PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FOXH1	1	IARS	5	affinity chromatography technology	Li X (2015)	1
FOXH1	1	MYEF2	2	affinity chromatography technology	Li X (2015)	1
FOXH1	1	SMAD3	1	affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology	Liu B (1999), Cui Q (2005), Cui Q (2005), Yoon SJ (2011), Cui Q (2005)	5
FOXG1	26	SMC4	2	affinity chromatography technology	Li X (2015)	1
1820	0	ARID3B	4	affinity chromatography technology	Huttlin EL (2017)	1
FOXH1	1	HEATR1	5	affinity chromatography technology	Li X (2015)	1
FOXH1	1	A2ML1	4	affinity chromatography technology	Li X (2015)	1
SMAD2	5	ELAC2	3	affinity chromatography technology, pull down	Noda D (2006), Noda D (2006)	2
SMAD4	9	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moren A (2003), Wotton D (1999), Mori N (2001), Wu JW (2002), Wu JW (2002), Nakao A (1997), Wicks SJ (2000), Wu JW (2001), Chen X (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Razani B (2001), Razani B (2001), Wang B (2008), Moren A (2005), Kurisaki K (2003), Prunier C (2003), Kato Y (2002), Xu J (2000), Wang L (2011), He W (2006), He W (2006), Dupont S (2009), Brown JD (1999), Pardali K (2000), Fu G (2011), Chen W (2007), Gao S (2009), Lin X (2003), Seo SR (2006), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Barrios-Rodiles M (2005), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Ali A (2013), Yamakawa N (2002), Yamakawa N (2002), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Zhou F (2017)	56
FOXG1	26	ADAR	1	affinity chromatography technology	Li X (2015)	1
FOXH1	1	DARS2	2	affinity chromatography technology	Li X (2015)	1
FOXG1	26	DDX39A	3	affinity chromatography technology	Li X (2015)	1
TCF3	7	COX7A2	1	affinity chromatography technology	Teachenor R (2012)	1
FOXG1	26	SCRIB	8	affinity chromatography technology	Li X (2015)	1
ELAC2	3	FOXH1	1	affinity chromatography technology	Noda D (2006)	1
LARS	1	VARS	5	biochemical	Havugimana PC (2012)	1
FOXH1	1	ZBTB33	1	affinity chromatography technology	Li X (2015)	1
FOXG1	26	ZBTB33	1	affinity chromatography technology	Li X (2015)	1
FOXH1	1	PA2G4	1	affinity chromatography technology	Li X (2015)	1
FOXH1	1	RCC1	2	affinity chromatography technology	Li X (2015)	1
FOXH1	1	GSDMA	0	affinity chromatography technology	Li X (2015)	1
SMAD2	5	TGIF1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wotton D (1999), Wotton D (1999), Wotton D (1999), Pessah M (2001)	4
TCF12	14	SMAD2	5	affinity chromatography technology	Yoon SJ (2011)	1
FOXG1	26	FOXH1	1	affinity chromatography technology, two hybrid	Dou C (2000), Ravasi T (2010)	2
FOXH1	1	SERPINB3	0	affinity chromatography technology	Li X (2015)	1
FOXH1	1	VARS	5	affinity chromatography technology	Li X (2015)	1
FOXH1	1	YARS	3	affinity chromatography technology	Li X (2015)	1
FOXH1	1	ARID3B	4	affinity chromatography technology	Li X (2015)	1
FOXH1	1	CCAR2	9	affinity chromatography technology	Li X (2015)	1
FOXH1	1	BTAF1	6	affinity chromatography technology	Li X (2015)	1
FOXH1	1	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wotton D (1999), Liu B (1999), Liu F (1997), Liu F (1997), Dou C (2000), Chen X (1997), Chen X (1997), Prunier C (2003), Yoon SJ (2011), Seo SR (2006), Cui Q (2005)	11
FOXH1	1	TCF3	7	affinity chromatography technology	Yoon SJ (2011)	1
FOXH1	1	UQCRC1	1	affinity chromatography technology	Li X (2015)	1
FOXG1	26	HEATR1	5	affinity chromatography technology	Li X (2015)	1
FOXG1	26	SYMPK	3	affinity chromatography technology	Li X (2015)	1
FOXG1	26	VARS	5	affinity chromatography technology	Li X (2015)	1
IARS	5	LARS	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
TCF12	14	TCF3	7	affinity chromatography technology	Yoon SJ (2011)	1
FOXH1	1	NISCH	11	affinity chromatography technology	Li X (2015)	1
1820	0	NISCH	11	affinity chromatography technology	Boldt K (2016)	1
FOXH1	1	HK2	3	affinity chromatography technology	Li X (2015)	1
FOXG1	26	PDS5A	5	affinity chromatography technology	Li X (2015)	1
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
FOXH1	1	DRAP1	2	affinity chromatography technology, pull down	Iratni R (2002), Iratni R (2002)	2
WAPL	1	PDS5A	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Nishiyama T (2010), Kueng S (2006), Kueng S (2006), Kueng S (2006), Kueng S (2006), Hein MY (2015)	7
FOXG1	26	SMPD4	3	affinity chromatography technology	Li X (2015)	1
FOXH1	1	1820	0	affinity chromatography technology	Li X (2015)	1
FOXH1	1	PDS5A	5	affinity chromatography technology	Li X (2015)	1
FOXH1	1	DDX39A	3	affinity chromatography technology	Li X (2015)	1
FOXH1	1	SCRIB	8	affinity chromatography technology	Li X (2015)	1
FOXH1	1	SMC4	2	affinity chromatography technology	Li X (2015)	1
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
TCF12	14	SMAD3	1	affinity chromatography technology	Yoon SJ (2011)	1
FOXH1	1	TGIF1	1	affinity chromatography technology	Wotton D (1999)	1
FOXH1	1	COX7A2	1	affinity chromatography technology	Li X (2015)	1
FOXG1	26	BTAF1	6	affinity chromatography technology	Li X (2015)	1
SMC4	2	CCAR2	9	biochemical	Kristensen AR (2012)	1
TCF12	14	FOXH1	1	affinity chromatography technology	Yoon SJ (2011)	1
FOXH1	1	LARS	1	affinity chromatography technology	Li X (2015)	1
FOXH1	1	SMAD4	9	pull down, two hybrid	Chen X (1997), Chen X (1997)	2
RCC1	2	TRMT2A	4	two hybrid	Vinayagam A (2011)	1
FOXH1	1	TRMT2A	4	affinity chromatography technology	Li X (2015)	1
SOX4	5	FOXH1	1	two hybrid	Jang SM (2015)	1
FOXH1	1	ADAR	1	affinity chromatography technology	Li X (2015)	1
FOXH1	1	SYMPK	3	affinity chromatography technology	Li X (2015)	1
FOXH1	1	SMPD4	3	affinity chromatography technology	Li X (2015)	1
FOXH1	1	WAPL	1	affinity chromatography technology	Li X (2015)	1
SMAD3	1	ELAC2	3	affinity chromatography technology	Noda D (2006)	1
TGIF1	1	SMAD3	1	affinity chromatography technology, pull down	Melhuish TA (2001), Liberati NT (2001)	2