (2014), Cheng Q (2014), Zhang HH (2014), Perry ME (2000), Nishizaki M (2004), Sanchez-Aguilera A (2006), Chen YC (2013), Bertamino A (2013), Ding G (2013), Kubo N (2013), Kubo N (2013), Hsueh KW (2013), Kofod-Olsen E (2014), Fogeron ML (2013), Chang YS (2013), Gotoh T (2014), Gotoh T (2014), Oi N (2014), Corcoran CA (2009), Corcoran CA (2009), Ayroldi E (2014), Wu G (2014), Rajendra R (2004), Zhang J (2014), Lee MG (2014), Lee MG (2014), Freedman DA (1997), Freedman DA (1997), Saxena A (2006), Shi D (2009), Lohrum MA (2001), Lohrum MA (2001), Grossman SR (2003), Yan S (2013), Xirodimas DP (2004), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Saville MK (2004), Rodriguez MS (1999), Lui K (2013), Wu PY (2003), Pavithra L (2009), He Y (2013), Tan BX (2014), Huttlin EL (2015), Marcar L (2015), Borcherds W (2014), Borcherds W (2014), Li YC (2014), Ayroldi E (2014), Ling X (2014), Batuello CN (2015), Zhu N (2006), Mo XL (2015), Chen TC (2014), Stindt MH (2015), Caratozzolo MF (2014), Li X (2015), Saxena R (2016), Reed SM (2014), Du C (2016), Du C (2016), Du C (2016), Fraser JA (2015), Fraser JA (2015), Wu B (2015), Qin JJ (2015), Raza S (2015), Raza S (2015), Yamauchi T (2014), Yamauchi T (2014), Yamauchi T (2014), Shi Y (2010), Ahn HJ (2015), Lim KH (2015), Kang JH (2016), Chen J (2015), Liu X (2016), Yang P (2016), Yang P (2016), Liu D (2016), Liu D (2016), Liu D (2016), Datta D (2015), Reddy BA (2014), He X (2016), Shostak K (2014), Liu LJ (2016), Liu LJ (2016), Stegh AH (2010), Liu XH (2005), Medina-Medina I (2016), Medina-Medina I (2016), Kayama K (2017), Singh AK (2016), Liu WT (2016), Yue X (2016), Soares J (2015), Mukhopadhyay R (2016), Mukhopadhyay R (2016), Zhou X (2016), Zhou X (2016), Xie X (2016), Leao M (2015), Luo H (2016), Luo H (2016), Xie N (2016), Maeda R (2017), Maeda R (2017), Maeda R (2017), Sheng W (2017), Sheng W (2017), Liu M (2010), Huttlin EL (2017), Chauhan KM (2016), Goetz C (1999), Zhang J (2017), Unger T (1999), Liu Z (2004), Wu W (2015), Tan G (2017), Nomura K (2017), Lu W (2017), Lu W (2017), Hjerrild M (2001), Landre V (2017), Landre V (2017), Landre V (2017), Landre V (2017), Shangary S (2008), Shangary S (2008), Du WW (2017), Du WW (2017), Bista M (2013), Bista M (2013), Jin M (2017), LaRusch GA (2007), LaRusch GA (2007), Kurokawa M (2013), Ivanov AA (2017), Wong JH (2017), Wong JH (2017)	496
CCNG1	1	DDB1	6	affinity chromatography technology	Huttlin EL (2017)	1
CDK2	0	CUL4B	8	affinity chromatography technology	Neganova I (2011)	1
LMNA	2	CCNG1	1	two hybrid	Dittmer TA (2014)	1
TP53	0	DDB1	6	affinity chromatography technology	Fogeron ML (2013)	1
TP53	0	PPP2R5C	3	imaging technique, affinity chromatography technology	Chen TC (2014), Shouse GP (2011)	2
CDK2	0	TP53	0	enzymatic study, enzymatic study, imaging technique	Luciani MG (2000), Tsai CH (2009), Chen TC (2014)	3
TRIM25	5	SHKBP1	4	affinity chromatography technology	Choudhury NR (2017)	1
CCNG1	1	PPP2R5D	29	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DDB1	6	TP73	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Malatesta M (2012), Malatesta M (2012), Malatesta M (2012)	3
CCNG1	1	TP73	2	affinity chromatography technology	Ohtsuka T (2003)	1
CCNG1	1	TFAP2C	4	two hybrid	Wang J (2011)	1
MOV10	6	TFIP11	5	affinity chromatography technology	Castello A (2012)	1
CCNG1	1	UBR4	15	affinity chromatography technology	Huttlin EL (2017)	1
CUL4B	8	NXF1	0	biochemical	Wan C (2015)	1
CCNG1	1	CUL4B	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53	0	LMNA	2	affinity chromatography technology	Horikawa I (2014)	1
PPP2R5E	4	APP	1	pull down	Olah J (2011)	1
TRIM25	5	MDM2	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	PTPA	0	affinity chromatography technology	Choudhury NR (2017)	1
TP53	0	PPP2R1A	8	imaging technique, affinity chromatography technology	Chen TC (2014), Kikuchi J (2003)	2
CCNG1	1	CUL4A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
LMNA	2	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
CCNG1	1	HMBOX1	2	two hybrid	Rolland T (2014)	1
CCNG1	1	RBPMS	0	two hybrid	Rolland T (2014)	1
LMNA	2	TFIP11	5	bioid	Roux KJ (2012)	1
CCNG1	1	HECTD3	8	affinity chromatography technology	Huttlin EL (2015)	1
CCNG1	1	APP	1	pull down	Olah J (2011)	1
CCNG1	1	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
GAK	5	CCNG1	1	affinity chromatography technology, pull down	Kanaoka Y (1997), Kanaoka Y (1997)	2
GAK	5	APP	1	pull down	Olah J (2011)	1
HECTD3	8	TP53	0	two hybrid	Li Y (2013)	1
CCNG1	1	PAK5	0	two hybrid	Rolland T (2014)	1
CUL4A	2	PPP2R1A	8	affinity chromatography technology	Bennett EJ (2010)	1
MOV10	6	CCNG1	1	affinity chromatography technology	Castello A (2012)	1
NXF1	0	LMNA	2	affinity chromatography technology	Castello A (2012)	1
CCNG1	1	PPP2R5E	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NXF1	0	UBR4	15	affinity chromatography technology	Castello A (2012)	1
PPP2R1A	8	PPP2R5C	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Glatter T (2009), Dozier C (2004), Fogeron ML (2013), Wan C (2015), Hein MY (2015), Boldt K (2016), Shouse GP (2011), Yadav L (2017), Yadav L (2017)	10
TRIM25	5	CCNG1	1	affinity chromatography technology	Choudhury NR (2017)	1
MOV10	6	PTPA	0	affinity chromatography technology	Castello A (2012)	1
TP53	0	MOV10	6	affinity chromatography technology	Li X (2015)	1
MDM2	2	TP73	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Balint E (1999), Zeng X (1999), Zeng X (1999), Chen L (2010), Zdzalik M (2010), Kim JW (2008), Balint E (1999), Balint E (1999), Wang J (2011), Ongkeko WM (1999), Ongkeko WM (1999), Ongkeko WM (1999), Ongkeko WM (1999), Wu H (2015), Stindt MH (2015), Zhou X (2015), Zhou X (2015)	17
CCNG1	1	LTBP3	6	two hybrid	Wang J (2011)	1
CCNG1	1	GRN	2	two hybrid	Wang J (2011)	1
NXF1	0	CCNG1	1	affinity chromatography technology	Castello A (2012)	1
NXF1	0	KRT40	0	two hybrid	Rolland T (2014)	1
TRIM25	5	PPP2R5C	3	affinity chromatography technology	Choudhury NR (2017)	1
CDK2	0	TP73	2	enzymatic study	Gaiddon C (2003)	1
LARP1B	0	APP	1	pull down	Olah J (2011)	1
PPP2R1A	8	PTPA	0	affinity chromatography technology	Kong M (2009)	1
PTPA	0	CCNG1	1	affinity chromatography technology, two hybrid	Okamoto K (1996), Okamoto K (1996)	2
CCNG1	1	SPERT	0	two hybrid	Rolland T (2014)	1
CCNG1	1	ZZEF1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRN	2	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
KRTAP10-7	0	APP	1	pull down	Olah J (2011)	1
CUL4A	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Angers S (2006), Bennett EJ (2010), Bennett EJ (2010), Sertic S (2013)	5
TRIM25	5	GAK	5	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	PPP2R1A	8	affinity chromatography technology	Choudhury NR (2017)	1
PPP2R1A	8	PPP2R5E	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Glatter T (2009), Fogeron ML (2013), Wallach T (2013), Wan C (2015), Hein MY (2015), Boldt K (2016), Yadav L (2017), Yadav L (2017)	9
CUL4B	8	TP53	0	affinity chromatography technology	Thirunavukarasou A (2014)	1
PPP2R1A	8	PPP2R5D	29	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Glatter T (2009), Havugimana PC (2012), Fogeron ML (2013), Wallach T (2013), Wan C (2015), Hein MY (2015), Hein MY (2015), Boldt K (2016), Yadav L (2017), Yadav L (2017)	11
CCNG1	1	PNMA1	0	two hybrid	Rolland T (2014)	1
PPP2R5C	3	MDM2	2	affinity chromatography technology	Shouse GP (2011)	1
MOV10	6	LMNA	2	affinity chromatography technology	Castello A (2012)	1
TRIM25	5	LMNA	2	affinity chromatography technology	Choudhury NR (2017)	1
MDM2	2	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Zhang Y (2003), Zhang Y (2003), Zhang Y (2003), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Clark PA (2002), Clark PA (2002), Clark PA (2002), Pomerantz J (1998), Ivanchuk SM (2008), Wang C (2005), Wang X (2001), Midgley CA (2000), Shen J (2011), Li L (2010), Li L (2010), Li X (2011), Woods YL (2004), Bouska A (2008), Lindstroem MS (2007), Lohrum MA (2000), Wang J (2006), Wang J (2006), Wang J (2006), Drago-Ferrante R (2008), Schuster K (2007), Hogan C (2008), Rizos H (2000), Gargano B (2008), Kamijo T (1998), Wang S (2010), Jones R (2007), Stott FJ (1998), Lo D (2014), Pimkina J (2009), Blattner C (2002), Leslie PL (2015), Bothner B (2003), Ivanov AA (2017)	42
TRIM25	5	DDB1	6	affinity chromatography technology	Choudhury NR (2017)	1
NXF1	0	CDKN2A	1	affinity chromatography technology	Castello A (2012)	1
MDM2	2	APP	1	pull down	Miyamoto-Sato E (2010)	1
CUL4B	8	APP	1	pull down	Olah J (2011)	1
RBPMS	0	LZTS2	4	two hybrid	Rual JF (2005)	1
CCNG1	1	MDM2	2	pull down, affinity chromatography technology	Zhao L (2003), Zhao L (2003)	2
CCNG1	1	PPP2R5C	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Shouse GP (2011)	3
CCNG1	1	CDKN2A	1	pull down, affinity chromatography technology	Zhao L (2003), Zhao L (2003)	2
CCNG1	1	KRT40	0	two hybrid	Rolland T (2014)	1
PPP2R5E	4	PPP2R5C	3	biochemical	Wan C (2015)	1
CPSF4L	1	CCNG1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCNG1	1	TNIP1	1	affinity chromatography technology, two hybrid, two hybrid, two hybrid	Wang J (2011), Wang J (2011), Rolland T (2014), Yu H (2011)	4
TP53	0	TFAP2C	4	pull down	McPherson LA (2002)	1
MOV10	6	CDKN2A	1	affinity chromatography technology	Castello A (2012)	1