PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BNIP3	2	BNIP3L	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Venkatesan K (2009), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	6
SLC7A1	2	YIPF4	1	affinity chromatography technology	Huttlin EL (2017)	1
RPRM	1	FATE1	0	two hybrid	Rolland T (2014)	1
EMD	0	TRAF3IP3	0	two hybrid	Rolland T (2014)	1
LMNA	2	AGTRAP	1	two hybrid	Dittmer TA (2014)	1
BSND	3	FATE1	0	two hybrid	Rolland T (2014)	1
BTN2A2	2	FATE1	0	two hybrid	Rolland T (2014)	1
NDUFB11	0	FATE1	0	two hybrid	Rolland T (2014)	1
TM4SF4	0	FATE1	0	two hybrid	Rolland T (2014)	1
BNIP3	2	TMEM11	2	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005), Rolland T (2014), Huttlin EL (2017)	4
KCNS2	0	FATE1	0	two hybrid	Rolland T (2014)	1
CD79A	2	FATE1	0	two hybrid	Rolland T (2014)	1
MARCH2	2	FATE1	0	two hybrid	Rolland T (2014)	1
CD302	0	FATE1	0	two hybrid	Rolland T (2014)	1
EMD	0	FATE1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
OCLN	1	SYNE4	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
SLC7A1	2	FATE1	0	two hybrid	Rolland T (2014)	1
LMNA	2	BNIP3L	1	two hybrid	Dittmer TA (2014)	1
BCL2L2	0	CCDC155	2	two hybrid	Rolland T (2014)	1
SLC7A1	2	SYNGR2	0	affinity chromatography technology	Huttlin EL (2017)	1
FATE1	0	NRG4	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
GPR25	0	FATE1	0	two hybrid	Rolland T (2014)	1
TBP	0	FATE1	0	two hybrid	Lim J (2006)	1
FATE1	0	SYNPR	2	two hybrid	Rolland T (2014)	1
SLC7A1	2	TMEM11	2	affinity chromatography technology	Huttlin EL (2017)	1
LMNA	2	BCL2L2	0	two hybrid	Dittmer TA (2014)	1
YIPF4	1	FATE1	0	two hybrid	Rolland T (2014)	1
BNIP2	0	FATE1	0	two hybrid	Rolland T (2014)	1
CCDC70	0	FATE1	0	two hybrid	Rolland T (2014)	1
SYNDIG1	3	FATE1	0	two hybrid	Rolland T (2014)	1
FATE1	0	CCDC155	2	two hybrid	Rolland T (2014)	1
USP20	3	FATE1	0	two hybrid	Rolland T (2014)	1
SEC22A	0	SYNE4	1	two hybrid	Rolland T (2014)	1
LMNA	2	CCDC155	2	two hybrid	Dittmer TA (2014)	1
SEC22C	1	FATE1	0	two hybrid	Rolland T (2014)	1
BCL2L2	0	BIK	0	affinity chromatography technology, two hybrid, unspecified method	Holmgreen SP (1999), Rolland T (2014), Certo M (2006)	3
LMNA	2	TMEM11	2	two hybrid	Dittmer TA (2014)	1
DCTN5	1	FATE1	0	two hybrid	Rolland T (2014)	1
FATE1	0	SYNE4	1	two hybrid	Rolland T (2014)	1
LMNA	2	GPR25	0	two hybrid	Dittmer TA (2014)	1
FATE1	0	RNF183	0	two hybrid	Rual JF (2005)	1
SMIM14	0	FATE1	0	two hybrid	Yu H (2011)	1
FATE1	0	SNAP47	2	two hybrid	Rolland T (2014)	1
AQP9	1	FATE1	0	two hybrid	Rolland T (2014)	1
LMNA	2	RPRM	1	two hybrid	Dittmer TA (2014)	1
BCL2L2	0	FATE1	0	two hybrid	Rolland T (2014)	1
LMNA	2	FATE1	0	two hybrid	Dittmer TA (2014)	1
LMNA	2	SEC22A	0	two hybrid	Dittmer TA (2014)	1
MARCH2	2	SYNE4	1	two hybrid	Rolland T (2014)	1
LMNA	2	BNIP3	2	two hybrid	Dittmer TA (2014)	1
FATE1	0	SYNGR2	0	two hybrid	Yu H (2011)	1
LMNA	2	SYNGR1	3	two hybrid	Dittmer TA (2014)	1
LMNA	2	BTN2A2	2	two hybrid	Dittmer TA (2014)	1
BNIP3L	1	FATE1	0	two hybrid	Rolland T (2014)	1
TIMMDC1	0	FATE1	0	two hybrid	Rolland T (2014)	1
INPP5K	6	FATE1	0	two hybrid	Rolland T (2014)	1
SEC23B	0	FATE1	0	two hybrid	Rolland T (2014)	1
FATE1	0	TMEM74	1	two hybrid	Rolland T (2014)	1
BNIP3	2	FATE1	0	two hybrid	Rolland T (2014)	1
LMNA	2	USP20	3	two hybrid	Dittmer TA (2014)	1
TRAF3IP3	0	CCDC155	2	two hybrid	Rolland T (2014)	1
FATE1	0	NRSN1	0	two hybrid	Rolland T (2014)	1
AGTRAP	1	FATE1	0	two hybrid	Rolland T (2014)	1
LMNA	2	BNIP2	0	two hybrid	Dittmer TA (2014)	1
SEC22A	0	FATE1	0	two hybrid	Rolland T (2014)	1
MR1	1	FATE1	0	two hybrid	Rolland T (2014)	1
GPR25	0	CCDC155	2	two hybrid	Rolland T (2014)	1
SEC23B	0	SYNE4	1	two hybrid	Rolland T (2014)	1
USHBP1	1	FATE1	0	two hybrid	Rual JF (2005)	1
LMNA	2	TMEM74	1	two hybrid	Dittmer TA (2014)	1
SYNE4	1	SYNGR2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAF2	1	FATE1	0	two hybrid	Rual JF (2005)	1
SLC38A1	2	FATE1	0	two hybrid	Rolland T (2014)	1
BIK	0	FATE1	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TMEM11	2	FATE1	0	two hybrid	Yu H (2011)	1
PRRG2	3	FATE1	0	two hybrid	Rolland T (2014)	1
YIPF2	1	FATE1	0	two hybrid	Yu H (2011)	1
BNIP3L	1	TMEM11	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MARCH5	0	FATE1	0	two hybrid	Rolland T (2014)	1
TRAF3IP3	0	FATE1	0	two hybrid	Rolland T (2014)	1
SYNGR1	3	FATE1	0	two hybrid	Rolland T (2014)	1
MARCH2	2	CCDC155	2	two hybrid	Rolland T (2014)	1
LNPEP	1	FATE1	0	two hybrid	Rolland T (2014)	1
LMNA	2	SLC7A1	2	two hybrid	Dittmer TA (2014)	1
EMD	0	LMNA	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, bioid, bioid, affinity chromatography technology	Wilkinson FL (2003), Wilkinson FL (2003), Lattanzi G (2003), Sakaki M (2001), Sakaki M (2001), Clements L (2000), Holaska JM (2007), Roux KJ (2012), Kim DI (2014), Depreux FF (2015)	10
CSF2RA	1	FATE1	0	two hybrid	Rolland T (2014)	1
OCLN	1	FATE1	0	two hybrid	Yu H (2011)	1
PIN4	0	FATE1	0	two hybrid	Rolland T (2014)	1