PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRAF2	1	LNX1	7	two hybrid	Rual JF (2005)	1
TNFRSF18	4	TNFRSF18	4	pull down	Gurney AL (1999)	1
TNFRSF18	4	TRAF3	1	affinity chromatography technology, two hybrid	Kwon B (1999), Esparza EM (2005)	2
TRAF2	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Li S (2011), He L (2004), He L (2004), Pullen SS (1998)	4
TNFRSF18	4	TRAF1	0	affinity chromatography technology, two hybrid	Kwon B (1999), Esparza EM (2005)	2
TRAF1	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Pullen SS (1998), Greenfeld H (2015)	2
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
LNX1	7	TNFRSF18	4	two hybrid	Guo Z (2012)	1
TNFRSF18	4	TRAF2	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Kwon B (1999), Esparza EM (2005), Esparza EM (2005)	3