PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2V2	0	UBC	7	x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down	McKenna S (2003), McKenna S (2003), McKenna S (2003), Lewis MJ (2006), McKenna S (2001)	5
TRIM5	4	UBC	7	enzymatic study	Pertel T (2011)	1
LGALS3	0	TRIM6	1	pull down	Chauhan S (2016)	1
UBE2H	3	TRIM5	4	two hybrid	Markson G (2009)	1
UBE2D3	1	MKRN3	2	two hybrid	Markson G (2009)	1
TRIM21	0	TRIM5	4	pull down	Li X (2006)	1
UBE2V1	0	TRIM5	4	two hybrid	Markson G (2009)	1
UBE2U	0	TRIM5	4	two hybrid	Markson G (2009)	1
UBE2D4	0	TRIM35	1	two hybrid	Markson G (2009)	1
OTUB2	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down	Edelmann MJ (2009), Mevissen TE (2013), Altun M (2015), Altun M (2015), Kwasna D (2018)	5
MAP3K1	4	UBE2K	0	enzymatic study	Charlaftis N (2014)	1
USP2	0	MNAT1	0	two hybrid	Hayes SD (2012)	1
TAB3	1	UBC	7	x-ray crystallography, pull down, pull down, pull down	Sato Y (2009), Kanayama A (2004), Wang J (2015), Zhang X (2017)	4
MAP3K7	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Takaesu G (2000), Takaesu G (2001), Ishitani T (2003), Ishitani T (2003), Ea CK (2006), Broglie P (2010), Liu XY (2008), Li S (2011), Li S (2011), Jiang Z (2003), Mendoza H (2008), Ear T (2010), Criollo A (2011), Kim SY (2012), Jiang Z (2002), Jiang Z (2002), Hong S (2007), Shibuya H (1996), Minoda Y (2009), Li M (2010), Scholz R (2010), Kim SI (2009), Yong Kim S (2013), Liu R (2014), Wang J (2015), Moon G (2015), Wade EM (2016), Min Y (2016), Zhang J (2017)	31
USP2	0	IKBKG	0	enzymatic study	Zhou H (2004)	1
TRIM5	4	CUEDC1	4	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D4	0	TRIM5	4	two hybrid	Markson G (2009)	1
TRIM32	2	UBE2V2	0	two hybrid, two hybrid, affinity chromatography technology	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	3
UBE2D2	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
TRIM5	4	PSMC5	4	affinity chromatography technology	Lukic Z (2011)	1
CFTR	5	XPO1	8	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Pankow S (2015)	2
TRIM6	1	TRIM5	4	two hybrid, pull down	Zhang F (2006), Li X (2006)	2
UBE2U	0	MKRN3	2	two hybrid	Markson G (2009)	1
TRIM32	2	UBE2D1	0	affinity chromatography technology, pull down, pull down, pull down, pull down	Napolitano LM (2011), Zhang J (2012), Streich FC (2013), Albor A (2006), Mokhonova EI (2015)	5
XPO1	8	COIL	1	affinity chromatography technology	Kirli K (2015)	1
PSMC4	6	PSMC2	2	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Ewing RM (2007), Hartmann-Petersen R (2001), Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	8
UBE2V2	0	TRIM5	4	two hybrid	Markson G (2009)	1
UBE2D3	1	TRIM35	1	two hybrid	Markson G (2009)	1
MNAT1	0	TRIM21	0	two hybrid	Woodsmith J (2012)	1
UBE2V1	0	UBE2V2	0	biochemical	Havugimana PC (2012)	1
TAB2	5	IKBKG	0	affinity chromatography technology, two hybrid, pull down, pull down	Suzuki S (2007), Wang J (2011), Emmerich CH (2013), Emmerich CH (2013)	4
UBE2N	1	MKRN3	2	two hybrid	Markson G (2009)	1
UBE2D4	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
LZTR1	16	IKBKG	0	two hybrid	Ravasi T (2010)	1
SQSTM1	0	PSMC2	2	affinity chromatography technology, affinity chromatography technology	Seibenhener ML (2004), Seibenhener ML (2004)	2
LGALS3	0	SQSTM1	0	imaging technique	Chen X (2014)	1
TRIM5	4	YARS	3	affinity chromatography technology	Huttlin EL (2017)	1
TRIM5	4	TRIM5	4	two hybrid, enzymatic study, affinity chromatography technology, biochemical, two hybrid, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, enzymatic study, enzymatic study, enzymatic study, pull down	Reymond A (2001), Yamauchi K (2008), Lienlaf M (2011), Langelier CR (2008), Zhang F (2006), Li X (2008), Li X (2007), Mische CC (2005), Li X (2007), Javanbakht H (2006), Woodsmith J (2012), Xu L (2003), Langelier CR (2008), Yudina Z (2015), Yudina Z (2015)	15
TRIM21	0	UBE2H	3	pull down	Wada K (2006)	1
SUMO1	0	TRIM5	4	pull down, imaging technique, imaging technique	Arriagada G (2011), Dutrieux J (2015), Portilho DM (2016)	3
UBE2D1	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
TRIM5	4	PSMC2	2	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Lukic Z (2011), Lukic Z (2011), Lukic Z (2011)	3
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
TRIM5	4	MAP3K1	4	affinity chromatography technology	Pertel T (2011)	1
TRIM5	4	SQSTM1	0	affinity chromatography technology	OConnor C (2010)	1
SQSTM1	0	UBC	7	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, affinity chromatography technology, unspecified method, pull down, pull down, pull down, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, imaging technique, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Vinayagam A (2011), Vadlamudi RK (1996), Tanji K (2012), Matsumoto G (2011), Long J (2008), Long J (2008), Najat D (2009), Najat D (2009), Hocking LJ (2004), Boh BK (2011), Long J (2010), Seibenhener ML (2004), Seibenhener ML (2004), Seibenhener ML (2004), Fenner BJ (2009), Nathan JA (2013), Ciani B (2003), Shi J (2013), Goode A (2014), Bish RA (2007), Lu K (2014), Zhou L (2014), Zhou L (2014), Vadlamudi RK (1996), Long J (2008), Cavey JR (2006), Cavey JR (2006), Kirkin V (2009), Nakayasu ES (2013), Nakayasu ES (2013), Lim J (2015), Milan E (2015), Milan E (2015), Ordureau A (2015), Wurzer B (2015), Zhang X (2017), Wang L (2017), Liu X (2017), Peng H (2017), Donohue E (2014), Nibe Y (2017), Nibe Y (2017), Govindaraju VK (2017)	43
SQSTM1	0	UBE2D3	1	two hybrid, affinity chromatography technology, pull down, enzymatic study, pull down	Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017)	5
UBE2K	0	MKRN3	2	two hybrid	Markson G (2009)	1
OTUD6A	2	TRIM5	4	two hybrid	Hayes SD (2012)	1
TRIM5	4	MAP3K7	2	affinity chromatography technology	Pertel T (2011)	1
UBE2U	0	TRIM34	1	two hybrid	van Wijk SJ (2009)	1
TRIM21	0	UBC	7	enzymatic study	McEwan WA (2013)	1
TRIM5	4	MAP3K11	7	affinity chromatography technology	Lukic Z (2011)	1
TRIM34	1	MKRN3	2	two hybrid	Woodsmith J (2012)	1
USP21	2	OTUB2	0	enzymatic study	Loch CM (2012)	1
UBC	7	PSMC5	4	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhu Q (2004), Zhang X (2017)	3
UBC	7	SUMO1	0	affinity chromatography technology	Sahin U (2014)	1
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
TRIM5	4	PSMD7	1	affinity chromatography technology	Lukic Z (2011)	1
CFTR	5	PSMC4	6	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Pankow S (2015)	2
USP2	0	TRIM5	4	two hybrid	Hayes SD (2012)	1
TNFAIP3	3	UBE2N	1	pull down	Wertz IE (2004)	1
XPO1	8	TRIM5	4	affinity chromatography technology	Kirli K (2015)	1
TNFAIP3	3	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
CFTR	5	PSMC2	2	affinity chromatography technology	Pankow S (2015)	1
MNAT1	0	MKRN3	2	two hybrid	Woodsmith J (2012)	1
TRIM21	0	UBE2D1	0	pull down, pull down	Mallery DL (2010), Kong HJ (2007)	2
MAP3K7	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Neil JR (2009), Yang Y (2011), Wu X (2007), Emmerich CH (2013)	4
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
TRIM35	1	PIAS1	4	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	MAP3K7	2	pull down	Zhang X (2017)	1
EWSR1	2	PSMD7	1	bioid	Elzi DJ (2014)	1
IKBKG	0	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	SQSTM1	0	affinity chromatography technology	Kirli K (2015)	1
UBE2K	0	UBE2N	1	biochemical	Wan C (2015)	1
UBC	7	CUEDC1	4	pull down	Zhang X (2017)	1
TAB2	5	UBC	7	pull down, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down	Kulathu Y (2009), Kulathu Y (2009), Sato Y (2009), van Wijk SJ (2012), Kanayama A (2004), Niu J (2011), van Wijk SJ (2013), Hooper C (2014), Komander D (2009), Emmerich CH (2013), Wauer T (2015), Kristariyanto YA (2015), Zhang X (2017)	13
PSMC2	2	UBC	7	pull down, pull down	Jacobson AD (2014), Zhang X (2017)	2
TRIM32	2	UBC	7	enzymatic study, pull down	Streich FC (2013), Zhang X (2017)	2
UBE2H	3	MKRN3	2	two hybrid	Markson G (2009)	1
UBE2D1	0	TRIM35	1	two hybrid	Markson G (2009)	1
UBC	7	PSMD7	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
TNFAIP3	3	TRIM5	4	two hybrid	Hayes SD (2012)	1
CFTR	5	PSMC5	4	affinity chromatography technology	Pankow S (2015)	1
PSMC2	2	PSMC5	4	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Tipler CP (1997), Kim YC (2011), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	7
USP39	1	TRIM5	4	two hybrid	Hayes SD (2012)	1
XPO1	8	MAP3K7	2	affinity chromatography technology	Kirli K (2015)	1
UBE2V2	0	MKRN3	2	two hybrid	Markson G (2009)	1
UBE2D2	0	MKRN3	2	two hybrid	Markson G (2009)	1
UBE2D2	0	TRIM35	1	two hybrid	Markson G (2009)	1
UBE2V1	0	UBC	7	pull down	McKenna S (2003)	1
EWSR1	2	SUMO1	0	bioid	Elzi DJ (2014)	1
USP21	2	XPO1	8	imaging technique	Garcia-Santisteban I (2012)	1
CREB1	1	PIAS1	4	two hybrid	Bandyopadhyay S (2010)	1
LGALS8	4	TRIM6	1	pull down	Chauhan S (2016)	1
TAB3	1	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Li S (2011), Li S (2011)	4
UBE2H	3	USP5	2	biochemical	Havugimana PC (2012)	1
UBE2K	0	TRIM35	1	two hybrid	Markson G (2009)	1
TRIM32	2	UBE2D3	1	affinity chromatography technology, pull down, pull down, pull down	Napolitano LM (2011), Zhang J (2012), Streich FC (2013), Mokhonova EI (2015)	4
USP15	4	PSMD7	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015)	2
USP21	2	USP15	4	enzymatic study, enzymatic study	Loch CM (2012), Loch CM (2012)	2
CFTR	5	SQSTM1	0	imaging technique, affinity chromatography technology, biochemical	Luciani A (2010), Villella VR (2013), Villella VR (2013)	3
TRIM5	4	IKBKG	0	affinity chromatography technology	Pertel T (2011)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
UBE2V1	0	MKRN3	2	two hybrid	Markson G (2009)	1
MAP3K1	4	CUEDC1	4	enzymatic study	Charlaftis N (2014)	1
IKBKG	0	CUEDC1	4	pull down	Fenner BJ (2010)	1
LGALS3	0	TRIM5	4	pull down, affinity chromatography technology	Chauhan S (2016), Chauhan S (2016)	2
USP21	2	TRIM5	4	two hybrid	Hayes SD (2012)	1
UBE2D2	0	UBB	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
CFTR	5	TRIM5	4	affinity chromatography technology	Pankow S (2015)	1
TRIM35	1	TRIM5	4	pull down	Li X (2006)	1
PSMC4	6	PSMD7	1	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Ewing RM (2007), Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
TRIM5	4	TAB2	5	affinity chromatography technology	Pertel T (2011)	1
TRIM5	4	MKRN3	2	two hybrid	Woodsmith J (2012)	1
OTUB2	0	TRIM5	4	two hybrid	Hayes SD (2012)	1
ZWINT	1	TRIM5	4	affinity chromatography technology	Hutchins JR (2010)	1
LZTR1	16	TRIM5	4	two hybrid	Ravasi T (2010)	1
SUMO1	0	PIAS1	4	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, pull down	Lee BH (2003), Kahyo T (2001), Stehmeier P (2009), Stehmeier P (2009), Stehmeier P (2009), Ullmann R (2012), Ullmann R (2012), Hecker CM (2006), Hecker CM (2006), Gocke CB (2008), Ullmann R (2012), Ledsaak M (2016)	12
UBE2N	1	TRIM5	4	two hybrid, pull down, x-ray crystallography	Markson G (2009), Yudina Z (2015), Yudina Z (2015)	3
USP5	2	UBC	7	pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down	Reyes-Turcu FE (2008), Nicassio F (2007), Zhang YH (2012), Bremm A (2010), Komander D (2009), Melandri F (1996), Sokratous K (2012), Fenner BJ (2009), Schulz S (2012), Raasi S (2005), Nathan JA (2013), Ernst A (2013), Bish RA (2007), Reyes-Turcu FE (2006), Reyes-Turcu FE (2006), Zhang YH (2012), Liu Y (2014), Scott D (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	22
TNFAIP3	3	UBE2D1	0	pull down, pull down	Wertz IE (2004), Lee JH (2017)	2
USP15	4	TRIM5	4	two hybrid	Hayes SD (2012)	1
USP15	4	TRIM21	0	two hybrid, two hybrid	Hayes SD (2012), Rolland T (2014)	2
UBE2D3	1	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	TRIM35	1	two hybrid	van Wijk SJ (2009)	1
UBE2D4	0	MKRN3	2	two hybrid	Markson G (2009)	1
TRIM5	4	COIL	1	imaging technique	Portilho DM (2016)	1
UBE2U	0	TRIM32	2	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
CFTR	5	PSMD7	1	affinity chromatography technology	Pankow S (2015)	1
OTUD6A	2	UBC	7	enzymatic study	Mevissen TE (2013)	1
IKBKG	0	TNFAIP3	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhang SQ (2000), Zhang SQ (2000), Skaug B (2011), Skaug B (2011), Klinkenberg M (2001), Verhelst K (2012), Verhelst K (2012), Wang J (2011), Zilberman-Rudenko J (2016)	9
UBE2V1	0	UBE2K	0	biochemical	Wan C (2015)	1
EWSR1	2	TRIM5	4	two hybrid	Ravasi T (2010)	1
USP2	0	TRIM35	1	two hybrid	Hayes SD (2012)	1
PSMD7	1	PSMC2	2	affinity chromatography technology, biochemical, biochemical, biochemical	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
UBE2D1	0	TRIM5	4	two hybrid	Markson G (2009)	1
UBE2N	1	UBE2V1	0	biochemical, pull down, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deng L (2000), Deng L (2000), Zhang M (2005), Andersen PL (2005), Andersen PL (2005), Scheper J (2010), Scheper J (2010), Scheper J (2010), Wooff J (2004), Plans V (2006), Huen MS (2008), Huen MS (2008), Havugimana PC (2012), Bohgaki M (2008), Petroski MD (2007), Sawasaki T (2008), Wan C (2015), Chen J (2015), Boldt K (2016), Zhang Y (2018)	20
MAP3K7	2	TAB3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Ishitani T (2003), Ishitani T (2003), Li S (2011), Li S (2011), Mendoza H (2008), Criollo A (2011), Hong S (2007), Minoda Y (2009), Liu R (2014), Shinohara H (2016), Zhang J (2017)	13
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
USP15	4	UBC	7	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Hetfeld BK (2005), Bremm A (2010), Komander D (2009), Loch CM (2012), Herhaus L (2014), Wauer T (2015), Das T (2017), Zhang X (2017), Kwasna D (2018)	9
UBE2K	0	TRIM5	4	two hybrid	Markson G (2009)	1
LGALS8	4	TRIM5	4	pull down	Chauhan S (2016)	1
PCBD1	0	TRIM5	4	two hybrid	Ravasi T (2010)	1
USP2	0	UBC	7	x-ray crystallography, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, unspecified method, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Renatus M (2006), Matsumoto M (2005), Bremm A (2010), Komander D (2009), Bozza WP (2012), Bozza WP (2012), Ernst A (2013), Durcan TM (2011), Mullen JR (2010), Ernst A (2013), Wauer T (2015), Louis M (2015), Castaneda CA (2016), Kliza K (2017), Kwasna D (2018), Leung I (2016)	16
TRIM32	2	UBE2D2	0	affinity chromatography technology, pull down, pull down	Napolitano LM (2011), Streich FC (2013), Mokhonova EI (2015)	3
UBE2V1	0	TRIM32	2	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	4
TRIM5	4	CREB1	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM34	1	TRIM5	4	two hybrid, two hybrid	Zhang F (2006), Woodsmith J (2012)	2
MAP3K7	2	USP2	0	affinity chromatography technology	Li Y (2013)	1
USP2	0	TRIM21	0	two hybrid	Hayes SD (2012)	1
XPO1	8	TAB2	5	affinity chromatography technology	Kirli K (2015)	1
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
UBE2K	0	TRIM34	1	two hybrid	Markson G (2009)	1
PIAS1	4	TRIM5	4	enzymatic study	Dutrieux J (2015)	1
MNAT1	0	TRIM34	1	two hybrid	Woodsmith J (2012)	1
UBE2D3	1	TRIM5	4	two hybrid, pull down, pull down	Markson G (2009), Langelier CR (2008), Yudina Z (2015)	3
MAP3K1	4	UBE2V1	0	enzymatic study	Charlaftis N (2014)	1
TRIM5	4	TRIM32	2	two hybrid	Woodsmith J (2012)	1
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
UBE2D2	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
XPO1	8	MAP3K1	4	affinity chromatography technology	Kirli K (2015)	1
PSMD7	1	PSMC5	4	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
UBC	7	PSMC4	6	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
PSMC2	2	XPO1	8	biochemical	Havugimana PC (2012)	1
USP2	0	TRIM34	1	two hybrid	Hayes SD (2012)	1
UBE2D1	0	MKRN3	2	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
IKBKG	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Martin P (2006), Zotti T (2014)	2
TRIM5	4	UBB	4	two hybrid	Lukic Z (2011)	1
TAB3	1	IKBKG	0	pull down, pull down	Kanayama A (2004), Emmerich CH (2013)	2
TRIM5	4	TAB3	1	affinity chromatography technology	Pertel T (2011)	1
USP21	2	USP2	0	enzymatic study	Loch CM (2012)	1
MNAT1	0	TRIM5	4	two hybrid	Woodsmith J (2012)	1
TRIM32	2	UBE2N	1	two hybrid, affinity chromatography technology, two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Saccone V (2008), Saccone V (2008), van Wijk SJ (2009), Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Boldt K (2016)	8
PSMC4	6	PSMC5	4	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Hendil KB (2009), Kaneko T (2009), Kaneko T (2009), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Albers M (2005), Albers M (2005), Huttlin EL (2017)	13
SQSTM1	0	UBE2D2	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017)	5
TRIM21	0	UBE2D2	0	pull down, pull down, pull down, pull down	Wada K (2006), Wada K (2006), Wada K (2009), Wada K (2006)	4
SQSTM1	0	TRIM21	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim JY (2009), Kim JY (2009), Kimura T (2015), Milan E (2015), Pan JA (2016), Pan JA (2016)	6
TRIM5	4	PSMC4	6	affinity chromatography technology	Lukic Z (2011)	1
OTUB2	0	UBE2N	1	pull down	Nakada S (2010)	1
UBE2D2	0	TRIM5	4	two hybrid, pull down, pull down	Markson G (2009), Yamauchi K (2008), Xu L (2003)	3
CFTR	5	TRIM21	0	affinity chromatography technology	Pankow S (2015)	1
USP21	2	UBC	7	enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study	Bremm A (2010), Faesen AC (2011), Ye Y (2011), Urbe S (2012), Loch CM (2012), Ernst A (2013), Ye Y (2011), Wauer T (2015), Leung I (2016), Michel MA (2017)	10
UBE2V2	0	UBE2N	1	pull down, two hybrid, x-ray crystallography, two hybrid, two hybrid, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, two hybrid, pull down, pull down, affinity chromatography technology, two hybrid, pull down, biochemical, x-ray crystallography, pull down, affinity chromatography technology, pull down, x-ray crystallography, biochemical, x-ray crystallography, affinity chromatography technology	Andersen PL (2005), Andersen PL (2005), Markin CJ (2010), Wooff J (2004), Wooff J (2004), Plans V (2006), Wu PY (2003), McKenna S (2003), McKenna S (2003), Zou W (2005), Takeuchi T (2005), Pastushok L (2005), Pastushok L (2005), Pastushok L (2005), Huen MS (2008), Huen MS (2008), Ye Y (2003), Havugimana PC (2012), Moraes TF (2001), Pastushok L (2007), Zou W (2005), McKenna S (2001), Hodge CD (2015), Wan C (2015), Branigan E (2015), Boldt K (2016)	26
CFTR	5	LGALS3	0	affinity chromatography technology	Wang X (2006)	1
PRKCG	3	TRIM5	4	pull down	Rex EB (2010)	1
USP5	2	TRIM5	4	two hybrid	Hayes SD (2012)	1