PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
POU1F1	2	NCOR1	9	affinity chromatography technology, affinity chromatography technology, pull down	Voss TC (2005), Xu L (1998), Xu L (1998)	3
TP53	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Wang C (2003), Akakura S (2001), Peng Y (2001), Nagata Y (1999), Wang J (2011), Burch L (2004), Taipale M (2012), Fogeron ML (2013), Walerych D (2004)	9
HSP90AA1	7	RPS6KB1	1	affinity chromatography technology	Taipale M (2012)	1
RPS6KB1	1	NR1I2	5	enzymatic study	Pondugula SR (2009)	1
MAPK7	1	NR1I2	5	two hybrid	Wang J (2011)	1
RXRA	1	NCOA1	6	pull down, pull down, two hybrid, far western blotting, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, two hybrid, pull down	Jeyakumar M (1997), Yang W (2000), Shao G (2000), Shao G (2000), Mouchon A (1999), Herdick M (2000), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Monden T (1999), Kurtev V (2004), Osburn DL (2001), DiRenzo J (1997)	13
NCOA6	6	CEBPA	0	affinity chromatography technology	Hong S (2001)	1
NCOR1	9	UBE2I	0	pull down, affinity chromatography technology	Tiefenbach J (2006), Tiefenbach J (2006)	2
NCOA6	6	NCOR2	12	two hybrid	Lee SK (2001)	1
NCOA3	3	NR5A2	4	two hybrid	Lee YK (2002)	1
NR1I2	5	RBBP7	1	affinity chromatography technology, affinity chromatography technology	Ong SS (2014), Ong SS (2014)	2
NCOA3	3	PSMC5	4	affinity chromatography technology, imaging technique	Ferry C (2009), Ferry C (2009)	2
UBR5	13	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Ling S (2011), Ling S (2011), Ling S (2011), Fogeron ML (2013), Flack JE (2017)	5
NR1I2	5	NUCB2	1	two hybrid	Albers M (2005)	1
NCOR1	9	NCOA3	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Li X (2002), Li X (2002), Li X (2002), Li X (2002)	4
NR1I2	5	TFAP2C	4	two hybrid	Wang J (2011)	1
POU1F1	2	NR1I2	5	pull down	Gonzalez MM (2002)	1
NCOA1	6	UBR5	13	affinity chromatography technology	Jung SY (2005)	1
TP53	0	PRMT1	3	pull down	An W (2004)	1
HNF4A	2	PPARGC1A	3	pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, two hybrid, affinity chromatography technology	Surapureddi S (2008), Bhalla S (2004), Bhalla S (2004), Ponugoti B (2007), Inoue S (2011), Felder TK (2011), Zhang Z (2012), Li T (2005), Li T (2005)	9
TP53	0	PPARGC1A	3	affinity chromatography technology, affinity chromatography technology, pull down	Sen N (2011), Sen N (2011), Sen N (2011)	3
TFAP2C	4	UBE2I	0	two hybrid	Eloranta JJ (2002)	1
UBE2I	0	NR5A2	4	enzymatic study, enzymatic study	Yang SH (2006), Ogawa H (2009)	2
NR0B2	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Yang Z (2012), Yang Z (2012), Yang Z (2012), Yang Z (2012), Yang Z (2012)	5
NR1I2	5	CHMP1A	3	two hybrid	Albers M (2005)	1
NR1I2	5	RXRA	1	two hybrid, two hybrid, pull down	Albers M (2005), Rana R (2013), Doricakova A (2013)	3
TADA3	0	RXRA	1	pull down, affinity chromatography technology	Zeng M (2002), Zeng M (2002)	2
HSP90AA1	7	NR1I2	5	affinity chromatography technology	Taipale M (2012)	1
HNF4A	2	TP53	0	pull down, affinity chromatography technology	Maeda Y (2002), Huttlin EL (2017)	2
NCOA1	6	NCOA2	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Wu RC (2002), Lodrini M (2008), McKenna NJ (1998), Eng FC (1998)	4
RXRG	1	RXRA	1	affinity chromatography technology	Huttlin EL (2017)	1
CHMP1A	3	UBE2I	0	two hybrid	Tsang HT (2006)	1
NCOA6	6	NCOA2	2	affinity chromatography technology	Goo YH (2003)	1
HNF4A	2	NCOA2	2	two hybrid	Wang JC (1998)	1
NR1I2	5	SDF4	1	two hybrid	Wang J (2011)	1
NCOA1	6	PPARGC1A	3	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Puigserver P (1999), Puigserver P (1999), Puigserver P (1999), Puigserver P (1999)	4
RBBP7	1	DDB1	6	affinity chromatography technology	Mouysset J (2015)	1
RXRA	1	PSMC5	4	pull down, two hybrid	vom Baur E (1996), Choi HS (1996)	2
NR1I2	5	RXRB	0	two hybrid, affinity chromatography technology	Albers M (2005), Elias A (2013)	2
RXRA	1	PPARGC1A	3	affinity chromatography technology, pull down, two hybrid, two hybrid	Delerive P (2002), Delerive P (2002), Delerive P (2002), Delerive P (2002)	4
NCOA1	6	NCOA3	3	affinity chromatography technology, affinity chromatography technology	Lodrini M (2008), Lodrini M (2008)	2
UBE2I	0	PPARGC1A	3	enzymatic study	Rytinki MM (2009)	1
HNF4A	2	NCOA6	6	pull down, pull down, two hybrid, pull down, two hybrid	Surapureddi S (2008), Surapureddi S (2008), Albers M (2005), Surapureddi S (2011), Surapureddi S (2011)	5
UBE2I	0	NR1I2	5	enzymatic study	Hu G (2010)	1
CEBPA	0	NR1I2	5	affinity chromatography technology, affinity chromatography technology	Li H (2010), Li H (2010)	2
TP53	0	DDB1	6	affinity chromatography technology	Fogeron ML (2013)	1
NCOR2	12	HNF4A	2	pull down	Torres-Padilla ME (2002)	1
DNMT3L	2	NR1I2	5	pull down	Pacaud R (2014)	1
NR1I2	5	NCOA3	3	two hybrid	Johnson DR (2006)	1
NR1I2	5	UBR5	13	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ong SS (2014), Ong SS (2014), Ong SS (2014)	3
HSP90AA1	7	MAPK7	1	affinity chromatography technology	Taipale M (2012)	1
HNF4A	2	PRMT1	3	affinity chromatography technology, pull down, enzymatic study	Barrero MJ (2006), Barrero MJ (2006), Barrero MJ (2006)	3
HNF4A	2	NCOA1	6	two hybrid	Wang JC (1998)	1
NR0B2	1	RXRA	1	two hybrid, pull down, two hybrid	Lee YK (2000), Brendel C (2002), Wang J (2011)	3
NCOA3	3	NCOA2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu RC (2002), Lodrini M (2008), Lodrini M (2008)	3
DNMT3L	2	TP53	0	pull down	Pacaud R (2014)	1
NR1I2	5	ACTN2	2	two hybrid	Albers M (2005)	1
NCOR2	12	RXRA	1	two hybrid, pull down, two hybrid, two hybrid	Tagami T (1998), Mouchon A (1999), Li H (1997), Albers M (2005)	4
NR5A2	4	NR0B2	1	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Brendel C (2002), Brendel C (2002), Lee YK (2002), Chanda D (2010), Kanamaluru D (2011), Zhou T (2010), Miao J (2011), Park YY (2004)	8
TP53	0	NCOA1	6	two hybrid, pull down	Lee SK (1999), Lee SK (1999)	2
NCOA3	3	NR0B2	1	two hybrid	Lee YK (2002)	1
UBE2I	0	NCOR2	12	enzymatic study	Jiang J (2010)	1
TADA3	0	NR1I2	5	two hybrid	Li CW (2010)	1
RXRA	1	NCOA2	2	pull down, pull down, pull down, pull down	Lee WY (2002), Zhang C (2001), Kindle KB (2005), Voegel JJ (1998)	4
NCOA6	6	NR1I2	5	pull down, two hybrid	Surapureddi S (2011), Surapureddi S (2011)	2
NR0B2	1	HNF4A	2	two hybrid, pull down, pull down, two hybrid, pull down, two hybrid	Lee YK (2000), Lee YK (2000), Zhou T (2010), Albers M (2005), Li T (2006), Zhang M (2001)	6
PSMC5	4	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Zhu Q (2007), Zhu Q (2007), Kulikov R (2010), Kulikov R (2010)	4
TP53	0	NCOA2	2	pull down	Miyamoto-Sato E (2010)	1
NCOA3	3	RXRA	1	pull down, pull down, imaging technique, pull down, pull down	Chen H (1997), Lee WY (2002), Sinkkonen L (2005), Yang W (2000), Takeshita A (1997)	5
TADA3	0	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang T (2001), Gamper AM (2008), Sekaric P (2007), Fogeron ML (2013), Nag A (2007), Nag A (2007)	6
NR0B2	1	NR1I2	5	two hybrid, pull down	Li T (2006), Li T (2006)	2
HSP90AA1	7	FGR	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012)	2
NCOA6	6	PPARGC1A	3	pull down	Surapureddi S (2008)	1
NR1I2	5	RXRG	1	two hybrid	Albers M (2005)	1
NFATC4	2	NR1I2	5	two hybrid	Wang J (2011)	1
NCOA6	6	RXRA	1	pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down	Lee SK (1999), Lee SK (1999), Lee SK (2001), Kong HJ (2003), Kong HJ (2003), Ko L (2002), Mahajan MA (2000), Mahajan MA (2000), Caira F (2000)	9
NCOR1	9	RXRA	1	pull down, pull down, pull down	Sun Y (2004), Herdick M (2000), Krogsdam AM (2002)	3
NR1I2	5	TP53	0	affinity chromatography technology, affinity chromatography technology	Elias A (2013), Elias A (2013)	2
HNF4A	2	NR1I2	5	two hybrid, pull down, pull down, two hybrid, affinity chromatography technology	Li T (2006), Li T (2006), Li T (2006), Li T (2005), Li T (2005)	5
MAPK7	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Yang Q (2013), Yang Q (2013)	2
NCOR2	12	NR1I2	5	pull down, pull down, two hybrid, two hybrid	Mani S (2005), Johnson DR (2006), Johnson DR (2006), Takeshita A (2002)	4
NCOA3	3	CEBPA	0	genetic interference	Louet JF (2006)	1
DYRK2	1	UBR5	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Maddika S (2009), Maddika S (2009), Maddika S (2009), Maddika S (2009), Hossain D (2017)	5
NR5A2	4	NCOA1	6	two hybrid, two hybrid	Chan CM (2013), Albers M (2005)	2
NR1I2	5	NR5A2	4	two hybrid	Li T (2005)	1
NCOR1	9	NCOA1	6	pull down	Stevens A (2003)	1
NR1I2	5	RBCK1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Rana R (2013), Rana R (2013), Rana R (2013), Rana R (2013)	4
PRMT1	3	NCOA2	2	pull down	Koh SS (2001)	1
NCOR2	12	NCOA3	3	affinity chromatography technology, pull down, pull down	Karmakar S (2010), Karmakar S (2010), Karmakar S (2010)	3
NFATC4	2	CEBPA	0	affinity chromatography technology	Kim HB (2010)	1
NCOA6	6	NCOA1	6	pull down, pull down, two hybrid, affinity chromatography technology	Surapureddi S (2011), Lee SK (1999), Lee SK (1999), Goo YH (2003)	4
RXRB	0	NCOA1	6	two hybrid	Albers M (2005)	1
NCOR2	12	RXRG	1	two hybrid	Albers M (2005)	1
PRMT1	3	NCOA3	3	pull down	Koh SS (2001)	1
NR1I2	5	NCOA2	2	two hybrid	Rana R (2013)	1
NR1I2	5	NCOR1	9	two hybrid, affinity chromatography technology	Li CW (2009), Li CW (2009)	2
PPARGC1A	3	NR5A2	4	affinity chromatography technology	Yazawa T (2010)	1
NCOA2	2	UBR5	13	affinity chromatography technology	Jung SY (2005)	1
NR1I2	5	PRMT1	3	affinity chromatography technology	Xie Y (2009)	1
ATP6AP1	0	NR1I2	5	two hybrid	Wang J (2011)	1
TP53	0	NCOA3	3	pull down	Lee SK (1999)	1
NR1I2	5	DDB1	6	affinity chromatography technology, affinity chromatography technology	Ong SS (2014), Ong SS (2014)	2
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
NCOR2	12	NCOR1	9	biochemical, two hybrid	Li J (2000), Korutla L (2005)	2
TP53	0	RBBP7	1	affinity chromatography technology	Fogeron ML (2013)	1
DNMT3L	2	RXRA	1	pull down	Pacaud R (2014)	1
NR1I2	5	PSMC5	4	two hybrid	Albers M (2005)	1
PPARGC1A	3	NR1I2	5	pull down, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid	Bhalla S (2004), Bhalla S (2004), Bhalla S (2004), Albers M (2005), Li T (2006), Li T (2006), Li T (2005)	7
DDB1	6	UBR5	13	affinity chromatography technology	Maddika S (2009)	1
FGR	1	NR1I2	5	two hybrid	Wang J (2011)	1
NR0B2	1	RXRG	1	pull down	Seol W (1996)	1
DYRK2	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Maddika S (2009), Taipale M (2012)	2
PRMT1	3	NCOA1	6	pull down	Koh SS (2001)	1
NR1I2	5	NCOA1	6	x-ray crystallography, two hybrid, two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid	Watkins RE (2003), Rana R (2013), Takeshita A (2002), Pondugula SR (2009), Albers M (2005), Lim YP (2007), Lim YP (2007), Wang H (2008), Li T (2006), Li T (2006), Li T (2005)	11
NR1I2	5	DYRK2	1	affinity chromatography technology, enzymatic study	Ong SS (2014), Ong SS (2014)	2
TP53	0	TFAP2C	4	pull down	McPherson LA (2002)	1
DYRK2	1	DDB1	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Maddika S (2009), Maddika S (2009), Maddika S (2009), Maddika S (2009), Hossain D (2017)	5
RBCK1	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Donley C (2013), Donley C (2013)	2
HNF4A	2	UBE2I	0	two hybrid, enzymatic study	Albers M (2005), Zhou W (2012)	2
UBE2I	0	RXRA	1	enzymatic study	Ogawa H (2009)	1
TP53	0	NCOR1	9	affinity chromatography technology, imaging technique	Dohi Y (2008), Ali A (2013)	2