PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TNFRSF14	2	NDUFS2	0	two hybrid	Vinayagam A (2011)	1
TNFSF14	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Kuai J (2003), Kuai J (2003)	2
UBQLN4	2	TRAF2	1	two hybrid	Lim J (2006)	1
TNFSF13	0	TNFRSF14	2	pull down	Kelly K (2000)	1
TNFRSF14	2	CEP126	0	two hybrid	Vinayagam A (2011)	1
TNFRSF14	2	MBTPS1	4	two hybrid	Vinayagam A (2011)	1
CHD3	19	VIM	0	two hybrid	Goehler H (2004)	1
TNFRSF14	2	PDIA6	1	affinity chromatography technology	Ewing RM (2007)	1
TNFRSF14	2	SERPINA4	0	two hybrid	Vinayagam A (2011)	1
TNFRSF14	2	VIM	0	two hybrid	Stelzl U (2005)	1
TNFRSF14	2	DYNLL1	0	two hybrid	Vinayagam A (2011)	1
TNFRSF14	2	CHD3	19	two hybrid	Stelzl U (2005)	1
DRAP1	2	APP	1	pull down	Olah J (2011)	1
TNFRSF14	2	ZBTB48	3	two hybrid	Vinayagam A (2011)	1
TRAF5	1	TRAF2	1	affinity chromatography technology, pull down, pull down	Li S (2011), Li S (2011), Pullen SS (1998)	3
TNFRSF14	2	TRAF1	0	pull down	Marsters SA (1997)	1
BTLA	0	TNFRSF14	2	pull down	Ramani SR (2012)	1
TNFRSF14	2	UBQLN4	2	two hybrid	Vinayagam A (2011)	1
TNFSF14	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Kuai J (2003), Kuai J (2003)	2
CD160	0	TNFRSF14	2	pull down	Ramani SR (2012)	1
TNFRSF14	2	ITFG1	1	two hybrid	Vinayagam A (2011)	1
TNFRSF14	2	TRAF3	1	pull down	Marsters SA (1997)	1
TRAF2	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Li S (2011), He L (2004), He L (2004), Pullen SS (1998)	4
TNFRSF14	2	A2M	8	two hybrid	Vinayagam A (2011)	1
TNFRSF14	2	SEC11A	0	affinity chromatography technology	Ewing RM (2007)	1
TNFRSF14	2	IMPA2	0	two hybrid	Vinayagam A (2011)	1
TNFRSF14	2	DGKD	6	two hybrid	Vinayagam A (2011)	1
TRAF5	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Li S (2011), He L (2004), Chen TC (2014)	3
TRAF1	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Pullen SS (1998), Greenfeld H (2015)	2
RAD21	3	TNFRSF14	2	two hybrid	Panigrahi AK (2011)	1
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
TNFSF14	0	APP	1	pull down	Olah J (2011)	1
TNFSF14	0	TNFRSF14	2	pull down, affinity chromatography technology	Zhang J (2001), Yu KY (1999)	2
A2M	8	APP	1	two hybrid	Soler-Lopez M (2011)	1
NDUFS2	0	APP	1	pull down	Olah J (2011)	1
TNFRSF14	2	APP	1	pull down	Olah J (2011)	1
TNFRSF14	2	P4HB	1	affinity chromatography technology	Ewing RM (2007)	1
TNFRSF14	2	TRAF2	1	two hybrid, affinity chromatography technology, pull down	Hsu H (1997), Hsu H (1997), Marsters SA (1997)	3
TNFRSF14	2	GCN1	6	affinity chromatography technology	Ewing RM (2007)	1
TNFRSF14	2	UGGT1	6	affinity chromatography technology	Ewing RM (2007)	1
RAD21	3	CHD3	19	biochemical	Hakimi MA (2002)	1
P4HB	1	PDIA6	1	biochemical	Havugimana PC (2012)	1
TNFRSF14	2	DRAP1	2	two hybrid	Vinayagam A (2011)	1
TNFRSF14	2	WDR73	2	two hybrid	Vinayagam A (2011)	1
TNFRSF14	2	TRAF5	1	two hybrid, affinity chromatography technology, pull down	Hsu H (1997), Hsu H (1997), Marsters SA (1997)	3
VIM	0	APP	1	pull down	Olah J (2011)	1