PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ADAM33	3	ADAM15	2	affinity chromatography technology	Huttlin EL (2017)	1
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
SP4	4	ADAM15	2	two hybrid	Rolland T (2014)	1
MAD2L1	0	TRIP13	0	affinity chromatography technology, pull down, affinity chromatography technology	Wang K (2014), Miniowitz-Shemtov S (2015), Sedgwick GG (2016)	3
SH3GL2	1	ADAM15	2	two hybrid, pull down, affinity chromatography technology	Howard L (1999), Howard L (1999), Howard L (1999)	3
SRC	2	MAPK3	4	affinity chromatography technology	Lee J (2013)	1
TRIP13	0	RBPMS	0	two hybrid	Rual JF (2005)	1
ADAM15	2	PACSIN3	2	pull down	Kaerkkaeinen S (2006)	1
FHL3	0	ADAM15	2	two hybrid	Rolland T (2014)	1
RBPMS	0	BANP	1	two hybrid	Rolland T (2014)	1
TRIM25	5	MAPK1	1	affinity chromatography technology	Choudhury NR (2017)	1
YES1	1	FYN	1	affinity chromatography technology, affinity chromatography technology	Piedra J (2003), Huttlin EL (2017)	2
ADAM15	2	NUP62	1	two hybrid	Rolland T (2014)	1
ADAM15	2	SORBS2	2	pull down	Kaerkkaeinen S (2006)	1
ADAM15	2	TRIP13	0	two hybrid	Rual JF (2005)	1
TRIM25	5	SH3PXD2A	4	affinity chromatography technology	Choudhury NR (2017)	1
ADAM15	2	SH3RF3	6	pull down	Kaerkkaeinen S (2006)	1
MAD2L2	0	MAD2L1	0	pull down, pull down	Murakumo Y (2000), Murakumo Y (2000)	2
TRIM25	5	PTK6	1	affinity chromatography technology	Choudhury NR (2017)	1
ADAM15	2	RBPMS	0	two hybrid	Rolland T (2014)	1
TRIM25	5	MAD2L2	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	BANP	1	affinity chromatography technology	Choudhury NR (2017)	1
MAPK3	4	LYN	2	affinity chromatography technology	Wei S (2000)	1
SRC	2	LYN	2	unspecified method	Pirozzi G (1997)	1
NCK1	0	GRB2	2	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
GRB2	2	ARHGEF7	3	affinity chromatography technology	Bisson N (2011)	1
ADAM15	2	PTK6	1	affinity chromatography technology	Zhong JL (2008)	1
LCK	0	MAPK1	1	enzymatic study	Tapinos N (2005)	1
ADAM15	2	ARHGEF7	3	pull down	Kaerkkaeinen S (2006)	1
ADAM15	2	YES1	1	pull down	Kaerkkaeinen S (2006)	1
ADAM15	2	ARHGEF6	0	pull down	Kaerkkaeinen S (2006)	1
NPHP1	2	SNX9	1	bioid	Gupta GD (2015)	1
ADAM15	2	NCK1	0	pull down, affinity chromatography technology	Kaerkkaeinen S (2006), Zhong JL (2008)	2
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
ADAM15	2	MAD2L1	0	affinity chromatography technology	Poghosyan Z (2002)	1
ADAM15	2	SRC	2	pull down, affinity chromatography technology	Kaerkkaeinen S (2006), Zhong JL (2008)	2
HCK	5	SRC	2	affinity chromatography technology	Howlett CJ (2002)	1
FBXO6	0	TRIP13	0	affinity chromatography technology	Liu B (2012)	1
TRIM25	5	TRIP13	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
ADAM15	2	GRB2	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Poghosyan Z (2002), Poghosyan Z (2002), Kaerkkaeinen S (2006), Zhong JL (2008)	4
MAPK1	1	BANP	1	enzymatic study	Nakka KK (2015)	1
ADAM15	2	LCK	0	affinity chromatography technology, pull down, pull down	Poghosyan Z (2002), Poghosyan Z (2002), Kaerkkaeinen S (2006)	3
HCK	5	ADAM15	2	enzymatic study, pull down, pull down	Poghosyan Z (2002), Poghosyan Z (2002), Kaerkkaeinen S (2006)	3
TRIM25	5	GRB2	2	affinity chromatography technology	Choudhury NR (2017)	1
SRC	2	GRB2	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Saci A (2002)	2
SNX9	1	ADAM15	2	two hybrid, pull down, affinity chromatography technology, pull down	Howard L (1999), Howard L (1999), Howard L (1999), Kaerkkaeinen S (2006)	4
ADAM15	2	SH3PXD2A	4	pull down, affinity chromatography technology	Kaerkkaeinen S (2006), Zhong JL (2008)	2
GRB2	2	SH3PXD2A	4	affinity chromatography technology	Bisson N (2011)	1
MAD2L2	0	TRIP13	0	two hybrid	Venkatesan K (2009)	1
SRC	2	MAPK1	1	affinity chromatography technology	Lee J (2013)	1
ADAM15	2	NPHP1	2	pull down	Kaerkkaeinen S (2006)	1
TRIM25	5	ADAM15	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	SH3RF3	6	affinity chromatography technology	Choudhury NR (2017)	1
ARHGEF6	0	ARHGEF7	3	affinity chromatography technology, affinity chromatography technology	Feng Q (2004), Huttlin EL (2017)	2
ADAM15	2	BANP	1	two hybrid	Rolland T (2014)	1
ADAM15	2	SH3GLB1	2	pull down	Kaerkkaeinen S (2006)	1
FBXO6	0	ADAM15	2	affinity chromatography technology	Liu B (2012)	1
ADAM15	2	MAPK1	1	affinity chromatography technology	Zhong JL (2008)	1
ADAM15	2	MAPK3	4	affinity chromatography technology	Zhong JL (2008)	1
SH3RF3	6	SH3PXD2A	4	affinity chromatography technology	Boldt K (2016)	1
MAD2L2	0	ADAM15	2	two hybrid	Nelson KK (1999)	1
FYN	1	ADAM15	2	pull down, pull down	Poghosyan Z (2002), Kaerkkaeinen S (2006)	2
ADAM15	2	SNX30	2	pull down	Kaerkkaeinen S (2006)	1
ADAM15	2	LYN	2	pull down	Kaerkkaeinen S (2006)	1
TRIM25	5	LYN	2	affinity chromatography technology	Choudhury NR (2017)	1