PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
STX19	3	VAMP3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MLH1	6	VAMP8	0	two hybrid	Brieger A (2010)	1
STX12	2	VAMP2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SYPL1	2	VAMP3	0	affinity chromatography technology	Huttlin EL (2017)	1
FN1	17	VAMP8	0	affinity chromatography technology	Humphries JD (2009)	1
STX2	1	VAMP8	0	affinity chromatography technology	Imai A (2003)	1
ITGA4	4	VAMP8	0	affinity chromatography technology	Byron A (2012)	1
VAMP8	0	USP8	7	affinity chromatography technology	Mukai A (2008)	1
SNAP23	0	VAMP3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai A (2003), Paumet F (2000), Freedman SJ (2003)	3
NAPA	2	VAMP2	3	pull down, biochemical	Hanson PI (1995), Havugimana PC (2012)	2
STX7	2	STX8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Antonin W (2000), Antonin W (2000), Huttlin EL (2015), Huttlin EL (2017)	4
STX3	3	SNAP23	0	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, pull down, pull down, pull down	Imai A (2003), Imai A (2003), Imai A (2003), Araki S (1997), Araki S (1997), Ravichandran V (1996), Steegmaier M (1998), Vogel GF (2015)	8
STX11	1	SNAP23	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rual JF (2005), Valdez AC (1999), Valdez AC (1999), Valdez AC (1999), Vinayagam A (2011), Rolland T (2014), Karim ZA (2015), Huttlin EL (2017)	9
STX4	2	STX12	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
STX11	1	STX6	0	affinity chromatography technology	Huttlin EL (2017)	1
STX7	2	STX3	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FN1	17	NAPA	2	affinity chromatography technology	Humphries JD (2009)	1
VAMP2	3	VAMP3	0	pull down	Polgar J (2002)	1
VCAM1	2	VAMP8	0	affinity chromatography technology	Humphries JD (2009)	1
STX2	1	SNAP23	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology	Imai A (2003), Imai A (2003), Imai A (2003), Li G (2003), Araki S (1997), Araki S (1997), Ravichandran V (1996), Paumet F (2000)	8
ITGA4	4	NAPA	2	affinity chromatography technology	Byron A (2012)	1
STX7	2	STX12	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX7	2	SNAP23	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX4	2	VAMP2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid	Paumet F (2000), Mollinedo F (2003), Jagadish MN (1996), Reed GL (1999), Rolland T (2014)	5
STX4	2	STX6	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	4
STX6	0	NAPA	2	affinity chromatography technology	Huttlin EL (2015)	1
YWHAE	0	USP8	7	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Gloeckner CJ (2007), Choudhary C (2009), Ma ZY (2015), Reincke M (2015), Reincke M (2015)	5
STX12	2	VTI1A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VCAM1	2	NAPA	2	affinity chromatography technology	Humphries JD (2009)	1
STX6	0	VTI1A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX4	2	STX8	0	two hybrid	Rolland T (2014)	1
TMEM17	0	STX7	2	bioid	Gupta GD (2015)	1
STX3	3	STX8	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATP4A	6	VAMP3	0	affinity chromatography technology	Lapierre LA (2007)	1
TMEM17	0	SNAP23	0	bioid	Gupta GD (2015)	1
STX12	2	STX18	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX7	2	STX6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wade N (2001), Huttlin EL (2015), Huttlin EL (2017)	3
STX6	0	STX12	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX1A	2	SNAP23	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid	Imai A (2003), Li G (2003), Araki S (1997), Araki S (1997), Ravichandran V (1996), Steegmaier M (1998), Corominas R (2014)	7
FN1	17	YWHAE	0	affinity chromatography technology	Humphries JD (2009)	1
STX8	0	VAMP8	0	affinity chromatography technology, biochemical, affinity chromatography technology	Antonin W (2000), Antonin W (2000), Gordon DE (2009)	3
VTI1A	1	STX7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Antonin W (2000), Antonin W (2000), Huttlin EL (2015), Huttlin EL (2017)	4
SYPL1	2	VAMP2	3	affinity chromatography technology	Huttlin EL (2017)	1
CEP170	4	STX8	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX3	3	VAMP8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Vogel GF (2015), Huttlin EL (2017)	3
ATP4A	6	STX12	2	affinity chromatography technology, affinity chromatography technology	Lapierre LA (2007), Lapierre LA (2007)	2
ATP6V1B1	4	STX8	0	affinity chromatography technology	Nylandsted J (2011)	1
VTI1A	1	VAMP8	0	affinity chromatography technology, biochemical	Antonin W (2000), Antonin W (2000)	2
SNAP23	0	STX12	2	pull down, affinity chromatography technology, affinity chromatography technology	Tang BL (1998), Huttlin EL (2015), Huttlin EL (2017)	3
STX3	3	STX4	2	two hybrid	Rolland T (2014)	1
STX18	0	STX8	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX12	2	VAMP3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX19	3	VAMP2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX18	0	VAMP8	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NAPA	2	STX7	2	pull down, affinity chromatography technology, affinity chromatography technology	Wong SH (1998), Huttlin EL (2015), Huttlin EL (2017)	3
STX18	0	SNAP23	0	affinity chromatography technology	Hirose H (2004)	1
STX7	2	STX18	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX4	2	VAMP3	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Rual JF (2005), Imai A (2003), Paumet F (2000), Polgar J (2002), Rolland T (2014)	5
STX11	1	VAMP3	0	affinity chromatography technology	Huttlin EL (2017)	1
VAMP2	3	VAMP8	0	pull down	Polgar J (2002)	1
STX2	1	VAMP2	3	two hybrid	Imai A (2003)	1
ATP4A	6	VAMP8	0	affinity chromatography technology, affinity chromatography technology	Lapierre LA (2007), Lapierre LA (2007)	2
NAPA	2	STX12	2	pull down, affinity chromatography technology, affinity chromatography technology	Tang BL (1998), Huttlin EL (2015), Huttlin EL (2017)	3
UBE2G2	0	VAMP8	0	two hybrid	Wang J (2011)	1
STX2	1	VAMP3	0	two hybrid	Imai A (2003)	1
SYPL1	2	VAMP8	0	affinity chromatography technology	Huttlin EL (2017)	1
SNAP23	0	VAMP2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Imai A (2003), Paumet F (2000), Kawanishi M (2000), Kawanishi M (2000)	4
ATP4A	6	STX3	3	affinity chromatography technology, affinity chromatography technology	Lapierre LA (2007), Lapierre LA (2007)	2
FN1	17	ITGA4	4	affinity chromatography technology	Humphries JD (2009)	1
TMEM17	0	STX8	0	bioid	Gupta GD (2015)	1
VAMP3	0	VAMP8	0	pull down	Polgar J (2002)	1
CDC25A	2	VAMP8	0	two hybrid	Wang J (2011)	1
STX3	3	VAMP3	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai A (2003), Huttlin EL (2015), Vogel GF (2015), Vogel GF (2015), Huttlin EL (2017)	5
STX4	2	VAMP8	0	affinity chromatography technology, affinity chromatography technology	Paumet F (2000), Polgar J (2002)	2
VAMP3	0	STX6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mallard F (2002), Mallard F (2002), Gordon DE (2009), Huttlin EL (2015), Huttlin EL (2017)	5
DTNBP1	1	VAMP8	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATP6V1B1	4	VAMP8	0	affinity chromatography technology	Nylandsted J (2011)	1
CDC25A	2	YWHAE	0	two hybrid	Conklin DS (1995)	1
STX7	2	VAMP2	3	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
STX1A	2	ATP6V1B1	4	pull down	Li G (2003)	1
STX1A	2	VAMP8	0	pull down, affinity chromatography technology	Nagamatsu S (2001), Nagamatsu S (2001)	2
VAMP3	0	VTI1A	1	affinity chromatography technology	Mallard F (2002)	1
TMEM17	0	VAMP2	3	bioid	Gupta GD (2015)	1
STX4	2	STX7	2	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	4
STX12	2	VAMP8	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX4	2	SNAP23	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, biochemical	Imai A (2003), Imai A (2003), Imai A (2003), Li G (2003), Araki S (1997), Araki S (1997), Araki S (1997), Paumet F (2000), Paumet F (2000), Ravichandran V (1996), Kawanishi M (2000), Kawanishi M (2000), Steegmaier M (1998), Freedman SJ (2003), Havugimana PC (2012)	15
ATP4A	6	VAMP2	3	affinity chromatography technology	Lapierre LA (2007)	1
STX1A	2	NAPA	2	affinity chromatography technology, pull down	McMahon HT (1995), Hanson PI (1995)	2
STX11	1	STX8	0	affinity chromatography technology	Huttlin EL (2017)	1
CEP170	4	VAMP8	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SNAP23	0	VAMP8	0	affinity chromatography technology, affinity chromatography technology	Imai A (2003), Paumet F (2000)	2
ATP4A	6	SYPL1	2	affinity chromatography technology, affinity chromatography technology	Lapierre LA (2007), Lapierre LA (2007)	2
ATP4A	6	STX7	2	affinity chromatography technology, affinity chromatography technology	Lapierre LA (2007), Lapierre LA (2007)	2
ATP6V1B1	4	STX12	2	affinity chromatography technology	Nylandsted J (2011)	1
MED21	1	VAMP3	0	affinity chromatography technology	Huttlin EL (2017)	1
STX12	2	STX8	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ITGA4	4	YWHAE	0	affinity chromatography technology	Byron A (2012)	1
YWHAE	0	VAMP8	0	affinity chromatography technology	Gloeckner CJ (2007)	1
VCAM1	2	ITGA4	4	affinity chromatography technology, affinity chromatography technology	Humphries JD (2009), Byron A (2012)	2
DTNBP1	1	STX8	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TMEM17	0	VAMP3	0	bioid	Gupta GD (2015)	1
STX7	2	VAMP8	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Antonin W (2000), Antonin W (2000), Wade N (2001), Gordon DE (2009), Huttlin EL (2015), Huttlin EL (2017)	6
STX3	3	VAMP2	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Imai A (2003), Huttlin EL (2015), Huttlin EL (2017)	3
ATP4A	6	NAPA	2	affinity chromatography technology	Lapierre LA (2007)	1
STX19	3	VAMP8	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SNAP23	0	STX6	0	pull down, affinity chromatography technology, affinity chromatography technology	Martin-Martin B (2000), Martin-Martin B (2000), Huttlin EL (2015)	3
VAMP8	0	STAMBP	2	affinity chromatography technology	Mukai A (2008)	1
FN1	17	STX4	2	affinity chromatography technology	Humphries JD (2009)	1
STX6	0	STX8	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FN1	17	SNAP23	0	affinity chromatography technology	Humphries JD (2009)	1
STX4	2	NAPA	2	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
HAUS7	0	VAMP8	0	affinity chromatography technology	Huttlin EL (2015)	1
TMEM17	0	VAMP8	0	bioid	Gupta GD (2015)	1
VCAM1	2	YWHAE	0	affinity chromatography technology	Humphries JD (2009)	1
STX6	0	STX3	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VAMP2	3	STX11	1	pull down, affinity chromatography technology	Valdez AC (1999), Huttlin EL (2017)	2
TMEM17	0	STX6	0	bioid	Gupta GD (2015)	1
VAMP3	0	STX8	0	affinity chromatography technology	Gordon DE (2009)	1
SNAP23	0	NAPA	2	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
STX19	3	SNAP23	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
YWHAE	0	CEP170	4	affinity chromatography technology	Boldt K (2016)	1
STX1A	2	VAMP2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, two hybrid, far western blotting, x-ray crystallography	Dulubova I (1999), McMahon HT (1995), Perez-Branguli F (2002), Margittai M (1999), Hao JC (1997), Hao JC (1997), Hao JC (1997), Chen X (2002)	8
STX11	1	VAMP8	0	affinity chromatography technology, affinity chromatography technology	Karim ZA (2015), Huttlin EL (2017)	2
MED21	1	VAMP8	0	affinity chromatography technology	Huttlin EL (2017)	1
STX6	0	STX18	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX6	0	VAMP8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mallard F (2002), Gordon DE (2009), Huttlin EL (2015), Huttlin EL (2017)	4
VAMP3	0	STX7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gordon DE (2009), Huttlin EL (2015), Huttlin EL (2017)	3
MED21	1	STX8	0	affinity chromatography technology	Huttlin EL (2017)	1
TMEM17	0	STX12	2	bioid	Gupta GD (2015)	1
VTI1A	1	STX8	0	affinity chromatography technology, affinity chromatography technology	Antonin W (2000), Antonin W (2000)	2
STX8	0	NAPA	2	affinity chromatography technology	Subramaniam VN (2000)	1
NAPA	2	VAMP8	0	pull down	Wong SH (1998)	1