PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FAS	2	TCAP	0	two hybrid	Wang J (2011)	1
CRK	0	TCAP	0	two hybrid	Grossmann A (2015)	1
TTN	102	ANKRD2	3	pull down	Miller MK (2003)	1
TTN	102	TRIM63	0	two hybrid, pull down, two hybrid, x-ray crystallography, pull down, two hybrid	Centner T (2001), Centner T (2001), Witt SH (2005), Mrosek M (2007), Bogomolovas J (2014), Witt CC (2008)	6
TRIM55	2	TCAP	0	two hybrid	Witt CC (2008)	1
ATXN1	2	HSPA8	4	affinity chromatography technology	Choi JY (2007)	1
RELA	1	TCAP	0	two hybrid	Wang J (2011)	1
MDM2	2	TCAP	0	two hybrid, pull down, affinity chromatography technology, imaging technique	Tian LF (2006), Tian LF (2006), Tian LF (2006), Tian LF (2006)	4
TRIM63	0	HSPA4	3	affinity chromatography technology	Kawaguchi Y (2017)	1
TCAP	0	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1
ATXN1	2	TCAP	0	two hybrid	Lim J (2006)	1
CRK	0	HSPA8	4	affinity chromatography technology	Brehme M (2009)	1
FYN	1	TCAP	0	two hybrid	Wang J (2011)	1
MYOZ2	2	TCAP	0	affinity chromatography technology	Frey N (2002)	1
HSPB2	1	MYOZ2	2	two hybrid	Grose JH (2015)	1
PDPK1	0	TCAP	0	two hybrid	Vinayagam A (2011)	1
TRIM55	2	TTN	102	two hybrid	Witt CC (2008)	1
MDM2	2	RELA	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Wang J (2011), Heyne K (2013), Heyne K (2013), Heyne K (2013)	4
MYOZ1	1	TRIM63	0	two hybrid, two hybrid, pull down	Moriscot AS (2010), Witt CC (2008), Witt CC (2008)	3
TRIM55	2	MYOZ1	1	two hybrid	Witt CC (2008)	1
CETN3	0	TCAP	0	affinity chromatography technology	Huttlin EL (2017)	1
ATXN1	2	FYN	1	two hybrid	Lim J (2006)	1
STUB1	4	HSPA4	3	pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Dai Q (2005), Tateishi Y (2004), Tateishi Y (2004), Ko HS (2009), Qian SB (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Wang L (2011), Wang L (2011), Graf C (2010), Kundrat L (2010), Matsumoto K (2011), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Luo W (2010), Soss SE (2011), Zhou P (2003), Kalia LV (2011), Gao Y (2010), Gao Y (2010), Grelle G (2006), Rao SN (2010), Tetzlaff JE (2008), Kim SA (2005), Dai Q (2003), Zhang X (2011), Zhang X (2011), Muller P (2012), Jang KW (2011), Schuelke JP (2010), Jinwal UK (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Mao RF (2013), Lee JS (2013), Lee JS (2013)	42
MYOZ3	1	TCAP	0	affinity chromatography technology	Frey N (2002)	1
STUB1	4	RELA	1	affinity chromatography technology	Wang S (2012)	1
CRK	0	MYOZ2	2	two hybrid	Grossmann A (2015)	1
TCAP	0	ANKRD2	3	affinity chromatography technology, pull down	Kojic S (2004), Kojic S (2004)	2
STUB1	4	HSPA8	4	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, unspecified method, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Tateishi Y (2004), Tateishi Y (2004), Jiang J (2001), Wang L (2011), Wang L (2011), Wang L (2011), Stankiewicz M (2010), Yang M (2011), Yang M (2011), Urushitani M (2004), Grelle G (2006), Kim SA (2005), Arndt V (2005), Alberti S (2004), Meacham GC (2001), Smith MC (2013), Smith MC (2013), Matsumura Y (2013), Spooner RA (2008), Taipale M (2014), Taipale M (2014), Heimdal K (2014), Grelle G (2006), Grelle G (2006), Kamynina E (2007), Zhang H (2015), Zhang H (2015), Zhang H (2015), Li P (2015), Guo Y (2016), Zhang H (2017), Pakdaman Y (2017)	35
TCAP	0	STUB1	4	affinity chromatography technology	Huttlin EL (2017)	1
TCAP	0	TTN	102	two hybrid, enzymatic study, biochemical, two hybrid, pull down, two hybrid, enzymatic study	Gregorio CC (1998), Mayans O (1998), Zou P (2003), Zou P (2003), Mues A (1998), Mues A (1998), Lange S (2005)	7
HSPA4	3	HSPA8	4	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical	Hidalgo-de-Quintana J (2008), Havugimana PC (2012), Taipale M (2014), Taipale M (2014), Wan C (2015)	5
ATXN1	2	HSPA4	3	affinity chromatography technology	Choi JY (2007)	1
MDM2	2	HSPA4	3	affinity chromatography technology	Lu TL (2010)	1
ATXN1	2	STUB1	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Al-Ramahi I (2006), Al-Ramahi I (2006), Choi JY (2007), Choi JY (2007)	4
TCAP	0	CBX5	3	affinity chromatography technology	Huttlin EL (2017)	1
TRIM63	0	TRIM55	2	two hybrid, two hybrid	Centner T (2001), Witt CC (2008)	2
SIVA1	0	TCAP	0	two hybrid, pull down	Mihatsch K (2009), Mihatsch K (2009)	2
HSPA8	4	RELA	1	affinity chromatography technology, affinity chromatography technology	Milanovic M (2013), Milanovic M (2013)	2
SIVA1	0	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Du W (2009), Du W (2009), Iorio-Morin C (2012)	3
ATXN1	2	CRK	0	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Suter B (2013)	3
TRIM63	0	TCAP	0	two hybrid, two hybrid	Witt SH (2005), Witt CC (2008)	2
MYOZ1	1	TCAP	0	affinity chromatography technology, pull down	Frey N (2002), Faulkner G (2000)	2
FYN	1	FAS	2	affinity chromatography technology	Atkinson EA (1996)	1
HSPB2	1	TCAP	0	two hybrid	Grose JH (2015)	1
TCAP	0	HSPA4	3	affinity chromatography technology	Huttlin EL (2017)	1
TCAP	0	LHX4	1	two hybrid	Yu H (2011)	1
MDM2	2	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Lu TL (2010), Okoro DR (2013)	2
HSPB2	1	TTN	102	two hybrid	Grose JH (2015)	1
HSPA4	3	RELA	1	affinity chromatography technology, pull down	Guzhova IV (1997), Guzhova IV (1997)	2
PDPK1	0	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1