PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
COPS3	1	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Min KW (2005), Enchev RI (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	9
CUL5	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ehrlich ES (2009), Ehrlich ES (2009), Bennett EJ (2010)	3
ELOC	0	ELOB	1	two hybrid, pull down, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, pull down, two hybrid, biochemical, biochemical, two hybrid	Rual JF (2005), Ohh M (1999), Aso T (1995), Li Z (2002), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Lievens S (2009), Brower CS (1999), Stebbins CE (1999), Pause A (1999), Pause A (1999), Havugimana PC (2012), Wang X (2013), Kristensen AR (2012), Costessi A (2011), Rolland T (2014), Kim DY (2013), Wan C (2015), Yu H (2011)	21
DTL	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2006), Higa LA (2006), Higa LA (2006), Sertic S (2013), Shibata E (2014), Hein MY (2015), Shibata E (2011), Higa LA (2006), Higa LA (2006)	9
FBXO7	1	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
DCAF8	1	COPS7A	0	biochemical	Kristensen AR (2012)	1
DDA1	1	DCAF8	1	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
FBXW4	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2012), Lockwood WW (2013), Lockwood WW (2013), Hauri S (2016)	4
COPS5	0	FEM1B	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS8	2	COPS7A	0	biochemical, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Luke-Glaser S (2007), Kapelari B (2000), Olma MH (2009), Huang X (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	10
FBXO7	1	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL2	3	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Hein MY (2015)	3
CUL5	1	ELOC	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology	Kamura T (2001), Nishiya T (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Kershaw NJ (2014), Huttlin EL (2017)	18
COPS5	0	SRP14	0	affinity chromatography technology	Bennett EJ (2010)	1
DDA1	1	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Jin J (2006), Hein MY (2015)	3
HSP90AA1	7	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Hein MY (2015)	2
NFKBIA	0	COPS2	5	affinity chromatography technology	Schweitzer K (2007)	1
COPS2	5	FEM1B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DCAF1	5	CUL4A	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahn J (2010), Belzile JP (2007), He YJ (2006), McCall CM (2008), McCall CM (2008), McCall CM (2008), McCall CM (2008), Hrecka K (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006), Kyei GB (2015)	14
DDB1	6	COPS6	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006), Emberley ED (2012), Bennett EJ (2010), Olma MH (2009)	5
COPS3	1	MLF1	2	affinity chromatography technology, affinity chromatography technology	Yoneda-Kato N (2005), Yoneda-Kato N (2005)	2
NEDD8	0	FEM1B	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	KLHL42	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cummings CM (2009), Cummings CM (2009), Bennett EJ (2010), Plafker KS (2009), Olma MH (2009), Wimuttisuk W (2014), Huttlin EL (2017)	7
DCUN1D1	0	COPS3	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	CRBN	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Ito T (2010), Bennett EJ (2010), Liu Y (2015), Liu Y (2015), Diaz-Rodriguez E (2016), Xu Q (2016), Xu G (2013), Nguyen TV (2016), Nguyen TV (2016), Eichner R (2016), Eichner R (2016), Huttlin EL (2017), Kroenke J (2014)	14
GPS1	1	COPS2	5	affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, two hybrid, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Stotland A (2012), Huang X (2005), Sharon M (2009), Kapelari B (2000), Tsuge T (2001), Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	11
COPS2	5	DCAF4	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL1	7	COPS9	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Ebina M (2013)	2
HSP90AA1	7	VCP	6	affinity chromatography technology, affinity chromatography technology	Vij N (2006), Yu CC (2013)	2
HSP90AA1	7	SKP1	0	pull down	Zhang M (2008)	1
LRR1	1	ELOB	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Kamura T (2004), Kamura T (2004)	3
ERCC6	6	CUL4A	2	affinity chromatography technology	Latini P (2011)	1
FBXO6	0	ARAF	0	affinity chromatography technology	Liu B (2012)	1
COPS7B	0	FEM1B	1	affinity chromatography technology	Huttlin EL (2017)	1
APBB3	2	COPS6	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS6	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
NTRK1	1	CSNK2B	5	affinity chromatography technology	Emdal KB (2015)	1
COPS8	2	DCAF4	3	affinity chromatography technology	Huttlin EL (2017)	1
DCAF4L2	3	COPS2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Wang H (2016)	2
COPS6	0	FBXO7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2017)	3
IKBKG	0	SNW1	0	two hybrid	Ravasi T (2010)	1
COPS3	1	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Bennett EJ (2010), Olma MH (2009), Kristensen AR (2012), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	7
COPS5	0	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Fang L (2008), Bennett EJ (2010), Oh W (2006), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	11
COPS7A	0	DCAF11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Hein MY (2015), Huttlin EL (2017)	3
ELOC	0	APPBP2	3	affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Mahrour N (2008)	2
DDB1	6	COPS7B	0	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006)	2
RBX1	2	CUL2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Dias DC (2002), Ohta T (1999), Ohta T (1999), Maine GN (2007), Hu J (2004), Furukawa M (2002), Mao X (2011), Sufan RI (2006), Sufan RI (2006), Sufan RI (2006), Brower CS (2002), Tron AE (2012), Kamura T (2004), Kristensen AR (2012), Costessi A (2011), Huang DT (2009), Kamura T (1999), Kamura T (1999), Xu J (2015), Cardote TAF (2017)	20
CUL3	17	SRP14	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS4	0	COPS7B	0	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	7
IKBKG	0	NFKBIA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Stempin CC (2011), Pringle LM (2011), Wu CJ (2006), Higashimoto T (2008), Ducut Sigala JL (2004), Shibata Y (2011), Liu L (2002), Xiao G (2000), Chan H (2005), Funakoshi-Tago M (2005), Wu X (2007), Kato T (2008), Niu J (2011), Neumann M (2011), Keusekotten K (2013), Fu J (2013), Dan HC (2008), Criollo A (2010), Hein MY (2015), Baratchian M (2016)	20
COPS4	0	CRBN	2	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Kroenke J (2014)	2
SNW1	0	COPS6	0	affinity chromatography technology	Lleres D (2010)	1
NEDD8	0	KLHL15	1	affinity chromatography technology	Bennett EJ (2010)	1
ERCC8	1	VCP	6	affinity chromatography technology	He J (2016)	1
CUL5	1	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017), Zhu Z (2017)	3
HSP90AA1	7	FBXO17	1	affinity chromatography technology	Taipale M (2012)	1
CENPJ	6	WRAP73	1	bioid	Gupta GD (2015)	1
CUL4B	8	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Jin J (2006), Wang H (2006), Higa LA (2006), Higa LA (2006), Kawajiri K (2009), Bennett EJ (2010), Havugimana PC (2012), Ji Q (2014), Wan C (2015), Hein MY (2015), Mo Y (2017), Mo Y (2017), Yang Y (2015), Yang Y (2015), Yang Y (2015), Higa LA (2006), Higa LA (2006), Ohtake F (2007), Ohtake F (2007), Ohtake F (2007)	23
COPS5	0	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS7A	0	DCAF4	3	affinity chromatography technology	Hein MY (2015)	1
FBXO6	0	COPS5	0	affinity chromatography technology	Liu B (2012)	1
IKBKB	1	COPS5	0	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, affinity chromatography technology	Orel L (2010), Orel L (2010), Orel L (2010), Orel L (2010), Asare Y (2013), Asare Y (2013)	6
SKP1	0	FBXL5	3	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Winston JT (1999), Vashisht AA (2009), Salahudeen AA (2009), Vinas-Castells R (2013), Moroishi T (2014), Moroishi T (2014), Rolland T (2014), Yu H (2011), Wu WD (2016), Huttlin EL (2017)	10
CSNK2B	5	ERCC8	1	two hybrid	Vinayagam A (2011)	1
DDB1	6	COPS2	5	affinity chromatography technology, affinity chromatography technology, pull down	Angers S (2006), Jin J (2006), Emberley ED (2012)	3
CUL5	1	COPS5	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
DCAF8	1	COPS2	5	affinity chromatography technology	Olma MH (2009)	1
NTRK1	1	CHUK	5	affinity chromatography technology	Emdal KB (2015)	1
COPS7A	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uhle S (2003), Bennett EJ (2010), Huang X (2016), Reitsma JM (2017)	4
COPS5	0	FBXL14	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	COPS4	0	affinity chromatography technology	Bennett EJ (2010)	1
KLHL18	2	RBX1	2	affinity chromatography technology	Moghe S (2012)	1
FBXW4	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2003), Lockwood WW (2013), Chung FZ (2014), Low TY (2014), Reitsma JM (2017)	5
FBXO6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2007), Nelson RF (2007), Glenn KA (2008), Yoshida Y (2011), Liu B (2012), Liu B (2012), Huttlin EL (2015), Huttlin EL (2017), Reitsma JM (2017), Reitsma JM (2017)	10
COPS6	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Kristensen AR (2012), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
CRBN	2	COPS7B	0	affinity chromatography technology	Kroenke J (2014)	1
DCAF11	2	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	3
WRAP73	1	COPS4	0	affinity chromatography technology	Ewing RM (2007)	1
COPS5	0	LRRC14	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
EWSR1	2	DDB1	6	bioid	Elzi DJ (2014)	1
CUL4A	2	DCUN1D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	9
HSP90AA1	7	DET1	2	affinity chromatography technology	Taipale M (2012)	1
FBXL5	3	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
DCUN1D1	0	ELOB	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	GPS1	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	ERCC8	1	affinity chromatography technology	Bennett EJ (2010)	1
FBXL5	3	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
NEDD8	0	COPS2	5	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
VCP	6	SKP1	0	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
ERCC8	1	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Olma MH (2009)	3
DCUN1D1	0	COPS6	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	KLHL18	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	CUL3	17	affinity chromatography technology	Bennett EJ (2010)	1
COPS3	1	COPS7B	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Enchev RI (2010), Olma MH (2009), Havugimana PC (2012), Huttlin EL (2015), Huang X (2016), Huttlin EL (2017)	6
DCUN1D1	0	COPS8	2	affinity chromatography technology	Bennett EJ (2010)	1
IKBKB	1	CUL1	7	affinity chromatography technology	Orel L (2010)	1
COPS5	0	KLHL42	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	DDB1	6	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Bennett EJ (2010), Sertic S (2013), Rossi M (2013), Jin J (2006), Shibata E (2011), Higa LA (2006)	7
COPS6	0	COPS9	1	affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Bennett EJ (2010), Rozen S (2015)	3
FBXW7	2	RBX1	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2012), Matsumoto A (2011), Strohmaier H (2001), Ye M (2017)	4
COPS5	0	ELOC	0	affinity chromatography technology	Bennett EJ (2010)	1
RFWD2	0	DDB2	1	affinity chromatography technology	Olma MH (2009)	1
COPS5	0	BTBD2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
IRF5	0	COPS2	5	affinity chromatography technology	Korczeniewska J (2012)	1
CHUK	5	COPS3	1	affinity chromatography technology	Asare Y (2013)	1
KLHL10	1	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
IRF5	0	COPS3	1	affinity chromatography technology	Korczeniewska J (2012)	1
FBXW7	2	COPS3	1	genetic interference	Bailey ML (2015)	1
DDIT3	1	CUL3	17	affinity chromatography technology, biochemical	Huang X (2012), Huang X (2012)	2
LRR1	1	COPS7B	0	affinity chromatography technology	Olma MH (2009)	1
DCUN1D1	0	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
DCAF4L2	3	GPS1	1	affinity chromatography technology	Wang H (2016)	1
IRF5	0	COPS7B	0	affinity chromatography technology, affinity chromatography technology	Korczeniewska J (2012), Korczeniewska J (2012)	2
COPS2	5	COPS4	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Huang X (2005), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	8
DTL	0	COPS2	5	affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Higa LA (2006)	2
CSNK2A1	15	COPS5	0	affinity chromatography technology	Bhansali M (2014)	1
DDB1	6	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Angers S (2006), Jin J (2006), Min KW (2005), Emberley ED (2012), Olma MH (2009)	5
KLHL10	1	CUL3	17	affinity chromatography technology	Huttlin EL (2017)	1
CEBPE	0	DDIT3	1	two hybrid, pull down	Chih DY (2004), Chih DY (2004)	2
COPS3	1	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	5
DDB2	1	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, imaging technique	Kapetanaki MG (2006), Takedachi A (2010), Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Matsumoto S (2015), Hein MY (2015), Groisman R (2006), Groisman R (2006), Chitale S (2017)	10
COPS6	0	COPS4	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sharon M (2009), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	14
FBXO6	0	GPS1	1	affinity chromatography technology	Liu B (2012)	1
FBXW4	0	COPS7B	0	affinity chromatography technology	Lockwood WW (2013)	1
COPS5	0	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Stotland A (2012), Bennett EJ (2010), Oh W (2006), Chun Y (2013), Chun Y (2013), Chun Y (2013), Lingaraju GM (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	11
NTRK1	1	COPS4	0	affinity chromatography technology	Emdal KB (2015)	1
WRAP73	1	KLHL15	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS5	0	TOR1AIP2	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
DDA1	1	DCAF11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	4
FBXW7	2	COPS6	0	genetic interference	Bailey ML (2015)	1
DET1	2	COPS5	0	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	COPS5	0	affinity chromatography technology	Emdal KB (2015)	1
COPS9	1	COPS8	2	affinity chromatography technology, biochemical	Rozen S (2015), Rozen S (2015)	2
IRF5	0	COPS5	0	affinity chromatography technology	Korczeniewska J (2012)	1
FBXW4	0	COPS2	5	affinity chromatography technology, affinity chromatography technology	Lockwood WW (2013), Lockwood WW (2013)	2
DCUN1D1	0	DCAF1	5	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	COPS8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	4
CUL5	1	SMARCA5	4	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
PBRM1	5	COPS3	1	biochemical	Wan C (2015)	1
DCAF8	1	COPS3	1	affinity chromatography technology	Olma MH (2009)	1
CUL4A	2	CUL5	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
COPS3	1	FEM1B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DET1	2	RFWD2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Wertz IE (2004), Vitari AC (2011), Lu G (2014), Lu G (2014), Pick E (2007), Huttlin EL (2017)	7
DDIT3	1	CSNK2A1	15	pull down, enzymatic study	Ubeda M (2003), Ubeda M (2003)	2
COPS8	2	COPS3	1	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Min KW (2005), Enchev RI (2010), Sharon M (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	11
IKBKB	1	COPS4	0	two hybrid, affinity chromatography technology	Orel L (2010), Orel L (2010)	2
UNK	3	CSNK2B	5	affinity chromatography technology	Murn J (2015)	1
COPS8	2	COPS2	5	biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Yang X (2002), Huang X (2005), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	9
CUL5	1	ELOB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Kamura T (2001), Nie L (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Antonioli M (2014), Kershaw NJ (2014)	18
IRF5	0	GPS1	1	affinity chromatography technology, affinity chromatography technology	Li S (2011), Korczeniewska J (2012)	2
CUL4A	2	DDA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Pick E (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006)	7
RBX1	2	CUL4B	8	affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, imaging technique	Dias DC (2002), Ji Q (2014), Huang DT (2009), Hein MY (2015), Yang Y (2015)	5
NEDD8	0	COPS8	2	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	CUL1	7	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Wu K (2011), Bennett EJ (2010), Huang G (2011), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Huang G (2014), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	16
DET1	2	COPS6	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS5	0	DCAF1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), McCall CM (2008), Bennett EJ (2010), Olma MH (2009)	4
ERCC8	1	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Groisman R (2003), Groisman R (2003), Bennett EJ (2010), Fei J (2012), Jin J (2006), He J (2016), Groisman R (2006), Groisman R (2006)	8
COPS4	0	FBXO17	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	3
KLHL10	1	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
FBXO7	1	HSP90AA1	7	affinity chromatography technology	Teixeira FR (2016)	1
DDB1	6	DCAF11	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Angers S (2006), Jin J (2006), He YJ (2006), Olma MH (2009), Jin J (2006), Huttlin EL (2017), Lo JY (2017)	8
COPS4	0	TOR1AIP2	2	affinity chromatography technology	Olma MH (2009)	1
COPS2	5	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Huang X (2005), Bennett EJ (2010), Olma MH (2009), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	6
COPS6	0	DDB2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Groisman R (2003), Groisman R (2003), Bennett EJ (2010), Kulaksiz G (2005), Olma MH (2009), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
COPS6	0	TOR1AIP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009)	3
CEBPE	0	COPS3	1	two hybrid	Chih DY (2004)	1
COPS5	0	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Sertic S (2013), Higa LA (2006), Higa LA (2006)	5
RFWD2	0	COPS7B	0	affinity chromatography technology	Olma MH (2009)	1
CUL5	1	COPS7B	0	affinity chromatography technology	Bennett EJ (2010)	1
EPB41L1	4	COPS3	1	biochemical	Kristensen AR (2012)	1
CUL4A	2	DDB2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Kapetanaki MG (2006), Matsuda N (2005), Higa LA (2006), Nag A (2001), Takedachi A (2010), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), Groisman R (2003), Groisman R (2003), Hrecka K (2007), Shiyanov P (1999), Shiyanov P (1999), Bennett EJ (2010), Kulaksiz G (2005), Kulaksiz G (2005), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006), Groisman R (2003), Huttlin EL (2015), Hein MY (2015), Groisman R (2006), Yang Y (2016), Huttlin EL (2017), Fantini D (2017)	31
NEDD8	0	ELOC	0	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
COPS7A	0	PTGS2	0	affinity chromatography technology, pull down	Neuss H (2007), Neuss H (2007)	2
COPS3	1	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, far western blotting, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Yang X (2002), Enchev RI (2010), Huang X (2005), Kapelari B (2000), Kapelari B (2000), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Rozen S (2015), Huttlin EL (2017)	13
CRBN	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu Q (2016), Eichner R (2016), Huttlin EL (2017), Kroenke J (2014)	4
COPS3	1	HSP90AA1	7	affinity chromatography technology	Min KW (2005)	1
NEDD8	0	COPS7B	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	TOR1AIP2	2	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	COPS7B	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS4	0	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Shibata E (2011), Higa LA (2006)	3
RBX1	2	ELOC	0	affinity chromatography technology	Brower CS (2002)	1
DCAF1	5	RBX1	2	pull down	Ahn J (2010)	1
CUL3	17	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Schenkova K (2012)	3
FBXO6	0	COPS7B	0	affinity chromatography technology	Liu B (2012)	1
NTRK1	1	EWSR1	2	affinity chromatography technology	Emdal KB (2015)	1
FBXO17	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017), Reitsma JM (2017)	5
DDB1	6	DDA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Angers S (2006), Behrends C (2010), Pick E (2007), Pick E (2007), Hrecka K (2007), Hrecka K (2007), Olma MH (2009), Olma MH (2009), Jin J (2006), Wan C (2015)	10
COPS6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Reitsma JM (2017)	7
CUL4A	2	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Angers S (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Rao F (2014), Rao F (2014), Huttlin EL (2015), Cavadini S (2016), Scherer PC (2016), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	13
CRBN	2	COPS7A	0	affinity chromatography technology	Kroenke J (2014)	1
COPS5	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Rao F (2014), Pick E (2012), Groisman R (2003), Groisman R (2003), Huttlin EL (2015), Cavadini S (2016), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	19
CUL4A	2	COPS9	1	affinity chromatography technology	Bennett EJ (2010)	1
NTRK1	1	CUL5	1	affinity chromatography technology	Emdal KB (2015)	1
SKP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Kumar R (2005), Wang W (2004), Ohta T (2001), Oshikawa K (2003), Liu J (2002), Li X (2003), Zhou W (2014), Zhou W (2014), Hao J (2015), Hauri S (2016)	11
COPS6	0	APPBP2	3	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	COPS7A	0	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
DCAF4	3	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
DDIT3	1	CUL1	7	affinity chromatography technology	Huang X (2012)	1
CUL3	17	VCP	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Besten Wd (2012)	2
RFWD2	0	BTBD2	4	affinity chromatography technology	Olma MH (2009)	1
NFKBIA	0	COPS3	1	affinity chromatography technology	Lee JH (2013)	1
RFWD2	0	DCAF11	2	affinity chromatography technology	Olma MH (2009)	1
DDA1	1	COPS2	5	affinity chromatography technology	Olma MH (2009)	1
CUL2	3	COPS7B	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
FBXW4	0	COPS3	1	affinity chromatography technology	Lockwood WW (2013)	1
NEDD8	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
SNW1	0	COPS3	1	affinity chromatography technology	Lleres D (2010)	1
COPS6	0	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Higa LA (2006)	4
DCAF4L2	3	DDB1	6	affinity chromatography technology, affinity chromatography technology	Wang H (2016), Wang H (2016)	2
FBXO6	0	NEDD8	0	affinity chromatography technology	Liu B (2012)	1
COPS8	2	BTBD2	4	affinity chromatography technology	Huttlin EL (2017)	1
DTL	0	GPS1	1	affinity chromatography technology	Higa LA (2006)	1
FBXO6	0	COPS6	0	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015)	2
COPS7A	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Hein MY (2015)	2
COPS7A	0	BTBD2	4	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	SMARCA5	4	affinity chromatography technology	Emdal KB (2015)	1
COPS3	1	SKP1	0	affinity chromatography technology	Olma MH (2009)	1
FBXO7	1	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL2	3	GPS1	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lyapina S (2001)	2
CUL3	17	SKP1	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	DDB1	6	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Min KW (2005), Lee JE (2011), Bennett EJ (2010), Lyapina S (2001), Reitsma JM (2017)	6
CUL3	17	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huang X (2016), Huttlin EL (2017)	3
ARAF	0	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RFWD2	0	CUL2	3	affinity chromatography technology	Olma MH (2009)	1
IKBKG	0	CHUK	5	pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Agou F (2002), Chen G (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Rothwarf DM (1998), Rothwarf DM (1998), Hasegawa M (2008), Liu J (2009), Li S (2011), Li S (2011), Xia X (2011), Kensche T (2012), May MJ (2002), Wu ZH (2006), Wu ZH (2006), Palkowitsch L (2008), Le Page C (2001), Le Page C (2001), Huang TT (2002), Sebban-Benin H (2007), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), McKenzie FR (2000), Solt LA (2007), Li XH (2001), Rottenberg S (2002), Poyet JL (2000), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Strnad J (2006), Funakoshi-Tago M (2005), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Marinis JM (2012), Mitsuhashi S (2008), Mitsuhashi S (2008), Fujita H (2014), Lee SH (2012), Jackson SS (2014), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), Liu D (2014), Hein MY (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Bal E (2017)	57
DCUN1D1	0	COPS2	5	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	DCAF8	1	affinity chromatography technology	Olma MH (2009)	1
CUL4A	2	COPS8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2017), Boldt K (2016)	7
COPS2	5	FBXO7	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lyapina S (2001), Huttlin EL (2017)	3
CTNNB1	30	COPS3	1	affinity chromatography technology	Huang X (2009)	1
CUL4B	8	DCAF1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Jin J (2006), Hein MY (2015), Wang X (2017)	4
DET1	2	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
NEDD8	0	COPS4	0	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
DCUN1D1	0	FEM1B	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	KLHL15	1	affinity chromatography technology	Bennett EJ (2010)	1
LRRC14	2	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
CUL3	17	BTBD2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Maerki S (2009)	5
IRF5	0	COPS4	0	affinity chromatography technology	Korczeniewska J (2012)	1
HSP90AA1	7	CEBPE	0	affinity chromatography technology	Taipale M (2012)	1
CRBN	2	VCP	6	affinity chromatography technology	Nguyen TV (2016)	1
COPS5	0	LRR1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009)	3
COPS6	0	KLHL18	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
FBXW4	0	COPS7A	0	affinity chromatography technology	Lockwood WW (2013)	1
CUL1	7	COPS8	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Menon S (2008), Bennett EJ (2010), Enchev RI (2012), Reitsma JM (2017)	4
VCP	6	SMARCA5	4	affinity chromatography technology	Yu CC (2013)	1
COPS3	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Bennett EJ (2010), Olma MH (2009), Reitsma JM (2017)	4
COPS6	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	6
COPS2	5	EPB41L1	4	biochemical	Kristensen AR (2012)	1
COPS5	0	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Fang L (2008), Bennett EJ (2010), Oh W (2006), Olma MH (2009), Olma MH (2009), Kotiguda GG (2012), Kristensen AR (2012), Huttlin EL (2015), Bhansali M (2014), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	13
COPS5	0	ERCC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Sowa ME (2009), Groisman R (2003), Groisman R (2003), Bennett EJ (2010), Groisman R (2006)	5
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
CUL3	17	CUL2	3	biochemical	Wan C (2015)	1
HSP90AA1	7	KLHL10	1	affinity chromatography technology	Taipale M (2012)	1
COPS4	0	BTBD2	4	affinity chromatography technology	Olma MH (2009)	1
CSNK2A1	15	CHUK	5	enzymatic study	Heilker R (1999)	1
COPS7B	0	BTBD1	2	affinity chromatography technology	Huttlin EL (2017)	1
WRAP73	1	VCP	6	affinity chromatography technology	Ewing RM (2007)	1
RFWD2	0	KLHL42	1	affinity chromatography technology	Olma MH (2009)	1
FBXW4	0	COPS6	0	affinity chromatography technology	Lockwood WW (2013)	1
ELOB	1	APPBP2	3	affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Mahrour N (2008)	2
WRAP73	1	COPS2	5	affinity chromatography technology	Ewing RM (2007)	1
CUL4A	2	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	CRBN	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Olma MH (2009), Kroenke J (2014)	3
COPS6	0	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
CSNK2A1	15	STK11	2	genetic interference	Srivas R (2016)	1
ERCC6	6	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Anindya R (2010), Latini P (2011), Latini P (2011)	3
COPS6	0	FBXL14	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
COPS2	5	COPS7B	0	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	7
DDB1	6	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006), Olma MH (2009)	3
NTRK1	1	PSMD11	0	affinity chromatography technology	Emdal KB (2015)	1
LCA5	1	WRAP73	1	bioid	Gupta GD (2015)	1
NTRK1	1	CTNNB1	30	affinity chromatography technology	Emdal KB (2015)	1
COPS8	2	GPS1	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Stotland A (2012), Sharon M (2009), Sun Y (2002), Kristensen AR (2012), Lingaraju GM (2014), Lyapina S (2001), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	10
CSNK2A1	15	COPS4	0	affinity chromatography technology	Bhansali M (2014)	1
NEDD8	0	ELOB	1	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
COPS6	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	SKP1	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	DCAF11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009)	3
CUL4B	8	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Hein MY (2015), Hein MY (2015)	4
GPS1	1	SKP1	0	affinity chromatography technology	Lyapina S (2001)	1
VCP	6	CSNK2B	5	affinity chromatography technology	Yu CC (2013)	1
FBXO6	0	TOR1AIP2	2	affinity chromatography technology	Liu B (2012)	1
FBXO7	1	ELOC	0	affinity chromatography technology	Hein MY (2015)	1
COPS5	0	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	4
KLHL10	1	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
DDB1	6	TOR1AIP2	2	affinity chromatography technology	Angers S (2006)	1
IBTK	3	COPS4	0	affinity chromatography technology	Pisano A (2015)	1
RFWD2	0	COPS2	5	biochemical, affinity chromatography technology	Yi C (2002), Olma MH (2009)	2
APBB3	2	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL4B	8	CUL5	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
GPS1	1	RBX1	2	affinity chromatography technology	Lyapina S (2001)	1
COPS3	1	APPBP2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KLHL10	1	COPS5	0	affinity chromatography technology	Huttlin EL (2017)	1
RBX1	2	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Furukawa M (2005), Hu J (2004), Furukawa M (2002), Ichikawa T (2009), Ichikawa T (2009), Lee DF (2009), Tron AE (2012), Oshikawa K (2003), Plafker KS (2009), Lu A (2013), Meyer-Schaller N (2009), Theurillat JP (2014), Huang DT (2009), Ibeawuchi SR (2015), Schumacher FR (2015), Kasahara K (2014), Kasahara K (2014)	18
CSNK2B	5	FBXL5	3	two hybrid	Vinayagam A (2011)	1
RFWD2	0	SKP1	0	affinity chromatography technology	Olma MH (2009)	1
FBXO7	1	CENPJ	6	enzymatic study	Teixeira FR (2016)	1
DDA1	1	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pick E (2007), Olma MH (2009), Olma MH (2009)	3
NFKBIA	0	GPS1	1	affinity chromatography technology	Lee JH (2013)	1
KLHL10	1	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
FBXW7	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Jiang JX (2016), Jiang JX (2016)	2
NTRK1	1	CUL3	17	affinity chromatography technology	Emdal KB (2015)	1
FBXW4	0	COPS5	0	affinity chromatography technology, affinity chromatography technology	Lockwood WW (2013), Lockwood WW (2013)	2
DCUN1D1	0	COPS7A	0	affinity chromatography technology	Bennett EJ (2010)	1
PTGS2	0	COPS5	0	biochemical, affinity chromatography technology, pull down	Neuss H (2007), Neuss H (2007), Neuss H (2007)	3
DDB2	1	DDB1	6	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bergametti F (2002), Martinez E (2001), Guerrero-Santoro J (2008), Angers S (2006), Wang H (2006), Kapetanaki MG (2006), Kapetanaki MG (2006), Higa LA (2006), Takedachi A (2010), Fischer ES (2011), Scrima A (2008), Groisman R (2003), Groisman R (2003), Schroefelbauer B (2007), Kulaksiz G (2005), Inoki T (2004), Bontron S (2002), Rapic-Otrin V (2003), Olma MH (2009), Liu W (2000), Jin J (2006), Huttlin EL (2015), Zhao R (2014), Xie X (2015), Groisman R (2006), Yang Y (2016), Huttlin EL (2017), Chitale S (2017), Fantini D (2017), Fantini D (2017), Ohtake F (2007)	31
NTRK1	1	SNW1	0	affinity chromatography technology	Emdal KB (2015)	1
BTBD2	4	COPS6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	5
DET1	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Angers S (2006), Jin J (2006), Pick E (2007), Pick E (2007), Pick E (2007), Jin J (2006), Huttlin EL (2017)	8
CSNK2A1	15	CSNK2B	5	pull down, affinity chromatography technology, far western blotting, two hybrid, two hybrid, two hybrid, pull down, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, biochemical, far western blotting, far western blotting, x-ray crystallography, enzymatic study, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim MS (1998), Kim MS (1998), Marin O (1997), Bosc DG (2000), Ahn BH (2001), Kusk M (1999), Benitez MJ (2001), Uhle S (2003), Olsen BB (2008), Son MY (1999), Son MY (1999), Havugimana PC (2012), Llorens F (2003), Llorens F (2003), Niefind K (2001), Lee NY (2009), Wang J (2011), So J (2015), Wallach T (2013), Wan C (2015), Gao Z (2014), Ren K (2011), Goetz C (1999), Hauri S (2016)	24
DDB1	6	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down	Wang H (2006), Kapetanaki MG (2006), Hu J (2004), Ahn J (2010), Fischer ES (2011), Groisman R (2006)	6
DCAF1	5	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McCall CM (2008), Olma MH (2009), Hein MY (2015)	3
DET1	2	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
FBXO6	0	COPS8	2	affinity chromatography technology	Liu B (2012)	1
APBB3	2	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
RFWD2	0	COPS7A	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
HSP90AA1	7	KLHL15	1	affinity chromatography technology	Taipale M (2012)	1
CUL2	3	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
VCP	6	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dai RM (1998), Dai RM (1998), Gao Y (2000), Hotta K (2013), Yu CC (2013), Li JM (2013), Li JM (2013), Schweitzer K (2016)	8
CUL5	1	LRR1	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Fang L (2008), Huang X (2005), Bennett EJ (2010), Kapelari B (2000), Oh W (2006), Olma MH (2009), Havugimana PC (2012), Christmann M (2013), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Scherer PC (2016), Huttlin EL (2017), Boldt K (2016)	15
COPS7B	0	DCAF11	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
CUL4A	2	VCP	6	affinity chromatography technology	Besten Wd (2012)	1
PSMD11	0	COPS6	0	two hybrid	Stelzl U (2005)	1
COPS5	0	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Cayli S (2009), Cayli S (2009), Cayli S (2009), Cayli S (2009), Bennett EJ (2010)	5
DCAF11	2	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
RFWD2	0	ELOB	1	affinity chromatography technology	Olma MH (2009)	1
COPS4	0	DCAF11	2	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2017)	2
CUL3	17	IBTK	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Pisano A (2015), Pisano A (2015), Pisano A (2015), Huttlin EL (2017)	5
FBXO7	1	NEDD8	0	affinity chromatography technology	Teixeira FR (2016)	1
CUL5	1	CUL1	7	affinity chromatography technology	Bennett EJ (2010)	1
COPS8	2	APPBP2	3	affinity chromatography technology	Huttlin EL (2017)	1
CTNNB1	30	COPS5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huang X (2009), Jumpertz S (2014), Jumpertz S (2014)	3
ERCC6	6	CUL4B	8	affinity chromatography technology	Latini P (2011)	1
CUL2	3	COPS8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017), Boldt K (2016)	3
COPS3	1	ELOB	1	affinity chromatography technology	Olma MH (2009)	1
CUL4A	2	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Min KW (2005), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	10
COPS3	1	FBXO17	1	affinity chromatography technology	Olma MH (2009)	1
CUL4A	2	DCAF8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Jin J (2006), Huttlin EL (2017)	5
RFWD2	0	ERCC8	1	affinity chromatography technology	Olma MH (2009)	1
LRR1	1	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Kamura T (2004), Kamura T (2004)	3
COPS6	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
COPS3	1	DTL	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Higa LA (2006)	2
SNW1	0	SF3A3	2	affinity chromatography technology	Lleres D (2010)	1
RFWD2	0	CUL1	7	affinity chromatography technology	Olma MH (2009)	1
NTRK1	1	SF3A3	2	affinity chromatography technology	Emdal KB (2015)	1
FBXO6	0	COPS7A	0	affinity chromatography technology	Liu B (2012)	1
DCUN1D1	0	COPS4	0	affinity chromatography technology	Bennett EJ (2010)	1
DCAF1	5	COPS8	2	affinity chromatography technology, affinity chromatography technology	Hrecka K (2007), Huttlin EL (2017)	2
CUL4A	2	TOR1AIP2	2	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Bennett EJ (2010)	2
COPS3	1	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
CUL1	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
COPS6	0	FEM1B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
CUL3	17	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huang X (2016), Huttlin EL (2017)	5
COPS2	5	BTBD1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS3	1	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, two hybrid, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Min KW (2005), Enchev RI (2010), Stotland A (2012), Sharon M (2009), Kapelari B (2000), Tsuge T (2001), Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	12
CUL4B	8	COPS7B	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
COPS7A	0	COPS2	5	affinity chromatography technology, far western blotting, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uhle S (2003), Kapelari B (2000), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	10
LRR1	1	COPS8	2	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2017)	2
SMARCA5	4	COPS3	1	biochemical	Wan C (2015)	1
RFWD2	0	COPS4	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
COPS6	0	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	COPS3	1	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
CUL1	7	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Min KW (2005), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Reitsma JM (2017)	6
COPS5	0	KLHL18	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
CUL4A	2	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009)	7
FBXO17	1	COPS2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DDB2	1	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Olma MH (2009), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	7
CUL3	17	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	5
CRBN	2	COPS2	5	affinity chromatography technology	Kroenke J (2014)	1
APBB3	2	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	KLHL18	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Moghe S (2012), Moghe S (2012), Huttlin EL (2017)	5
FBXO7	1	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
RFWD2	0	COPS8	2	biochemical, affinity chromatography technology	Yi C (2002), Olma MH (2009)	2
NTRK1	1	CUL1	7	affinity chromatography technology	Emdal KB (2015)	1
STK11	2	COPS4	0	affinity chromatography technology	So J (2015)	1
FBXL14	2	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
COPS8	2	CRBN	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Kroenke J (2014)	2
SNW1	0	DDB1	6	affinity chromatography technology	Zhang C (2003)	1
DDB1	6	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2006), Jin J (2006), Jin J (2006), Higa LA (2006), Rossi M (2013), Shibata E (2011), Higa LA (2006), Higa LA (2006)	8
CUL4B	8	DCUN1D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016)	8
DCUN1D1	0	KLHL15	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS3	1	DCAF11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	4
CUL1	7	FBXL14	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017), Reitsma JM (2017)	3
NEDD8	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012)	4
RFWD2	0	COPS3	1	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
VCP	6	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Bennett EJ (2010), Besten Wd (2012)	3
UNK	3	CUL2	3	affinity chromatography technology	Murn J (2015)	1
HSP90AA1	7	CHUK	5	affinity chromatography technology, affinity chromatography technology	Qu X (2012), Gano JJ (2010)	2
IBTK	3	COPS2	5	affinity chromatography technology	Pisano A (2015)	1
CRBN	2	DDA1	1	affinity chromatography technology	Kroenke J (2014)	1
SKP1	0	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down	Hattori K (1999), Tan P (1999), Suzuki H (1999), Winston JT (1999), Surjit M (2012), Chong RA (2014)	6
DCUN1D1	0	GPS1	1	affinity chromatography technology	Bennett EJ (2010)	1
SF3A3	2	COPS3	1	biochemical	Wan C (2015)	1
DCAF8	1	CUL4B	8	affinity chromatography technology, affinity chromatography technology	Jin J (2006), Huttlin EL (2017)	2
COPS3	1	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	3
DDB1	6	GPS1	1	affinity chromatography technology, pull down, fluorescent resonance energy transfe	Jin J (2006), Emberley ED (2012), Cavadini S (2016)	3
CUL2	3	SNW1	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS3	1	PHYH	1	affinity chromatography technology	Ewing RM (2007)	1
SNW1	0	HSP90AA1	7	affinity chromatography technology	Lleres D (2010)	1
CUL3	17	CTNNB1	30	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
CUL4A	2	DCAF4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Bennett EJ (2010), Jin J (2006), Huttlin EL (2017)	4
BTBD1	2	BTBD2	4	affinity chromatography technology	Huttlin EL (2017)	1
COPS8	2	COPS7B	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	5
CUL1	7	DCAF1	5	affinity chromatography technology	McCall CM (2008)	1
CUL4B	8	DDB2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Higa LA (2006), Bennett EJ (2010), Jin J (2006), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	9
FBXL14	2	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
COPS6	0	DCAF4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
FBXL5	3	RBX1	2	affinity chromatography technology, biochemical	Salahudeen AA (2009), Vinas-Castells R (2013)	2
ERCC8	1	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Olma MH (2009)	3
ERCC6	6	COPS6	0	affinity chromatography technology	Latini P (2011)	1
EWSR1	2	COPS3	1	bioid	Elzi DJ (2014)	1
ERCC8	1	COPS2	5	affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003)	2
CUL3	17	LRR1	1	affinity chromatography technology	Wimuttisuk W (2014)	1
IKBKG	0	CUL1	7	affinity chromatography technology	Orel L (2010)	1
COPS8	2	DCAF11	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
COPS3	1	CSNK2A1	15	far western blotting	Uhle S (2003)	1
DCUN1D1	0	CUL5	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	9
DCUN1D1	0	COPS5	0	affinity chromatography technology	Bennett EJ (2010)	1
DCAF4	3	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2006), Hein MY (2015), Huttlin EL (2017)	3
NTRK1	1	COPS3	1	affinity chromatography technology	Emdal KB (2015)	1
COPS6	0	ERCC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Groisman R (2003), Groisman R (2003), Bennett EJ (2010), Olma MH (2009)	5
DCAF4L2	3	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Wang H (2016)	3
CUL4A	2	CTNNB1	30	affinity chromatography technology	Tripathi R (2007)	1
COPS6	0	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Enchev RI (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	11
COPS5	0	SKP1	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Bennett EJ (2010), Taipale M (2012)	3
DDB1	6	COPS8	2	affinity chromatography technology, pull down	Angers S (2006), Emberley ED (2012)	2
HSP90AA1	7	FBXW7	2	affinity chromatography technology	Taipale M (2012)	1
COPS5	0	FBXO7	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
CTNNB1	30	COPS8	2	affinity chromatography technology	Huang X (2009)	1
CUL5	1	COPS2	5	affinity chromatography technology	Bennett EJ (2010)	1
VCP	6	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012), Zhang Z (2015)	3
FBXL5	3	APPBP2	3	affinity chromatography technology	Huttlin EL (2017)	1
WRAP73	1	PHYH	1	affinity chromatography technology	Ewing RM (2007)	1
FEM1B	1	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Bennett EJ (2010), Huttlin EL (2017)	3
IBTK	3	COPS3	1	affinity chromatography technology	Pisano A (2015)	1
DCUN1D1	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
CHUK	5	NFKBIA	0	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	DiDonato JA (1997), Cohen L (1998), Woronicz JD (1997), Ninomiya-Tsuji J (1999), Burke JR (2002), Wu ZH (2010), Tong KM (2008), Singhirunnusorn P (2005), Heilker R (1999), Huang TT (2002), Lee FS (1998), Kim KS (2002), Cappello C (2007), Hong S (2007), Morrison BH (2007), Zandi E (1998), Li Q (2006), Manna SK (2010), Li XH (2001), Poyet JL (2001), Zhang W (2010), Bauer JA (2007), Chan H (2005), Munzert G (2002), Stehlik C (2002), Shambharkar PB (2007), Cui J (2010), Li Q (2006), Bernier M (2006), Mitsuhashi S (2008), Hayashi T (2007), Niu J (2013), Dan HC (2008), Criollo A (2010), Kim Y (2002), Huttlin EL (2015), Liu D (2014), Zhang H (2004), Aggarwal S (2006), Ninomiya-Tsuji J (2003), Huttlin EL (2017)	41
LRRC14	2	ELOB	1	affinity chromatography technology	Olma MH (2009)	1
COPS6	0	ELOB	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009)	2
COPS7A	0	EPB41L1	4	biochemical	Kristensen AR (2012)	1
DDB1	6	COPS4	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Angers S (2006), Jin J (2006), Emberley ED (2012), Olma MH (2009)	4
CUL3	17	ELOC	0	affinity chromatography technology, two hybrid	Bennett EJ (2010), Wang J (2011)	2
COPS6	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	6
CUL1	7	DDB1	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Gastaldello S (2012)	2
COPS6	0	FBXO17	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
CHUK	5	COPS5	0	enzymatic study, affinity chromatography technology	Orel L (2010), Asare Y (2013)	2
COPS3	1	CRBN	2	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Kroenke J (2014)	2
DCUN1D1	0	CUL2	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Monda JK (2013), Heir P (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016), Chen K (2016)	13
CUL3	17	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Wimuttisuk W (2014), Maerki S (2009), Huttlin EL (2017)	6
DDIT3	1	IKBKG	0	two hybrid	Wang J (2011)	1
DR1	1	COPS3	1	biochemical	Wan C (2015)	1
COPS5	0	CRBN	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Kroenke J (2014)	2
LRR1	1	COPS4	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
CRBN	2	HSP90AA1	7	affinity chromatography technology	Nguyen TV (2016)	1
COPS3	1	DCAF4	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL4B	8	TOR1AIP2	2	affinity chromatography technology	Bennett EJ (2010)	1
NTRK1	1	COPS6	0	affinity chromatography technology	Emdal KB (2015)	1
CUL4B	8	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	ELOB	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kamura T (2001), Menon S (2008), Megumi Y (2005), Kamura T (2002), Brower CS (2002), Bennett EJ (2010), Pause A (1997), Kamura T (2004), Kelsall IR (2013)	9
COPS5	0	COPS9	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bennett EJ (2010), Ebina M (2013), Ebina M (2013), Rozen S (2015), Rozen S (2015)	5
CUL5	1	DCAF1	5	affinity chromatography technology	Bennett EJ (2010)	1
COPS8	2	COPS5	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Sowa ME (2009), Fang L (2008), Bennett EJ (2010), Olma MH (2009), Asare Y (2013), Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	9
CTNNB1	30	SMARCA5	4	affinity chromatography technology, pull down, affinity chromatography technology	Sierra J (2006), Sierra J (2006), Gomes NP (2006)	3
ERCC6	6	COPS4	0	affinity chromatography technology	Latini P (2011)	1
CTNNB1	30	PTGS2	0	unspecified method, affinity chromatography technology	Kim I (2012), Kim I (2012)	2
CSNK2B	5	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Tsuchiya Y (2010), Tsuchiya Y (2010)	2
CUL4B	8	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Hein MY (2015), Yang Y (2015)	4
GPS1	1	COPS7A	0	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Wan C (2015), Hein MY (2015), Huang X (2016)	6
DDB1	6	COPS5	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Angers S (2006), Jin J (2006), Emberley ED (2012), Bennett EJ (2010), Olma MH (2009), He F (2013)	6
DET1	2	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
DDB2	1	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Olma MH (2009), Olma MH (2009), Hein MY (2015)	6
DDB1	6	CRBN	2	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology	Angers S (2006), Ito T (2010), Chamberlain PP (2014), Liu Y (2015), Diaz-Rodriguez E (2016), Xu Q (2016), Xu G (2013), Nguyen TV (2016), Nguyen TV (2016), Eichner R (2016), Matyskiela ME (2018), Kroenke J (2014)	12
CSNK2B	5	ARAF	0	two hybrid	Boldyreff B (1997)	1
CUL4B	8	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Olma MH (2009)	2
COPS4	0	ELOC	0	affinity chromatography technology	Olma MH (2009)	1
COPS3	1	HBB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS3	1	TOR1AIP2	2	affinity chromatography technology	Olma MH (2009)	1
CUL4A	2	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2017)	6
PTGS2	0	VCP	6	affinity chromatography technology	Chen SF (2013)	1
DCUN1D1	0	CUL3	17	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Monda JK (2013), Wan C (2015), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Huttlin EL (2017)	19
FBXO7	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Kirk R (2008), Hsu JM (2004), Hagens O (2006), Bennett EJ (2010), Hein MY (2015), Vingill S (2016), Huttlin EL (2017), Teixeira FR (2016), Reitsma JM (2017), Reitsma JM (2017)	11
IKBKB	1	COPS7A	0	two hybrid, affinity chromatography technology	Orel L (2010), Orel L (2010)	2
COPS7A	0	CSNK2A1	15	affinity chromatography technology, far western blotting, enzymatic study	Uhle S (2003), Uhle S (2003), Uhle S (2003)	3
CUL2	3	LRR1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Kamura T (2004), Kamura T (2004), Kamura T (2004)	5
HSP90AA1	7	ARAF	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012)	2
DCAF4L2	3	COPS5	0	affinity chromatography technology	Wang H (2016)	1
VCP	6	CUL5	1	affinity chromatography technology	Yu CC (2013)	1
COPS5	0	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Fang L (2008), Enchev RI (2010), Bennett EJ (2010), Oh W (2006), Olma MH (2009), Olma MH (2009), Asare Y (2013), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	13
COPS6	0	COPS7A	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sharon M (2009), Bennett EJ (2010), Luke-Glaser S (2007), Kapelari B (2000), Olma MH (2009), Olma MH (2009), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	15
APBB3	2	COPS5	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL4B	8	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Higa LA (2006)	5
DCAF4L2	3	COPS7B	0	affinity chromatography technology	Wang H (2016)	1
DDB2	1	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Hein MY (2015)	4
CUL3	17	COPS8	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Schumacher FR (2015)	2
COPS6	0	DCAF1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), McCall CM (2008), Bennett EJ (2010), Olma MH (2009)	4
NEDD8	0	DCAF11	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS4	0	FEM1B	1	affinity chromatography technology	Olma MH (2009)	1
RFWD2	0	COPS6	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Olma MH (2009), Olma MH (2009), Choi HH (2011), Choi HH (2011)	4
SNW1	0	CUL1	7	affinity chromatography technology	Lleres D (2010)	1
FBXL14	2	SKP1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
COPS8	2	BTBD1	2	affinity chromatography technology	Huttlin EL (2017)	1
FEM1B	1	RBX1	2	affinity chromatography technology	Kamura T (2004)	1
DCAF4L2	3	COPS8	2	affinity chromatography technology	Wang H (2016)	1
HSP90AA1	7	FBXL14	2	affinity chromatography technology	Taipale M (2012)	1
DDA1	1	ERCC8	1	affinity chromatography technology	Olma MH (2009)	1
COPS3	1	CSNK2B	5	far western blotting	Uhle S (2003)	1
COPS5	0	DCAF4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2017)	3
NTRK1	1	GPS1	1	affinity chromatography technology	Emdal KB (2015)	1
CUL3	17	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
VCP	6	COPS7A	0	affinity chromatography technology	Yu CC (2013)	1
COPS8	2	COPS6	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	10
DDB1	6	CTNNB1	30	affinity chromatography technology	Kawajiri K (2009)	1
CUL1	7	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Min KW (2005), Min KW (2005), Yang X (2002), Yang X (2002), Huang X (2005), Bennett EJ (2010), Scherer PC (2016), Scherer PC (2016), Reitsma JM (2017)	9
COPS5	0	KLHL15	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
DCUN1D1	0	DDB1	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Keuss MJ (2016)	2
SOX2	4	COPS3	1	affinity chromatography technology	Cox JL (2013)	1
GPS1	1	COPS7B	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Stotland A (2012), Havugimana PC (2012), Huang X (2016), Huttlin EL (2017)	4
CENPJ	6	IBTK	3	bioid	Gupta GD (2015)	1
ELOB	1	FEM1B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Mahrour N (2008), Kamura T (2004)	3
DDB1	6	ERCC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Jin J (2006), Groisman R (2003), Groisman R (2003), Meulenbroek EM (2012), Fei J (2012), Jin J (2006), He J (2016), Groisman R (2006), Chitale S (2017), Ohtake F (2007)	10
COPS5	0	FBXO17	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
DCUN1D1	0	NEDD8	0	affinity chromatography technology	Bennett EJ (2010)	1
APBB3	2	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
RFWD2	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Higa LA (2006), He YJ (2006), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Lu G (2014)	7
CUL3	17	ELOB	1	affinity chromatography technology	Bennett EJ (2010)	1
IKBKB	1	NFKBIA	0	pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Mercurio F (1999), Cohen L (1998), Woronicz JD (1997), Burke JR (2002), Tsuchiya Y (2010), Tsuchiya Y (2010), Da Silva-Ferrada E (2011), Ducut Sigala JL (2004), Heilker R (1999), Edinger RS (2009), Lee FS (1998), Hai T (2006), Zandi E (1998), Henkler F (2003), Li XH (2001), Byun MS (2006), Mauro C (2003), Zhang W (2010), Munzert G (2002), Shibata Y (2012), Shambharkar PB (2007), Cui J (2010), Li Q (2006), Bernier M (2006), Gao H (2004), Hauenstein AV (2014), Fujita H (2014), Zhang J (2013), Chong RA (2014), Dan HC (2008), Sun L (2004), Criollo A (2010), Liu D (2014), Vincendeau M (2016), Zhang L (2015), Zilberman-Rudenko J (2016), Minassian A (2015), Lindstroem TM (2008), Kim BH (2008), Pandey MK (2008), Joo M (2005), Ninomiya-Tsuji J (2003), Chang YJ (2004), Huang WC (2004), Kim EK (2017), Mei ZZ (2016), Shinohara H (2016), Shkoda A (2012)	48
COPS4	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
DCUN1D1	0	COPS9	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
COPS4	0	KLHL18	2	affinity chromatography technology	Olma MH (2009)	1
ERCC8	1	COPS7A	0	affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003)	2
COPS5	0	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Neuss H (2007), Fang L (2008), Orel L (2010), Uhle S (2003), Bennett EJ (2010), Luke-Glaser S (2007), Kapelari B (2000), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	17
CEBPE	0	ELOB	1	two hybrid	Ravasi T (2010)	1
DTL	0	RBX1	2	affinity chromatography technology	Shibata E (2011)	1
NTRK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rao R (2010), Taipale M (2012), Emdal KB (2015)	3
DCAF1	5	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McCall CM (2008), Hrecka K (2007), Olma MH (2009)	3
PSMD11	0	COPS3	1	biochemical	Wan C (2015)	1
FBXO17	1	RBX1	2	affinity chromatography technology	Glenn KA (2008)	1
DDA1	1	COPS7A	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Hein MY (2015)	2
APBB3	2	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
RBX1	2	NEDD8	0	affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Norman JA (2006)	2
COPS6	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	12
DCAF4L2	3	COPS3	1	affinity chromatography technology	Wang H (2016)	1
DCAF11	2	VCP	6	biochemical	Kristensen AR (2012)	1
COPS6	0	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009)	5
COPS6	0	DCAF11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	5
SOX2	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cox JL (2013), Xu C (2013), Xu C (2013)	3
FBXW7	2	CUL1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu G (2001), Tron AE (2012), Busino L (2012), Busino L (2012), Busino L (2012), Matsumoto A (2011), Bennett EJ (2010), Strohmaier H (2001), Davis MA (2013), JunGang Z (2012), Busino L (2003), Pierce NW (2013), Chung FZ (2014), Yumimoto K (2012), Low TY (2014), Kourtis N (2015), Gorelik M (2016), Gorelik M (2016), Huttlin EL (2017), Reiterer V (2017), Reiterer V (2017), Ye M (2017), Reitsma JM (2017)	23
COPS6	0	GPS1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Stotland A (2012), Sharon M (2009), Bennett EJ (2010), Lingaraju GM (2014), Huttlin EL (2015), Huttlin EL (2017)	7
EWSR1	2	COPS7B	0	bioid	Elzi DJ (2014)	1
COPS8	2	DTL	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS4	0	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	3
CRBN	2	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ito T (2010), Xu G (2013), Nguyen TV (2016), Nguyen TV (2016), Kroenke J (2014)	5
COPS3	1	KLHL15	1	affinity chromatography technology	Huttlin EL (2015)	1
COPS6	0	ELOC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009)	3
DDA1	1	DTL	0	affinity chromatography technology	Olma MH (2009)	1
ERCC6	6	COPS3	1	affinity chromatography technology	Latini P (2011)	1
COPS2	5	BTBD2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS7B	0	COPS7A	0	biochemical, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2017)	2
DDA1	1	COPS4	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
PTGS2	0	COPS3	1	affinity chromatography technology	Neuss H (2007)	1
CUL2	3	ELOC	0	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Kamura T (2001), Maine GN (2007), Megumi Y (2005), Mao X (2009), Lonergan KM (1998), Lonergan KM (1998), Bennett EJ (2010), Pause A (1997), Pause A (1999), Kamura T (2004), Kelsall IR (2013), Lee SB (2016)	12
CUL1	7	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
DDA1	1	DDB2	1	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Hein MY (2015)	2
COPS4	0	KLHL42	1	affinity chromatography technology	Olma MH (2009)	1
COPS5	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	ERCC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Fei J (2012), Hein MY (2015)	3
COPS5	0	COPS6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Fang L (2008), Sharon M (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Choi HH (2011), Kristensen AR (2012), Birol M (2014), Birol M (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	18
CSNK2B	5	NFKBIA	0	affinity chromatography technology, enzymatic study, affinity chromatography technology	Tsuchiya Y (2010), Taylor JA (1999), Taylor JA (1999)	3
COPS5	0	DCAF8	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
DCAF4	3	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
LCA5	1	COPS3	1	affinity chromatography technology	Gupta GD (2015)	1
IKBKB	1	HSP90AA1	7	affinity chromatography technology	Xue J (2010)	1
CUL4A	2	DCAF11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), He YJ (2006), He YJ (2006), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006), Huttlin EL (2017), Lo JY (2017)	10
CUL5	1	BTBD1	2	affinity chromatography technology	Bennett EJ (2010)	1
BTBD1	2	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
COPS4	0	ELOB	1	affinity chromatography technology	Olma MH (2009)	1
RFWD2	0	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Jin J (2006), He YJ (2006), Olma MH (2009), Lu G (2014), Lu G (2014)	6
DCAF4	3	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
SNW1	0	SMARCA5	4	affinity chromatography technology	Lleres D (2010)	1
CUL4A	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Angers S (2006), Bennett EJ (2010), Bennett EJ (2010), Sertic S (2013)	5
DCAF1	5	COPS7B	0	affinity chromatography technology	McCall CM (2008)	1
LRR1	1	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	4
KLHL10	1	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
UNK	3	COPS3	1	affinity chromatography technology	Murn J (2015)	1
CHUK	5	IRF5	0	affinity chromatography technology	Balkhi MY (2010)	1
RFWD2	0	COPS5	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
DDB2	1	ERCC8	1	affinity chromatography technology	Groisman R (2003)	1
CUL5	1	DCAF11	2	affinity chromatography technology	Bennett EJ (2010)	1
FBXO7	1	SKP1	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Hsu JM (2004), Nelson DE (2011), Hagens O (2006), Kang J (2014), Winston JT (1999), Hein MY (2015), Hein MY (2015), Vingill S (2016), Vingill S (2016), Huttlin EL (2017), Teixeira FR (2016), Teixeira FR (2016), Hauri S (2016)	16
DCAF8	1	DDB1	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006), Olma MH (2009), Klein CJ (2014), Jin J (2006), Huttlin EL (2017)	6
CUL2	3	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS4	0	COPS7A	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Sharon M (2009), Luke-Glaser S (2007), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huang X (2016)	13
FEM1B	1	ELOC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Subauste MC (2009), Mahrour N (2008), Mahrour N (2008), Kamura T (2004)	4
CTNNB1	30	IKBKB	1	affinity chromatography technology, pull down, imaging technique	Lamberti C (2001), Lamberti C (2001), Chen TC (2014)	3
ERCC6	6	ERCC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study	Anindya R (2010), Fousteri M (2006), Henning KA (1995), Latini P (2011), Latini P (2011), Fei J (2012), He J (2016), Groisman R (2006), Groisman R (2006), Groisman R (2006)	10
COPS6	0	KLHL42	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
COPS3	1	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	5
CRBN	2	GPS1	1	affinity chromatography technology	Kroenke J (2014)	1
GPS1	1	COPS4	0	affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical	Stotland A (2012), Tsuge T (2001), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Wan C (2015)	7
IRF5	0	COPS8	2	affinity chromatography technology	Korczeniewska J (2012)	1
UNK	3	HSP90AA1	7	affinity chromatography technology	Murn J (2015)	1
VCP	6	COPS3	1	affinity chromatography technology	Yu CC (2013)	1
UNK	3	COPS9	1	affinity chromatography technology	Murn J (2015)	1
COPS2	5	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Yang X (2002), Choo YY (2011), Bennett EJ (2010), Huttlin EL (2015), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	7
COPS6	0	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	9
CTNNB1	30	CUL1	7	affinity chromatography technology	Read MA (2000)	1
COPS2	5	COPS9	1	affinity chromatography technology	Rozen S (2015)	1
DCAF4L2	3	COPS4	0	affinity chromatography technology	Wang H (2016)	1
NTRK1	1	VCP	6	affinity chromatography technology	Emdal KB (2015)	1
LRRC14	2	ELOC	0	affinity chromatography technology	Olma MH (2009)	1
NEDD8	0	DCAF1	5	affinity chromatography technology	Bennett EJ (2010)	1
DDA1	1	DCAF1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Behrends C (2010), Hrecka K (2007), Hrecka K (2007), Olma MH (2009), Olma MH (2009), Wan C (2015)	6
DET1	2	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Angers S (2006), Jin J (2006), Pick E (2007), Huttlin EL (2017)	5
CUL5	1	FBXO17	1	affinity chromatography technology	Bennett EJ (2010)	1
DET1	2	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
CUL5	1	COPS3	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009)	2
NTRK1	1	CSNK2A1	15	affinity chromatography technology	Emdal KB (2015)	1
CUL5	1	KLHL42	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Hein MY (2015)	7
CUL2	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
CUL1	7	SRP14	0	affinity chromatography technology	Bennett EJ (2010)	1
CHUK	5	CUL1	7	affinity chromatography technology	Kumar A (2007)	1
CUL4B	8	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Hein MY (2015), Higa LA (2006)	3
ARAF	0	COPS3	1	two hybrid	Yuryev A (2003)	1
COPS3	1	ELOC	0	affinity chromatography technology	Olma MH (2009)	1
NEDD8	0	GPS1	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	LRRC14	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009)	2
CUL4A	2	CUL1	7	biochemical	He YJ (2006)	1
NTRK1	1	CUL4B	8	affinity chromatography technology	Emdal KB (2015)	1
STK11	2	COPS3	1	affinity chromatography technology	So J (2015)	1
DDB2	1	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
CENPJ	6	COPS3	1	bioid	Gupta GD (2015)	1
DCAF4L2	3	COPS6	0	affinity chromatography technology	Wang H (2016)	1
SNW1	0	PSMD11	0	affinity chromatography technology	Lleres D (2010)	1
WRAP73	1	GPS1	1	affinity chromatography technology	Ewing RM (2007)	1
DDIT3	1	COPS8	2	affinity chromatography technology, biochemical	Huang X (2012), Huang X (2012)	2
VCP	6	ERCC6	6	affinity chromatography technology	He J (2016)	1
DDB1	6	DCAF4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006), Jin J (2006), Huttlin EL (2017)	4
DET1	2	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
RFWD2	0	DCAF1	5	affinity chromatography technology	Olma MH (2009)	1
FBXO17	1	COPS7B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IKBKB	1	COPS3	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Orel L (2010), Orel L (2010), Asare Y (2013)	3
CUL5	1	RBX1	2	x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Duda DM (2008), Ohta T (1999), Furukawa M (2002), Tron AE (2012), Tron AE (2012), Yu Y (2004), Huang DT (2009), Wang X (2015), Wang X (2015), Wang X (2015)	10
LRR1	1	COPS7A	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Hein MY (2015)	2
COPS5	0	DDB2	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), He YJ (2006), Groisman R (2003), Groisman R (2003), Bennett EJ (2010), Kulaksiz G (2005), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
FBXO6	0	COPS3	1	affinity chromatography technology	Liu B (2012)	1
CUL5	1	COPS9	1	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Hauri S (2016)	3
BTBD1	2	LRR1	1	affinity chromatography technology	Wimuttisuk W (2014)	1
NEDD8	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
CUL3	17	KLHL15	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Oberg EA (2012), Huttlin EL (2017), Ferretti LP (2016)	4
APPBP2	3	CUL2	3	affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Bennett EJ (2010)	2
CUL5	1	DDB2	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS7A	0	DDIT3	1	affinity chromatography technology	Huang X (2012)	1
DDA1	1	COPS8	2	affinity chromatography technology	Olma MH (2009)	1
FBXO17	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Yoshida Y (2011), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	6
NEDD8	0	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS3	1	KLHL18	2	affinity chromatography technology	Olma MH (2009)	1
COPS6	0	KLHL15	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
NFKBIA	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kawakami T (2001), Read MA (2000), Suzuki H (1999), Surjit M (2012), Furukawa M (2000), Furukawa M (2000)	6
FEM1B	1	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Bennett EJ (2010), Kamura T (2004), Kamura T (2004)	4
DET1	2	DDA1	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pick E (2007), Pick E (2007), Pick E (2007), Olma MH (2009), Pick E (2007), Huttlin EL (2017)	6
LRR1	1	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
CUL2	3	COPS9	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Olma MH (2009)	3
COPS2	5	CSNK2A1	15	affinity chromatography technology, enzymatic study	Huang X (2005), Uhle S (2003)	2
FBXO6	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Taipale M (2012)	2
DDIT3	1	COPS3	1	biochemical	Huang X (2012)	1
FBXO6	0	COPS4	0	affinity chromatography technology	Liu B (2012)	1
NEDD8	0	COPS9	1	affinity chromatography technology	Bennett EJ (2010)	1
SOX2	4	DCAF1	5	affinity chromatography technology, affinity chromatography technology	Cox JL (2013), Huttlin EL (2015)	2
COPS7A	0	DTL	0	affinity chromatography technology	Hein MY (2015)	1
DDA1	1	TOR1AIP2	2	affinity chromatography technology	Olma MH (2009)	1
DCUN1D1	0	ELOC	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	SNW1	0	affinity chromatography technology	Bennett EJ (2010)	1
UNK	3	CUL4A	2	affinity chromatography technology	Murn J (2015)	1
CUL5	1	COPS7A	0	affinity chromatography technology	Bennett EJ (2010)	1
GPS1	1	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Stotland A (2012), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Scherer PC (2016)	5
CUL3	17	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
COPS7B	0	APPBP2	3	affinity chromatography technology	Huttlin EL (2017)	1
DDB2	1	COPS8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
COPS3	1	BTBD2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	3
DDB2	1	COPS7B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NTRK1	1	CUL2	3	affinity chromatography technology	Emdal KB (2015)	1
DDB1	6	SF3A3	2	biochemical	Wan C (2015)	1
COPS5	0	ELOB	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	LRR1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	5
LRRC14	2	COPS3	1	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
DCUN1D1	0	KLHL42	1	affinity chromatography technology	Bennett EJ (2010)	1
ELOB	1	RBX1	2	affinity chromatography technology, affinity chromatography technology	Kamura T (2002), Brower CS (2002)	2
FBXW4	0	GPS1	1	affinity chromatography technology	Lockwood WW (2013)	1
CUL1	7	FBXL5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vashisht AA (2009), Salahudeen AA (2009), Liu B (2012), Vinas-Castells R (2013), Moroishi T (2014), Moroishi T (2014), Chen ZW (2015), Wu WD (2016), Huttlin EL (2017)	9
FBXW7	2	SF3A3	2	affinity chromatography technology	Kourtis N (2015)	1
DET1	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology	Jin J (2006), Huttlin EL (2017)	2
FBXL14	2	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
FBXL14	2	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS5	0	SF3A3	2	affinity chromatography technology	Bennett EJ (2010)	1
DCAF1	5	COPS4	0	affinity chromatography technology, affinity chromatography technology	McCall CM (2008), Olma MH (2009)	2
SKP1	0	FBXW7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Wu G (2001), Wu G (2001), Wu G (2001), Hao B (2007), Schuelein C (2011), Busino L (2012), Busino L (2012), Busino L (2012), Matsumoto A (2011), Watanabe N (2004), Strohmaier H (2001), Choi BH (2014), Yumimoto K (2012), Kourtis N (2015), Kourtis N (2015), Hao J (2015), Tian X (2015), Liu YQ (2015), Gorelik M (2016), Gorelik M (2016), Gorelik M (2016), Yeh CH (2016), Reiterer V (2017), Reiterer V (2017), Reiterer V (2017), Kuchay S (2017), Ye M (2017)	28
CRBN	2	SF3A3	2	affinity chromatography technology	Nguyen TV (2016)	1
SOX2	4	SMARCA5	4	affinity chromatography technology	Engelen E (2011)	1
DDB1	6	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Norman JA (2006), Bennett EJ (2010)	3
NTRK1	1	DDB1	6	affinity chromatography technology	Emdal KB (2015)	1
COPS5	0	FBXL5	3	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
EPB41L1	4	COPS4	0	biochemical	Kristensen AR (2012)	1
FBXO6	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2007), Yoshida Y (2007), Nelson RF (2007), Glenn KA (2008), Yoshida Y (2011), Liu B (2012), Liu B (2012), Tian X (2015), Hauri S (2016)	9
CUL3	17	COPS9	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Ebina M (2013)	2
DDA1	1	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Lu G (2014)	2
COPS7A	0	BTBD1	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
COPS5	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), He F (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
DET1	2	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS6	0	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huang X (2005), Bennett EJ (2010), Kapelari B (2000), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	11
LRR1	1	ELOC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Kamura T (2004), Kamura T (2004)	3
FBXW4	0	COPS4	0	affinity chromatography technology	Lockwood WW (2013)	1
IKBKB	1	CHUK	5	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Zandi E (1997), Chen G (2002), Otsuki T (2002), May MJ (2000), May MJ (2000), Woronicz JD (1997), Woronicz JD (1997), Deng L (2000), Yeung KC (2001), Mercurio F (1997), Mercurio F (1997), Rothwarf DM (1998), Wu ZH (2010), Li S (2011), Li S (2011), May MJ (2002), Heilker R (1999), Leotoing L (2011), McKenzie FR (2000), Zandi E (1998), Lee DF (2007), Li XH (2001), Yeh PY (2011), Yeh PY (2011), Stehlik C (2002), Li Q (2006), So J (2015), Chen TC (2014), Karim ZA (2015), Huttlin EL (2017)	30
COPS3	1	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	10
STK11	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nony P (2003), Brajenovic M (2004), Gaude H (2012), Taipale M (2012), Huttlin EL (2017)	5
ERCC8	1	COPS8	2	affinity chromatography technology, affinity chromatography technology, biochemical	Groisman R (2003), Groisman R (2003), Groisman R (2006)	3
DDA1	1	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
KLHL10	1	COPS6	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
PTGS2	0	CUL4A	2	affinity chromatography technology	Neuss H (2007)	1
COPS5	0	DDA1	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009)	2
COPS3	1	SRP14	0	affinity chromatography technology	Huttlin EL (2015)	1
COPS6	0	DDA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Olma MH (2009)	4
FBXL5	3	COPS6	0	affinity chromatography technology	Huttlin EL (2017)	1
FBXO6	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Yoshida Y (2011)	2
FBXW4	0	COPS8	2	affinity chromatography technology	Lockwood WW (2013)	1
HSP90AA1	7	CSNK2A1	15	pull down, enzymatic study, enzymatic study, affinity chromatography technology	Miyata Y (1995), Muller P (2012), Zhang M (2011), Woo SH (2009)	4
COPS8	2	FEM1B	1	affinity chromatography technology	Huttlin EL (2017)	1
KLHL10	1	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
FBXO6	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Yoshida Y (2005), Yoshida Y (2005)	2
RBX1	2	CUL4A	2	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, enzymatic study, pull down, biochemical	Dias DC (2002), Ohta T (1999), Guerrero-Santoro J (2008), Hu J (2004), Furukawa M (2002), Maddika S (2009), Tron AE (2012), Tron AE (2012), He YJ (2006), Gastaldello S (2012), Olma MH (2009), Kristensen AR (2012), Huang DT (2009), Pick E (2007), Yang Y (2016), Scherer PC (2016), Nguyen TV (2016)	17
CTNNB1	30	SKP1	0	affinity chromatography technology, unspecified method, affinity chromatography technology, imaging technique	Matsuzawa SI (2001), Winston JT (1999), Wang D (2011), Chen TC (2014)	4
DDB2	1	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	6
CUL5	1	CUL2	3	affinity chromatography technology	Bennett EJ (2010)	1
ERCC8	1	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Groisman R (2003), Groisman R (2003), Groisman R (2006), Groisman R (2006)	4
CTNNB1	30	CHUK	5	affinity chromatography technology, pull down, enzymatic study	Lamberti C (2001), Lamberti C (2001), Albanese C (2003)	3
CUL4B	8	COPS9	1	affinity chromatography technology	Bennett EJ (2010)	1
DCAF8	1	COPS4	0	biochemical	Kristensen AR (2012)	1
IKBKB	1	IKBKG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, biochemical, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, pull down, affinity chromatography technology	Chen G (2002), Chen G (2002), Chariot A (2002), Wu RC (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010), Lee KY (2005), Rothwarf DM (1998), Ea CK (2006), Thurston TL (2009), Orel L (2010), Wu ZH (2010), Napolitano G (2009), Liu J (2009), Skaug B (2011), Li S (2011), Li S (2011), Kensche T (2012), Chiaravalli J (2011), Wu CJ (2006), Wu ZH (2006), Ahmad R (2007), Ahmad R (2007), Palkowitsch L (2008), Palkowitsch L (2008), Lo YC (2008), Mabb AM (2006), Baima ET (2010), Tegethoff S (2003), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), Lee DF (2007), Rottenberg S (2002), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Funakoshi-Tago M (2005), Ivins FJ (2009), Shibata Y (2012), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Wu ZH (2008), Mitsuhashi S (2008), Fujita H (2014), Golden MS (2013), Lee SH (2012), Cote SM (2013), Kim HJ (2014), Jackson SS (2014), Liao W (2008), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), So J (2015), Liu D (2014), Guo B (2014), Guo B (2014), Guo B (2014), Zhou L (2014), Zhou L (2014), Hein MY (2015), Bagneris C (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Rushe M (2008), Hauenstein AV (2017), Bal E (2017)	78
FBXO7	1	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
DCUN1D1	0	RBX1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Kim AY (2008), Bommelje CC (2013), Meyer-Schaller N (2009), Huang G (2014), Huang G (2014), Keuss MJ (2016), Keuss MJ (2016)	9
COPS6	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009)	2
CUL5	1	COPS8	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	IKBKB	1	affinity chromatography technology	Lee DF (2009)	1
MCPH1	4	COPS3	1	two hybrid	Liu X (2017)	1
COPS4	0	LRRC14	2	affinity chromatography technology	Olma MH (2009)	1
COPS7A	0	CSNK2B	5	far western blotting	Uhle S (2003)	1
WRAP73	1	COPS3	1	affinity chromatography technology	Ewing RM (2007)	1
COPS3	1	KLHL42	1	affinity chromatography technology	Olma MH (2009)	1
PTGS2	0	CUL1	7	affinity chromatography technology	Neuss H (2007)	1
DCAF11	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2006), Hein MY (2015), Huttlin EL (2017)	3
UNK	3	CTNNB1	30	affinity chromatography technology	Murn J (2015)	1
DCUN1D1	0	KLHL18	2	affinity chromatography technology	Bennett EJ (2010)	1
DDB1	6	DCAF1	5	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Jin J (2006), Jin J (2006), Ahn J (2010), Maddika S (2009), Maddika S (2009), McCall CM (2008), McCall CM (2008), Hrecka K (2007), Hrecka K (2007), Le Rouzic E (2007), Le Rouzic E (2007), Olma MH (2009), Pham TN (2011), Gerard FC (2014), Nakagawa T (2015), Wan C (2015), Kyei GB (2015), Cassiday PA (2015), Gao J (2015), Gao J (2015), Wu Y (2016), Wu Y (2016), Wang H (2017), Zhou X (2016), Zhou X (2016), Wang X (2017)	26
COPS4	0	SKP1	0	affinity chromatography technology	Olma MH (2009)	1
FBXO6	0	COPS2	5	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015)	2
CUL4A	2	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Angers S (2006), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009)	7
DET1	2	RBX1	2	affinity chromatography technology	Wertz IE (2004)	1
COPS3	1	COPS9	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology	Huttlin EL (2015), Rozen S (2015), Rozen S (2015), Rozen S (2015), Rozen S (2015), Huttlin EL (2017)	6
COPS5	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
CUL4A	2	SKP1	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Gastaldello S (2012)	2
FBXO7	1	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vingill S (2016), Teixeira FR (2016), Teixeira FR (2016)	3
CUL1	7	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huang X (2016), Reitsma JM (2017)	3
COPS5	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
APBB3	2	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
NEDD8	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Wimuttisuk W (2007)	4
COPS8	2	COPS4	0	biochemical, affinity chromatography technology, biochemical, biochemical, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Olma MH (2009), Havugimana PC (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	9
COPS5	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Pick E (2012)	7
DCAF8	1	DCAF11	2	biochemical	Kristensen AR (2012)	1
PTGS2	0	RBX1	2	affinity chromatography technology	Neuss H (2007)	1
IKBKG	0	COPS3	1	affinity chromatography technology	Hong X (2001)	1
EPB41L1	4	COPS5	0	biochemical	Kristensen AR (2012)	1
DCAF4L2	3	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Wang H (2016)	3
COPS2	5	APPBP2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IRF5	0	COPS6	0	affinity chromatography technology	Korczeniewska J (2012)	1
LRR1	1	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	3
IBTK	3	RBX1	2	affinity chromatography technology	Pisano A (2015)	1
RFWD2	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Olma MH (2009)	2
DDA1	1	COPS7B	0	affinity chromatography technology	Olma MH (2009)	1
COPS9	1	GPS1	1	affinity chromatography technology, biochemical	Rozen S (2015), Rozen S (2015)	2
NTRK1	1	DCAF1	5	affinity chromatography technology	Emdal KB (2015)	1
COPS6	0	LRRC14	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009)	3
ERCC8	1	GPS1	1	affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003)	2