PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TNFSF11	0	TMOD3	0	two hybrid	Vinayagam A (2011)	1
TNFSF11	0	SBF1	15	two hybrid	Vinayagam A (2011)	1
TNFSF11	0	PLK1	0	two hybrid	Vinayagam A (2011)	1
TNFSF11	0	PHAX	0	two hybrid	Vinayagam A (2011)	1
TNFSF11	0	MED24	4	two hybrid	Vinayagam A (2011)	1
TNFSF11	0	FAM213B	0	two hybrid	Vinayagam A (2011)	1
TNFSF11	0	ATP5G1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNFSF11	0	TRMT2A	4	two hybrid	Vinayagam A (2011)	1
TNFSF11	0	GOSR1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNFSF11	0	SNRNP35	1	two hybrid	Vinayagam A (2011)	1
TNFSF11	0	ZC3HC1	1	two hybrid	Vinayagam A (2011)	1
TNFSF11	0	ND1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNFSF11	0	GALNT7	0	affinity chromatography technology	Huttlin EL (2015)	1
LMO4	1	ZNF675	3	two hybrid	Colland F (2004)	1
TNFSF11	0	CEP126	0	two hybrid	Vinayagam A (2011)	1
TNFSF11	0	MBTPS1	4	two hybrid	Vinayagam A (2011)	1
TNFSF11	0	ZNF675	3	genetic interference	Shin JN (2002)	1
TNFSF11	0	DDAH2	1	two hybrid	Vinayagam A (2011)	1
TNFSF11	0	EZH2	4	two hybrid	Vinayagam A (2011)	1
TNFSF11	0	DNAJB9	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNFRSF11B	0	TNFSF11	0	pull down	Yasuda H (1998)	1
TNFSF11	0	BBS10	2	two hybrid	Vinayagam A (2011)	1
ZC3HC1	1	PLK1	0	affinity chromatography technology	Huttlin EL (2017)	1
PLK1	0	LMO4	1	two hybrid	Vinayagam A (2011)	1
TNFSF11	0	EEF1A1	0	two hybrid	Vinayagam A (2011)	1
DNAJB9	1	PLK1	0	two hybrid	Stelzl U (2005)	1
TNFSF11	0	B4GALT7	1	affinity chromatography technology	Huttlin EL (2015)	1
TNFSF11	0	LMO4	1	two hybrid	Vinayagam A (2011)	1
TNFSF11	0	SRC	2	affinity chromatography technology	Wong BR (1999)	1