PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ATXN7	0	KALRN	7	two hybrid	Kahle JJ (2011)	1
NDEL1	2	KALRN	7	two hybrid	Camargo LM (2007)	1
RAC1	7	KALRN	7	pull down	Alam MR (1997)	1
DISC1	6	NDEL1	2	two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Morris JA (2003), Morris JA (2003), Ozeki Y (2003), Ozeki Y (2003), Ozeki Y (2003), Park YU (2010), Camargo LM (2007), Brandon NJ (2004), Brandon NJ (2004), Huttlin EL (2017)	10
KALRN	7	GNB1	4	affinity chromatography technology	Nishida K (1999)	1
DISC1	6	KALRN	7	two hybrid	Camargo LM (2007)	1
DISC1	6	CDC5L	2	two hybrid	Camargo LM (2007)	1
CACNA1A	21	KALRN	7	two hybrid	Kahle JJ (2011)	1
SPTAN1	9	KALRN	7	two hybrid	Oh Y (2007)	1
CDC5L	2	KALRN	7	two hybrid	Camargo LM (2007)	1
DISC1	6	GNB1	4	two hybrid	Camargo LM (2007)	1
FASLG	0	KALRN	7	unspecified method	Voss M (2009)	1
COIL	1	KALRN	7	two hybrid	Lim J (2006)	1
LNX1	7	KALRN	7	two hybrid	Guo Z (2012)	1
LNX1	7	NDEL1	2	affinity chromatography technology	Lenihan JA (2017)	1
CDC5L	2	SPTAN1	9	affinity chromatography technology	Lleres D (2010)	1
KALRN	7	SNCAIP	2	affinity chromatography technology, two hybrid, affinity chromatography technology	Tsai YC (2013), Tsai YC (2013), Tsai YC (2013)	3
DISC1	6	SPTAN1	9	two hybrid	Camargo LM (2007)	1
GFI1B	1	KALRN	7	two hybrid	Lim J (2006)	1
DTNBP1	1	KALRN	7	two hybrid	Camargo LM (2007)	1
COIL	1	LNX1	7	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
KALRN	7	DICER1	4	biochemical	Wan C (2015)	1
KALRN	7	PAM	2	two hybrid, two hybrid	Alam MR (1997), Alam MR (1997)	2