PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HESX1	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
STAT3	HESX1	0	two hybrid	Grossmann A (2015)	1
STAT3	KDM1A	2	affinity chromatography technology, enzymatic study	Yang J (2010), Yang J (2010)	2
HESX1	KDM1A	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
HESX1	RBP4	0	affinity chromatography technology	Huttlin EL (2017)	1
NPAS2	HESX1	0	two hybrid	Ravasi T (2010)	1
HESX1	TLE1	6	affinity chromatography technology, pull down	Dasen JS (2001), Dasen JS (2001)	2
HESX1	NCOR1	9	pull down	Xu L (1998)	1