PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CBFA2T3	3	LDHA	2	imaging technique	Kumar P (2015)	1
HDAC1	4	RUNX1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Reed-Inderbitzin E (2006), Guo H (2011), Guo H (2011), Guo H (2011), Shia WJ (2012), Leong WY (2016)	6
CBFA2T3	3	EGLN1	3	affinity chromatography technology	Kumar P (2015)	1
TRIM33	4	TCF4	26	affinity chromatography technology, affinity chromatography technology	Bai X (2010), Li X (2015)	2
TRIM33	4	TAL1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bai X (2010), Bai X (2010), Bai X (2010)	3
HDAC1	4	SIN3B	5	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (1999), Koipally J (1999), Romm E (2005), Humphrey GW (2001), Terhune SS (2010), Joshi P (2013), Wan C (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	10
CBFA2T3	3	ZBTB47	0	affinity chromatography technology, affinity chromatography technology	Kumar R (2010), Kumar R (2010)	2
TRIM33	4	LDB1	2	affinity chromatography technology, affinity chromatography technology	Bai X (2010), Howard PW (2010)	2
TCF4	26	TCF3	7	two hybrid, affinity chromatography technology	Ravasi T (2010), Huttlin EL (2017)	2
PRDM14	1	CBFA2T3	3	affinity chromatography technology	Huttlin EL (2017)	1
HDAC2	1	RUNX1T1	1	affinity chromatography technology	Amann JM (2001)	1
TCF3	7	HDAC2	1	affinity chromatography technology	Kim MS (2007)	1
HDAC1	4	HIF1A	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahon PC (2001), Yoo YG (2006), Kim SH (2007), Kim SH (2007), Bodily JM (2011), Yeh IJ (2013), Yeh IJ (2013)	7
NCOR1	9	RUNX1T1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid	Amann JM (2001), Zhang J (2001), Amann JM (2005), Zhang J (2004), Minucci S (2000), Gelmetti V (1998), Gelmetti V (1998), Wei Y (2007)	8
HDAC2	1	CBFA2T3	3	affinity chromatography technology	Amann JM (2001)	1
CBFA2T3	3	MATN2	6	two hybrid	Wang J (2011)	1
CBFA2T3	3	RUNX1T1	1	affinity chromatography technology, affinity chromatography technology	Lindberg SR (2003), Hoogeveen AT (2002)	2
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
HDAC3	5	HIF1A	1	pull down, affinity chromatography technology, pull down	Mahon PC (2001), Kim SH (2007), Kim SH (2007)	3
TAL1	0	LDB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goardon N (2006), Goardon N (2006), Goardon N (2006), Hu X (2009)	4
CBFA2T3	3	SEC24A	6	two hybrid	Wang J (2011)	1
TCF4	26	CBFA2T2	3	affinity chromatography technology	Li X (2015)	1
TCF3	7	CBFA2T3	3	affinity chromatography technology, affinity chromatography technology, pull down	Goardon N (2006), Goardon N (2006), Goardon N (2006)	3
HIF1A	1	HK1	5	imaging technique	Kumar P (2015)	1
NCOR1	9	CBFA2T2	3	affinity chromatography technology	Amann JM (2005)	1
CBFA2T3	3	PRKAR2A	0	affinity chromatography technology, pull down	Schillace RV (2002), Schillace RV (2002)	2
CBFA2T3	3	ZBTB4	6	two hybrid	Barrett CW (2012)	1
CBFA2T3	3	ZBTB38	5	two hybrid	Barrett CW (2012)	1
HIF1A	1	PDK1	1	imaging technique	Kumar P (2015)	1
HIF1A	1	PFKFB4	0	imaging technique	Kumar P (2015)	1
TAL1	0	TCF3	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Goardon N (2006), Goardon N (2006), Goardon N (2006), Goardon N (2006), Hsu HL (1994), Hsu HL (1994), Hu X (2009)	7
RUNX1T1	1	PRKAR2A	0	two hybrid, pull down, affinity chromatography technology	Fukuyama T (2001), Fukuyama T (2001), Fukuyama T (2001)	3
CBFA2T3	3	CBFA2T2	3	affinity chromatography technology	Hoogeveen AT (2002)	1
TRIM33	4	RUNX1T1	1	affinity chromatography technology	Bai X (2010)	1
HDAC6	0	HIF1A	1	affinity chromatography technology	Qian DZ (2006)	1
CBFA2T3	3	ZBTB33	1	two hybrid, affinity chromatography technology	Barrett CW (2012), Barrett CW (2012)	2
RUNX1	0	CBFA2T2	3	affinity chromatography technology, affinity chromatography technology	Kitabayashi I (1998), Shia WJ (2012)	2
CBFA2T3	3	HDAC3	5	affinity chromatography technology, affinity chromatography technology	Hoogeveen AT (2002), Amann JM (2001)	2
TAL1	0	CBFA2T3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Goardon N (2006), Goardon N (2006), Goardon N (2006), Goardon N (2006), Hu X (2009)	5
ZBTB4	6	SIN3B	5	affinity chromatography technology	Weber A (2008)	1
TCF4	26	RUNX1T1	1	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
TAL1	0	TCF4	26	pull down, affinity chromatography technology, two hybrid	Goldfarb AN (1996), Goardon N (2006), Langlands K (1997)	3
PFKFB3	2	PFKFB4	0	affinity chromatography technology	Huttlin EL (2017)	1
TCF3	7	LDB1	2	affinity chromatography technology, affinity chromatography technology	Goardon N (2006), Goardon N (2006)	2
RUNX1	0	CBFA2T3	3	affinity chromatography technology	Shia WJ (2012)	1
NCOR1	9	TRIM33	4	affinity chromatography technology	Yoon HG (2003)	1
CBFA2T3	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Hoogeveen AT (2002), Amann JM (2001)	2
CBFA2T3	3	PDK1	1	imaging technique	Kumar P (2015)	1
HIF1A	1	PFKFB3	2	imaging technique	Kumar P (2015)	1
CBFA2T3	3	PFKM	4	imaging technique	Kumar P (2015)	1
RUNX1	0	TCF3	7	affinity chromatography technology	Zhang J (2004)	1
CBFA2T3	3	GMEB2	1	two hybrid	Wang J (2011)	1
HDAC2	1	HIF1A	1	pull down, imaging technique	Mahon PC (2001), Chen TC (2014)	2
RUNX1	0	RUNX1T1	1	biochemical, affinity chromatography technology	Minucci S (2000), Shia WJ (2012)	2
HIF1A	1	CBFA2T3	3	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Kumar P (2015), Kumar P (2015), Kumar P (2015), Kumar P (2015)	4
TCF4	26	CBFA2T3	3	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
HDAC3	5	RUNX1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Reed-Inderbitzin E (2006), Guo H (2011), Guo H (2011), Guo H (2011), Leong WY (2016)	5
CBFA2T3	3	SIN3B	5	affinity chromatography technology	Olsson A (2008)	1
HDAC1	4	RUNX1T1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Amann JM (2001), Zhang J (2004), Gelmetti V (1998), Liu S (2007), Liu S (2007), Chen TC (2014)	6
HDAC8	9	RUNX1T1	1	affinity chromatography technology	Amann JM (2001)	1
NCOR1	9	RUNX1	0	pull down	Minucci S (2000)	1
RUNX1T1	1	CBFA2T2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Lindberg SR (2003), Hoogeveen AT (2002), Zhang J (2004)	4
TRIM33	4	RUNX1	0	affinity chromatography technology	Bai X (2010)	1
NCOR1	9	CBFA2T3	3	affinity chromatography technology, affinity chromatography technology	Amann JM (2001), Olsson A (2008)	2
TAL1	0	CBFA2T2	3	affinity chromatography technology	Goardon N (2006)	1
SIN3B	5	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Romm E (2005), Bantscheff M (2011)	2
HDAC3	5	ZBTB33	1	affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003)	2
CBFA2T2	3	PRDM14	1	two hybrid, two hybrid, affinity chromatography technology	Ravasi T (2010), Rolland T (2014), Huttlin EL (2017)	3
HIF1A	1	PFKM	4	imaging technique	Kumar P (2015)	1
TAL1	0	RUNX1	0	affinity chromatography technology	Hu X (2009)	1
NCOR1	9	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, two hybrid, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, imaging technique, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Fischle W (2002), Fischle W (2002), Fischle W (2001), Zhang J (2002), Zhang J (2002), Zhang J (2002), Li J (2000), Li J (2000), Li J (2000), Li J (2000), Underhill C (2000), Alenghat T (2006), Jiang S (2006), Wen YD (2000), Wen YD (2000), Wen YD (2000), Liu XF (2004), Yoon HG (2005), Yoon HG (2005), Zhu P (2006), Bantscheff M (2011), Joshi P (2013)	26
CBFA2T3	3	PFKFB3	2	imaging technique	Kumar P (2015)	1
CBFA2T3	3	PFKFB4	0	imaging technique	Kumar P (2015)	1
HIF1A	1	EGLN1	3	pull down, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Percy MJ (2006), Baek JH (2005), Yoo YG (2008), Chowdhury R (2009), Choi YK (2010), Park MH (2014), Park MH (2015), Park MH (2015), Barth S (2007), Song D (2013), Guo J (2016), Kumar P (2015)	12
RUNX1	0	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Kraemer OH (2008), Shia WJ (2012)	2
HDAC8	9	CBFA2T3	3	affinity chromatography technology	Amann JM (2001)	1
TAL1	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goardon N (2006), Hu X (2009), Hu X (2009)	3
TRIM33	4	CBFA2T3	3	affinity chromatography technology	Bai X (2010)	1
TRIM33	4	TCF3	7	affinity chromatography technology	Bai X (2010)	1
RUNX1T1	1	PRDM14	1	two hybrid, two hybrid, affinity chromatography technology	Ravasi T (2010), Rolland T (2014), Huttlin EL (2017)	3
TAL1	0	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goardon N (2006), Hu X (2009), Hu X (2009)	3
LDB1	2	CBFA2T3	3	affinity chromatography technology, affinity chromatography technology	Goardon N (2006), Goardon N (2006)	2
HDAC3	5	CBFA2T2	3	affinity chromatography technology	Amann JM (2005)	1
HIF1A	1	LDHA	2	imaging technique	Kumar P (2015)	1
CBFA2T3	3	HK1	5	imaging technique	Kumar P (2015)	1
HDAC6	0	CBFA2T3	3	affinity chromatography technology	Amann JM (2001)	1
HDAC3	5	RUNX1T1	1	affinity chromatography technology, affinity chromatography technology	Amann JM (2001), Zhang J (2004)	2
RUNX1T1	1	TCF3	7	affinity chromatography technology	Zhang J (2004)	1
NCOR1	9	ZBTB33	1	affinity chromatography technology, affinity chromatography technology, pull down	Yoon HG (2003), Yoon HG (2003), Yoon HG (2003)	3