PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
AKAP4	1	FSIP2	10	two hybrid	Brown PR (2003)	1
AKAP4	1	AKAP3	0	two hybrid, pull down	Brown PR (2003), Brown PR (2003)	2
AKAP4	1	FSIP1	0	two hybrid	Brown PR (2003)	1
AKAP4	1	PRKAR1A	4	two hybrid, two hybrid, pull down	Brown PR (2003), Miki K (1998), Miki K (1998)	3
AKAP3	0	PRKAR2A	0	far western blotting, two hybrid, pull down	Vijayaraghavan S (1999), Carr DW (2001), Carr DW (2001)	3
PRKAR1A	4	AKAP3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AKAP4	1	PRKAR2A	0	pull down	Miki K (1998)	1