PPI network (data source: BioGrid)

Symbol A GeneA coding DNM count Symbol B GeneB coding DNM count Interaction detection method Publication Evidence
TP53 0 RPA1 0 pull down, affinity chromatography technology, affinity chromatography technology, pull down Romanova LY (2004), Romanova LY (2004), Riva F (2001), Glanzer JG (2013) 4
HERC2 9 HOOK1 0 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
EIF3H 3 EIF3E 1 affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology Sowa ME (2009), Luke-Glaser S (2007), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017) 7
DNAJA1 2 HERC2 9 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
EIF3E 1 EIF3I 0 affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology Luke-Glaser S (2007), Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017) 4
XPA 1 RPA1 0 two hybrid, pull down, affinity chromatography technology Li L (1995), Li L (1995), Lange SS (2009) 3
HERC2 9 HLA-A 0 affinity chromatography technology, affinity chromatography technology Galligan JT (2015), Galligan JT (2015) 2
LRRK2 5 HERC2 9 affinity chromatography technology, affinity chromatography technology Imai Y (2015), Imai Y (2015) 2
BRCA1 7 EIF3H 3 affinity chromatography technology Ertych N (2016) 1
RNF166 0 NEURL4 3 affinity chromatography technology Huttlin EL (2015) 1
HERC2 9 KIF20A 3 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Galligan JT (2015), Galligan JT (2015), Hein MY (2015) 3
HERC2 9 EIF3H 3 affinity chromatography technology, affinity chromatography technology Galligan JT (2015), Galligan JT (2015) 2
HERC2 9 CCDC88A 3 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
UBE3A 4 MAPK6 1 affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology Martinez-Noel G (2012), Martinez-Noel G (2012), Rodriguez J (2016), Rodriguez J (2016) 4
TP53 0 UBC 7 affinity chromatography technology, affinity chromatography technology Ayroldi E (2014), Ke JY (2014) 2
CLSPN 1 HERC2 9 affinity chromatography technology, affinity chromatography technology Izawa N (2011), Zhu M (2014) 2
HERC2 9 DNAJB5 4 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
HERC2 9 RPA1 0 affinity chromatography technology, affinity chromatography technology Al-Hakim AK (2012), Elia AE (2015) 2
SIRT1 3 HERC2 9 affinity chromatography technology, affinity chromatography technology Bai B (2016), Bai B (2016) 2
BRCA1 7 HERC2 9 affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology Wu W (2010), Wu W (2010), Wu W (2010), Peng Y (2015) 4
USP20 3 HERC2 9 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology Sowa ME (2009), Galligan JT (2015), Yuan J (2014), Yuan J (2014), Yuan J (2014), Zhu M (2014), Zhu M (2014) 7
MUS81 1 EME1 3 pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down Ciccia A (2003), Fekairi S (2009), Matos J (2011), Zeng S (2009), Nair N (2014), Huttlin EL (2017), Gwon GH (2014), Zhou X (2016), Phung HTT (2018) 9
HERC2 9 EIF3M 0 affinity chromatography technology, affinity chromatography technology Galligan JT (2015), Galligan JT (2015) 2
HERC2 9 BIRC6 15 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Galligan JT (2015), Huttlin EL (2017) 3
MAPK6 1 UBC 7 affinity chromatography technology Rodriguez J (2016) 1
EIF3H 3 EIF3I 0 affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology Sowa ME (2009), Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017) 4
LRRK2 5 NEURL4 3 affinity chromatography technology, affinity chromatography technology Imai Y (2015), Imai Y (2015) 2
EIF3I 0 HERC2 9 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Galligan JT (2015) 2
EIF3M 0 UBE2N 1 affinity chromatography technology Boldt K (2016) 1
UBC 7 HERC2 9 affinity chromatography technology, pull down Rendtlew Danielsen J (2012), Zhang X (2017) 2
PSMD14 3 NCOA4 4 affinity chromatography technology Hein MY (2015) 1
BRCA1 7 UBE3A 4 pull down Wu-Baer F (2003) 1
NEURL4 3 MAPK6 1 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Al-Hakim AK (2012), Varjosalo M (2013), Huttlin EL (2017), Rodriguez J (2016) 4
BRCA1 7 KIF20A 3 affinity chromatography technology, affinity chromatography technology Hill SJ (2014), Ertych N (2016) 2
UBC 7 ZFYVE9 5 pull down Kostaras E (2012) 1
NCOA4 4 NEURL4 3 affinity chromatography technology Huttlin EL (2017) 1
HERC2 9 FDFT1 1 affinity chromatography technology, affinity chromatography technology Galligan JT (2015), Galligan JT (2015) 2
PCM1 5 CEP170 4 affinity chromatography technology, bioid, bioid Gupta GD (2015), Gupta GD (2015), Gupta GD (2015) 3
HERC2 9 STK11 2 affinity chromatography technology, affinity chromatography technology, enzymatic study Bai B (2016), Bai B (2016), Bai B (2016) 3
XPA 1 HERC2 9 affinity chromatography technology, enzymatic study Lee TH (2012), Lee TH (2012) 2
UBE3A 4 NEURL4 3 affinity chromatography technology, biochemical Martinez-Noel G (2012), Martinez-Noel G (2012) 2
HERC2 9 CEP170 4 affinity chromatography technology, affinity chromatography technology Al-Hakim AK (2012), Galligan JT (2015) 2
HERC2 9 RABEP1 4 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
RNF8 2 UBC 7 enzymatic study, enzymatic study, enzymatic study Feng L (2012), Hodge CD (2015), Ho YK (2015) 3
HERC2 9 EIF3E 1 affinity chromatography technology, affinity chromatography technology Galligan JT (2015), Galligan JT (2015) 2
EIF3I 0 EIF3M 0 biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Havugimana PC (2012), Huttlin EL (2015), Luke-Glaser S (2007), Huttlin EL (2017) 4
NEURL4 3 RPA1 0 affinity chromatography technology Al-Hakim AK (2012) 1
USP16 0 HERC2 9 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Sowa ME (2009), Zhang Z (2014), Zhang Z (2014), Huttlin EL (2017) 4
SIRT1 3 STK11 2 enzymatic study, affinity chromatography technology, affinity chromatography technology Lan F (2008), Lan F (2008), Bai B (2016) 3
UBC 7 PSMD14 3 affinity chromatography technology, pull down Matsumoto M (2005), Zhang X (2017) 2
USP20 3 CLSPN 1 affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study Yuan J (2014), Yuan J (2014), Yuan J (2014), Yuan J (2014), Zhu M (2014), Zhu M (2014), Zhu M (2014) 7
HERC2 9 RNF115 1 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
DBNL 2 NEURL4 3 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
BRCA1 7 RPA1 0 affinity chromatography technology, imaging technique, affinity chromatography technology Suhasini AN (2011), Mok MT (2010), Tian F (2013) 3
SPZ1 0 HERC2 9 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
HERC2 9 EME1 3 affinity chromatography technology, affinity chromatography technology Galligan JT (2015), Galligan JT (2015) 2
MAPK6 1 TP53 0 affinity chromatography technology Rodriguez J (2016) 1
EIF3E 1 EIF3M 0 biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Luke-Glaser S (2007), Luke-Glaser S (2007), Huttlin EL (2017) 6
RNF166 0 HERC2 9 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
USP20 3 EIF3E 1 affinity chromatography technology Sowa ME (2009) 1
BRCA1 7 EIF3I 0 affinity chromatography technology Ertych N (2016) 1
UBE2N 1 HERC2 9 affinity chromatography technology, pull down Bekker-Jensen S (2010), Bai B (2016) 2
SIRT1 3 TP53 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology Zhao W (2008), Liu X (2011), Inoue Y (2011), Jain AK (2012), Langley E (2002), Langley E (2002), Langley E (2002), Kim JE (2008), Kim JE (2008), Kim EJ (2007), Kim EJ (2007), Busch F (2012), Busch F (2012), Hasegawa K (2008), Hasegawa K (2008), Hasegawa K (2008), Zannini L (2012) 17
USP20 3 MAPK6 1 affinity chromatography technology, enzymatic study Mathien S (2017), Mathien S (2017) 2
KIF20A 3 NEURL4 3 affinity chromatography technology Hein MY (2015) 1
PHKG2 2 PHKB 0 affinity chromatography technology, affinity chromatography technology Hein MY (2015), Huttlin EL (2017) 2
USP16 0 UBC 7 unspecified method, enzymatic study, pull down, unspecified method, pull down, pull down Pai MT (2007), Faesen AC (2011), Kovacs JJ (2004), Ernst A (2013), Zhang X (2017), Kwasna D (2018) 6
PSMD14 3 UBE3A 4 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Wang X (2007), Jacobson AD (2014), Jacobson AD (2014), Hein MY (2015) 4
BRCA1 7 UBE2N 1 two hybrid, x-ray crystallography, pull down, two hybrid, pull down Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Christensen DE (2007), David Y (2011) 5
NEURL4 3 PCM1 5 affinity chromatography technology Al-Hakim AK (2012) 1
MAPK6 1 PSMD14 3 affinity chromatography technology Rodriguez J (2016) 1
TP53 0 STK11 2 affinity chromatography technology, fluorescent resonance energy transfe Karuman P (2001), Ivanov AA (2017) 2
LRRK2 5 DNAJA1 2 affinity chromatography technology Sen S (2009) 1
UBE3A 4 HERC2 9 affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology Martinez-Noel G (2012), Martinez-Noel G (2012), Kuehnle S (2011), Kuehnle S (2011), Galligan JT (2015) 5
UBE3A 4 UBC 7 enzymatic study, enzymatic study, pull down Schwarz SE (1998), Ronchi VP (2013), Zhang X (2017) 3
UBE3A 4 PHKG2 2 affinity chromatography technology Jung SY (2005) 1
KIF20A 3 SSSCA1 0 affinity chromatography technology Hein MY (2015) 1
NEURL4 3 SSSCA1 0 affinity chromatography technology Al-Hakim AK (2012) 1
DBNL 2 HERC2 9 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Ewing RM (2007), Huttlin EL (2015), Huttlin EL (2017) 3
UBC 7 UBE2N 1 affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001) 12
TP53 0 UBE2N 1 pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study Laine A (2006), Laine A (2006), Laine A (2006), Topisirovic I (2009), Topisirovic I (2009) 5
MAPK6 1 SSSCA1 0 affinity chromatography technology Rodriguez J (2016) 1
HERC2 9 SSSCA1 0 affinity chromatography technology, affinity chromatography technology Al-Hakim AK (2012), Huttlin EL (2017) 2
MAPK6 1 NCOA4 4 affinity chromatography technology Rodriguez J (2016) 1
MAPK6 1 DNAJA1 2 affinity chromatography technology Rodriguez J (2016) 1
BRCA1 7 EIF3E 1 affinity chromatography technology Ertych N (2016) 1
UBE2N 1 RNF8 2 two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, pull down, two hybrid Markson G (2009), Bekker-Jensen S (2010), Lok GT (2011), Lok GT (2011), Campbell SJ (2012), Plans V (2006), Plans V (2006), Huen MS (2008), Zhang X (2013), Guerra-Rebollo M (2012), Zhao H (2014), Hodge CD (2015), Ho YK (2015), Weber E (2017), Weber E (2017), Schimmack G (2017) 16
DBNL 2 USP20 3 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
PCM1 5 KIF20A 3 affinity chromatography technology Gupta GD (2015) 1
MAPK6 1 HERC2 9 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Varjosalo M (2013), Huttlin EL (2017), Rodriguez J (2016) 3
TP53 0 UBE3A 4 pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study Nuber U (1998), Huibregtse JM (1993), Yang Y (2007), Kim HC (2009), Scheffner M (1994), Mishra A (2012), Burch L (2004), Ro HS (2006), Nakagawa S (2000), Nakagawa S (2000), Nakagawa S (2000), Huibregtse JM (1991), Honda R (1997), Huibregtse JM (1995), Martinez-Zapien D (2016), Martinez-Zapien D (2016), Rolfe M (1995) 17
BRCA1 7 PSMD14 3 affinity chromatography technology Ertych N (2016) 1
SPZ1 0 NEURL4 3 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
HERC2 9 PCM1 5 affinity chromatography technology, affinity chromatography technology Galligan JT (2015), Gupta GD (2015) 2
HERC2 9 MUS81 1 affinity chromatography technology, affinity chromatography technology Galligan JT (2015), Galligan JT (2015) 2
HERC2 9 TP53 0 affinity chromatography technology, affinity chromatography technology, pull down, pull down Cubillos-Rojas M (2014), Cubillos-Rojas M (2014), Cubillos-Rojas M (2014), Bai B (2016) 4
TP53 0 FTH1 0 affinity chromatography technology Fogeron ML (2013) 1
TP53 0 BIRC6 15 affinity chromatography technology, affinity chromatography technology Tang W (2015), Tang W (2015) 2
UBC 7 EIF3H 3 affinity chromatography technology Matsumoto M (2005) 1
UBC 7 DNAJA1 2 affinity chromatography technology Matsumoto M (2005) 1
DBNL 2 UBE3A 4 biochemical Kristensen AR (2012) 1
MAPK6 1 HLA-A 0 affinity chromatography technology Rodriguez J (2016) 1
HERC2 9 BICD2 0 affinity chromatography technology, affinity chromatography technology Galligan JT (2015), Galligan JT (2015) 2
UBC 7 BIRC6 15 affinity chromatography technology Matsumoto M (2005) 1
RNF115 1 UBC 7 two hybrid, pull down, protein complementation assay, pull down Amemiya Y (2008), Amemiya Y (2008), Amemiya Y (2008), Amemiya Y (2008) 4
PCM1 5 BICD2 0 bioid Gupta GD (2015) 1
RPA1 0 UBC 7 affinity chromatography technology Marechal A (2014) 1
USP16 0 NEURL4 3 affinity chromatography technology Huttlin EL (2017) 1
HERC2 9 ZFYVE9 5 affinity chromatography technology, affinity chromatography technology Galligan JT (2015), Galligan JT (2015) 2
NEURL4 3 CEP170 4 affinity chromatography technology Al-Hakim AK (2012) 1
RNF115 1 UBE2N 1 pull down Smith CJ (2013) 1
BRCA1 7 TP53 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015) 17
MAPK6 1 CEP170 4 affinity chromatography technology Rodriguez J (2016) 1
TP53 0 DNAJA1 2 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Fogeron ML (2013), Horikawa I (2014), Parrales A (2016), Parrales A (2016) 4
HERC2 9 NEURL4 3 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Al-Hakim AK (2012), Al-Hakim AK (2012), Al-Hakim AK (2012), Al-Hakim AK (2012), Galligan JT (2015) 5
NCOA4 4 FTH1 0 affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology Mancias JD (2015), Mancias JD (2015), Huttlin EL (2017), Goodwin JM (2017) 4
UBC 7 BRCA1 7 pull down, enzymatic study Sobhian B (2007), Zhao GY (2007) 2
TP53 0 PHKB 0 affinity chromatography technology Fogeron ML (2013) 1
MAPK6 1 HOOK1 0 affinity chromatography technology Rodriguez J (2016) 1
UBC 7 HLA-A 0 affinity chromatography technology Matsumoto M (2005) 1
RNF8 2 USP16 0 affinity chromatography technology, affinity chromatography technology Zhang Z (2014), Zhang Z (2014) 2
CCDC88A 3 EME1 3 affinity chromatography technology Hein MY (2015) 1
USP20 3 NEURL4 3 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Sowa ME (2009), Li J (2013), Li J (2013) 3
PSMD14 3 HERC2 9 affinity chromatography technology, affinity chromatography technology Jacobson AD (2014), Jacobson AD (2014) 2
HERC2 9 PHKB 0 affinity chromatography technology, affinity chromatography technology Galligan JT (2015), Galligan JT (2015) 2
CLSPN 1 BRCA1 7 affinity chromatography technology, affinity chromatography technology, enzymatic study Lin SY (2004), Lin SY (2004), Sato K (2012) 3
EIF3H 3 EIF3M 0 affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology Sowa ME (2009), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Luke-Glaser S (2007), Huttlin EL (2017) 6
UBE3A 4 PHKB 0 affinity chromatography technology Jung SY (2005) 1
LRRK2 5 TP53 0 enzymatic study, affinity chromatography technology, affinity chromatography technology Ho DH (2015), Ho DH (2015), Ho DH (2015) 3
HERC2 9 NCOA4 4 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology Galligan JT (2015), Mancias JD (2015), Mancias JD (2015), Mancias JD (2015), Huttlin EL (2017) 5
BRCA1 7 DNAJA1 2 two hybrid, affinity chromatography technology, affinity chromatography technology Woods NT (2012), Hill SJ (2014), Ertych N (2016) 3
HERC2 9 FTH1 0 affinity chromatography technology, affinity chromatography technology Galligan JT (2015), Galligan JT (2015) 2
RNF8 2 HERC2 9 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology Bekker-Jensen S (2010), Bekker-Jensen S (2010), Bekker-Jensen S (2010), Rendtlew Danielsen J (2012), Guerra-Rebollo M (2012), Zhang Z (2014) 6
HERC2 9 PHKG2 2 affinity chromatography technology, affinity chromatography technology Galligan JT (2015), Galligan JT (2015) 2
RNF166 0 SSSCA1 0 affinity chromatography technology Huttlin EL (2015) 1
FBXL5 3 HERC2 9 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Moroishi T (2014), Moroishi T (2014), Moroishi T (2014), Huttlin EL (2017) 4
TP53 0 PHKG2 2 affinity chromatography technology Fogeron ML (2013) 1
FBXL5 3 NEURL4 3 affinity chromatography technology Huttlin EL (2017) 1
BRCA1 7 EIF3M 0 affinity chromatography technology Ertych N (2016) 1
FBXL5 3 MUS81 1 affinity chromatography technology Tan MK (2013) 1
HERC2 9 HERC2 9 enzymatic study, enzymatic study Sheng Y (2012), Zhang W (2016) 2
UBC 7 RABEP1 4 pull down, pull down Nathan JA (2013), Zhang X (2017) 2
UBC 7 USP20 3 pull down Kwasna D (2018) 1
HERC2 9 HM13 0 affinity chromatography technology, affinity chromatography technology Galligan JT (2015), Galligan JT (2015) 2