PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SHANK1	7	SHANK3	18	affinity chromatography technology	Mameza MG (2013)	1
COPS5	0	SHANK3	18	two hybrid	Wang J (2011)	1
CRKL	1	SHANK3	18	two hybrid	Wang J (2011)	1
COPS5	0	SPTAN1	9	affinity chromatography technology	Bennett EJ (2010)	1
ABCC2	2	SHANK3	18	two hybrid	Wang J (2011)	1
GRB2	2	PPP1CC	2	affinity chromatography technology	Bisson N (2011)	1
COPS5	0	DLGAP3	2	affinity chromatography technology	Bennett EJ (2010)	1
SHANK3	18	DLGAP1	6	two hybrid	Boeckers TM (1999)	1
CSNK2B	5	SHANK3	18	two hybrid	Wang J (2011)	1
NCK1	0	GRB2	2	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
GRB2	2	ARHGEF7	3	affinity chromatography technology	Bisson N (2011)	1
NCK1	0	SHANK3	18	two hybrid	Wang J (2011)	1
MAPK1	1	SHANK3	18	two hybrid	Wang J (2011)	1
SHANK3	18	DLGAP3	2	two hybrid	Boeckers TM (1999)	1
GRB2	2	DLGAP1	6	two hybrid	Bandyopadhyay S (2010)	1
ARHGEF7	3	SHANK1	7	two hybrid, affinity chromatography technology, pull down	Park E (2003), Park E (2003), Park E (2003)	3
SHANK3	18	SPTAN1	9	two hybrid	Boeckers TM (2001)	1
SHANK3	18	DLGAP4	4	two hybrid	Boeckers TM (1999)	1
ARHGEF7	3	SHANK3	18	two hybrid, affinity chromatography technology	Park E (2003), Park E (2003)	2
COPS5	0	PPP1CC	2	affinity chromatography technology, two hybrid, two hybrid	Bennett EJ (2010), Esteves SL (2012), Fardilha M (2011)	3
SHANK1	7	DLGAP1	6	x-ray crystallography	Im YJ (2003)	1
PRMT2	3	SHANK3	18	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SPTAN1	9	SHANK1	7	pull down, affinity chromatography technology	Boeckers TM (2001), Boeckers TM (2001)	2
GRB2	2	SHANK3	18	two hybrid	Wang J (2011)	1
MAPK1	1	PPP1CC	2	affinity chromatography technology	Quevedo C (2003)	1
CSNK2B	5	PPP1CC	2	two hybrid	Wallach T (2013)	1
SHANK3	18	DLGAP2	4	two hybrid	Boeckers TM (1999)	1
PPP1CC	2	SHANK3	18	two hybrid	Esteves SL (2012)	1
GRB2	2	CRKL	1	affinity chromatography technology	Park RK (1999)	1