PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ARHGDIA	3	MSN	0	biochemical, biochemical	Gajate C (2005), Wan C (2015)	2
CASP8AP2	3	FADD	1	affinity chromatography technology	Imai Y (1999)	1
EZR	8	TNFRSF1A	3	biochemical	Gajate C (2005)	1
BID	1	FASLG	0	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
CFLAR	1	TNFRSF1A	3	genetic interference	Ma Y (2017)	1
CASP10	1	RIPK1	2	affinity chromatography technology	Chaudhary PM (2000)	1
TNFRSF1A	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Won M (2010), Zilberman-Rudenko J (2016), Moquin DM (2013)	3
TNF	0	TNFAIP3	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skaug B (2011), Tokunaga F (2012), Verhelst K (2012), Yamaguchi N (2015), Draber P (2015)	5
FAF1	1	CUL3	17	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
BID	1	TNFRSF1A	3	biochemical	Gajate C (2005)	1
CASP8	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (2000), Oshima S (2009), Bertrand MJ (2008), Knox PG (2011), Kim S (2010), Cheung HH (2009), Tenev T (2011), Tenev T (2011), Mahul-Mellier AL (2011), Legarda-Addison D (2009), Biton S (2011), Bellail AC (2012), Bellail AC (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Puliyappadamba VT (2013), Wu P (2014), Wu P (2014), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Moquin DM (2013), Ranjan K (2016), Zinngrebe J (2016), Nakazawa S (2016), Zheng M (2016)	27
TNFRSF10A	0	FADD	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (1997), Sinha SK (2004), Guo F (2005), Gonzalvez F (2012), Jeong M (2017), Huttlin EL (2017)	6
LRRK2	5	TRADD	0	affinity chromatography technology	Ho CC (2009)	1
FAS	2	MAPK8	3	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
CASP8	1	PARK7	0	pull down	Fu K (2012)	1
TLR3	2	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Cusson-Hermance N (2005), Zinngrebe J (2016)	2
RHOA	0	BID	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
EHD1	5	FADD	1	biochemical	Wan C (2015)	1
DAXX	5	SPOP	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	La M (2004), Liu F (2012), Kwon JE (2006), Kwon JE (2006), Wang J (2011), Wang J (2011), Zhang P (2017)	7
IKBKG	0	ARHGDIA	3	pull down	Kim HJ (2014)	1
TAB1	1	TRAF2	1	affinity chromatography technology	Bouwmeester T (2004)	1
CASP10	1	TNFRSF10B	1	biochemical, affinity chromatography technology	Gajate C (2005), MacFarlane M (1997)	2
ARHGDIA	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
23429	0	FADD	1	affinity chromatography technology	Zheng L (2001)	1
MSN	0	BID	1	biochemical	Gajate C (2005)	1
CASP10	1	FASLG	0	biochemical	Gajate C (2005)	1
DAXX	5	CUL3	17	affinity chromatography technology, affinity chromatography technology	Kwon JE (2006), Kwon JE (2006)	2
TRAF2	1	RIPK3	2	affinity chromatography technology	Yu PW (1999)	1
MAPK8	3	TRAF2	1	affinity chromatography technology	Gravestein LA (1998)	1
TLR3	2	FADD	1	affinity chromatography technology	Zinngrebe J (2016)	1
FAS	2	FADD	1	biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Gajate C (2005), MacFarlane M (1997), Pan G (1997), Huang B (1996), Huang B (1996), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Thomas LR (2002), Kumar A (2001), Lee EW (2012), Zhang M (2011), Huttlin EL (2015), Chen TC (2014), Jeong M (2017), Huttlin EL (2017), Kleber S (2008), Torii S (1999), Torii S (1999), Chang HY (1999)	20
RIPK1	2	CLIP3	4	affinity chromatography technology	Fujikura D (2012)	1
CASP8	1	FADD	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Srinivasula SM (1997), Srinivasula SM (1997), Henshall DC (2003), Boldin MP (1996), Oshima S (2009), Thomas LR (2002), Ikner A (2011), Tenev T (2011), Ramakrishnan P (2011), Mahul-Mellier AL (2011), Won M (2010), Ryu SW (2003), Sinha SK (2004), Biton S (2011), Fu K (2012), Fu K (2012), Gonzalvez F (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Wang J (2011), Puliyappadamba VT (2013), Choi H (2011), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Saitoh Y (2016), Moquin DM (2013), Ranjan K (2016), Nakazawa S (2016), Jeong M (2017), Jeong M (2017), Pescatore A (2016)	35
FAS	2	ARHGDIA	3	biochemical	Gajate C (2005)	1
FAS	2	DAXX	5	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, pull down	Ko YG (2001), Kim YY (2003), Cermak L (2002), Yang X (1997), Yang X (1997), Yang X (1997), Charette SJ (2000), Chen TC (2014), Chang HY (1999)	9
TNFRSF10A	0	CASP8	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kaunisto A (2009), Kaunisto A (2009), Sinha SK (2004), Guo F (2005), Jin Z (2009), Gonzalvez F (2012), Gonzalvez F (2012), Jeong M (2017), Huttlin EL (2017)	10
FADD	1	FADD	1	affinity chromatography technology	Jeong M (2017)	1
TRADD	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Park YC (2000), Tsao DH (2000), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Vince JE (2009), Jang HD (2001), Park KJ (2003), Lin B (2016)	12
RAP1A	1	RALGDS	4	two hybrid, pull down, two hybrid	Boettner B (2000), Nancy V (1999), Nancy V (2002)	3
TNFRSF1A	3	MOB4	0	affinity chromatography technology	Huttlin EL (2017)	1
CLIP3	4	TNFRSF1A	3	two hybrid, affinity chromatography technology	Fujikura D (2012), Fujikura D (2012)	2
EHD1	5	NOL3	0	biochemical	Kristensen AR (2012)	1
EZR	8	CASP8	1	biochemical	Gajate C (2005)	1
TNFAIP3	3	IRF7	2	affinity chromatography technology, affinity chromatography technology	Ning S (2010), Ning S (2010)	2
LRRK2	5	DAPK1	6	affinity chromatography technology, affinity chromatography technology	Klein CL (2009), Klein CL (2009)	2
BID	1	TNFRSF10B	1	biochemical	Gajate C (2005)	1
RIPK1	2	FADD	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen D (2002), Young JA (2011), Tenev T (2011), Ramakrishnan P (2011), Legarda-Addison D (2009), ODonnell MA (2012), Vanlangenakker N (2011), Biton S (2011), Biton S (2011), Lee EW (2012), Puliyappadamba VT (2013), Wu P (2014), Huttlin EL (2015), Baratchian M (2016), Moquin DM (2013), Ranjan K (2016), Pescatore A (2016), Zheng M (2016)	18
MYD88	1	SPOP	1	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Wang J (2011), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	5
PEA15	0	FADD	1	pull down, affinity chromatography technology	Kitsberg D (1999), Condorelli G (1999)	2
HIPK3	5	FAS	2	affinity chromatography technology	Rochat-Steiner V (2000)	1
RHOA	0	FADD	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
ARHGDIA	3	EZR	8	biochemical, biochemical	Gajate C (2005), Wan C (2015)	2
FADD	1	THAP12	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK8	3	CASP10	1	biochemical	Gajate C (2005)	1
MAPK8	3	FASLG	0	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
TNFAIP3	3	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Song HY (1996), Song HY (1996), Fries KL (1999), Yamaguchi N (2013), Rolland T (2014)	5
MSN	0	FASLG	0	biochemical	Gajate C (2005)	1
CASP8	1	FAF1	1	affinity chromatography technology, affinity chromatography technology	Knox PG (2011), Caballero-Lopez MJ (2017)	2
TNF	0	TRADD	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Legler DF (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Skaug B (2011), Fu J (2013), Fritsch J (2014), Schlicher L (2016)	10
TNFSF10	2	TNFAIP3	3	affinity chromatography technology	Bellail AC (2012)	1
CUL3	17	ARHGDIA	3	affinity chromatography technology	Bennett EJ (2010)	1
TNFRSF1A	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
FADD	1	NEFH	4	affinity chromatography technology	Huttlin EL (2015)	1
SPOP	1	FAF1	1	two hybrid	Zhang P (2017)	1
CASP8	1	TNFRSF1A	3	biochemical	Gajate C (2005)	1
TNFRSF10A	0	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kaunisto A (2009), Gonzalvez F (2012), Jeong M (2017)	4
RAP1A	1	FADD	1	pull down	Stoletov KV (2004)	1
ARHGDIA	3	RHOA	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, biochemical, pull down, x-ray crystallography	Ewing RM (2007), Gajate C (2005), Michaelson D (2001), Gorvel JP (1998), Faure J (2001), Man JH (2010), Rolland T (2014), Wan C (2015), Jaffe AB (2004), Kuhlmann N (2016), Kuhlmann N (2016), Kuhlmann N (2016)	12
CFLAR	1	NOL3	0	genetic interference	Koseki T (1998)	1
TNF	0	CASP8	1	affinity chromatography technology	Fritsch J (2014)	1
CASP10	1	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Micheau O (2003), Guo Y (2002), Srinivasula SM (1996), Srinivasula SM (1996), Sinha SK (2004), Lee EW (2012), Feoktistova M (2011)	9
PARK7	0	FADD	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Fu K (2012), Fu K (2012), Fu K (2012), Fu K (2012)	4
TNFRSF1A	3	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Shu HB (1996), Vince JE (2009), Mahul-Mellier AL (2011), Won M (2010), Kolliputi N (2009), Park KJ (2002), Lee IT (2010), Kim WJ (2005), Zheng L (2006), Vince JE (2007), Jeon J (2014), Chen TC (2014), Lee CK (2015), Jeong M (2017)	16
DEDD	0	CASP8	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Zhan Y (2002), Alcivar A (2003), Stegh AH (1998), Stegh AH (1998)	4
FADD	1	RIPK3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vanlangenakker N (2011), Lee EW (2012), Lee EW (2012), Moriwaki K (2016), Pescatore A (2016)	5
TRIM21	0	DAXX	5	affinity chromatography technology, two hybrid	Tanaka M (2010), Tanaka M (2010)	2
LRRK2	5	RIPK1	2	affinity chromatography technology	Ho CC (2009)	1
CUL3	17	FADD	1	affinity chromatography technology	Gonzalvez F (2012)	1
TNF	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006), Tokunaga F (2012), Verhelst K (2012), Draber P (2015), Pescatore A (2016)	6
BID	1	CASP10	1	biochemical	Gajate C (2005)	1
MAPK8	3	CASP8	1	biochemical	Gajate C (2005)	1
TNF	0	FAS	2	affinity chromatography technology	Legler DF (2003)	1
TNFRSF1A	3	TNF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Bouwmeester T (2004), Micheau O (2003), Legler DF (2003), Kuai J (2004), Skaug B (2011), Tokunaga F (2012), Klingseisen L (2012), Thoma B (1990), Keusekotten K (2013), Crowe PD (1994), Liu LS (1998), Higuchi M (1992), Chaturvedi MM (1994), Schaeffer V (2014), Fritsch J (2014), Chainy GB (1996), Huttlin EL (2015), Chen TC (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Huttlin EL (2017), Nielsen FS (2004), Ameloot P (2001)	24
FASLG	0	CFLAR	1	affinity chromatography technology	Tao RH (2011)	1
DAPK1	6	CUL3	17	affinity chromatography technology	Lee YR (2010)	1
BID	1	CASP8	1	biochemical, enzymatic study	Gajate C (2005), Guo Y (2002)	2
TNFRSF10A	0	DAP3	1	affinity chromatography technology, two hybrid	Miyazaki T (2001), Miyazaki T (2001)	2
RHOA	0	NAXE	2	biochemical	Wan C (2015)	1
EZR	8	CASP10	1	biochemical	Gajate C (2005)	1
RHOA	0	CASP8	1	biochemical	Gajate C (2005)	1
IRF7	2	TRIM21	0	affinity chromatography technology	Higgs R (2010)	1
EZR	8	MAPK8	3	biochemical	Gajate C (2005)	1
EDAR	1	TRADD	0	affinity chromatography technology	Kumar A (2001)	1
FAS	2	CASP10	1	biochemical, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Vincenz C (1997), MacFarlane M (1997)	3
RALGDS	4	FADD	1	affinity chromatography technology	Ikner A (2011)	1
FADD	1	NACA	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Stilo R (2003), Stilo R (2003), Stilo R (2003), Zeng W (2014)	4
TLR3	2	CASP8	1	affinity chromatography technology	Zinngrebe J (2016)	1
TNF	0	FADD	1	affinity chromatography technology	Fritsch J (2014)	1
CASP8	1	FASLG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Legler DF (2003), Tao RH (2011)	4
FADD	1	TRIM21	0	affinity chromatography technology, affinity chromatography technology, pull down	Young JA (2011), Young JA (2011), Young JA (2011)	3
RHOA	0	MAPK8	3	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
FADD	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Won M (2010), Saitoh Y (2016)	2
TNF	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Fritsch J (2014), Yamaguchi N (2015)	7
TNFSF10	2	RIPK1	2	affinity chromatography technology	Bellail AC (2012)	1
RHOA	0	CASP10	1	biochemical	Gajate C (2005)	1
LRRK2	5	RHOA	0	affinity chromatography technology	Chan D (2011)	1
FAS	2	EZR	8	biochemical	Gajate C (2005)	1
TNFRSF10A	0	TRADD	0	affinity chromatography technology	Chaudhary PM (1997)	1
CASP8	1	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin Z (2009), Jin Z (2009), Gonzalvez F (2012), Xu J (2015)	4
ARHGDIA	3	MAPK8	3	biochemical	Gajate C (2005)	1
TNFRSF1A	3	TRADD	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Y (1999), Schuetze S (1999), Pan G (1997), Hsu H (1996), Hsu H (1996), Hsu H (1996), Shu HB (1996), Blankenship JW (2009), Kolliputi N (2009), Fujikura D (2012), Park KJ (2002), Guan YJ (2011), Hsu H (1995), Kumar A (2001), Zheng L (2006), Kim TW (2013), Zhang H (2004), Chang YL (2014), Nakazawa S (2016), Huttlin EL (2017)	20
CASP10	1	DEDD	0	affinity chromatography technology	Alcivar A (2003)	1
MSN	0	FADD	1	biochemical	Gajate C (2005)	1
MAVS	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2010), Li S (2011), Li S (2011), Wang L (2012), Wang L (2012), Zhou Z (2014)	6
CASP10	1	CASP8AP2	3	two hybrid	McDonald ER (2004)	1
FAS	2	TRADD	0	affinity chromatography technology	Kumar A (2001)	1
CASP8	1	TRADD	0	affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kolliputi N (2009)	2
PIN1	0	FADD	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Oh J (2013), Oh J (2013), Oh J (2013), Oh J (2013)	4
TNF	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legler DF (2003), Haas TL (2009), Ea CK (2006), Ramakrishnan P (2011), Skaug B (2011), Darding M (2011), Tokunaga F (2012), Klingseisen L (2012), Schaeffer V (2014), Fritsch J (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Schlicher L (2016)	14
CFLAR	1	DEDD	0	affinity chromatography technology, pull down	Roth W (2002), Zhan Y (2002)	2
MSN	0	CASP8	1	biochemical	Gajate C (2005)	1
CFLAR	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kataoka T (2000), Chaudhary PM (2000), Rebe C (2007), Feoktistova M (2011), Ranjan K (2016), Ranjan K (2016)	6
TNFRSF10B	1	CUL3	17	affinity chromatography technology	Gonzalvez F (2012)	1
DAP3	1	FADD	1	affinity chromatography technology, two hybrid	Miyazaki T (2001), Miyazaki T (2001)	2
PIN1	0	TRAF2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
FADD	1	NLRC4	2	affinity chromatography technology	Raghawan AK (2017)	1
TNFRSF1A	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Zhang SQ (2000), Nakazawa S (2016)	2
TRAF2	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), Kataoka T (2000), Kataoka T (2000)	3
RAP1A	1	ARHGDIA	3	biochemical	Wan C (2015)	1
TNFSF10	2	CASP8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bangert A (2012), Bellail AC (2012), Gonzalvez F (2012), Jennewein C (2012), Li Y (2013), Xu J (2015)	6
CASP8AP2	3	FAS	2	affinity chromatography technology	Imai Y (1999)	1
EDAR	1	FADD	1	affinity chromatography technology	Kumar A (2001)	1
HIPK3	5	FADD	1	affinity chromatography technology	Rochat-Steiner V (2000)	1
CASP8	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Shu HB (1997), Goltsev YV (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Micheau O (2002), Han DK (1997), Han DK (1997), Han DK (1997), Roth W (2002), Zhang L (2009), Tenev T (2011), Kerr E (2012), Sinha SK (2004), Lee EW (2012), Rebe C (2007), Rebe C (2007), Kaunisto A (2009), Feoktistova M (2011), Feoktistova M (2011), Huttlin EL (2015), Huttlin EL (2017)	23
TNF	0	TAB1	1	affinity chromatography technology	Haas TL (2009)	1
FAS	2	RIPK1	2	two hybrid	Stanger BZ (1995)	1
CASP10	1	FADD	1	biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, pull down, pull down	Gajate C (2005), Vincenz C (1997), Vincenz C (1997), Srinivasula SM (1997), Srinivasula SM (1997), Wang J (2001), McDonald ER (2004), Choi H (2011), Choi H (2011)	9
FADD	1	IRF7	2	affinity chromatography technology	Young JA (2011)	1
ARHGDIA	3	CASP8	1	biochemical	Gajate C (2005)	1
CASP8	1	CLIP3	4	affinity chromatography technology	Fujikura D (2012)	1
BID	1	FADD	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
TNFRSF10B	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Chaudhary PM (1997), Bellail AC (2012)	2
ATG12	1	ATG5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Behrends C (2010), Behrends C (2010), Chen D (2012), Zheng Y (2017)	5
FAS	2	MSN	0	biochemical	Gajate C (2005)	1
FAS	2	MBD4	1	two hybrid	Wang J (2011)	1
TRADD	0	NOL3	0	genetic interference	Koseki T (1998)	1
MYD88	1	IRF7	2	affinity chromatography technology, two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Zhao J (2006), Kawai T (2004), Kawai T (2004), Kawai T (2004)	4
TNFRSF10A	0	CUL3	17	affinity chromatography technology	Gonzalvez F (2012)	1
PIDD1	5	RIPK1	2	affinity chromatography technology	Janssens S (2005)	1
NAXE	2	FADD	1	biochemical	Wan C (2015)	1
LRRK2	5	PRKCZ	5	enzymatic study	Zach S (2010)	1
TNFRSF10B	1	TRADD	0	affinity chromatography technology	Chaudhary PM (1997)	1
ARHGDIA	3	BID	1	biochemical	Gajate C (2005)	1
TNFRSF1A	3	KHDRBS1	1	affinity chromatography technology	Pincheira R (2008)	1
CUL3	17	RHOA	0	affinity chromatography technology, affinity chromatography technology	Chen Y (2009), Dubiel D (2017)	2
RHOA	0	TNFRSF10B	1	biochemical	Gajate C (2005)	1
FADD	1	PRKCZ	5	affinity chromatography technology	de Thonel A (2001)	1
MAPK8	3	TNFRSF1A	3	biochemical	Gajate C (2005)	1
FADD	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Chaudhary PM (1997), Kim Y (2002), Guo F (2005), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017)	8
FAF1	1	FADD	1	pull down, affinity chromatography technology	Ryu SW (2003), Ryu SW (2003)	2
RHOA	0	TNFRSF1A	3	biochemical	Gajate C (2005)	1
EZR	8	FASLG	0	biochemical, affinity chromatography technology	Gajate C (2005), Parlato S (2000)	2
CASP10	1	23429	0	affinity chromatography technology, affinity chromatography technology	Zheng L (2001), Zheng L (2001)	2
RHOA	0	FASLG	0	biochemical	Gajate C (2005)	1
LRRK2	5	FADD	1	affinity chromatography technology	Ho CC (2009)	1
FAS	2	NOL3	0	genetic interference	Koseki T (1998)	1
TNFRSF10B	1	TNFAIP3	3	affinity chromatography technology	Bellail AC (2012)	1
PIDD1	5	FADD	1	affinity chromatography technology, affinity chromatography technology	Telliez JB (2000), Janssens S (2005)	2
LRRK2	5	TRAF2	1	enzymatic study	Zach S (2010)	1
PARK7	0	TAB1	1	affinity chromatography technology	Malty RH (2017)	1
ABCA1	5	IKBKG	0	two hybrid	Wang J (2011)	1
MBD4	1	FADD	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Screaton RA (2003), Screaton RA (2003), Screaton RA (2003)	3
FAS	2	TNFRSF1A	3	biochemical	Gajate C (2005)	1
MAVS	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Yu H (2011), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	7
FAS	2	FAF1	1	affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology	Chu K (1995), Ryu SW (1999), Ryu SW (1999), Imai Y (2002), Ryu SW (2003)	5
FAS	2	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Shu HB (1997), MacFarlane M (1997), Huttlin EL (2015), Jeong M (2017), Huttlin EL (2017), Kleber S (2008)	7
TNFRSF10A	0	CASP10	1	affinity chromatography technology	MacFarlane M (1997)	1
FADD	1	ATG12	1	affinity chromatography technology	Pyo JO (2005)	1
TNFRSF1A	3	DAPK1	6	affinity chromatography technology	Henshall DC (2003)	1
FAS	2	BID	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
IKBKG	0	RHOA	0	pull down	Kim HJ (2014)	1
TNFSF10	2	FADD	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bangert A (2012), Bellail AC (2012), Jennewein C (2012), Xu J (2015)	4
CFLAR	1	FADD	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Han DK (1997), Kerr E (2012), Rebe C (2007), Choi H (2011), Feoktistova M (2011), Ranjan K (2016), Jeong M (2017)	13
TRIM21	0	CASP8AP2	3	two hybrid	Tanaka M (2010)	1
FADD	1	TRADD	0	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henshall DC (2003), Hsu H (1996), Hsu H (1996), Thomas LR (2002), Guan YJ (2011), Park KJ (2003), Qi Z (2014)	7
IKBKG	0	TNFAIP3	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhang SQ (2000), Zhang SQ (2000), Skaug B (2011), Skaug B (2011), Klinkenberg M (2001), Verhelst K (2012), Verhelst K (2012), Wang J (2011), Zilberman-Rudenko J (2016)	9
MSN	0	TNFRSF1A	3	biochemical	Gajate C (2005)	1
IKBKG	0	FADD	1	affinity chromatography technology	Biton S (2011)	1
ABCA1	5	FADD	1	two hybrid, pull down, pull down	Buechler C (2002), Buechler C (2002), Buechler C (2002)	3
TNFRSF10A	0	TNFRSF10B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guo F (2005), Jin Z (2009), Huttlin EL (2017)	3
RIPK3	2	RIPK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu PW (1999), Yu PW (1999), Li S (2011), Lee EW (2012), Petersen SL (2015), Moquin DM (2013), Moriwaki K (2016)	7
FADD	1	MYD88	1	two hybrid	Wang J (2011)	1
TRAF2	1	CASP8AP2	3	pull down, affinity chromatography technology	Choi YH (2001), Choi YH (2001)	2
FADD	1	DAXX	5	affinity chromatography technology	Meinecke I (2007)	1
FADD	1	FASLG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Gajate C (2005), Micheau O (2003), Legler DF (2003), Tao RH (2011), Chen TC (2014)	5
DAXX	5	RIPK3	2	pull down, pull down, affinity chromatography technology, enzymatic study	Lee YS (2013), Lee YS (2013), Lee YS (2013), Lee YS (2013)	4
FASLG	0	TNFRSF10B	1	biochemical	Gajate C (2005)	1
MSN	0	CASP10	1	biochemical	Gajate C (2005)	1
RIPK3	2	TNFRSF1A	3	affinity chromatography technology	Yu PW (1999)	1
FAS	2	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), MacFarlane M (1997), Jeong M (2017)	3
CASP10	1	TNFRSF1A	3	biochemical, affinity chromatography technology	Gajate C (2005), Vincenz C (1997)	2
FADD	1	DAPK1	6	affinity chromatography technology, affinity chromatography technology, imaging technique	Henshall DC (2003), Henshall DC (2004), Chen TC (2014)	3
FADD	1	KHDRBS1	1	affinity chromatography technology, affinity chromatography technology	Ramakrishnan P (2011), Ramakrishnan P (2011)	2
FADD	1	MKRN1	1	affinity chromatography technology, affinity chromatography technology, pull down	Lee EW (2012), Lee EW (2012), Lee EW (2012)	3
TNFRSF10A	0	TRAF2	1	affinity chromatography technology	Gonzalvez F (2012)	1
RHOA	0	EZR	8	biochemical	Gajate C (2005)	1
MAPK8	3	FADD	1	biochemical	Gajate C (2005)	1
CASP8	1	NLRC4	2	affinity chromatography technology, affinity chromatography technology	Kumar Y (2010), Raghawan AK (2017)	2
TLR3	2	IKBKG	0	affinity chromatography technology	Zinngrebe J (2016)	1
ARHGDIA	3	TNFRSF1A	3	biochemical	Gajate C (2005)	1
FADD	1	CLIP3	4	affinity chromatography technology	Fujikura D (2012)	1
PARK7	0	DAXX	5	two hybrid, affinity chromatography technology	Junn E (2005), Junn E (2005)	2
IRF7	2	MAVS	1	affinity chromatography technology	Xu LG (2005)	1
CASP8	1	RIPK3	2	affinity chromatography technology	Lee EW (2012)	1
FADD	1	SPOP	1	two hybrid	Wang J (2011)	1
RHOA	0	MSN	0	biochemical	Gajate C (2005)	1
CASP8AP2	3	CASP8	1	affinity chromatography technology	Imai Y (1999)	1
EHD1	5	NAXE	2	biochemical	Wan C (2015)	1
CASP8	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Kaunisto A (2009), Guo F (2005), Gonzalvez F (2012), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017), Xu L (2017)	12
PIN1	0	DAXX	5	affinity chromatography technology, affinity chromatography technology	Ryo A (2007), Ryo A (2007)	2
TNFRSF1A	3	DAXX	5	two hybrid, pull down	Yang X (1997), Yang X (1997)	2
FADD	1	DEDD	0	affinity chromatography technology, pull down, affinity chromatography technology	Roth W (2002), Stegh AH (1998), Stegh AH (1998)	3
TNFSF10	2	TRAF2	1	affinity chromatography technology	Bellail AC (2012)	1
TNFSF10	2	CUL3	17	affinity chromatography technology	Xu J (2015)	1
FAS	2	TNFRSF10B	1	biochemical	Gajate C (2005)	1
CUL3	17	NACA	1	affinity chromatography technology	Bennett EJ (2010)	1
TNFSF10	2	CFLAR	1	affinity chromatography technology, affinity chromatography technology	Bangert A (2012), Jennewein C (2012)	2
RAP1A	1	FAS	2	pull down, imaging technique	Stoletov KV (2004), Chen TC (2014)	2
BID	1	MAPK8	3	biochemical	Gajate C (2005)	1
DAXX	5	CFLAR	1	affinity chromatography technology, affinity chromatography technology	Kim YY (2003), Kim YY (2003)	2
CUL3	17	KHDRBS1	1	affinity chromatography technology	Bennett EJ (2010)	1
RAP1A	1	FAF1	1	pull down	Stoletov KV (2004)	1
IKBKG	0	MYD88	1	pull down	Emmerich CH (2013)	1
NOL3	0	DAXX	5	affinity chromatography technology, affinity chromatography technology	Donath S (2016), Donath S (2016)	2
EZR	8	FADD	1	biochemical, affinity chromatography technology, imaging technique	Gajate C (2005), Young JA (2011), Chen TC (2014)	3
FADD	1	TNFRSF1A	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Hsu H (1996), Kumar A (2001), Zheng L (2006)	4
CASP8	1	NOL3	0	genetic interference, affinity chromatography technology	Koseki T (1998), Koseki T (1998)	2
RIPK1	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Li H (2006), Ea CK (2006), Dynek JN (2010), Skaug B (2011), Wagner S (2008), Wu CJ (2006), Legarda-Addison D (2009), Yang Y (2011), Bohgaki M (2008), Lucas PC (2001), Biton S (2011), Zhu G (2007), Zhu G (2007), Keusekotten K (2013), Jeon J (2014), Wu CJ (2006), Vincendeau M (2016), Baratchian M (2016), Zilberman-Rudenko J (2016), Medunjanin S (2016), Bal E (2017), Bal E (2017)	23
MAPK8	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
ARHGDIA	3	CASP10	1	biochemical	Gajate C (2005)	1
FAS	2	RHOA	0	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
RIPK1	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim JW (2000), Duan H (1997), Hsu H (1996), Blankenship JW (2009), Newton K (2008), Varfolomeev E (2008), Fearns C (2006), Vince JE (2009), Dynek JN (2010), Kim S (2010), Cheung HH (2009), Tenev T (2011), Mahul-Mellier AL (2011), Won M (2010), Glowacka WK (2012), Fan YH (2011), Cusson-Hermance N (2005), ODonnell MA (2012), Zheng L (2006), Vince JE (2007), Mitsuhashi S (2008), Kim TW (2013), Wertz IE (2004), Liao W (2008), Wang YB (2015), Chang YL (2014), Zilberman-Rudenko J (2016), Zemirli N (2014), Moquin DM (2013), Nakazawa S (2016), Jeong M (2017), Huttlin EL (2017), Elliott PR (2016)	33
MAVS	1	FADD	1	affinity chromatography technology	Kawai T (2005)	1
CASP8	1	RALGDS	4	affinity chromatography technology, affinity chromatography technology	Ikner A (2011), Ikner A (2011)	2
FAS	2	EHD1	5	affinity chromatography technology	Huttlin EL (2015)	1
MSN	0	EZR	8	biochemical, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Gary R (1995), Gary R (1993), Gary R (1993), Hein MY (2015)	5
TAB1	1	FADD	1	two hybrid	Vinayagam A (2011)	1
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
KHDRBS1	1	RIPK1	2	pull down, affinity chromatography technology	Ramakrishnan P (2011), Ramakrishnan P (2011)	2
TRAF2	1	IKBKG	0	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Poyet JL (2000), Shen RR (2012), Shen RR (2012), Bal E (2017), Bal E (2017)	6
MSN	0	TNFRSF10B	1	biochemical	Gajate C (2005)	1
TRAF2	1	FADD	1	affinity chromatography technology	Gonzalvez F (2012)	1
KHDRBS1	1	CASP8	1	affinity chromatography technology	Ramakrishnan P (2011)	1
MSN	0	MAPK8	3	biochemical	Gajate C (2005)	1
TNFRSF1A	3	NOL3	0	genetic interference	Koseki T (1998)	1
LRRK2	5	CASP8	1	affinity chromatography technology	Ho CC (2009)	1
FADD	1	NOL3	0	genetic interference	Koseki T (1998)	1
CASP8	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Micheau O (2003), Knox PG (2011), Mahul-Mellier AL (2011), Gonzalvez F (2012), Gonzalvez F (2012), Xu L (2017), Xu L (2017)	7
FASLG	0	TNFRSF1A	3	biochemical, affinity chromatography technology	Gajate C (2005), Legler DF (2003)	2
FAS	2	FASLG	0	biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Gajate C (2005), Micheau O (2003), Starling GC (1997), Schneider P (1997), Legler DF (2003), Tao RH (2011), Chen TC (2014)	7
PEA15	0	CASP8	1	pull down, affinity chromatography technology	Kitsberg D (1999), Condorelli G (1999)	2
TNFSF10	2	TNFRSF10B	1	pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaptein A (2000), Walczak H (1997), Hymowitz SG (1999), Hymowitz SG (1999), Bellail AC (2012), Jennewein C (2012), Xu J (2015)	7
23429	0	CASP8	1	affinity chromatography technology	Tan K (2017)	1
MOB4	0	FADD	1	two hybrid	Stelzl U (2005)	1
FADD	1	TPPP	3	affinity chromatography technology	Huttlin EL (2017)	1
TRADD	0	RIPK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Hsu H (1996), Ea CK (2006), Guan YJ (2011), Jeon J (2014), Lin B (2016)	7
TLR3	2	MYD88	1	pull down	Doyle SE (2003)	1
TNFRSF10B	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Bellail AC (2012), Gonzalvez F (2012)	2
ATG5	0	FADD	1	pull down, affinity chromatography technology, imaging technique	Pyo JO (2005), Pyo JO (2005), Pyo JO (2005)	3
CASP10	1	CFLAR	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Micheau O (2003), Goltsev YV (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Feoktistova M (2011), Chen TC (2014)	7
TNFRSF10B	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Gonzalvez F (2012)	4
SPOP	1	CUL3	17	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li C (2011), Cummings CM (2009), Choo YY (2011), Choo YY (2012), Plafker KS (2009), Kwon JE (2006), Kwon JE (2006), Wang J (2011), Wimuttisuk W (2014), Theurillat JP (2014), Sakaue T (2017)	11
EZR	8	TNFRSF10B	1	biochemical	Gajate C (2005)	1
ARHGDIA	3	FASLG	0	biochemical	Gajate C (2005)	1
EZR	8	BID	1	biochemical	Gajate C (2005)	1
PIDD1	5	IKBKG	0	affinity chromatography technology	Janssens S (2005)	1
FADD	1	IL37	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CASP8	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Oshima S (2009), Saitoh Y (2016)	2
IKBKG	0	TAB1	1	pull down	Emmerich CH (2013)	1
TNFRSF10A	0	TNFSF10	2	affinity chromatography technology	Pan G (1997)	1
ARHGDIA	3	FADD	1	biochemical	Gajate C (2005)	1
RIPK1	2	TNFAIP3	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Shembade N (2009), Wertz IE (2004), Wertz IE (2004), Wertz IE (2004), Shembade N (2008), Bellail AC (2012)	6
IKBKG	0	DAPK1	6	pull down	Fenner BJ (2010)	1