PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DNMT3B	3	MBD4	1	pull down	Boland MJ (2008)	1
SUV39H1	0	KDM1A	2	two hybrid	Weimann M (2013)	1
MBD4	1	TRIM27	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid	Fukushige S (2006), Fukushige S (2006), Fukushige S (2006), Fukushige S (2006), Yu H (2011)	5
MLH1	6	MBD4	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Bellacosa A (1999), Bellacosa A (1999), Meng H (2014), Meng H (2014)	4
KIF20A	3	MBD4	1	affinity chromatography technology	Hein MY (2015)	1
UHRF1	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Achour M (2008), Achour M (2008), Achour M (2009), Unoki M (2004), Unoki M (2004), Ma H (2012)	6
MBD4	1	KDM1A	2	two hybrid	Weimann M (2013)	1
FAS	2	FADD	1	biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Gajate C (2005), MacFarlane M (1997), Pan G (1997), Huang B (1996), Huang B (1996), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Thomas LR (2002), Kumar A (2001), Lee EW (2012), Zhang M (2011), Huttlin EL (2015), Chen TC (2014), Jeong M (2017), Huttlin EL (2017), Kleber S (2008), Torii S (1999), Torii S (1999), Chang HY (1999)	20
USP7	14	UHRF1	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Felle M (2011), Felle M (2011), Felle M (2011), Felle M (2011), Qin W (2011), Qin W (2011), Ma H (2012), Ma H (2012), Ma H (2012), Chen H (2013), Nishiyama A (2013), Hein MY (2015), Zhang ZM (2015), Zhang ZM (2015), Zhang ZM (2015), Pfoh R (2015), Pfoh R (2015), Ferry L (2017)	18
UHRF1	3	DNMT3B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meilinger D (2009), Meilinger D (2009), Zhang J (2011)	3
DNMT3B	3	SIN3A	13	biochemical	Geiman TM (2004)	1
HDAC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Yao YL (2003), Fleischer TC (2003), Fleischer TC (2003), Yang L (2003), Grozinger CM (1999), Zhang J (2002), Zhang J (2002), You A (2001), Zhang Y (1999), Zhang Y (2002), Tong JK (1998), Hassig CA (1998), Yasui D (2002), Huang EY (2000), Huang EY (2000), Kuzmichev A (2002), Kuzmichev A (2002), Martinowich K (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006), Nakamura T (2002), Wei Q (2005), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Skowyra D (2001), Humphrey GW (2001), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Oh YM (2009), Wan C (2015), Hein MY (2015), Hsu DS (2014), Huttlin EL (2017)	45
MBD4	1	USP7	14	affinity chromatography technology, affinity chromatography technology	Meng H (2014), Meng H (2014)	2
DNMT3B	3	SUV39H1	0	pull down, pull down	Geiman TM (2004), Geiman TM (2004)	2
MBD4	1	SIN3A	13	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Kondo E (2005), Kondo E (2005), Kondo E (2005), Kondo E (2005), Kondo E (2005)	5
APC	5	USP7	14	affinity chromatography technology, affinity chromatography technology	Novellasdemunt L (2017), Novellasdemunt L (2017)	2
HDAC1	4	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Hakimi MA (2003), You A (2001), You A (2001), Shi YJ (2005), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Humphrey GW (2001), Godmann M (2007), Godmann M (2007), Terhune SS (2010), Godmann M (2010), Godmann M (2010), Wang Y (2009), Nicholson TB (2011), Li Q (2011), Cui S (2011), Cui S (2011), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Wang Q (2016), Huttlin EL (2017)	26
KDM1A	2	SIN3A	13	affinity chromatography technology	You A (2001)	1
HDAC1	4	TRIM27	2	imaging technique, affinity chromatography technology	Kato T (2009), Shimono Y (2003)	2
DNMT3B	3	HDAC1	4	biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Geiman TM (2004), Suzuki M (2006), Geiman TM (2004), Geiman TM (2004), Cai Y (2014)	5
NXF1	0	CSNK2B	5	affinity chromatography technology	Castello A (2012)	1
NXF1	0	SIN3A	13	affinity chromatography technology	Castello A (2012)	1
MBD4	1	HDAC1	4	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Kondo E (2005), Kondo E (2005), Kondo E (2005), Kondo E (2005), Kondo E (2005)	5
FAS	2	MBD4	1	two hybrid	Wang J (2011)	1
MBD4	1	FADD	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Screaton RA (2003), Screaton RA (2003), Screaton RA (2003)	3
HDAC1	4	CSNK2B	5	affinity chromatography technology	Joshi P (2013)	1
MOV10	6	MBD4	1	affinity chromatography technology	Castello A (2012)	1
USP7	14	SUV39H1	0	affinity chromatography technology, affinity chromatography technology	Mungamuri SK (2016), Mungamuri SK (2016)	2
CSNK2B	5	MBD4	1	two hybrid	Lehner B (2004)	1
SUV39H1	0	HDAC1	4	affinity chromatography technology, pull down	Vaute O (2002), Vaute O (2002)	2
SHMT2	3	MBD4	1	affinity chromatography technology	Castello A (2012)	1
UHRF1	3	SUV39H1	0	affinity chromatography technology, affinity chromatography technology	Babbio F (2012), Babbio F (2012)	2
MBD4	1	CDCA2	3	two hybrid	Vinayagam A (2011)	1
APC	5	CSNK2B	5	affinity chromatography technology, affinity chromatography technology	Homma MK (2002), Homma MK (2002)	2
APC	5	MBD4	1	affinity chromatography technology	Hein MY (2015)	1
NXF1	0	MBD4	1	affinity chromatography technology	Castello A (2012)	1
HTT	14	MBD4	1	two hybrid, affinity chromatography technology	Suter B (2013), Suter B (2013)	2
USP7	14	TRIM27	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hayes SD (2012), Hein MY (2015), Zaman MM (2013), Zaman MM (2013)	4
MBD4	1	UHRF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Meng H (2014), Meng H (2014), Meng H (2014), Meng H (2014), Meng H (2014)	5
MBD4	1	SUV39H1	0	two hybrid	Weimann M (2013)	1