PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDK5R1	0	UBXN1	0	affinity chromatography technology	Huttlin EL (2017)	1
CDK2	0	SET	8	affinity chromatography technology	Neganova I (2011)	1
SIAH1	2	CDK5R1	0	two hybrid	Rolland T (2014)	1
CDK5	0	ODF1	0	affinity chromatography technology	Rosales JL (2007)	1
CDK4	2	CDK6	0	affinity chromatography technology, fluorescent resonance energy transfe	Varjosalo M (2013), Ivanov AA (2017)	2
AMPH	4	CDK5R1	0	affinity chromatography technology, pull down	Floyd SR (2001), Floyd SR (2001)	2
APP	1	MAPT	1	pull down, unspecified method	Guo JP (2006), Guo JP (2006)	2
CDK5R1	0	MTUS2	4	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
CDK5R1	0	MAPT	1	enzymatic study	Sasaki K (2009)	1
CDK5R1	0	ACTN1	5	two hybrid, affinity chromatography technology, pull down	Dhavan R (2002), Dhavan R (2002), Dhavan R (2002)	3
CDK5R1	0	HMGCS1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK5R1	0	MVB12A	0	affinity chromatography technology	Huttlin EL (2017)	1
SET	8	CDK5R1	0	pull down, affinity chromatography technology	Qu D (2002), Qu D (2002)	2
CDK5R1	0	CAMK2A	6	two hybrid, affinity chromatography technology, pull down	Dhavan R (2002), Dhavan R (2002), Dhavan R (2002)	3
HSP90AA1	7	CDK4	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsutsumi S (2012), Wang H (2002), Taipale M (2012), Varjosalo M (2013), Huttlin EL (2015), Woodford MR (2016), Huttlin EL (2017)	7
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
CTNNB1	30	CDK5R1	0	pull down, affinity chromatography technology	Kesavapany S (2001), Kesavapany S (2001)	2
HSP90AA1	7	ACTN1	5	affinity chromatography technology	Falsone SF (2005)	1
CDK5R1	0	KRT40	0	two hybrid	Rolland T (2014)	1
UBXN1	0	PLPBP	4	biochemical	Kristensen AR (2012)	1
CDK2	0	MAPT	1	enzymatic study	Sadik G (2009)	1
CDK5R1	0	BLOC1S6	0	two hybrid	Rolland T (2014)	1
CDK5	0	HSP90AA1	7	affinity chromatography technology	Varjosalo M (2013)	1
NEDD4	2	CDK5	0	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
CDK5R1	0	RSPRY1	0	affinity chromatography technology	Huttlin EL (2017)	1
CDK2	0	ACTN1	5	affinity chromatography technology	Neganova I (2011)	1
CTNNB1	30	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vietor I (2005), Billin AN (2000), Iguchi H (2007), Iioka H (2009)	4
HSP90AA1	7	CAMK2A	6	affinity chromatography technology	Taipale M (2012)	1
HDAC1	4	CDK5R1	0	affinity chromatography technology	Kim D (2008)	1
CDK5	0	MAPT	1	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Sengupta A (1998), Liu F (2002), Paudel HK (1997), Sasaki K (2009), Liu F (2006)	5
CDK5RAP1	1	CDK5R1	0	pull down	Wang X (2000)	1
CDK5	0	APP	1	pull down	Olah J (2011)	1
CDK5R1	0	HSP90AA1	7	pull down	Stankiewicz M (2010)	1
CDK2	0	CDK6	0	biochemical, imaging technique	Cheng A (2000), Chen TC (2014)	2
CAMK2A	6	MAPT	1	enzymatic study	Virdee K (2007)	1
TSC22D4	1	KRT40	0	two hybrid	Rolland T (2014)	1
CDK16	0	CDK5R1	0	two hybrid, affinity chromatography technology, pull down	Cheng K (2002), Cheng K (2002), Cheng K (2002)	3
CDK5R1	0	UBE2T	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK5R1	0	APP	1	pull down	Olah J (2011)	1
CDK5	0	CDK5R1	0	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Chen F (2001), Tarricone C (2001), Tarricone C (2001), Lee JH (2007), Sahlgren CM (2006), Zhang J (2012), Rosales JL (2007), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017), Jin N (2017)	11
CDK5	0	CDK3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Huttlin EL (2017)	3
CDK5R1	0	NES	2	affinity chromatography technology	Sahlgren CM (2006)	1
CDK5RAP2	3	CDK5	0	pull down	Wang X (2000)	1
CDK5R1	0	MMAB	1	affinity chromatography technology	Huttlin EL (2017)	1
TPM2	2	ACTN1	5	biochemical	Wan C (2015)	1
HSP90AA1	7	CDK3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Huttlin EL (2015), Huttlin EL (2017)	3
CDK2	0	CDK16	0	affinity chromatography technology	Hein MY (2015)	1
CTNNB1	30	CDK2	0	pull down, affinity chromatography technology	Park CS (2004), Park CS (2004)	2
CDK5R1	0	TSC22D4	1	two hybrid	Rual JF (2005)	1
MAPT	1	DENR	2	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	CDK6	0	affinity chromatography technology	Taipale M (2012)	1
CDK5R1	0	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
CDK4	2	UBXN1	0	affinity chromatography technology	Ewing RM (2007)	1
CDK16	0	APP	1	pull down	Olah J (2011)	1
CDK9	3	CDK5R1	0	affinity chromatography technology	Zhang J (2012)	1
CDK4	2	HDAC1	4	genetic interference	Shen JP (2017)	1
ODF1	0	MTUS2	4	two hybrid	Rolland T (2014)	1
NES	2	HSP90AA1	7	affinity chromatography technology	Hein MY (2015)	1
MVB12A	0	APP	1	pull down	Olah J (2011)	1
CDK5R1	0	CDK5RAP2	3	pull down, pull down	Wang X (2000), Wang X (2000)	2
CDK5RAP3	0	CDK5R1	0	pull down	Wang X (2000)	1
CDK6	0	CTNNB1	30	imaging technique	Chen TC (2014)	1
RSPRY1	0	NES	2	affinity chromatography technology	Huttlin EL (2017)	1
CDK6	0	CDK5R1	0	affinity chromatography technology	Zhang J (2012)	1
DENR	2	UBXN1	0	biochemical	Kristensen AR (2012)	1
CDK4	2	APP	1	pull down	Olah J (2011)	1
NEDD4	2	CDK5R1	0	pull down	Persaud A (2009)	1
CDK4	2	CDK5R1	0	affinity chromatography technology	Zhang J (2012)	1
CDK5	0	NES	2	enzymatic study, affinity chromatography technology, affinity chromatography technology	Sahlgren CM (2003), Sahlgren CM (2003), Sahlgren CM (2006)	3
KRTAP10-3	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
CDK3	0	CDK5R1	0	affinity chromatography technology	Zhang J (2012)	1
CDK2	0	CDK5R1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang J (2012), Huttlin EL (2015), Huttlin EL (2017)	3
SET	8	APP	1	unspecified method, affinity chromatography technology	Madeira A (2005), Briand S (2011)	2
CDK5	0	AMPH	4	enzymatic study	Liang S (2007)	1
CDK5R1	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
CDK9	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mak AB (2010), Taipale M (2012), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	5
CTNNB1	30	APP	1	pull down	Olah J (2011)	1
CDK5R1	0	DENR	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BLOC1S6	0	APP	1	pull down	Olah J (2011)	1
ODF1	0	CDK5R1	0	affinity chromatography technology, enzymatic study	Rosales JL (2007), Rosales JL (2007)	2
CDK2	0	UBE2T	0	enzymatic study	Lv Z (2017)	1
CDK5R1	0	TPM2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK5R1	0	PLPBP	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SIAH1	2	CTNNB1	30	enzymatic study, affinity chromatography technology, affinity chromatography technology	Dimitrova YN (2010), Jumpertz S (2014), Shin M (2016)	3
CDK5	0	CDK16	0	enzymatic study	Cheng K (2002)	1
CDK2	0	TPM2	2	affinity chromatography technology	Hein MY (2015)	1
CDK3	0	APP	1	pull down	Olah J (2011)	1
ACTN1	5	CAMK2A	6	imaging technique	Chen TC (2014)	1
CDK2	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Varjosalo M (2013)	2
CDK2	0	CDK3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3