PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HNRNPL	3	SYNJ2	2	affinity chromatography technology	Fei T (2017)	1
ITSN1	5	ITSN2	7	protein complementation assay	Wong KA (2012)	1
GRB2	2	SH3KBP1	1	pull down, pull down	Gout I (2000), Borinstein SC (2000)	2
SYNJ2	2	ITSN2	7	two hybrid, two hybrid	Nakayama M (2002), Wong KA (2012)	2
ITSN1	5	SYNJ2	2	two hybrid	Wong KA (2012)	1
ITSN2	7	SH3KBP1	1	two hybrid	Wong KA (2012)	1
CDH1	4	SYNJ2	2	bioid	Guo Z (2014)	1
SFN	1	SYNJ2	2	affinity chromatography technology	Benzinger A (2005)	1
SYNJ2	2	SYNJ2BP	0	two hybrid, pull down	Nemoto Y (1999), Nemoto Y (1999)	2
CDH1	4	SH3KBP1	1	bioid	Guo Z (2014)	1
ITSN1	5	SH3KBP1	1	affinity chromatography technology	Nikolaienko O (2009)	1
RAC1	7	SYNJ2	2	two hybrid, pull down, affinity chromatography technology, two hybrid	Malecz N (2000), Malecz N (2000), Malecz N (2000), Bandyopadhyay S (2010)	4
GRB2	2	SYNJ2	2	two hybrid	Bandyopadhyay S (2010)	1
CDH1	4	SFN	1	bioid	Guo Z (2014)	1
RAC1	7	GRB2	2	affinity chromatography technology	Huttlin EL (2017)	1
SH3KBP1	1	SYNJ2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havrylov S (2009), Kowanetz K (2004), Kowanetz K (2004), Huttlin EL (2017)	4