PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PDLIM7	0	TRADD	0	affinity chromatography technology	Ikeda O (2009)	1
TRAF6	0	BCL10	0	affinity chromatography technology	Bidere N (2006)	1
TRADD	0	STAT1	1	affinity chromatography technology, pull down	Wang Y (2000), Wang Y (2000)	2
TNFRSF1B	4	CHUK	5	affinity chromatography technology	Wicovsky A (2009)	1
TRAF2	1	IFIT3	1	affinity chromatography technology	Liu XY (2011)	1
CASP8	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (2000), Oshima S (2009), Bertrand MJ (2008), Knox PG (2011), Kim S (2010), Cheung HH (2009), Tenev T (2011), Tenev T (2011), Mahul-Mellier AL (2011), Legarda-Addison D (2009), Biton S (2011), Bellail AC (2012), Bellail AC (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Puliyappadamba VT (2013), Wu P (2014), Wu P (2014), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Moquin DM (2013), Ranjan K (2016), Zinngrebe J (2016), Nakazawa S (2016), Zheng M (2016)	27
TNFRSF10A	0	FADD	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (1997), Sinha SK (2004), Guo F (2005), Gonzalvez F (2012), Jeong M (2017), Huttlin EL (2017)	6
LRRK2	5	TRADD	0	affinity chromatography technology	Ho CC (2009)	1
USP2	0	RIPK1	2	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2012)	4
NGFR	3	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Ye X (1999), Gentry JJ (2004), Gentry JJ (2004), Gentry JJ (2004), Gentry JJ (2004), Geetha T (2012), Geetha T (2012)	7
CHUK	5	RIPK1	2	biochemical	Poyet JL (2000)	1
CHUK	5	CASP8	1	affinity chromatography technology	Chaudhary PM (2000)	1
FAS	2	FADD	1	biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Gajate C (2005), MacFarlane M (1997), Pan G (1997), Huang B (1996), Huang B (1996), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Thomas LR (2002), Kumar A (2001), Lee EW (2012), Zhang M (2011), Huttlin EL (2015), Chen TC (2014), Jeong M (2017), Huttlin EL (2017), Kleber S (2008), Torii S (1999), Torii S (1999), Chang HY (1999)	20
CASP8	1	FADD	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Srinivasula SM (1997), Srinivasula SM (1997), Henshall DC (2003), Boldin MP (1996), Oshima S (2009), Thomas LR (2002), Ikner A (2011), Tenev T (2011), Ramakrishnan P (2011), Mahul-Mellier AL (2011), Won M (2010), Ryu SW (2003), Sinha SK (2004), Biton S (2011), Fu K (2012), Fu K (2012), Gonzalvez F (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Wang J (2011), Puliyappadamba VT (2013), Choi H (2011), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Saitoh Y (2016), Moquin DM (2013), Ranjan K (2016), Nakazawa S (2016), Jeong M (2017), Jeong M (2017), Pescatore A (2016)	35
TNFRSF1B	4	CAV1	0	affinity chromatography technology	Feng X (2001)	1
ZMYND11	10	TRADD	0	affinity chromatography technology, affinity chromatography technology	Ikeda O (2009), Ikeda O (2009)	2
TNFRSF25	1	TRADD	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Kitson J (1996), Kitson J (1996), Pobezinskaya YL (2011)	3
TNFRSF10A	0	CASP8	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kaunisto A (2009), Kaunisto A (2009), Sinha SK (2004), Guo F (2005), Jin Z (2009), Gonzalvez F (2012), Gonzalvez F (2012), Jeong M (2017), Huttlin EL (2017)	10
USP2	0	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology	Mahul-Mellier AL (2011), Mahul-Mellier AL (2011)	2
TRAF2	1	ZMYND11	10	affinity chromatography technology	Ikeda O (2010)	1
CASP8	1	USP2	0	affinity chromatography technology	Mahul-Mellier AL (2011)	1
BCL10	0	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Yoneda T (2000), Yoneda T (2000), Yoneda T (2000), Yui D (2001), Rolland T (2014)	5
TRADD	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Park YC (2000), Tsao DH (2000), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Vince JE (2009), Jang HD (2001), Park KJ (2003), Lin B (2016)	12
TNFRSF21	2	TRADD	0	affinity chromatography technology	Pan G (1998)	1
HIPK2	0	TRADD	0	affinity chromatography technology	Li X (2000)	1
TRAF2	1	CAV1	0	affinity chromatography technology, affinity chromatography technology	Feng X (2001), Cao H (2002)	2
CHUK	5	TRAF6	0	affinity chromatography technology	Kishida S (2005)	1
TRPC4AP	4	CHUK	5	affinity chromatography technology	Soond SM (2003)	1
TNFRSF1A	3	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
RIPK1	2	FADD	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen D (2002), Young JA (2011), Tenev T (2011), Ramakrishnan P (2011), Legarda-Addison D (2009), ODonnell MA (2012), Vanlangenakker N (2011), Biton S (2011), Biton S (2011), Lee EW (2012), Puliyappadamba VT (2013), Wu P (2014), Huttlin EL (2015), Baratchian M (2016), Moquin DM (2013), Ranjan K (2016), Pescatore A (2016), Zheng M (2016)	18
XPO1	8	STAT1	1	unspecified method, affinity chromatography technology	Xu D (2012), Kirli K (2015)	2
TRIP12	20	TRADD	0	affinity chromatography technology, affinity chromatography technology	Chio II (2012), Chio II (2012)	2
TNF	0	TRADD	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Legler DF (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Skaug B (2011), Fu J (2013), Fritsch J (2014), Schlicher L (2016)	10
TNFRSF1A	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
CASP8	1	TNFRSF1A	3	biochemical	Gajate C (2005)	1
TRAF2	1	DAB2IP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang H (2007), Zhang H (2004), Dai X (2014)	3
TNF	0	CASP8	1	affinity chromatography technology	Fritsch J (2014)	1
BCL10	0	TRADD	0	affinity chromatography technology	Costanzo A (1999)	1
TRAF6	0	CASP8	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Bidere N (2006), Bidere N (2006), He L (2006), He L (2006), Zinngrebe J (2016)	5
TNFRSF1A	3	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Shu HB (1996), Vince JE (2009), Mahul-Mellier AL (2011), Won M (2010), Kolliputi N (2009), Park KJ (2002), Lee IT (2010), Kim WJ (2005), Zheng L (2006), Vince JE (2007), Jeon J (2014), Chen TC (2014), Lee CK (2015), Jeong M (2017)	16
USP2	0	TRADD	0	affinity chromatography technology	Mahul-Mellier AL (2011)	1
CHUK	5	TRADD	0	biochemical	Poyet JL (2000)	1
LRRK2	5	RIPK1	2	affinity chromatography technology	Ho CC (2009)	1
STAT1	1	USP2	0	affinity chromatography technology, affinity chromatography technology	Ren Y (2016), Ren Y (2016)	2
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
TNF	0	FAS	2	affinity chromatography technology	Legler DF (2003)	1
TNFRSF1A	3	TNF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Bouwmeester T (2004), Micheau O (2003), Legler DF (2003), Kuai J (2004), Skaug B (2011), Tokunaga F (2012), Klingseisen L (2012), Thoma B (1990), Keusekotten K (2013), Crowe PD (1994), Liu LS (1998), Higuchi M (1992), Chaturvedi MM (1994), Schaeffer V (2014), Fritsch J (2014), Chainy GB (1996), Huttlin EL (2015), Chen TC (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Huttlin EL (2017), Nielsen FS (2004), Ameloot P (2001)	24
TRADD	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Chang YL (2014), Chang YL (2014)	2
XPO1	8	CHUK	5	affinity chromatography technology	Kirli K (2015)	1
TRADD	0	DAB2IP	3	affinity chromatography technology	Zhang H (2004)	1
EDAR	1	TRADD	0	affinity chromatography technology	Kumar A (2001)	1
TRIP12	20	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Chen D (2010), Chen D (2010), Chen D (2010), Chio II (2012), Li Z (2012), Li Z (2012), Lo D (2014), Lee S (2016)	8
XPO1	8	TRADD	0	affinity chromatography technology	Kirli K (2015)	1
TNF	0	FADD	1	affinity chromatography technology	Fritsch J (2014)	1
TRAF2	1	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
PDLIM7	0	TRAF2	1	protein complementation assay, protein complementation assay	Talaty P (2011), Talaty P (2011)	2
TNF	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Fritsch J (2014), Yamaguchi N (2015)	7
TRPC4AP	4	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Soond SM (2003), Soond SM (2006)	2
TRADD	0	TRADD	0	biochemical, two hybrid	Shu HB (1996), Hsu H (1995)	2
TRAF1	0	TRADD	0	affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Wicovsky A (2009)	2
TNFRSF10A	0	TRADD	0	affinity chromatography technology	Chaudhary PM (1997)	1
TNFRSF25	1	RIPK1	2	affinity chromatography technology	Pobezinskaya YL (2011)	1
TNFRSF1A	3	TRADD	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Y (1999), Schuetze S (1999), Pan G (1997), Hsu H (1996), Hsu H (1996), Hsu H (1996), Shu HB (1996), Blankenship JW (2009), Kolliputi N (2009), Fujikura D (2012), Park KJ (2002), Guan YJ (2011), Hsu H (1995), Kumar A (2001), Zheng L (2006), Kim TW (2013), Zhang H (2004), Chang YL (2014), Nakazawa S (2016), Huttlin EL (2017)	20
TNFRSF1B	4	TRAF2	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Song HY (1995), Song HY (1995), Takeuchi M (1996), Hostager BS (2002), Rothe M (1996), Marsters SA (1997), Carpentier I (2008), Rothe M (1995), Park YC (1999), Boucher LM (1997), Rothe M (1994), Rothe M (1994)	13
FAS	2	TRADD	0	affinity chromatography technology	Kumar A (2001)	1
CASP8	1	TRADD	0	affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kolliputi N (2009)	2
TNF	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legler DF (2003), Haas TL (2009), Ea CK (2006), Ramakrishnan P (2011), Skaug B (2011), Darding M (2011), Tokunaga F (2012), Klingseisen L (2012), Schaeffer V (2014), Fritsch J (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Schlicher L (2016)	14
TNFRSF25	1	TRAF2	1	affinity chromatography technology	Pobezinskaya YL (2011)	1
TRAF2	1	USP2	0	two hybrid, affinity chromatography technology, pull down, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Rolland T (2014), Mahul-Mellier AL (2012), Mahul-Mellier AL (2012)	7
ZMYND11	10	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Wan J (2006), Ikeda O (2010)	2
XPO1	8	RIPK1	2	affinity chromatography technology	Kirli K (2015)	1
TNFRSF1A	3	BCL10	0	two hybrid	Costanzo A (1999)	1
TNF	0	OPTN	1	affinity chromatography technology	Klingseisen L (2012)	1
PDLIM7	0	ZMYND11	10	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Wan J (2006), Wan J (2006), Liu HP (2011), Ikeda O (2009)	4
NGFR	3	TRAF1	0	affinity chromatography technology	Ye X (1999)	1
RIPK1	2	DAB2IP	3	affinity chromatography technology, affinity chromatography technology	Zhang H (2007), Zhang H (2004)	2
TNF	0	CAV1	0	affinity chromatography technology	Legler DF (2003)	1
TRAF6	0	IFIT3	1	affinity chromatography technology	Liu XY (2011)	1
TNFRSF1B	4	TRADD	0	affinity chromatography technology	Wicovsky A (2009)	1
USP2	0	TRAF6	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, enzymatic study	Bremm A (2010), Li Y (2013), Li Y (2013), Rolland T (2014), Li Y (2013)	5
CASP8	1	OPTN	1	affinity chromatography technology, affinity chromatography technology	Nakazawa S (2016), Nakazawa S (2016)	2
TNFRSF1A	3	CAV1	0	biochemical	Legler DF (2003)	1
TNFRSF1A	3	STAT1	1	affinity chromatography technology	Wang Y (2000)	1
XPO1	8	BCL10	0	affinity chromatography technology	Kirli K (2015)	1
TOMM70	1	TRADD	0	affinity chromatography technology	Liu XY (2010)	1
EDAR	1	FADD	1	affinity chromatography technology	Kumar A (2001)	1
TRAF1	0	ZMYND11	10	affinity chromatography technology	Ikeda O (2010)	1
FAS	2	RIPK1	2	two hybrid	Stanger BZ (1995)	1
TNFRSF10B	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Chaudhary PM (1997), Bellail AC (2012)	2
NGFR	3	CAV1	0	pull down	Bilderback TR (1999)	1
KRT18	2	TRADD	0	two hybrid, affinity chromatography technology	Inada H (2001), Inada H (2001)	2
TRADD	0	NOL3	0	genetic interference	Koseki T (1998)	1
TNFRSF10B	1	TRADD	0	affinity chromatography technology	Chaudhary PM (1997)	1
TNFRSF10A	0	BCL10	0	two hybrid	Costanzo A (1999)	1
FADD	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Chaudhary PM (1997), Kim Y (2002), Guo F (2005), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017)	8
TRAF6	0	TNFRSF1B	4	affinity chromatography technology	Khursigara G (1999)	1
TRAF1	0	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
LRRK2	5	FADD	1	affinity chromatography technology	Ho CC (2009)	1
FAS	2	NOL3	0	genetic interference	Koseki T (1998)	1
LRRK2	5	TRAF2	1	enzymatic study	Zach S (2010)	1
XPO1	8	DAB2IP	3	affinity chromatography technology	Kirli K (2015)	1
CHUK	5	TNFRSF1A	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008)	3
FAS	2	TNFRSF1A	3	biochemical	Gajate C (2005)	1
FAS	2	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Shu HB (1997), MacFarlane M (1997), Huttlin EL (2015), Jeong M (2017), Huttlin EL (2017), Kleber S (2008)	7
TNFRSF1B	4	TNF	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Bouwmeester T (2004), Kuai J (2004), Montaldo PG (1994), Liu LS (1998), Zhang L (1994), Higuchi M (1992), Chaturvedi MM (1994), Chainy GB (1996), Nielsen FS (2004), Ameloot P (2001)	10
TNF	0	CHUK	5	affinity chromatography technology, genetic interference	Haas TL (2009), Sahu I (2014)	2
TNFRSF1A	3	TRPC4AP	4	affinity chromatography technology, pull down, affinity chromatography technology	Soond SM (2003), Soond SM (2003), Mace KE (2010)	3
FADD	1	TRADD	0	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henshall DC (2003), Hsu H (1996), Hsu H (1996), Thomas LR (2002), Guan YJ (2011), Park KJ (2003), Qi Z (2014)	7
CAV1	0	PPP2R1A	8	affinity chromatography technology	Li L (2003)	1
TNFRSF10A	0	TNFRSF10B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guo F (2005), Jin Z (2009), Huttlin EL (2017)	3
TNFRSF1A	3	DAB2IP	3	affinity chromatography technology	Zhang H (2004)	1
NGFR	3	TRAF2	1	affinity chromatography technology, pull down	Ye X (1999), Ye X (1999)	2
PDLIM7	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Uemura N (2006), Uemura N (2006)	2
TRAF1	0	CHUK	5	affinity chromatography technology, affinity chromatography technology	Wicovsky A (2009), Henkler F (2003)	2
TRPC4AP	4	TRADD	0	affinity chromatography technology	Soond SM (2003)	1
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
LRRK2	5	PPP2R1A	8	affinity chromatography technology	Liu Z (2011)	1
XPO1	8	PDLIM7	0	affinity chromatography technology	Kirli K (2015)	1
TNFRSF10A	0	TRAF2	1	affinity chromatography technology	Gonzalvez F (2012)	1
PPP2R1A	8	TRADD	0	affinity chromatography technology	Sablina AA (2007)	1
TNFRSF1A	3	TRAF6	0	affinity chromatography technology	Chang YL (2014)	1
TNFRSF1B	4	RIPK1	2	affinity chromatography technology	Wicovsky A (2009)	1
CASP8	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Kaunisto A (2009), Guo F (2005), Gonzalvez F (2012), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017), Xu L (2017)	12
TNFRSF1A	3	TRAF1	0	affinity chromatography technology, pull down, affinity chromatography technology	Hsu H (1996), Mosialos G (1995), Wicovsky A (2009)	3
CASP8	1	TRAF1	0	affinity chromatography technology, enzymatic study	Micheau O (2003), Leo E (2001)	2
XPO1	8	NEDD1	1	affinity chromatography technology	Kirli K (2015)	1
FAS	2	TNFRSF10B	1	biochemical	Gajate C (2005)	1
TOMM70	1	TRAF6	0	affinity chromatography technology	Liu XY (2010)	1
TNFRSF25	1	NOL3	0	genetic interference	Koseki T (1998)	1
FADD	1	TNFRSF1A	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Hsu H (1996), Kumar A (2001), Zheng L (2006)	4
CASP8	1	NOL3	0	genetic interference, affinity chromatography technology	Koseki T (1998), Koseki T (1998)	2
BPNT1	1	TRADD	0	affinity chromatography technology	Huttlin EL (2017)	1
CHUK	5	BCL10	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Poyet JL (2001), Poyet JL (2001), Marinis JM (2012), Zhou H (2004)	4
RIPK1	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim JW (2000), Duan H (1997), Hsu H (1996), Blankenship JW (2009), Newton K (2008), Varfolomeev E (2008), Fearns C (2006), Vince JE (2009), Dynek JN (2010), Kim S (2010), Cheung HH (2009), Tenev T (2011), Mahul-Mellier AL (2011), Won M (2010), Glowacka WK (2012), Fan YH (2011), Cusson-Hermance N (2005), ODonnell MA (2012), Zheng L (2006), Vince JE (2007), Mitsuhashi S (2008), Kim TW (2013), Wertz IE (2004), Liao W (2008), Wang YB (2015), Chang YL (2014), Zilberman-Rudenko J (2016), Zemirli N (2014), Moquin DM (2013), Nakazawa S (2016), Jeong M (2017), Huttlin EL (2017), Elliott PR (2016)	33
TNFRSF1B	4	KRT18	2	pull down	Caulin C (2000)	1
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
TRADD	0	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
TNFRSF1B	4	TRAF1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Marsters SA (1997), Mosialos G (1995), Mosialos G (1995), Boucher LM (1997), Rothe M (1994), Kato T (2008)	6
TRAF2	1	FADD	1	affinity chromatography technology	Gonzalvez F (2012)	1
TNFRSF1A	3	NOL3	0	genetic interference	Koseki T (1998)	1
OPTN	1	TRADD	0	affinity chromatography technology	Zhu G (2007)	1
BCL10	0	PPP2R1A	8	affinity chromatography technology	Eitelhuber AC (2011)	1
LRRK2	5	CASP8	1	affinity chromatography technology	Ho CC (2009)	1
FADD	1	NOL3	0	genetic interference	Koseki T (1998)	1
CASP8	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Micheau O (2003), Knox PG (2011), Mahul-Mellier AL (2011), Gonzalvez F (2012), Gonzalvez F (2012), Xu L (2017), Xu L (2017)	7
NEDD1	1	TRADD	0	affinity chromatography technology	Hein MY (2015)	1
TRADD	0	IFIT3	1	affinity chromatography technology	Liu XY (2011)	1
OPTN	1	TNFRSF1A	3	affinity chromatography technology	Klingseisen L (2012)	1
TRAF1	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, two hybrid	Hsu H (1996), Wicovsky A (2009), Rolland T (2014)	3
OPTN	1	RIPK1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nagabhushana A (2011), Zhu G (2007), Zhu G (2007), Klingseisen L (2012), Nakazawa S (2016)	5
TNFRSF1B	4	TNFRSF1A	3	affinity chromatography technology	Wicovsky A (2009)	1
CDKN2A	1	TRADD	0	affinity chromatography technology	Chio II (2012)	1
CHUK	5	TRAF2	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Regnier CH (1997), Devin A (2001), Li S (2009), Shen RR (2012), Zhang W (2010), Chen TC (2014)	6
TRPC4AP	4	RIPK1	2	affinity chromatography technology	Soond SM (2003)	1
CAV1	0	TRADD	0	affinity chromatography technology	Feng X (2001)	1
TRADD	0	RIPK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Hsu H (1996), Ea CK (2006), Guan YJ (2011), Jeon J (2014), Lin B (2016)	7
TNFRSF10B	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Bellail AC (2012), Gonzalvez F (2012)	2
TRAF1	0	TRAF6	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Wang J (2011), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	4
CAV1	0	FAS	2	affinity chromatography technology, affinity chromatography technology	Zhang M (2011), Zhang M (2011)	2
NGFR	3	TRADD	0	affinity chromatography technology	El Yazidi-Belkoura I (2003)	1