PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAP3K7	2	FYB1	0	affinity chromatography technology, affinity chromatography technology	Srivastava R (2010), Srivastava R (2010)	2
TRAF2	1	MAPK9	3	imaging technique	Chen TC (2014)	1
BIRC3	1	IKBKB	1	imaging technique	Chen TC (2014)	1
TRAF6	0	BCL10	0	affinity chromatography technology	Bidere N (2006)	1
RNF181	0	UBE2N	1	pull down	Pedersen SM (2015)	1
ELAVL1	0	CSNK1A1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
IKBKB	1	MAP3K7	2	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hofer-Warbinek R (2000), Wu ZH (2010), Wu ZH (2010), Prickett TD (2008), Fan YH (2011), Neil JR (2008), Wu X (2007), Shambharkar PB (2007), Shambharkar PB (2007), Niu J (2013), Yao F (2015), Yao F (2015), Mei ZZ (2016), Zheng C (2015)	14
MAP3K7	2	ATM	9	affinity chromatography technology	Yang Y (2011)	1
ATM	9	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wu ZH (2006), Wu ZH (2006), Rosato RR (2010), Wu ZH (2008), Wu ZH (2008), Mohanty S (2014)	6
ELAVL1	0	CDK9	3	affinity chromatography technology	Abdelmohsen K (2009)	1
BCL10	0	CAMK2G	4	affinity chromatography technology	Oruganti SR (2011)	1
MAPK9	3	MAP2K7	5	unspecified method, enzymatic study	Ho DT (2006), Enomoto A (2003)	2
RNF31	3	TRAF2	1	affinity chromatography technology	Schaeffer V (2014)	1
IKBKG	0	PPP2CA	7	affinity chromatography technology	Kray AE (2005)	1
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
BCL10	0	KRT33B	1	affinity chromatography technology	Ewing RM (2007)	1
NFKBIA	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2015)	1
IKBKB	1	TNFRSF1A	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Zhang SQ (2000), Chaudhary PM (2000), Fan YH (2011), Park KJ (2002), Guan YJ (2011), Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008), Chen TC (2014)	9
MAP3K7	2	NFKBIA	0	enzymatic study	Kanayama A (2004)	1
IKBKG	0	NFKBIA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Stempin CC (2011), Pringle LM (2011), Wu CJ (2006), Higashimoto T (2008), Ducut Sigala JL (2004), Shibata Y (2011), Liu L (2002), Xiao G (2000), Chan H (2005), Funakoshi-Tago M (2005), Wu X (2007), Kato T (2008), Niu J (2011), Neumann M (2011), Keusekotten K (2013), Fu J (2013), Dan HC (2008), Criollo A (2010), Hein MY (2015), Baratchian M (2016)	20
BCL10	0	UBE2N	1	pull down	Zhou H (2004)	1
UBE2N	1	BIRC3	1	two hybrid, pull down, two hybrid	van Wijk SJ (2009), Wu CJ (2006), Schimmack G (2017)	3
BIRC2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology	Goncharov T (2013), Schaeffer V (2014)	2
PRKCQ	3	MALT1	1	affinity chromatography technology	Shambharkar PB (2007)	1
PPP2R1A	8	AKT1	1	enzymatic study	Lin K (2012)	1
ELAVL1	0	OTULIN	0	affinity chromatography technology	Abdelmohsen K (2009)	1
BIRC3	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006), Yang W (2014), Yang W (2014)	4
UBE2V2	0	XIAP	0	two hybrid	Markson G (2009)	1
SLC9A3R1	2	AKT1	1	affinity chromatography technology, enzymatic study	Song GJ (2015), Song GJ (2015)	2
MAP3K7	2	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu XY (2008), Jiang Z (2002), Jiang Z (2002), Lee HJ (2012), Yao J (2007)	5
PPP2CA	7	CARD11	4	enzymatic study	Eitelhuber AC (2011)	1
PRKCQ	3	FYB1	0	affinity chromatography technology	Srivastava R (2010)	1
DPP4	3	BCL10	0	affinity chromatography technology	Ohnuma K (2007)	1
BCL10	0	CARD14	6	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Bertin J (2001), Bertin J (2001), Bertin J (2001), Howes A (2016)	4
ELAVL1	0	SRSF1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PRKCQ	3	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Srivastava R (2010), Srivastava R (2010), Shambharkar PB (2007)	3
BCL10	0	IL15RA	2	two hybrid	Wang J (2011)	1
DPP4	3	IKBKB	1	affinity chromatography technology	Ohnuma K (2007)	1
BCL10	0	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Yoneda T (2000), Yoneda T (2000), Yoneda T (2000), Yui D (2001), Rolland T (2014)	5
IRAK1	1	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Vig E (2001), Windheim M (2008)	2
TRAF2	1	UBE2V2	0	pull down	Sasai M (2010)	1
MALT1	1	IKBKB	1	affinity chromatography technology	Bidere N (2009)	1
CSNK1A1	1	MALT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Carvalho G (2010), Hatchi EM (2014), Bidere N (2009), Bidere N (2009)	4
XIAP	0	AKT1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique	Dan HC (2004), Dan HC (2004), Pramanik KC (2013), Pramanik KC (2013), Chen TC (2014)	5
TRADD	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Park YC (2000), Tsao DH (2000), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Vince JE (2009), Jang HD (2001), Park KJ (2003), Lin B (2016)	12
CSNK1A1	1	BCL10	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Carvalho G (2010), Hatchi EM (2014), Bidere N (2009)	3
TRAF2	1	XIAP	0	affinity chromatography technology	Vince JE (2009)	1
FYB1	0	CARD11	4	affinity chromatography technology	Srivastava R (2010)	1
IRAK1	1	BTRC	1	affinity chromatography technology	Cui W (2012)	1
CHUK	5	CARD11	4	affinity chromatography technology, imaging technique	McCully RR (2008), Sommer K (2005)	2
TRAF6	0	XIAP	0	affinity chromatography technology, two hybrid, imaging technique	Sanna MG (2002), Woodsmith J (2012), Chen TC (2014)	3
XPO1	8	ATG5	0	affinity chromatography technology	Kirli K (2015)	1
CHUK	5	TRAF6	0	affinity chromatography technology	Kishida S (2005)	1
BCL10	0	CDK9	3	two hybrid	Wang J (2011)	1
IRAK1	1	BCL10	0	pull down	Dong W (2006)	1
CARD11	4	DPP4	3	affinity chromatography technology, affinity chromatography technology	Ohnuma K (2007), Ohnuma K (2007)	2
BCL10	0	UBE2V2	0	pull down	Zhou H (2004)	1
IRAK1	1	CHUK	5	affinity chromatography technology, affinity chromatography technology	Vig E (2001), Windheim M (2008)	2
TRAF2	1	IL15RA	2	affinity chromatography technology	Pereno R (2000)	1
IKBKG	0	AKT1	1	pull down, affinity chromatography technology	Fenner BJ (2010), Hou Y (2010)	2
OTULIN	0	BCL10	0	enzymatic study	Yang YK (2016)	1
TRAF6	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wesche H (1999), Qian Y (2001), Cao Z (1996), Takatsuna H (2003), Li S (2002), Ling L (2000), Ling L (2000), Takaesu G (2001), Muzio M (1997), Chen F (2008), Li X (2001), Li X (2001), Xiong Y (2011), Xiong Y (2011), Tang H (2010), Muroi M (2011), Liu A (2012), Lee JY (2009), Lee JY (2009), Kollewe C (2004), Jiang Z (2002), Jensen LE (2001), Liu G (2007), Liu G (2007), Jiang Z (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Lakshmanan U (2007), Lee HJ (2012), Lee HJ (2012), Zhang X (2013), Yao J (2007), Hu MM (2014), Jeon J (2014), Conze DB (2008), Tanishima M (2017)	38
BTRC	1	CHUK	5	enzymatic study	Liu J (2002)	1
CARD19	0	BCL10	0	two hybrid, pull down	Woo HN (2004), Woo HN (2004)	2
TRAF2	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Hong S (2007), Tan B (2015)	4
CSNK1A1	1	CARD11	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hatchi EM (2014), Bidere N (2009), Bidere N (2009), Bidere N (2009)	4
BCL10	0	TRADD	0	affinity chromatography technology	Costanzo A (1999)	1
TNFRSF1A	3	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Shu HB (1996), Vince JE (2009), Mahul-Mellier AL (2011), Won M (2010), Kolliputi N (2009), Park KJ (2002), Lee IT (2010), Kim WJ (2005), Zheng L (2006), Vince JE (2007), Jeon J (2014), Chen TC (2014), Lee CK (2015), Jeong M (2017)	16
MALT1	1	RNF31	3	affinity chromatography technology	Yang Y (2014)	1
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
IKBKG	0	BCL10	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wu CJ (2008), Wu CJ (2008), Bhattacharyya S (2010), Stilo R (2004), Poyet JL (2001), Poyet JL (2001), Park Y (2013), Zhou H (2004), Yang YK (2016)	9
PPP2CA	7	CHUK	5	affinity chromatography technology	Kray AE (2005)	1
CHUK	5	TRADD	0	biochemical	Poyet JL (2000)	1
IKBKG	0	CHUK	5	pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Agou F (2002), Chen G (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Rothwarf DM (1998), Rothwarf DM (1998), Hasegawa M (2008), Liu J (2009), Li S (2011), Li S (2011), Xia X (2011), Kensche T (2012), May MJ (2002), Wu ZH (2006), Wu ZH (2006), Palkowitsch L (2008), Le Page C (2001), Le Page C (2001), Huang TT (2002), Sebban-Benin H (2007), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), McKenzie FR (2000), Solt LA (2007), Li XH (2001), Rottenberg S (2002), Poyet JL (2000), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Strnad J (2006), Funakoshi-Tago M (2005), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Marinis JM (2012), Mitsuhashi S (2008), Mitsuhashi S (2008), Fujita H (2014), Lee SH (2012), Jackson SS (2014), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), Liu D (2014), Hein MY (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Bal E (2017)	57
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
TRADD	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Chang YL (2014), Chang YL (2014)	2
MAP3K7	2	CHUK	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Sakurai H (1999), Ninomiya-Tsuji J (1999), Lin X (1998), Lin X (1998), Ear T (2010), Huangfu WC (2006), Chen TC (2014)	7
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
TRAF2	1	ELAVL1	0	affinity chromatography technology	Herjan T (2013)	1
IKBKG	0	CARD11	4	pull down, affinity chromatography technology, affinity chromatography technology	Stilo R (2004), McCully RR (2008), Shambharkar PB (2007)	3
XPO1	8	CHUK	5	affinity chromatography technology	Kirli K (2015)	1
CSNK1A1	1	NFKBIA	0	affinity chromatography technology, affinity chromatography technology	Carvalho G (2010), Carvalho G (2010)	2
CSNK1A1	1	PPP2CA	7	affinity chromatography technology	Dubois T (2002)	1
MAP3K7	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Neil JR (2009), Yang Y (2011), Wu X (2007), Emmerich CH (2013)	4
MAPK9	3	AKT1	1	enzymatic study	Xiao L (2010)	1
ELAVL1	0	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Abdelmohsen K (2009), Durie D (2011), Durie D (2011), Durie D (2011)	4
MALT1	1	USP9X	15	affinity chromatography technology	Park Y (2013)	1
XPO1	8	IRAK1	1	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	TRADD	0	affinity chromatography technology	Kirli K (2015)	1
MIB2	7	UBE2N	1	pull down	Li S (2011)	1
TNFRSF1A	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1996), Vince JE (2009), Vince JE (2007), Wang YB (2015)	4
ELAVL1	0	SLC20A1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
BIRC2	1	USP9X	15	affinity chromatography technology	Goncharov T (2013)	1
PRKCQ	3	IKBKB	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Khoshnan A (2000), Lee KY (2005), Lee KY (2005), Srivastava R (2010), Shambharkar PB (2007)	5
TRAF6	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanz L (2000), Sanz L (2000), Nakamura K (2010), Kim JY (2009), Seibenhener ML (2004), Feng Y (2005), Martin P (2006), Martin P (2006), Geetha T (2012), Geetha T (2012), Linares JF (2013), Linares JF (2011), Linares JF (2015), Schimmack G (2017), Tsai WT (2016)	15
RNF181	0	BCL10	0	enzymatic study	Pedersen SM (2015)	1
MAP3K7	2	CARD11	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Srivastava R (2010), McCully RR (2008), Shinohara H (2016), Shinohara H (2016)	4
XPO1	8	SQSTM1	0	affinity chromatography technology	Kirli K (2015)	1
BCL10	0	SLC9A3R1	2	two hybrid	Wang J (2011)	1
BCL10	0	SRSF1	0	two hybrid	Wang J (2011)	1
MALT1	1	UBE2N	1	pull down	Zhou H (2004)	1
ELAVL1	0	ATG5	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TNFRSF10A	0	TRADD	0	affinity chromatography technology	Chaudhary PM (1997)	1
ELAVL1	0	CHUK	5	affinity chromatography technology	Chu PC (2012)	1
PRKCQ	3	AKT1	1	pull down, affinity chromatography technology	Bauer B (2001), Bauer B (2001)	2
TNFRSF1A	3	TRADD	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Y (1999), Schuetze S (1999), Pan G (1997), Hsu H (1996), Hsu H (1996), Hsu H (1996), Shu HB (1996), Blankenship JW (2009), Kolliputi N (2009), Fujikura D (2012), Park KJ (2002), Guan YJ (2011), Hsu H (1995), Kumar A (2001), Zheng L (2006), Kim TW (2013), Zhang H (2004), Chang YL (2014), Nakazawa S (2016), Huttlin EL (2017)	20
AKT1	1	BCL10	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Yeh PY (2006), Yeh PY (2006), Yeh PY (2006)	3
CARD11	4	RNF31	3	affinity chromatography technology, affinity chromatography technology	Yang YK (2016), Yang YK (2016)	2
XPO1	8	MAP3K7	2	affinity chromatography technology	Kirli K (2015)	1
BIRC2	1	RNF181	0	two hybrid	Woodsmith J (2012)	1
MAPK9	3	BCL10	0	affinity chromatography technology, affinity chromatography technology	Blonska M (2007), Blonska M (2007)	2
BCL10	0	BCL10	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Hu S (2006), Stempin CC (2011), Rolland T (2014), Qiao Q (2013)	4
UBE2N	1	XIAP	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
BIRC3	1	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Uren AG (1996), Roy N (1997), Yoneda T (2000), Yoneda T (2000), Li X (2002), Behrends C (2010), Samuel T (2006), Vince JE (2009), Darding M (2011), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Rothe M (1995), Varfolomeev E (2006), Choudhary S (2013), Goncharov T (2013), Wang J (2011), Harikumar KB (2014), Shen RR (2012), Chen TC (2014), Akhtar N (2016)	23
TNFRSF1A	3	BCL10	0	two hybrid	Costanzo A (1999)	1
TNFRSF1A	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Zhang SQ (2000), Nakazawa S (2016)	2
ELAVL1	0	BTRC	1	affinity chromatography technology, affinity chromatography technology	Chu PC (2012), Chu PC (2012)	2
BCL10	0	IKBKB	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Lobry C (2007), Lobry C (2007), Poyet JL (2001), Zhou H (2004), Bidere N (2009)	5
TRAF2	1	IKBKB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Devin A (2001), Li S (2009), Li S (2009), Li HY (2008), Shen RR (2012), Shen RR (2012), Zhang W (2010), Chen TC (2014), Mei ZZ (2016)	9
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
BIRC2	1	BCL10	0	affinity chromatography technology, affinity chromatography technology	Yoneda T (2000), Hu S (2006)	2
BCL10	0	PRRG4	1	two hybrid	Wang J (2011)	1
TNFRSF10A	0	SQSTM1	0	affinity chromatography technology	Jin Z (2009)	1
ELAVL1	0	UBE2N	1	affinity chromatography technology	Abdelmohsen K (2009)	1
XPO1	8	MAP2K7	5	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	BCL10	0	affinity chromatography technology	Kirli K (2015)	1
AKT1	1	PPP2CA	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Beaulieu JM (2008), Beaulieu JM (2008), Calvo N (2010), Calvo N (2010), Xiao L (2010), Guo J (2016), Guo J (2016), Guo J (2016)	8
ELAVL1	0	ATM	9	affinity chromatography technology	Abdelmohsen K (2009)	1
RNF31	3	OTULIN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, unspecified method, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Rivkin E (2013), Rivkin E (2013), Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Draber P (2015), Draber P (2015), Draber P (2015), Goto E (2017), Schlicher L (2016), Elliott PR (2016), Schimmack G (2017)	20
MALT1	1	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Martin P (2006), Martin P (2006)	2
NLRC4	2	BCL10	0	affinity chromatography technology	Damiano JS (2001)	1
FGFR1OP	0	BCL10	0	bioid	Gupta GD (2015)	1
IKBKG	0	CARD10	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Stilo R (2004), Stilo R (2004), Stilo R (2004), Stilo R (2004), Stilo R (2004)	5
MAP1LC3A	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, pull down, affinity chromatography technology	Shvets E (2008), Shvets E (2008), Behrends C (2010), Gao Z (2010), Pan JA (2011), Pankiv S (2007), Pankiv S (2007), Shvets E (2011), Tung YT (2010), Bjorkoy G (2005), Kirkin V (2009), Lim J (2011), Lim J (2011), Pan JA (2012), Lee DY (2013), Wang BS (2013), Wang BS (2013), Sansanwal P (2012), Shi J (2013), Fujita N (2013), Chen X (2014), Liu XD (2014), Noda NN (2008), Noda NN (2008), Matsuzawa Y (2015), Matsuzawa Y (2015), Rui YN (2015), Rui YN (2015), Ciuffa R (2015), Wang N (2013), Hua F (2015), Rui YN (2015), Cha-Molstad H (2015), Paul S (2012), Puvirajesinghe TM (2016), Wang L (2017), Cha-Molstad H (2017), Peng H (2017), Lee Y (2017)	39
CDK9	3	TRAF2	1	affinity chromatography technology	MacLachlan TK (1998)	1
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
CARD11	4	MALT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang S (2013), Karim ZA (2015), Liu Y (2012)	3
CHUK	5	NFKBIA	0	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	DiDonato JA (1997), Cohen L (1998), Woronicz JD (1997), Ninomiya-Tsuji J (1999), Burke JR (2002), Wu ZH (2010), Tong KM (2008), Singhirunnusorn P (2005), Heilker R (1999), Huang TT (2002), Lee FS (1998), Kim KS (2002), Cappello C (2007), Hong S (2007), Morrison BH (2007), Zandi E (1998), Li Q (2006), Manna SK (2010), Li XH (2001), Poyet JL (2001), Zhang W (2010), Bauer JA (2007), Chan H (2005), Munzert G (2002), Stehlik C (2002), Shambharkar PB (2007), Cui J (2010), Li Q (2006), Bernier M (2006), Mitsuhashi S (2008), Hayashi T (2007), Niu J (2013), Dan HC (2008), Criollo A (2010), Kim Y (2002), Huttlin EL (2015), Liu D (2014), Zhang H (2004), Aggarwal S (2006), Ninomiya-Tsuji J (2003), Huttlin EL (2017)	41
BCL10	0	USHBP1	1	two hybrid	Wang J (2011)	1
BCL10	0	SQSTM1	0	affinity chromatography technology	Paul S (2012)	1
TNFRSF10A	0	BCL10	0	two hybrid	Costanzo A (1999)	1
UBE2N	1	RNF8	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, pull down, two hybrid	Markson G (2009), Bekker-Jensen S (2010), Lok GT (2011), Lok GT (2011), Campbell SJ (2012), Plans V (2006), Plans V (2006), Huen MS (2008), Zhang X (2013), Guerra-Rebollo M (2012), Zhao H (2014), Hodge CD (2015), Ho YK (2015), Weber E (2017), Weber E (2017), Schimmack G (2017)	16
MALT1	1	CAMK2G	4	affinity chromatography technology	Oruganti SR (2011)	1
ATM	9	CDK9	3	imaging technique	Fang L (2014)	1
ATM	9	BCL10	0	enzymatic study, affinity chromatography technology	Zhao H (2014), Zhao H (2014)	2
NFKBIA	0	MALT1	1	affinity chromatography technology	Carvalho G (2010)	1
PRKCQ	3	BCL10	0	affinity chromatography technology, affinity chromatography technology	Srivastava R (2010), Shambharkar PB (2007)	2
PPP2R1A	8	FGFR1OP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Glatter T (2009), Hein MY (2015), Hein MY (2015), Yadav L (2017), Yadav L (2017)	5
BCL10	0	ATG5	0	affinity chromatography technology	Paul S (2012)	1
CHUK	5	BCL3	2	enzymatic study	Wang VY (2017)	1
CHUK	5	TNFRSF1A	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008)	3
BIRC3	1	IKBKG	0	pull down, affinity chromatography technology	Gyrd-Hansen M (2008), Goncharov T (2013)	2
UBE2V2	0	USP9X	15	biochemical	Havugimana PC (2012)	1
TNFRSF1A	3	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
XPO1	8	NFKBIA	0	affinity chromatography technology	Kirli K (2015)	1
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
XPO1	8	CSNK1A1	1	affinity chromatography technology	Kirli K (2015)	1
MAP1LC3A	0	BCL10	0	affinity chromatography technology, affinity chromatography technology	Paul S (2012), Paul S (2012)	2
CARD11	4	PPP2R1A	8	affinity chromatography technology, two hybrid, affinity chromatography technology	Eitelhuber AC (2011), Eitelhuber AC (2011), Eitelhuber AC (2011)	3
CARD11	4	RNF181	0	fluorescent resonance energy transfe, affinity chromatography technology	Pedersen SM (2015), Pedersen SM (2015)	2
MAP3K7	2	MAP2K7	5	imaging technique	Chen TC (2014)	1
BCL10	0	CARD11	4	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bertin J (2001), Bertin J (2001), Bertin J (2001), Kojo S (2009), Welteke V (2009), Oruganti SR (2011), Langel FD (2008), McCully RR (2008), Sommer K (2005), Park Y (2013), Chen J (2015), Qiao Q (2013), Qiao Q (2013), Eitelhuber AC (2011), Yang YK (2016), Liu Y (2012), Bidere N (2009)	17
AKT1	1	IKBKB	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Vandermoere F (2005), Vandermoere F (2005), Chen TC (2014), Busch F (2012)	4
TNFRSF1A	3	RNF8	2	affinity chromatography technology, affinity chromatography technology	Fritsch J (2014), Fritsch J (2014)	2
AKT1	1	BCL3	2	enzymatic study	Wang VY (2017)	1
AKT1	1	NFKBIA	0	affinity chromatography technology	Koul D (2001)	1
ATM	9	TRAF6	0	pull down	Hinz M (2010)	1
IKBKB	1	NFKBIA	0	pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Mercurio F (1999), Cohen L (1998), Woronicz JD (1997), Burke JR (2002), Tsuchiya Y (2010), Tsuchiya Y (2010), Da Silva-Ferrada E (2011), Ducut Sigala JL (2004), Heilker R (1999), Edinger RS (2009), Lee FS (1998), Hai T (2006), Zandi E (1998), Henkler F (2003), Li XH (2001), Byun MS (2006), Mauro C (2003), Zhang W (2010), Munzert G (2002), Shibata Y (2012), Shambharkar PB (2007), Cui J (2010), Li Q (2006), Bernier M (2006), Gao H (2004), Hauenstein AV (2014), Fujita H (2014), Zhang J (2013), Chong RA (2014), Dan HC (2008), Sun L (2004), Criollo A (2010), Liu D (2014), Vincendeau M (2016), Zhang L (2015), Zilberman-Rudenko J (2016), Minassian A (2015), Lindstroem TM (2008), Kim BH (2008), Pandey MK (2008), Joo M (2005), Ninomiya-Tsuji J (2003), Chang YJ (2004), Huang WC (2004), Kim EK (2017), Mei ZZ (2016), Shinohara H (2016), Shkoda A (2012)	48
BCL10	0	CARD10	4	two hybrid, affinity chromatography technology, pull down, biochemical	Wang L (2001), Wang L (2001), Wang L (2001), Stilo R (2004)	4
TRAF6	0	UBE2N	1	genetic interference, pull down, two hybrid, biochemical, two hybrid, x-ray crystallography, two hybrid, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, two hybrid	Deng L (2000), Deng L (2000), Markson G (2009), Yin Q (2009), Dynek JN (2010), Yin Q (2009), Yin Q (2009), Petroski MD (2007), Mercier P (2007), Lamothe B (2008), Kanayama A (2004), Murata H (2013), Ning S (2008), Markson G (2009), Lin Y (2014), Chen J (2015), Zhang J (2016), Boldt K (2016), Rezaeian AH (2017), Xing J (2016), Schimmack G (2017), Schimmack G (2017)	22
BCL10	0	BTRC	1	affinity chromatography technology	Lobry C (2007)	1
BCL10	0	PPP2CA	7	affinity chromatography technology	Eitelhuber AC (2011)	1
XPO1	8	MALT1	1	affinity chromatography technology	Kirli K (2015)	1
AKT1	1	CHUK	5	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Ozes ON (1999), Ozes ON (1999), Romashkova JA (1999), Lu Y (2005), Chen TC (2014), Takada Y (2005), Koul D (2001)	7
MIB2	7	IKBKG	0	affinity chromatography technology	Stempin CC (2011)	1
NFKBIA	0	BCL10	0	affinity chromatography technology, affinity chromatography technology	Carvalho G (2010), Carvalho G (2010)	2
ELAVL1	0	TNFRSF1A	3	affinity chromatography technology	Abdelmohsen K (2009)	1
IRAK1	1	RNF31	3	affinity chromatography technology	Yang Y (2014)	1
TNFRSF10A	0	TRAF2	1	affinity chromatography technology	Gonzalvez F (2012)	1
CSNK1A1	1	SQSTM1	0	enzymatic study	Watanabe Y (2017)	1
FYB1	0	BCL10	0	affinity chromatography technology	Srivastava R (2010)	1
PPP2R1A	8	TRADD	0	affinity chromatography technology	Sablina AA (2007)	1
BCL10	0	HIST1H2BC	0	affinity chromatography technology	Ewing RM (2007)	1
TRAF6	0	AKT1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yang WL (2009), Mitra S (2011), Mitra S (2011)	3
BIRC3	1	RNF31	3	affinity chromatography technology	Goncharov T (2013)	1
TNFRSF1A	3	TRAF6	0	affinity chromatography technology	Chang YL (2014)	1
XIAP	0	BCL10	0	affinity chromatography technology	Hu S (2006)	1
MIB2	7	BCL10	0	affinity chromatography technology, pull down, affinity chromatography technology	Stempin CC (2011), Stempin CC (2011), Stempin CC (2011)	3
PPP2CA	7	FGFR1OP	0	affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Hein MY (2015)	2
IKBKG	0	MALT1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Duewel M (2009), Gyrd-Hansen M (2008), Oeckinghaus A (2007), Karim ZA (2015)	4
BIRC2	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Hinz M (2010), Hinz M (2010), Shibata Y (2012), Goncharov T (2013), Fu J (2013)	6
PRKCQ	3	CHUK	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee KY (2005), Srivastava R (2010), Shambharkar PB (2007)	3
MAP3K7	2	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sanna MG (2002), Resch U (2009), Sanna MG (2002), Sanna MG (2002)	4
AKT1	1	IRAK1	1	affinity chromatography technology	Chen BC (2002)	1
BIRC2	1	UBE2N	1	two hybrid	Schimmack G (2017)	1
ELAVL1	0	BCL10	0	affinity chromatography technology	Abdelmohsen K (2009)	1
BCL10	0	RNF31	3	affinity chromatography technology, affinity chromatography technology	Yang YK (2016), Yang YK (2016)	2
BCL3	2	BCL10	0	affinity chromatography technology, affinity chromatography technology	Yeh PY (2006), Yeh PY (2006)	2
IKBKG	0	BTRC	1	affinity chromatography technology	Orel L (2010)	1
XPO1	8	FGFR1OP	0	affinity chromatography technology	Kirli K (2015)	1
PRKCQ	3	CARD11	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Srivastava R (2010), Sommer K (2005), Eitelhuber AC (2011), Liu Y (2012), Brenner D (2009)	5
RNF8	2	UBE2V2	0	pull down	Campbell SJ (2012)	1
BCL10	0	USP9X	15	affinity chromatography technology	Park Y (2013)	1
BCL10	0	SLC20A1	2	two hybrid	Wang J (2011)	1
MAP2K7	5	BCL10	0	affinity chromatography technology	Blonska M (2007)	1
CHUK	5	BCL10	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Poyet JL (2001), Poyet JL (2001), Marinis JM (2012), Zhou H (2004)	4
TRAF2	1	UBE2N	1	genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Deng L (2000), Deng L (2000), Liu J (2011), Liu J (2011), Liu J (2011), Alvarez SE (2010), Sasai M (2010), Zhou AY (2013), Shen RR (2012)	9
UBE2N	1	CHUK	5	enzymatic study	Deng L (2000)	1
XPO1	8	USP9X	15	affinity chromatography technology	Kirli K (2015)	1
ELAVL1	0	MAP2K7	5	affinity chromatography technology	Abdelmohsen K (2009)	1
IKBKG	0	IRAK1	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Conze DB (2008), Conze DB (2008), Windheim M (2008), Windheim M (2008), Ordureau A (2008), Xiong Y (2011), Jeon J (2014), Emmerich CH (2013)	8
IRAK1	1	PPP2CA	7	affinity chromatography technology, affinity chromatography technology	Dobierzewska A (2011), Dobierzewska A (2011)	2
TNFRSF1A	3	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Blankenship JW (2009), Vince JE (2009)	2
RNF31	3	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Draber P (2015), Nakazawa S (2016), Elliott PR (2016)	3
RNF168	0	UBE2N	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakada S (2010), Stewart GS (2009), Zhang X (2013), Zhao H (2014), Stewart GS (2009)	5
BIRC2	1	TRAF2	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Uren AG (1996), Roy N (1997), Shu HB (1996), Yoneda T (2000), Yoneda T (2000), Li X (2002), Li X (2002), Li X (2002), Behrends C (2010), Samuel T (2006), Samuel T (2006), Samuel T (2006), Silke J (2005), Wu CJ (2005), Vince JE (2009), Csomos RA (2009), Li S (2011), Darding M (2011), Sanjo H (2010), Mace PD (2010), Choi JW (2009), Kanno Y (2010), Jang HD (2001), Rothe M (1995), Rothe M (1995), Cartier J (2011), Varfolomeev E (2006), Varfolomeev E (2006), Shen RR (2012), Shen RR (2012), Goncharov T (2013), Wang J (2011), Marivin A (2013), Shen RR (2012), Park ES (2015), Wang YB (2015), Chen TC (2014), Petersen SL (2015), Huttlin EL (2017), Akhtar N (2016)	41
MALT1	1	TRAF2	1	pull down, affinity chromatography technology	Sun L (2004), Garrison JB (2009)	2
MIB2	7	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Stempin CC (2011), Stempin CC (2011)	2
MALT1	1	TRAF6	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun L (2004), Sun L (2004), Garrison JB (2009), Li Y (2013), Oeckinghaus A (2007), Oeckinghaus A (2007), Nie Z (2015), Liu Y (2012), Liu Y (2012)	9
TRAF2	1	IKBKG	0	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Poyet JL (2000), Shen RR (2012), Shen RR (2012), Bal E (2017), Bal E (2017)	6
MALT1	1	BCL10	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uren AG (2000), Uren AG (2000), Uren AG (2000), Noels H (2009), Carvalho G (2010), Welteke V (2009), Oruganti SR (2011), Lucas PC (2001), Langel FD (2008), Langel FD (2008), Blonska M (2007), Oeckinghaus A (2007), Park Y (2013), Park Y (2013), Borthakur A (2013), Zhou H (2004), Zhou H (2004), Chen J (2015), Karim ZA (2015), Nie Z (2015), Eitelhuber AC (2011), Paul S (2012), Yang YK (2016), Liu Y (2012), Bidere N (2009), Bidere N (2009), Afonina IS (2016), Howes A (2016)	28
IKBKG	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Martin P (2006), Zotti T (2014)	2
IKBKB	1	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Heissmeyer V (2001), Orel L (2010), Tsuchiya Y (2010), Tsuchiya Y (2010)	4
PPP2CA	7	IKBKB	1	affinity chromatography technology	Kray AE (2005)	1
BCL10	0	PPP2R1A	8	affinity chromatography technology	Eitelhuber AC (2011)	1
MALT1	1	CARD14	6	affinity chromatography technology, affinity chromatography technology	Afonina IS (2016), Howes A (2016)	2
XPO1	8	SRSF1	0	affinity chromatography technology	Kirli K (2015)	1
TRAF6	0	CARD11	4	affinity chromatography technology	McCully RR (2008)	1
IKBKB	1	CHUK	5	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Zandi E (1997), Chen G (2002), Otsuki T (2002), May MJ (2000), May MJ (2000), Woronicz JD (1997), Woronicz JD (1997), Deng L (2000), Yeung KC (2001), Mercurio F (1997), Mercurio F (1997), Rothwarf DM (1998), Wu ZH (2010), Li S (2011), Li S (2011), May MJ (2002), Heilker R (1999), Leotoing L (2011), McKenzie FR (2000), Zandi E (1998), Lee DF (2007), Li XH (2001), Yeh PY (2011), Yeh PY (2011), Stehlik C (2002), Li Q (2006), So J (2015), Chen TC (2014), Karim ZA (2015), Huttlin EL (2017)	30
TNFRSF1A	3	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahmad R (2007), Fan YH (2011), Cusson-Hermance N (2005), Blonska M (2005), Mitsuhashi S (2008)	5
BIRC3	1	BCL10	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Yoneda T (2000), Hu S (2006), Yui D (2001), Hu S (2006), Hu S (2006), Hu S (2006), Hu S (2006)	7
BTRC	1	CSNK1A1	1	affinity chromatography technology, bioid	Coyaud E (2015), Coyaud E (2015)	2
ELAVL1	0	PPP2R1A	8	affinity chromatography technology	Abdelmohsen K (2009)	1
SQSTM1	0	IRAK1	1	affinity chromatography technology	Sanz L (2000)	1
MALT1	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Oeckinghaus A (2007), Karim ZA (2015)	2
TRAF6	0	IKBKB	1	affinity chromatography technology	Bidere N (2006)	1
PPP2R1A	8	MAP3K7	2	enzymatic study	Kajino T (2006)	1
PRKCQ	3	IKBKG	0	affinity chromatography technology	Lee KY (2005)	1
TRAF2	1	SRSF1	0	affinity chromatography technology	Sun D (2011)	1
CHUK	5	TRAF2	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Regnier CH (1997), Devin A (2001), Li S (2009), Shen RR (2012), Zhang W (2010), Chen TC (2014)	6
RNF31	3	TRAF6	0	enzymatic study	Kliza K (2017)	1
MAP3K7	2	BCL10	0	affinity chromatography technology	Blonska M (2007)	1
RNF168	0	BCL10	0	affinity chromatography technology	Zhao H (2014)	1
IKBKB	1	IKBKG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, biochemical, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, pull down, affinity chromatography technology	Chen G (2002), Chen G (2002), Chariot A (2002), Wu RC (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010), Lee KY (2005), Rothwarf DM (1998), Ea CK (2006), Thurston TL (2009), Orel L (2010), Wu ZH (2010), Napolitano G (2009), Liu J (2009), Skaug B (2011), Li S (2011), Li S (2011), Kensche T (2012), Chiaravalli J (2011), Wu CJ (2006), Wu ZH (2006), Ahmad R (2007), Ahmad R (2007), Palkowitsch L (2008), Palkowitsch L (2008), Lo YC (2008), Mabb AM (2006), Baima ET (2010), Tegethoff S (2003), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), Lee DF (2007), Rottenberg S (2002), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Funakoshi-Tago M (2005), Ivins FJ (2009), Shibata Y (2012), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Wu ZH (2008), Mitsuhashi S (2008), Fujita H (2014), Golden MS (2013), Lee SH (2012), Cote SM (2013), Kim HJ (2014), Jackson SS (2014), Liao W (2008), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), So J (2015), Liu D (2014), Guo B (2014), Guo B (2014), Guo B (2014), Zhou L (2014), Zhou L (2014), Hein MY (2015), Bagneris C (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Rushe M (2008), Hauenstein AV (2017), Bal E (2017)	78
ATG5	0	SQSTM1	0	pull down, affinity chromatography technology	Fracchiolla D (2016), Fracchiolla D (2016)	2
BCL10	0	CARD9	3	two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Bertin J (2000), Bertin J (2000), Bertin J (2000), Bertin J (2000), Bertin J (2000)	5
RNF31	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Niu J (2011), Fujita H (2014), Tokunaga F (2011), Tokunaga F (2011), Xia ZP (2009), Fu J (2013), Emmerich CH (2013), Chen Y (2015), Bal E (2017)	11
BTRC	1	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, bioid, enzymatic study, protein complementation assay	Suzuki H (2000), Spencer E (1999), Spencer E (1999), Spencer E (1999), Suzuki H (1999), Suzuki H (1999), Kroll M (1999), Kroll M (1999), Yaron A (1998), Choi YS (2010), Banerjee S (2010), Banerjee S (2010), Banerjee S (2010), Da Silva-Ferrada E (2011), Tsuchiya Y (2010), Tsuchiya Y (2010), Keutgens A (2010), Winston JT (1999), Winston JT (1999), Winston JT (1999), Winston JT (1999), Surjit M (2012), Busino L (2012), Evrard-Todeschi N (2008), Furukawa M (2000), Kovacev J (2014), Chong RA (2014), Chong RA (2014), Shi M (2014), Shirane M (1999), Read MA (2000), Tan M (2010), Coyaud E (2015), Coyaud E (2015), Wu K (2016), Villalobos V (2010)	36
PPP2CA	7	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Goudreault M (2009), Goudreault M (2009), Zhou J (2003), Zhou J (2003), Glatter T (2009), Glatter T (2009), Sablina AA (2007), Sablina AA (2007), Kong M (2009), Kong M (2009), Shamay M (2012), Havugimana PC (2012), Junttila MR (2007), Junttila MR (2007), Nazarenko I (2007), Kristensen AR (2012), Fogeron ML (2013), Sablina AA (2010), Lee CW (2014), Wan C (2015), Hein MY (2015), Hein MY (2015), Cianfanelli V (2015), St-Denis N (2016), Bryant JC (1999), Shouse GP (2011), Yadav L (2017), Yadav L (2017), Yadav L (2017), Yadav L (2017)	30
MALT1	1	UBE2V2	0	pull down	Zhou H (2004)	1
CDK9	3	SQSTM1	0	biochemical	Garcia-Martinez LF (1997)	1
UBE2V2	0	UBE2N	1	pull down, two hybrid, x-ray crystallography, two hybrid, two hybrid, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, two hybrid, pull down, pull down, affinity chromatography technology, two hybrid, pull down, biochemical, x-ray crystallography, pull down, affinity chromatography technology, pull down, x-ray crystallography, biochemical, x-ray crystallography, affinity chromatography technology	Andersen PL (2005), Andersen PL (2005), Markin CJ (2010), Wooff J (2004), Wooff J (2004), Plans V (2006), Wu PY (2003), McKenna S (2003), McKenna S (2003), Zou W (2005), Takeuchi T (2005), Pastushok L (2005), Pastushok L (2005), Pastushok L (2005), Huen MS (2008), Huen MS (2008), Ye Y (2003), Havugimana PC (2012), Moraes TF (2001), Pastushok L (2007), Zou W (2005), McKenna S (2001), Hodge CD (2015), Wan C (2015), Branigan E (2015), Boldt K (2016)	26
RNF8	2	BCL10	0	affinity chromatography technology	Zhao H (2014)	1
BIRC3	1	USP9X	15	affinity chromatography technology	Goncharov T (2013)	1