PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ODF2	1	CSPP1	7	bioid	Gupta GD (2015)	1
ODF2	1	TJP1	2	bioid	Gupta GD (2015)	1
CEP290	5	CEP162	3	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4
CNTROB	6	PLK1	0	bioid	Gupta GD (2015)	1
NIN	4	TJP1	2	bioid	Gupta GD (2015)	1
CDC14A	4	CDC6	0	enzymatic study	Bremmer SC (2012)	1
CEP135	2	CSPP1	7	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP135	2	C2CD3	7	bioid	Gupta GD (2015)	1
CHEK2	2	CHEK1	2	genetic interference	Srivas R (2016)	1
CCNB1	3	CDC6	0	enzymatic study	Jiang W (1999)	1
NIN	4	CEP131	9	bioid	Gupta GD (2015)	1
SPICE1	2	CCNB1	3	bioid	Gupta GD (2015)	1
CDC14A	4	CEP135	2	bioid	St-Denis N (2016)	1
TP53	0	CDC14A	4	two hybrid, affinity chromatography technology, pull down	Li L (2000), Li L (2000), Li L (2000)	3
CEP135	2	CCDC61	2	affinity chromatography technology	Hein MY (2015)	1
CDC14A	4	MTUS1	6	bioid	St-Denis N (2016)	1
SPICE1	2	CSPP1	7	bioid	Gupta GD (2015)	1
CDC14A	4	CEP290	5	bioid	St-Denis N (2016)	1
TP53	0	NPM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dhar SK (2006), Kurki S (2004), Kurki S (2004), Lambert B (2006), Colombo E (2002), Colombo E (2002), Colombo E (2002), Fogeron ML (2013), Li J (2005)	9
CHEK2	2	TP53	0	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Louria-Hayon I (2003), Shieh SY (2000), Bjorling-Poulsen M (2005), Hirao A (2000), Adams CJ (2008)	5
CUL7	4	NPM1	0	affinity chromatography technology	Hanson D (2014)	1
ODF2	1	TBC1D31	2	bioid	Gupta GD (2015)	1
PLK1	0	TP53	0	enzymatic study	Dias SS (2009)	1
CDC14A	4	CEP131	9	bioid	St-Denis N (2016)	1
CNTROB	6	MPHOSPH9	1	bioid	Gupta GD (2015)	1
CEP290	5	LUZP1	4	bioid	Gupta GD (2015)	1
ODF2	1	CEP131	9	bioid	Gupta GD (2015)	1
CDC14A	4	IGF2BP2	1	bioid	St-Denis N (2016)	1
TUBA1A	13	CHEK2	2	genetic interference	Srivas R (2016)	1
CHEK1	2	FZR1	1	genetic interference	Srivas R (2016)	1
TP53	0	PRRC2A	10	affinity chromatography technology	Fogeron ML (2013)	1
CDC14A	4	CDC25B	4	affinity chromatography technology, enzymatic study	Vazquez-Novelle MD (2010), Vazquez-Novelle MD (2010)	2
NIN	4	CSPP1	7	bioid	Gupta GD (2015)	1
CDC14A	4	LUZP1	4	bioid	St-Denis N (2016)	1
ODF2	1	CEP135	2	bioid	Gupta GD (2015)	1
CEP162	3	CCNB1	3	bioid	Gupta GD (2015)	1
NIN	4	LUZP1	4	bioid	Gupta GD (2015)	1
CHEK1	2	CDC14A	4	genetic interference	Srivas R (2016)	1
CDC25B	4	CCNB1	3	affinity chromatography technology	Li X (2016)	1
CEP135	2	CEP131	9	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP162	3	CEP131	9	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
PLK1	0	TUBA1A	13	affinity chromatography technology	Feng Y (1999)	1
NIN	4	TP53	0	bioid	Gupta GD (2015)	1
CHEK1	2	TP53	0	affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study	Tian H (2002), Sengupta S (2004), Tian H (2002), Goudelock DM (2003), Shieh SY (2000)	5
CEP135	2	PLK1	0	bioid	Gupta GD (2015)	1
SPICE1	2	LUZP1	4	bioid	Gupta GD (2015)	1
CEP135	2	CCDC77	1	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
SPICE1	2	MPHOSPH9	1	bioid	Gupta GD (2015)	1
POC5	5	CSPP1	7	bioid	Gupta GD (2015)	1
CEP135	2	CEP350	4	bioid	Gupta GD (2015)	1
CEP135	2	LUZP1	4	bioid	Gupta GD (2015)	1
CEP162	3	MPHOSPH9	1	bioid	Gupta GD (2015)	1
CDC14A	4	KIAA1328	1	bioid	St-Denis N (2016)	1
CDC14A	4	MPHOSPH9	1	bioid	St-Denis N (2016)	1
CDC6	0	FZR1	1	pull down, enzymatic study, enzymatic study	Ke PY (2004), Petersen BO (2000), Cotto-Rios XM (2011)	3
SPICE1	2	C2CD3	7	bioid	Gupta GD (2015)	1
CEP162	3	CSPP1	7	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CDC14A	4	C2CD3	7	bioid	St-Denis N (2016)	1
CEP290	5	CEP131	9	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
SPICE1	2	TBC1D31	2	bioid	Gupta GD (2015)	1
FZR1	1	PLK1	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Fukushima H (2013), Fukushima H (2013), Sedgwick GG (2012), Lee SB (2015), Williamson A (2011)	5
CEP290	5	TBC1D31	2	bioid	Gupta GD (2015)	1
CEP135	2	TJP1	2	bioid	Gupta GD (2015)	1
CNTROB	6	LUZP1	4	bioid	Gupta GD (2015)	1
TUBA1A	13	CDC14A	4	genetic interference	Srivas R (2016)	1
CDC14A	4	ODF2	1	bioid	St-Denis N (2016)	1
ODF2	1	PLK1	0	bioid	Gupta GD (2015)	1
CDC14A	4	CEP350	4	bioid	St-Denis N (2016)	1
CDC14A	4	CCDC77	1	bioid	St-Denis N (2016)	1
SPICE1	2	CEP135	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CDC14A	4	TOP3B	5	bioid	St-Denis N (2016)	1
SPICE1	2	CCDC77	1	bioid	Gupta GD (2015)	1
CEP135	2	MPHOSPH9	1	bioid	Gupta GD (2015)	1
FZR1	1	CKAP2	3	affinity chromatography technology, affinity chromatography technology	Hong KU (2007), Hong KU (2007)	2
CDC14A	4	MYCBP2	11	bioid	St-Denis N (2016)	1
CHEK2	2	FZR1	1	genetic interference	Srivas R (2016)	1
CHEK1	2	CDC6	0	genetic interference	Srivas R (2016)	1
CHEK2	2	CDC6	0	genetic interference	Srivas R (2016)	1
CEP162	3	CCDC61	2	affinity chromatography technology	Gupta GD (2015)	1
ODF2	1	CCDC77	1	bioid	Gupta GD (2015)	1
CDC14A	4	5430	0	enzymatic study	Clemente-Blanco A (2011)	1
CEP135	2	KIAA1328	1	affinity chromatography technology	Hein MY (2015)	1
CDC14A	4	TDRD3	0	bioid	St-Denis N (2016)	1
POC5	5	MPHOSPH9	1	bioid	Gupta GD (2015)	1
CEP135	2	TBC1D31	2	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CDC14A	4	PLEKHA7	7	bioid	St-Denis N (2016)	1
CDC14A	4	NEFL	1	bioid	St-Denis N (2016)	1
CEP290	5	MPHOSPH9	1	bioid	Gupta GD (2015)	1
CDC14A	4	CNTROB	6	bioid	St-Denis N (2016)	1
SPICE1	2	TRIM36	0	bioid	Gupta GD (2015)	1
CEP290	5	CSPP1	7	bioid	Gupta GD (2015)	1
CDC14A	4	EFL1	1	bioid	St-Denis N (2016)	1
CDC14A	4	CUL7	4	affinity chromatography technology	St-Denis N (2016)	1
CDC14A	4	CKAP2	3	bioid	St-Denis N (2016)	1
CEP162	3	PLK1	0	bioid	Gupta GD (2015)	1
ODF2	1	MPHOSPH9	1	bioid	Gupta GD (2015)	1
SPICE1	2	CEP131	9	bioid	Gupta GD (2015)	1
PLK1	0	CHEK2	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Tsvetkov L (2003), Tsvetkov L (2003), Tsvetkov L (2003), van Vugt MA (2010)	4
ROR2	0	CDC14A	4	two hybrid	Yao Z (2017)	1
CDC14A	4	KRT18	2	bioid	St-Denis N (2016)	1
POC5	5	CEP131	9	bioid	Gupta GD (2015)	1
CDC14A	4	CSPP1	7	bioid	St-Denis N (2016)	1
TP53	0	CUL7	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Andrews P (2006), Andrews P (2006), Andrews P (2006), Dowell JD (2007), Dowell JD (2007), Dowell JD (2007), Skaar JR (2007), Skaar JR (2007), Kim SS (2007), Kim SS (2007), Kim SS (2007), Kaustov L (2007), Kasper JS (2006), Kasper JS (2006), Kasper JS (2006), Fogeron ML (2013), Hanson D (2014), Hanson D (2014), Huttlin EL (2015), Li X (2015), Huttlin EL (2017), Guo H (2014)	22
CDC14A	4	PPP6R1	4	bioid	St-Denis N (2016)	1
CEP162	3	SPICE1	2	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4
NIN	4	CKAP2	3	bioid	Gupta GD (2015)	1
CDC14A	4	BRAP	0	two hybrid, affinity chromatography technology, pull down	Chen JS (2009), Chen JS (2009), Chen JS (2009)	3
CDC14A	4	POC5	5	bioid	St-Denis N (2016)	1
CDC14A	4	SPICE1	2	bioid	St-Denis N (2016)	1
TUBA1A	13	CHEK1	2	genetic interference	Srivas R (2016)	1
NIN	4	CCNB1	3	bioid	Gupta GD (2015)	1
POC5	5	NIN	4	bioid	Gupta GD (2015)	1
PTK7	8	CDC14A	4	two hybrid	Yao Z (2017)	1
CDC14A	4	TBC1D31	2	bioid	St-Denis N (2016)	1
CUL7	4	5430	0	affinity chromatography technology	Hanson D (2014)	1
CDC14A	4	TJP1	2	bioid	St-Denis N (2016)	1
TDRD3	0	5430	0	affinity chromatography technology, affinity chromatography technology	Zhao DY (2016), Zhao DY (2016)	2
SPICE1	2	CEP350	4	bioid	Gupta GD (2015)	1
CDC14A	4	TRIM36	0	bioid	St-Denis N (2016)	1
CHEK1	2	CDC25B	4	enzymatic study, pull down	Sanchez Y (1997), Sanchez Y (1997)	2
DAPK3	5	TP53	0	enzymatic study	Burch LR (2004)	1
NIN	4	CEP350	4	bioid	Gupta GD (2015)	1
FZR1	1	TP53	0	enzymatic study	Gmachl M (2000)	1
DAPK3	5	CHEK2	2	enzymatic study	Burch LR (2004)	1
CEP290	5	CCDC61	2	bioid	Gupta GD (2015)	1
CDC14A	4	KIF20A	3	pull down, two hybrid	Gruneberg U (2004), Gruneberg U (2004)	2
CCNB1	3	FZR1	1	pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Ke PY (2004), Huang NJ (2012), Pfleger CM (2001), Miller JJ (2006), Song MS (2011), Frye JJ (2013), Lau AW (2013), Brown NG (2014), Summers MK (2009), ODonovan KJ (2010), Wu T (2010), Shoji S (2014), Vodermaier HC (2003), Kim HS (2011), Lu L (2013), Yamaguchi M (2015), Brown NG (2015), Chen TC (2014), Williamson A (2011), Qiao R (2016), Brown NG (2016), Huttlin EL (2017)	22
CHEK2	2	CDC14A	4	genetic interference	Srivas R (2016)	1
CDC14A	4	NIN	4	bioid	St-Denis N (2016)	1
CDC14A	4	MAPRE2	0	bioid	St-Denis N (2016)	1
TP53	0	TUBA1A	13	affinity chromatography technology	Fogeron ML (2013)	1
CDC14A	4	CHRM1	3	enzymatic study	Bremmer SC (2012)	1
SPICE1	2	CKAP2	3	bioid	Gupta GD (2015)	1
CDC14A	4	JCAD	7	bioid	St-Denis N (2016)	1
ODF2	1	LUZP1	4	bioid	Gupta GD (2015)	1
NIN	4	PLK1	0	bioid	Gupta GD (2015)	1
CDC14A	4	FZR1	1	enzymatic study	Bembenek J (2001)	1
CUL7	4	KRT18	2	affinity chromatography technology	Hanson D (2014)	1
CEP290	5	CCDC77	1	affinity chromatography technology	Gupta GD (2015)	1
CDC25B	4	PLEKHA7	7	affinity chromatography technology	Boldt K (2016)	1
CEP290	5	CEP350	4	bioid	Gupta GD (2015)	1
CCNB1	3	CDC14A	4	affinity chromatography technology	Paulsen MT (2006)	1
CEP162	3	LUZP1	4	bioid	Gupta GD (2015)	1
CEP135	2	CEP290	5	affinity chromatography technology	Hein MY (2015)	1
CDC14A	4	CCDC61	2	bioid	St-Denis N (2016)	1
CUL7	4	TJP1	2	affinity chromatography technology	Hanson D (2014)	1
CEP162	3	CKAP2	3	bioid	Gupta GD (2015)	1
CEP162	3	TBC1D31	2	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
TOP3B	5	TDRD3	0	biochemical, affinity chromatography technology	Wan C (2015), Narayanan N (2017)	2
CDC14A	4	PLK1	0	affinity chromatography technology, enzymatic study	van Leuken R (2009), van Leuken R (2009)	2
CEP135	2	CEP162	3	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CDC14A	4	IFT57	1	bioid	St-Denis N (2016)	1
SPICE1	2	MTUS1	6	bioid	Gupta GD (2015)	1
AATK	6	CDC25B	4	two hybrid	Yao Z (2017)	1
CDC14A	4	DAPK3	5	bioid	St-Denis N (2016)	1
CDC14A	4	PRRC2A	10	bioid	St-Denis N (2016)	1
AATK	6	CDC14A	4	two hybrid	Yao Z (2017)	1
LMTK2	8	CDC14A	4	two hybrid	Yao Z (2017)	1
CDC14A	4	CEP162	3	bioid	St-Denis N (2016)	1
SPICE1	2	TP53	0	bioid	Gupta GD (2015)	1
CEP162	3	C2CD3	7	affinity chromatography technology	Gupta GD (2015)	1
NPM1	0	CDC14A	4	affinity chromatography technology	Crockett DK (2004)	1
CEP135	2	TP53	0	bioid	Gupta GD (2015)	1