PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTPA	0	APP	1	pull down	Olah J (2011)	1
PTPA	0	MDM2	2	affinity chromatography technology	Wei S (2012)	1
PPP2R5C	3	APP	1	pull down	Olah J (2011)	1
MAPK1	1	FHL2	0	two hybrid, pull down, pull down, affinity chromatography technology	Purcell NH (2004), Purcell NH (2004), Purcell NH (2004), Purcell NH (2004)	4
MAPK1	1	IER3	0	enzymatic study, enzymatic study	Garcia J (2002), Letourneux C (2006)	2
PML	7	IER3	0	affinity chromatography technology	Kruse ML (2005)	1
PML	7	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Warren DT (2010), Lim JH (2011), Lim JH (2011)	3
AQP2	0	IER3	0	two hybrid	Trimpert C (2017)	1
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
FHL2	0	APP	1	pull down	Olah J (2011)	1
PML	7	MDM2	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bernardi R (2004), Bernardi R (2004), Zhu H (2003), Zhu H (2003), Kurki S (2003), Kurki S (2003), Wei X (2003), Wei X (2003), Wu Q (2009), Chu Y (2011), Yang Q (2013), Yang Q (2013), Bursac S (2012)	13
FHL2	0	IER3	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Jin H (2016), Jin H (2016), Jin H (2016), Jin H (2016)	4
IER3	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PML	7	MAPK3	4	affinity chromatography technology	Warren DT (2010)	1
MAPK1	1	PPP2R5B	1	enzymatic study	Letourneux C (2006)	1
MDM2	2	FHL2	0	affinity chromatography technology, pull down	Jin H (2016), Jin H (2016)	2
PTPA	0	IER3	0	affinity chromatography technology	Letourneux C (2006)	1
MAPK3	4	IER3	0	affinity chromatography technology	Garcia J (2002)	1
PRNP	4	IER3	0	pull down	Satoh J (2009)	1
PPP2R5C	3	MDM2	2	affinity chromatography technology	Shouse GP (2011)	1
IER3	0	PPP2R5C	3	affinity chromatography technology, affinity chromatography technology	Letourneux C (2006), Letourneux C (2006)	2
MAPK1	1	PPP2R5C	3	enzymatic study	Letourneux C (2006)	1
IER3	0	PPP2R5B	1	affinity chromatography technology, affinity chromatography technology, pull down	Letourneux C (2006), Letourneux C (2006), Letourneux C (2006)	3
MDM2	2	APP	1	pull down	Miyamoto-Sato E (2010)	1
IER3	0	MDM2	2	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Jin H (2016), Jin H (2016), Jin H (2016), Jin H (2016)	4