PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZC3H12A	1	USP10	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Niu J (2013), Niu J (2013), Wang W (2015)	3
CDK2	0	PARP1	3	affinity chromatography technology	Neganova I (2011)	1
GIT2	2	NFKBIB	2	two hybrid	Wang J (2011)	1
BIRC3	1	IKBKB	1	imaging technique	Chen TC (2014)	1
IKBKG	0	KRT8	3	pull down, affinity chromatography technology, two hybrid	Fenner BJ (2010), Wang J (2011), Wang J (2011)	3
TRAF6	0	BCL10	0	affinity chromatography technology	Bidere N (2006)	1
IKBKG	0	CDK2	0	pull down, affinity chromatography technology, two hybrid	Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010)	3
CDK2	0	USP7	14	affinity chromatography technology	Neganova I (2011)	1
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
EGFR	5	CNTN2	4	protein complementation assay	Deribe YL (2009)	1
EGLN3	0	USP7	14	affinity chromatography technology	Rodriguez J (2016)	1
HSP90AA1	7	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Hein MY (2015)	2
FKBP5	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
IKBKB	1	MAP3K7	2	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hofer-Warbinek R (2000), Wu ZH (2010), Wu ZH (2010), Prickett TD (2008), Fan YH (2011), Neil JR (2008), Wu X (2007), Shambharkar PB (2007), Shambharkar PB (2007), Niu J (2013), Yao F (2015), Yao F (2015), Mei ZZ (2016), Zheng C (2015)	14
TNIP1	1	TBK1	1	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Gao L (2011)	2
MAP3K7	2	ATM	9	affinity chromatography technology	Yang Y (2011)	1
ATM	9	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wu ZH (2006), Wu ZH (2006), Rosato RR (2010), Wu ZH (2008), Wu ZH (2008), Mohanty S (2014)	6
NFKB1	2	TNFAIP3	3	affinity chromatography technology	Lapid D (2017)	1
TRAF2	1	TRAF3IP2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Qian Y (2004), Sun D (2011)	3
GSK3B	1	NFKB1	2	enzymatic study	Demarchi F (2001)	1
TNFAIP3	3	TNIP2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Van Huffel S (2001), Dong G (2011), Dong G (2011), Bohgaki M (2008), Klinkenberg M (2001)	5
IKBKG	0	RBCK1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Fenner BJ (2010), Verhelst K (2012), Zak DE (2011), Niu J (2011), Fu J (2013), Tokunaga F (2011), Xia ZP (2009), Emmerich CH (2013), Abdul-Sater AA (2017), Abdul-Sater AA (2017), Bal E (2017), Bal E (2017)	12
CYLD	2	USP10	2	affinity chromatography technology	Elliott PR (2016)	1
MAP3K14	1	IKBKB	1	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Luftig MA (2001), Woronicz JD (1997), Li Q (2006), Huttlin EL (2017)	4
TNFRSF1A	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Won M (2010), Zilberman-Rudenko J (2016), Moquin DM (2013)	3
LTBR	0	RNF31	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNF	0	TNFAIP3	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skaug B (2011), Tokunaga F (2012), Verhelst K (2012), Yamaguchi N (2015), Draber P (2015)	5
CYLD	2	TAB3	1	affinity chromatography technology	Elliott PR (2016)	1
CYLD	2	KRT8	3	affinity chromatography technology	Elliott PR (2016)	1
TAB3	1	UBC	7	x-ray crystallography, pull down, pull down, pull down	Sato Y (2009), Kanayama A (2004), Wang J (2015), Zhang X (2017)	4
IKBKB	1	USP18	1	affinity chromatography technology, affinity chromatography technology	Yang Z (2015), Yang Z (2015)	2
RIPK1	2	BIRC2	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Xu M (2009), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Fu J (2016), Vu NT (2016), Vu NT (2016)	12
MAP3K7	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Takaesu G (2000), Takaesu G (2001), Ishitani T (2003), Ishitani T (2003), Ea CK (2006), Broglie P (2010), Liu XY (2008), Li S (2011), Li S (2011), Jiang Z (2003), Mendoza H (2008), Ear T (2010), Criollo A (2011), Kim SY (2012), Jiang Z (2002), Jiang Z (2002), Hong S (2007), Shibuya H (1996), Minoda Y (2009), Li M (2010), Scholz R (2010), Kim SI (2009), Yong Kim S (2013), Liu R (2014), Wang J (2015), Moon G (2015), Wade EM (2016), Min Y (2016), Zhang J (2017)	31
TNFRSF1A	3	UBC	7	affinity chromatography technology	Nakazawa S (2016)	1
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
RNF31	3	TRAF2	1	affinity chromatography technology	Schaeffer V (2014)	1
TRAF3IP2	0	TRAF6	0	enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Liu C (2009), Kanamori M (2002), Kanamori M (2002), Kanamori M (2002), Qian Y (2007), Qu F (2012), Wu NL (2014), Wu NL (2014), Rolland T (2014), Garg AV (2013), Sun D (2011), Yu H (2011)	12
TNF	0	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Verhelst K (2012), Yamaguchi N (2015), Draber P (2015)	4
RIPK1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Fearns C (2006), Taipale M (2012)	2
NFKBIA	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2015)	1
RBCK1	0	TAB3	1	affinity chromatography technology	Tian Y (2007)	1
TRAF1	0	SQSTM1	0	affinity chromatography technology	Greenfeld H (2015)	1
IKBKB	1	TNFRSF1A	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Zhang SQ (2000), Chaudhary PM (2000), Fan YH (2011), Park KJ (2002), Guan YJ (2011), Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008), Chen TC (2014)	9
MAP3K7	2	NFKBIA	0	enzymatic study	Kanayama A (2004)	1
BIRC3	1	TRAF1	0	pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Roy N (1997), Li X (2002), Goncharov T (2013), Chen TC (2014), Greenfeld H (2015)	5
IKBKG	0	NFKBIA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Stempin CC (2011), Pringle LM (2011), Wu CJ (2006), Higashimoto T (2008), Ducut Sigala JL (2004), Shibata Y (2011), Liu L (2002), Xiao G (2000), Chan H (2005), Funakoshi-Tago M (2005), Wu X (2007), Kato T (2008), Niu J (2011), Neumann M (2011), Keusekotten K (2013), Fu J (2013), Dan HC (2008), Criollo A (2010), Hein MY (2015), Baratchian M (2016)	20
GSK3B	1	BIRC2	1	affinity chromatography technology	Sun M (2009)	1
IKBKE	2	UBC	7	affinity chromatography technology, pull down, affinity chromatography technology	Rajsbaum R (2014), Paz S (2009), Bharaj P (2016)	3
MAVS	1	BIRC3	1	affinity chromatography technology	Mao AP (2010)	1
CDC37	0	SQSTM1	0	two hybrid, affinity chromatography technology	Vinayagam A (2011), Li J (2013)	2
BIRC2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology	Goncharov T (2013), Schaeffer V (2014)	2
TNFRSF1A	3	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moquin DM (2013), Nakazawa S (2016), Elliott PR (2016)	3
RIPK1	2	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wright A (2007), Nagabhushana A (2011), ODonnell MA (2012), Wu GR (2017)	4
MACROD1	0	IKBKB	1	affinity chromatography technology	Wu Z (2015)	1
TANK	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Li S (2011), Goncharov T (2013)	2
TBK1	1	CYLD	2	affinity chromatography technology, imaging technique, affinity chromatography technology	Friedman CS (2008), Genin P (2015), Genin P (2015)	3
TRAF6	0	ZC3H12A	1	affinity chromatography technology	Wang W (2015)	1
HSP90AA1	7	TAB2	5	affinity chromatography technology	Gano JJ (2010)	1
IKBKG	0	PRKN	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Henn IH (2007), Henn IH (2007), Sha D (2010)	3
IKBKG	0	TBK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Fenner BJ (2010), Li S (2011), Wang L (2012), Wang L (2012), Ran Y (2016), Huttlin EL (2017)	7
PLK1	0	TBK1	1	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K14	1	TRAF1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Luftig MA (2001), Zheng C (2010), Song HY (1997), Liao G (2004), Choudhary S (2013), Choudhary S (2013)	6
IKBKE	2	BIRC2	1	affinity chromatography technology, enzymatic study	Zhou AY (2013), Zhou AY (2013)	2
CDC37	0	MTOR	14	two hybrid	Vinayagam A (2011)	1
RACGAP1	2	ERC1	0	affinity chromatography technology	Hein MY (2015)	1
USP10	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Niu J (2013), Niu J (2013), Niu J (2013), Wang W (2015)	4
IKBKG	0	RNF7	0	pull down, affinity chromatography technology, two hybrid	Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010)	3
IKBKE	2	TANK	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nomura F (2000), Nomura F (2000), Nomura F (2000), Gatot JS (2007), Renner F (2011), Shen RR (2012), Ryzhakov G (2007), So J (2015)	8
NFKBIA	0	NFKB1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hay DC (2001), Malek S (1998), Fagan-Garcia K (2011), Jeon YJ (2010), Roff M (1996), Keutgens A (2010), Inan MS (2000), Wang J (2011), Arenzana-Seisdedos F (1995), Jaffray E (1995), Wood KM (1998), Bell S (1996), Cockman ME (2006), Cockman ME (2006), Lu Y (2005), Huttlin EL (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017)	19
CHUK	5	RIPK1	2	biochemical	Poyet JL (2000)	1
INHA	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
TNFAIP3	3	TRAF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Song HY (1996), Song HY (1996), Heyninck K (1999), Greenfeld H (2015), Greenfeld H (2015)	5
TRAF6	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down	Cai B (2017), Fang R (2017), Fang R (2017)	3
RBCK1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, pull down	Tatematsu K (2008), Yoshimoto N (2009), Sato Y (2011), Kirisako T (2006), Haas TL (2009), Yoshimoto N (2009), Sato Y (2011), Emmerich CH (2013), Emmerich CH (2013), Zhang X (2017)	10
RNF31	3	RBCK1	0	affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down	Haas TL (2009), Yagi H (2012), Yagi H (2012), Yagi H (2012), Nakamura M (2006), Tokunaga F (2012), Kirisako T (2006), Kirisako T (2006), Rivkin E (2013), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Chen Y (2015), Draber P (2015), Draber P (2015), Klein T (2015), Klein T (2015), Stieglitz B (2012), Huttlin EL (2017), Liu J (2017), Liu J (2017)	21
TBK1	1	IKBKE	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Ikeda F (2007), Liu D (2015), Liu D (2015)	4
TRAF1	0	RBCK1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Abdul-Sater AA (2017)	4
RIPK2	0	RIPK1	2	affinity chromatography technology	Damgaard RB (2012)	1
TRAF6	0	SRC	2	affinity chromatography technology, pull down	Wong BR (1999), Liu A (2012)	2
AKT1	1	CREBBP	29	pull down, enzymatic study	Drendall CI (2010), Drendall CI (2010)	2
EPAS1	6	SQSTM1	0	affinity chromatography technology	Liu XD (2014)	1
PLK1	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Zhang W (2010), Zhang W (2010)	2
NFKBIB	2	NFKB1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CYLD	2	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Kim JY (2009), Kim JY (2009)	2
MAVS	1	RNF31	3	affinity chromatography technology	Khan M (2016)	1
TAB2	5	IKBKG	0	affinity chromatography technology, two hybrid, pull down, pull down	Suzuki S (2007), Wang J (2011), Emmerich CH (2013), Emmerich CH (2013)	4
MAP3K7	2	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu XY (2008), Jiang Z (2002), Jiang Z (2002), Lee HJ (2012), Yao J (2007)	5
UBC	7	IKBKB	1	pull down	Zhang X (2017)	1
CDC37	0	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
TRAF3IP2	0	UBC	7	enzymatic study	Liu C (2009)	1
CHUK	5	NFKBIB	2	enzymatic study, affinity chromatography technology, enzymatic study	Woronicz JD (1997), Le Page C (2001), Lee FS (1998)	3
TBK1	1	NFKBIA	0	enzymatic study	Zhang W (2010)	1
CDK2	0	TPM1	0	affinity chromatography technology	Hein MY (2015)	1
IKBKE	2	TRAF2	1	enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Shen RR (2012), Shen RR (2012), Shen RR (2012), Zhang W (2010), Zhou AY (2013), Zhou AY (2013), So J (2015), Fang R (2017)	8
EGFR	5	IKBKG	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
TANK	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, pull down	Wang W (2015), Wang W (2015), Wang W (2015)	3
TANK	1	USP10	2	affinity chromatography technology, affinity chromatography technology	Wang W (2015), Wang W (2015)	2
RIPK2	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Hasegawa M (2008)	2
TRIM13	1	SQSTM1	0	affinity chromatography technology	Tomar D (2011)	1
SHARPIN	1	CHUK	5	affinity chromatography technology	Tokunaga F (2011)	1
IKBKB	1	TNFAIP3	3	enzymatic study, affinity chromatography technology	Zetoune FS (2001), Xiong Y (2011)	2
TRAF2	1	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Yang Y (2013), Elliott PR (2016), Wu GR (2017)	7
TRIM23	3	TRAF1	0	two hybrid	Rolland T (2014)	1
CYLD	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, pull down	Almeida S (2008), Bremm A (2010), Komander D (2009), Kwasna D (2018)	4
TANK	1	CHUK	5	affinity chromatography technology	Chariot A (2002)	1
TRAF1	0	TBK1	1	affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Huttlin EL (2017)	2
RIPK1	2	IKBKB	1	biochemical, pull down	Yang Y (2011), Poyet JL (2000)	2
USP7	14	RBCK1	0	two hybrid	Hayes SD (2012)	1
TANK	1	ZC3H12A	1	two hybrid, affinity chromatography technology, pull down, pull down	Rual JF (2005), Wang W (2015), Wang W (2015), Wang W (2015)	4
IKBKG	0	SYT1	4	pull down, affinity chromatography technology, two hybrid	Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010)	3
HSP90AA1	7	EPAS1	6	pull down	Katschinski DM (2004)	1
RIPK2	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hasegawa M (2008), Kim JY (2008), Yang Y (2007), Yang Y (2007), Windheim M (2007)	5
HSP90AA1	7	HIF1A	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hogenesch JB (1997), Qian DZ (2006), Kong X (2006), Kubo T (2004), Zhou J (2004), Fu B (2007), Choi YK (2010), Choi YK (2010), Lee JM (2011), Liu YV (2007), Liu YV (2007), Katschinski DM (2004), Katschinski DM (2004), Katschinski DM (2004), Trisciuoglio D (2010), Trisciuoglio D (2010), Ueda K (2008), Sun H (2013), Kawanami D (2009), Prince TL (2015), Prince TL (2015), Isaacs JS (2004), Lee SH (2015)	23
BCL10	0	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Yoneda T (2000), Yoneda T (2000), Yoneda T (2000), Yui D (2001), Rolland T (2014)	5
IRAK1	1	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Vig E (2001), Windheim M (2008)	2
CDK2	0	PARP10	4	affinity chromatography technology	Hein MY (2015)	1
CREBBP	29	IKBKB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Verma UN (2004), Verma UN (2004), Verma UN (2004), Chen TC (2014)	4
MALT1	1	IKBKB	1	affinity chromatography technology	Bidere N (2009)	1
IKBKE	2	FKBP5	0	affinity chromatography technology	Bouwmeester T (2004)	1
SQSTM1	0	RIPK1	2	pull down, affinity chromatography technology, affinity chromatography technology	Sanz L (1999), Sanz L (1999), Sanz L (1999)	3
TNF	0	TNIP1	1	affinity chromatography technology	Haas TL (2009)	1
IKBKG	0	TRAF3IP2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down	Leonardi A (2000), Li X (2000), Mauro C (2003), Mauro C (2003), Mauro C (2003)	5
IKBKE	2	TRAF3IP2	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Qu F (2012), Qu F (2012), Qu F (2012), Ryzhakov G (2012)	4
TAB2	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takaesu G (2000), Li S (2009), Ishitani T (2003), Hong S (2007)	4
ERC1	0	IKBKG	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wu ZH (2010), Ducut Sigala JL (2004), Ducut Sigala JL (2004), Ducut Sigala JL (2004)	4
HIF1A	1	CREBBP	29	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Ema M (1999), Ema M (1999), Bhattacharya S (1999), Park YK (2008), Choi SM (2006), Matt T (2004), Hubbi ME (2012), Ruas JL (2010), Ruas JL (2010), Ruas JL (2010), Ruas JL (2010), Ruas JL (2005), Arany Z (1996), Ruas JL (2005), Gradin K (2002)	15
NFKBIA	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM14	1	IRAK1	1	bioid	Tan P (2017)	1
IFIT5	0	IKBKB	1	affinity chromatography technology	Zheng C (2015)	1
NSFL1C	1	HIF1A	1	affinity chromatography technology	Alexandru G (2008)	1
TNF	0	CYLD	2	affinity chromatography technology, affinity chromatography technology	Draber P (2015), Schlicher L (2016)	2
PARP1	3	PIAS4	5	affinity chromatography technology, pull down, pull down, enzymatic study	Martin N (2009), Martin N (2009), Martin N (2009), Ryu H (2010)	4
EGFR	5	ANXA1	1	affinity chromatography technology	Li J (2013)	1
TRIM14	1	NSFL1C	1	bioid	Tan P (2017)	1
EGFR	5	MAP3K14	1	affinity chromatography technology	Habib AA (2001)	1
SHARPIN	1	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, biochemical	Verhelst K (2012), Keusekotten K (2013), Schaeffer V (2014), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015), Draber P (2015), Draber P (2015), Draber P (2015), Stieglitz B (2012), Huttlin EL (2017), Elliott PR (2016), Liu J (2017), Liu J (2017), Liu J (2017), Liu J (2017), Liu J (2017)	21
IKBKB	1	MAVS	1	enzymatic study	Liu S (2015)	1
CHUK	5	CARD11	4	affinity chromatography technology, imaging technique	McCully RR (2008), Sommer K (2005)	2
TRAF1	0	RNF31	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	6
HSP90AA1	7	IKBKE	2	affinity chromatography technology	Taipale M (2012)	1
UBC	7	HIF1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haque M (2013), Haque M (2013), Kuo YC (2015), Fan CM (1990), Mabjeesh NJ (2003)	5
MAP3K7	2	HSP90AA1	7	affinity chromatography technology	Liu XY (2008)	1
SQSTM1	0	UBC	7	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, affinity chromatography technology, unspecified method, pull down, pull down, pull down, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, imaging technique, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Vinayagam A (2011), Vadlamudi RK (1996), Tanji K (2012), Matsumoto G (2011), Long J (2008), Long J (2008), Najat D (2009), Najat D (2009), Hocking LJ (2004), Boh BK (2011), Long J (2010), Seibenhener ML (2004), Seibenhener ML (2004), Seibenhener ML (2004), Fenner BJ (2009), Nathan JA (2013), Ciani B (2003), Shi J (2013), Goode A (2014), Bish RA (2007), Lu K (2014), Zhou L (2014), Zhou L (2014), Vadlamudi RK (1996), Long J (2008), Cavey JR (2006), Cavey JR (2006), Kirkin V (2009), Nakayasu ES (2013), Nakayasu ES (2013), Lim J (2015), Milan E (2015), Milan E (2015), Ordureau A (2015), Wurzer B (2015), Zhang X (2017), Wang L (2017), Liu X (2017), Peng H (2017), Donohue E (2014), Nibe Y (2017), Nibe Y (2017), Govindaraju VK (2017)	43
MALT1	1	TNFAIP3	3	affinity chromatography technology	Yang Y (2014)	1
EGLN3	0	BIRC3	1	affinity chromatography technology	Fu J (2016)	1
CHUK	5	TRAF6	0	affinity chromatography technology	Kishida S (2005)	1
IKBKG	0	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Brummelkamp TR (2003), Trompouki E (2003), Chu L (2006), Shibata Y (2012), Wang J (2011), Zilberman-Rudenko J (2016), Zilberman-Rudenko J (2016)	11
IKBKE	2	CDC37	0	affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Li S (2011)	2
IKBKG	0	TRIM23	3	affinity chromatography technology, affinity chromatography technology	Arimoto K (2010), Arimoto K (2010)	2
GSK3B	1	MTOR	14	two hybrid	Vinayagam A (2011)	1
IRAK1	1	BCL10	0	pull down	Dong W (2006)	1
AKT1	1	GSK3B	1	pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Thimmaiah KN (2005), Drendall CI (2010), Connor MK (2005), Hunter MG (2004), Zhu QS (2011), Li L (2003), Nam SY (2010), Yang WL (2009), Zeng L (2013), Yang H (2005), Boehme KA (2008), Cross DA (1995), Hinton CV (2007), Kapoor GS (2004), Pitre A (2012), Guo J (2016)	16
727764	0	IKBKG	0	two hybrid, affinity chromatography technology, pull down, two hybrid	Ye X (2011), Ye X (2011), Ye X (2011), Wang J (2011)	4
BIRC2	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
SHARPIN	1	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Draber P (2015), Draber P (2015), Elliott PR (2016)	3
CHUK	5	SRC	2	affinity chromatography technology, affinity chromatography technology	Huang WC (2003), Funakoshi-Tago M (2005)	2
IRAK1	1	CHUK	5	affinity chromatography technology, affinity chromatography technology	Vig E (2001), Windheim M (2008)	2
MTOR	14	PRKN	1	affinity chromatography technology	Park D (2014)	1
USP7	14	TRAF6	0	pull down, affinity chromatography technology, enzymatic study	Zapata JM (2001), Daubeuf S (2009), Bremm A (2010)	3
IKBKG	0	ANXA1	1	affinity chromatography technology, biochemical, affinity chromatography technology	Bist P (2011), Bist P (2011), Bist P (2011)	3
MAP3K14	1	CHUK	5	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Regnier CH (1997), Regnier CH (1997), Xiao G (2000), Luftig MA (2001), Ninomiya-Tsuji J (1999), Ninomiya-Tsuji J (1999), Qing G (2007), Sanjo H (2010), Hu WH (2004), Liao G (2004), Li Q (2006), Chen TC (2014), Huttlin EL (2017)	13
TNF	0	NFKBIA	0	enzymatic study	Rodriguez MS (1995)	1
TPM1	0	CDC37	0	biochemical	Kristensen AR (2012)	1
AKT1	1	SRC	2	imaging technique, affinity chromatography technology	Chen TC (2014), Lee J (2013)	2
PARP10	4	SQSTM1	0	imaging technique, affinity chromatography technology, affinity chromatography technology	Kleine H (2012), Kleine H (2012), Kleine H (2012)	3
CYLD	2	AKT1	1	enzymatic study, affinity chromatography technology	Yang WL (2013), Yang WL (2013)	2
IKBKG	0	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Zhao T (2007), Zhou AY (2013)	2
CYLD	2	PPM1B	2	affinity chromatography technology	Elliott PR (2016)	1
TRIM29	2	TRIM23	3	two hybrid, two hybrid, two hybrid	Reymond A (2001), Reymond A (2001), Rolland T (2014)	3
RACGAP1	2	TANK	1	two hybrid	Wang J (2011)	1
BIRC3	1	NFKB1	2	imaging technique	Chen TC (2014)	1
SQSTM1	0	MTOR	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Duran A (2011), Linares JF (2015), Linares JF (2015)	3
TNFAIP3	3	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Song HY (1996), Song HY (1996), Fries KL (1999), Yamaguchi N (2013), Rolland T (2014)	5
IKBKG	0	AKT1	1	pull down, affinity chromatography technology	Fenner BJ (2010), Hou Y (2010)	2
EGLN3	0	CHUK	5	affinity chromatography technology	Fu J (2013)	1
TNFAIP3	3	BIRC3	1	affinity chromatography technology	Yamaguchi N (2013)	1
PRKN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2003), Taipale M (2012), Zanon A (2013)	3
TRAF6	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wesche H (1999), Qian Y (2001), Cao Z (1996), Takatsuna H (2003), Li S (2002), Ling L (2000), Ling L (2000), Takaesu G (2001), Muzio M (1997), Chen F (2008), Li X (2001), Li X (2001), Xiong Y (2011), Xiong Y (2011), Tang H (2010), Muroi M (2011), Liu A (2012), Lee JY (2009), Lee JY (2009), Kollewe C (2004), Jiang Z (2002), Jensen LE (2001), Liu G (2007), Liu G (2007), Jiang Z (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Lakshmanan U (2007), Lee HJ (2012), Lee HJ (2012), Zhang X (2013), Yao J (2007), Hu MM (2014), Jeon J (2014), Conze DB (2008), Tanishima M (2017)	38
BIRC3	1	USP7	14	affinity chromatography technology	Goncharov T (2013)	1
HSP90AA1	7	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang K (2006), Taipale M (2012), Liu XY (2010)	3
CREBBP	29	IKBKG	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Verma UN (2004), Verma UN (2004), Verma UN (2004)	3
TRAF6	0	IKBKE	2	affinity chromatography technology	Fang R (2017)	1
EPAS1	6	UBC	7	affinity chromatography technology	Steunou AL (2012)	1
CDC37	0	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Basso AD (2002), Basso AD (2002), Kim H (2014), Sun L (2012)	4
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
TNF	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Draber P (2015), Pescatore A (2016), Schlicher L (2016)	5
BIRC3	1	RIPK2	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Thome M (1998), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	6
TNF	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Yamaguchi N (2015)	2
TRIM14	1	RIPK2	0	bioid	Tan P (2017)	1
CYLD	2	TRAF6	0	enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Bremm A (2010), Wu J (2015), Wu J (2015)	4
HIF1A	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Nowicka AM (2016), Nowicka AM (2016), Nowicka AM (2016), Nowicka AM (2016)	4
TRAF2	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Hong S (2007), Tan B (2015)	4
TBK1	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bouwmeester T (2004), Bonnard M (2000), Behrends C (2010), Li S (2011), Li S (2011), Shen RR (2012), Zhang W (2010), Huttlin EL (2017), Fang R (2017), Fang R (2017)	10
TANK	1	TRAF2	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, unspecified method	Bouwmeester T (2004), Rothe M (1996), Rothe M (1996), Nomura F (2000), Nomura F (2000), Pomerantz JL (1999), Behrends C (2010), Li S (2011), Li S (2011), Li C (2002), Shen RR (2012), Shen RR (2012), Wang J (2011), Huttlin EL (2017), Kim CM (2017)	15
CHUK	5	MTOR	14	affinity chromatography technology, affinity chromatography technology, biochemical	Dan HC (2008), Dan HC (2008), Dan HC (2008)	3
IKBKG	0	RPAP3	1	pull down, affinity chromatography technology	Fenner BJ (2010), Shimada K (2011)	2
USP10	2	UBC	7	enzymatic study, unspecified method, pull down	Bomberger JM (2009), Ernst A (2013), Kwasna D (2018)	3
BIRC3	1	IKBKE	2	enzymatic study	Zhou AY (2013)	1
CDK2	0	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
TNFRSF1A	3	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Shu HB (1996), Vince JE (2009), Mahul-Mellier AL (2011), Won M (2010), Kolliputi N (2009), Park KJ (2002), Lee IT (2010), Kim WJ (2005), Zheng L (2006), Vince JE (2007), Jeon J (2014), Chen TC (2014), Lee CK (2015), Jeong M (2017)	16
USP18	1	CARD11	4	affinity chromatography technology	Liu X (2013)	1
CDC37	0	SRC	2	pull down	Rao J (2001)	1
TBK1	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology	Qin Y (2016), Qin Y (2016)	2
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
MALT1	1	RNF31	3	affinity chromatography technology	Yang Y (2014)	1
TRIM13	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Tomar D (2014), Tomar D (2014)	2
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
CHUK	5	TAB2	5	affinity chromatography technology	Kishida S (2005)	1
IKBKG	0	TRIM14	1	affinity chromatography technology, pull down, affinity chromatography technology	Zhou Z (2014), Zhou Z (2014), Zhou Z (2014)	3
IKBKG	0	BCL10	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wu CJ (2008), Wu CJ (2008), Bhattacharyya S (2010), Stilo R (2004), Poyet JL (2001), Poyet JL (2001), Park Y (2013), Zhou H (2004), Yang YK (2016)	9
EGFR	5	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
MTOR	14	NFKBIA	0	biochemical, affinity chromatography technology	Dan HC (2008), Dan HC (2008)	2
USP18	1	TAB2	5	affinity chromatography technology	Liu X (2013)	1
IKBKB	1	TRIM40	0	affinity chromatography technology, affinity chromatography technology	Noguchi K (2011), Noguchi K (2011)	2
TAB2	5	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Windheim M (2008), Xia ZP (2009), Jiang Z (2002), Jeon J (2014), Emmerich CH (2013)	5
MAVS	1	TRAF1	0	affinity chromatography technology	Minassian A (2015)	1
EGFR	5	TNFRSF1A	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
IKBKG	0	CHUK	5	pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Agou F (2002), Chen G (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Rothwarf DM (1998), Rothwarf DM (1998), Hasegawa M (2008), Liu J (2009), Li S (2011), Li S (2011), Xia X (2011), Kensche T (2012), May MJ (2002), Wu ZH (2006), Wu ZH (2006), Palkowitsch L (2008), Le Page C (2001), Le Page C (2001), Huang TT (2002), Sebban-Benin H (2007), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), McKenzie FR (2000), Solt LA (2007), Li XH (2001), Rottenberg S (2002), Poyet JL (2000), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Strnad J (2006), Funakoshi-Tago M (2005), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Marinis JM (2012), Mitsuhashi S (2008), Mitsuhashi S (2008), Fujita H (2014), Lee SH (2012), Jackson SS (2014), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), Liu D (2014), Hein MY (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Bal E (2017)	57
RIPK1	2	BIRC3	1	affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Wu CJ (2006)	8
IKBKG	0	FGR	1	pull down, affinity chromatography technology	Fenner BJ (2010), Lee SH (2012)	2
TNF	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006), Tokunaga F (2012), Verhelst K (2012), Draber P (2015), Pescatore A (2016)	6
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
HSP90AA1	7	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Haendeler J (2003), Kawauchi K (2005), Sato S (2000), Basso AD (2002), Su CH (2011), Klein JB (2005), Sun L (2012)	7
CHUK	5	CDC37	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen G (2002), Li S (2011), Taipale M (2014), Taipale M (2014), Li J (2013)	5
TAB3	1	IKBKB	1	affinity chromatography technology	Shinohara H (2016)	1
TRAF1	0	TNIP1	1	affinity chromatography technology	Greenfeld H (2015)	1
UBC	7	TNIP1	1	affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down	Wagner S (2008), Wagner S (2008), Fenner BJ (2009), Verhelst K (2012), Zhang X (2017), Kliza K (2017)	6
TNFRSF1A	3	TNF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Bouwmeester T (2004), Micheau O (2003), Legler DF (2003), Kuai J (2004), Skaug B (2011), Tokunaga F (2012), Klingseisen L (2012), Thoma B (1990), Keusekotten K (2013), Crowe PD (1994), Liu LS (1998), Higuchi M (1992), Chaturvedi MM (1994), Schaeffer V (2014), Fritsch J (2014), Chainy GB (1996), Huttlin EL (2015), Chen TC (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Huttlin EL (2017), Nielsen FS (2004), Ameloot P (2001)	24
MAP3K7	2	CHUK	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Sakurai H (1999), Ninomiya-Tsuji J (1999), Lin X (1998), Lin X (1998), Ear T (2010), Huangfu WC (2006), Chen TC (2014)	7
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
IKBKG	0	CARD11	4	pull down, affinity chromatography technology, affinity chromatography technology	Stilo R (2004), McCully RR (2008), Shambharkar PB (2007)	3
LTBR	0	RBCK1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNFAIP3	3	MTOR	14	affinity chromatography technology, imaging technique	Matsuzawa Y (2015), Matsuzawa Y (2015)	2
TAB2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Takaesu G (2000), Takaesu G (2000), Takaesu G (2001), Takaesu G (2001), Walsh MC (2008), Ma Q (2008), Windheim M (2008), Xia ZP (2009), Jiang Z (2003), Kanayama A (2004), Kanayama A (2004), Yokota S (2008), Jiang Z (2002), Jiang Z (2002), Jiang Z (2003), Wang J (2011), Yong Kim S (2013), Jeon J (2014), Fujikawa H (2013)	20
MAP3K14	1	UBC	7	affinity chromatography technology	Sanjo H (2010)	1
EGLN3	0	CDC37	0	affinity chromatography technology	Rodriguez J (2016)	1
RIPK1	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bertrand MJ (2008), Li H (2006), Yang Y (2011), Yang Y (2011), Yang Y (2011), Hu MM (2014)	6
IKBKE	2	NFKBIA	0	enzymatic study	Zhang W (2010)	1
SHARPIN	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Verhelst K (2012), Verhelst K (2012)	2
MAP3K7	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Neil JR (2009), Yang Y (2011), Wu X (2007), Emmerich CH (2013)	4
BIRC2	1	USP7	14	affinity chromatography technology	Goncharov T (2013)	1
IKBKG	0	PIAS4	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mabb AM (2006), Mabb AM (2006), Wu ZH (2008), Mohanty S (2014), Wu Z (2015)	5
CHUK	5	USP18	1	affinity chromatography technology, affinity chromatography technology	Yang Z (2015), Yang Z (2015)	2
TRAF3IP2	0	CHUK	5	affinity chromatography technology, biochemical	Leonardi A (2000), Mauro C (2003)	2
NFKB1	2	IKBKG	0	affinity chromatography technology, pull down	Bouwmeester T (2004), Smolle M (2004)	2
AKT1	1	TRIM13	1	affinity chromatography technology, enzymatic study	Joo HM (2011), Joo HM (2011)	2
TRIM40	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Noguchi K (2011), Noguchi K (2011)	2
IKBKG	0	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Chen G (2002), Taipale M (2014), Taipale M (2014), Liu D (2014), Hein MY (2015), Hein MY (2015), Li J (2013)	8
MAP3K7	2	USP18	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang Z (2015), Liu X (2013), An S (2017), An S (2017)	4
MAP3K7	2	ERC1	0	affinity chromatography technology	Wu ZH (2010)	1
TNFRSF1A	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1996), Vince JE (2009), Vince JE (2007), Wang YB (2015)	4
EGLN3	0	BIRC2	1	affinity chromatography technology	Fu J (2016)	1
PPP4C	0	IKBKG	0	imaging technique, affinity chromatography technology	Griffiths DA (2013), Griffiths DA (2013)	2
UBC	7	MAP3K7	2	pull down	Zhang X (2017)	1
MAVS	1	BIRC2	1	affinity chromatography technology	Mao AP (2010)	1
TRAF6	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Sun H (2013), Sun H (2013), Sun H (2013), Rezaeian AH (2017), Rezaeian AH (2017)	5
TAB3	1	TRAF6	0	affinity chromatography technology, pull down, affinity chromatography technology	Ishitani T (2003), Kanayama A (2004), Shinohara H (2016)	3
TBK1	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Wang L (2012), Liu XY (2011), Liu S (2015), Fang R (2017), Zhang Q (2017)	7
NFKB1	2	TNIP2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Lang V (2004), Lang V (2004), Lang V (2004), Lang V (2004), Wang J (2011), Li X (2015)	7
TPM1	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAF6	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanz L (2000), Sanz L (2000), Nakamura K (2010), Kim JY (2009), Seibenhener ML (2004), Feng Y (2005), Martin P (2006), Martin P (2006), Geetha T (2012), Geetha T (2012), Linares JF (2013), Linares JF (2011), Linares JF (2015), Schimmack G (2017), Tsai WT (2016)	15
ZC3H12A	1	UBC	7	enzymatic study, pull down, affinity chromatography technology	Liang J (2010), Niu J (2013), Liang J (2010)	3
GSK3B	1	NCOA3	3	enzymatic study	Wu RC (2004)	1
MAP3K7	2	CARD11	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Srivastava R (2010), McCully RR (2008), Shinohara H (2016), Shinohara H (2016)	4
MAVS	1	SRC	2	affinity chromatography technology	Johnsen IB (2009)	1
TNIP2	1	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Leotoing L (2011), Leotoing L (2011)	2
TAB2	5	UBC	7	pull down, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down	Kulathu Y (2009), Kulathu Y (2009), Sato Y (2009), van Wijk SJ (2012), Kanayama A (2004), Niu J (2011), van Wijk SJ (2013), Hooper C (2014), Komander D (2009), Emmerich CH (2013), Wauer T (2015), Kristariyanto YA (2015), Zhang X (2017)	13
IKBKE	2	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Saitoh T (2005)	2
IFIT5	0	CHUK	5	affinity chromatography technology, pull down	Zheng C (2015), Zheng C (2015)	2
EGFR	5	IRAK1	1	affinity chromatography technology	Yao Z (2017)	1
TRAF3IP2	0	MAP3K7	2	affinity chromatography technology	Qian Y (2007)	1
TNF	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Fritsch J (2014), Yamaguchi N (2015)	7
TRAF1	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017), Abdul-Sater AA (2017)	4
MAP3K14	1	TRAF2	1	pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Luftig MA (2001), Luftig MA (2001), Malinin NL (1997), Malinin NL (1997), Malinin NL (1997), Sanjo H (2010), Kanno Y (2010), Zheng C (2010), Song HY (1997), Liao G (2004), Choudhary S (2013), Lee S (2014), Rolland T (2014)	13
RNF31	3	RIPK1	2	affinity chromatography technology	Draber P (2015)	1
PPM1B	2	MAP3K7	2	affinity chromatography technology, pull down	Hanada M (2001), Hanada M (2001)	2
ANXA1	1	KRT8	3	affinity chromatography technology	Croxtall JD (1998)	1
TNIP1	1	NFKB1	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Cohen S (2009), Cohen S (2009), Wang J (2011), Li X (2015)	4
BIRC3	1	TANK	1	affinity chromatography technology	Goncharov T (2013)	1
SQSTM1	0	HIF1A	1	affinity chromatography technology	Liu XW (2013)	1
LTBR	0	PLK1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAP3K14	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Ninomiya-Tsuji J (1999), Hofer-Warbinek R (2000)	2
AKT1	1	BCL10	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Yeh PY (2006), Yeh PY (2006), Yeh PY (2006)	3
TRAF6	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid, two hybrid	Heyninck K (1999), Evans PC (2001), Lin SC (2008), Xiong Y (2011), Bremm A (2010), Kelly C (2012), Hayes SD (2012), Lin SC (2008), Garg AV (2013), Boone DL (2004), Schimmack G (2017), Schimmack G (2017)	12
CARD11	4	RNF31	3	affinity chromatography technology, affinity chromatography technology	Yang YK (2016), Yang YK (2016)	2
USP7	14	TRAF2	1	pull down	Zapata JM (2001)	1
MAVS	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2010), Li S (2011), Li S (2011), Wang L (2012), Wang L (2012), Zhou Z (2014)	6
IKBKB	1	HIF1A	1	affinity chromatography technology	Nowicka AM (2016)	1
TNF	0	MAP3K7	2	affinity chromatography technology	Ea CK (2006)	1
PPM1B	2	IKBKB	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Prajapati S (2004), Prajapati S (2004), Prajapati S (2004)	3
PRKN	1	TPM1	0	affinity chromatography technology	Zanon A (2013)	1
EPAS1	6	IKBKG	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Nowicka AM (2016), Nowicka AM (2016), Nowicka AM (2016), Nowicka AM (2016), Bracken CP (2005), Bracken CP (2005), Bracken CP (2005), Bracken CP (2005), Bracken CP (2005)	9
GIT2	2	TNIP1	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
RNF31	3	UBC	7	pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Wauer T (2013), Fujita H (2014), Schaeffer V (2014), Tokunaga F (2011), Kirisako T (2006), Haas TL (2009), Emmerich CH (2013), Sakamoto H (2015), Lechtenberg BC (2016), Lechtenberg BC (2016), Stieglitz B (2012), Zhang X (2017), Kliza K (2017), Liu J (2017)	14
EPAS1	6	CREBBP	29	affinity chromatography technology	Steunou AL (2012)	1
GSK3B	1	HSP90AA1	7	enzymatic study	Muller P (2012)	1
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
TNF	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legler DF (2003), Haas TL (2009), Ea CK (2006), Ramakrishnan P (2011), Skaug B (2011), Darding M (2011), Tokunaga F (2012), Klingseisen L (2012), Schaeffer V (2014), Fritsch J (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Schlicher L (2016)	14
IKBKB	1	EPAS1	6	affinity chromatography technology	Nowicka AM (2016)	1
UBC	7	PARP10	4	pull down, pull down	Nicolae CM (2014), Verheugd P (2013)	2
CDC37	0	FKBP5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
IKBKG	0	TRAF1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	3
TRIM14	1	NFKB1	2	bioid	Tan P (2017)	1
CYLD	2	PARP1	3	affinity chromatography technology	Elliott PR (2016)	1
SHARPIN	1	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Verhelst K (2012), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Draber P (2015), Liu J (2017)	6
MACROD1	0	ERC1	0	affinity chromatography technology	Wu Z (2015)	1
MAVS	1	IKBKE	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paz S (2009), Li S (2011), Paz S (2011), Paz S (2011), Fang R (2017)	5
RNF31	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012)	2
BIRC3	1	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Uren AG (1996), Roy N (1997), Yoneda T (2000), Yoneda T (2000), Li X (2002), Behrends C (2010), Samuel T (2006), Vince JE (2009), Darding M (2011), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Rothe M (1995), Varfolomeev E (2006), Choudhary S (2013), Goncharov T (2013), Wang J (2011), Harikumar KB (2014), Shen RR (2012), Chen TC (2014), Akhtar N (2016)	23
MALT1	1	TAB2	5	affinity chromatography technology, affinity chromatography technology	Oeckinghaus A (2007), Karim ZA (2015)	2
MAP3K14	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Mochida Y (2000), Song HY (1997), Li Q (2006), Chen TC (2014)	4
PLK1	0	IKBKB	1	enzymatic study	Higashimoto T (2008)	1
TNFRSF1A	3	BCL10	0	two hybrid	Costanzo A (1999)	1
PRKN	1	RBCK1	0	two hybrid	Corominas R (2014)	1
CDC37	0	RPAP3	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
KRT18	2	PIAS4	5	two hybrid	Wang J (2011)	1
TNFRSF1A	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Zhang SQ (2000), Nakazawa S (2016)	2
TRAF1	0	TANK	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography	Rothe M (1996), Wang J (2011), Greenfeld H (2015), Huttlin EL (2017), Kim CM (2017), Kim CM (2017)	6
TAB3	1	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Li S (2011), Li S (2011)	4
TRAF1	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Wong BR (1999), Narita T (2005)	2
HSP90AA1	7	TNFAIP3	3	affinity chromatography technology	Taipale M (2012)	1
TRIM23	3	UBC	7	enzymatic study	Dawidziak DM (2017)	1
BCL10	0	IKBKB	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Lobry C (2007), Lobry C (2007), Poyet JL (2001), Zhou H (2004), Bidere N (2009)	5
BIRC2	1	TRAF1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Shu HB (1996), Li X (2002), Li S (2011), Mace PD (2010), Rothe M (1995), Varfolomeev E (2006), Goncharov T (2013), Wang J (2011), Greenfeld H (2015), Huttlin EL (2017)	11
RBCK1	0	MAP3K7	2	affinity chromatography technology	Tian Y (2007)	1
NCOA3	3	NFKB1	2	affinity chromatography technology	Wu RC (2004)	1
TRAF2	1	IKBKB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Devin A (2001), Li S (2009), Li S (2009), Li HY (2008), Shen RR (2012), Shen RR (2012), Zhang W (2010), Chen TC (2014), Mei ZZ (2016)	9
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
EGLN3	0	CYLD	2	affinity chromatography technology	Rodriguez J (2016)	1
BIRC2	1	BCL10	0	affinity chromatography technology, affinity chromatography technology	Yoneda T (2000), Hu S (2006)	2
PLK1	0	MAVS	1	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	FGR	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
IKBKG	0	IKBKG	0	affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Chiaravalli J (2011), Ahmad R (2007), Tegethoff S (2003), Tegethoff S (2003), Hai T (2006), Huang GJ (2002), Huang GJ (2002), Marienfeld RB (2006), Ivins FJ (2009), Wang J (2011), Lee SH (2012), Cote SM (2013), Cote SM (2013), Zilberman-Rudenko J (2016), Rushe M (2008), Hauenstein AV (2017), Bal E (2017)	17
MAP3K7	2	MAVS	1	affinity chromatography technology	Xu LG (2005)	1
IKBKB	1	NFKBIB	2	enzymatic study, affinity chromatography technology, enzymatic study	Woronicz JD (1997), Woronicz JD (1997), Lee FS (1998)	3
HSP90AA1	7	CHUK	5	affinity chromatography technology, affinity chromatography technology	Qu X (2012), Gano JJ (2010)	2
TBK1	1	CDC37	0	affinity chromatography technology	Bouwmeester T (2004)	1
IKBKG	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Verhelst K (2012), Zak DE (2011), Tokunaga F (2011), Tokunaga F (2011), Emmerich CH (2013), Abdul-Sater AA (2017), Abdul-Sater AA (2017), Bal E (2017), Bal E (2017), Bal E (2017)	10
RNF31	3	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Draber P (2015), Draber P (2015), Draber P (2015), Goto E (2017), Schlicher L (2016), Elliott PR (2016), Elliott PR (2016), Elliott PR (2016)	8
EGFR	5	PLK1	0	affinity chromatography technology	Tong J (2014)	1
MAP3K14	1	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
RIPK1	2	EGLN3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fu J (2016), Fu J (2016), Rodriguez J (2016)	3
EGLN3	0	CDK2	0	affinity chromatography technology	Rodriguez J (2016)	1
CYLD	2	TAB2	5	affinity chromatography technology	Elliott PR (2016)	1
PRKN	1	MAVS	1	affinity chromatography technology, affinity chromatography technology	Khan M (2016), Khan M (2016)	2
MALT1	1	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Martin P (2006), Martin P (2006)	2
USP7	14	CDC37	0	biochemical	Kristensen AR (2012)	1
ERC1	0	NFKBIA	0	affinity chromatography technology	Ducut Sigala JL (2004)	1
RIPK2	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McCarthy JV (1998), LeBlanc PM (2008), Marinis JM (2011)	3
LTBR	0	TRAF1	0	pull down, affinity chromatography technology, affinity chromatography technology	Marsters SA (1997), Huttlin EL (2015), Huttlin EL (2017)	3
IKBKG	0	PARP10	4	affinity chromatography technology, enzymatic study	Verheugd P (2013), Verheugd P (2013)	2
IKBKB	1	ERC1	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wu ZH (2010), Ducut Sigala JL (2004), Ducut Sigala JL (2004), Ducut Sigala JL (2004)	4
TRIM23	3	TNFAIP3	3	two hybrid	Rolland T (2014)	1
IKBKG	0	CARD10	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Stilo R (2004), Stilo R (2004), Stilo R (2004), Stilo R (2004), Stilo R (2004)	5
NFKBIA	0	MAVS	1	affinity chromatography technology	Liu S (2015)	1
RIPK2	0	RNF31	3	affinity chromatography technology	Damgaard RB (2012)	1
EGFR	5	TPM1	0	protein complementation assay	Deribe YL (2009)	1
USP7	14	FKBP5	0	biochemical	Kristensen AR (2012)	1
EGLN3	0	PLK1	0	affinity chromatography technology	Rodriguez J (2016)	1
HSP90AA1	7	MAP3K14	1	affinity chromatography technology, affinity chromatography technology	Qing G (2007), Taipale M (2012)	2
NFKB1	2	TBK1	1	affinity chromatography technology	Bouwmeester T (2004)	1
TNIP2	1	CHUK	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Leotoing L (2011), Leotoing L (2011), Leotoing L (2011)	3
TNFAIP3	3	CHUK	5	affinity chromatography technology	Zetoune FS (2001)	1
EGLN3	0	TBK1	1	affinity chromatography technology	Rodriguez J (2016)	1
CYLD	2	CDC37	0	affinity chromatography technology	Elliott PR (2016)	1
TRAF3IP2	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Qu F (2012), Qu F (2012), Qu F (2012)	3
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
CARD11	4	MALT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang S (2013), Karim ZA (2015), Liu Y (2012)	3
TRAF6	0	PPP4C	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Chen L (2008), Chen L (2008), Chen L (2008), Chen L (2008)	4
CHUK	5	NFKBIA	0	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	DiDonato JA (1997), Cohen L (1998), Woronicz JD (1997), Ninomiya-Tsuji J (1999), Burke JR (2002), Wu ZH (2010), Tong KM (2008), Singhirunnusorn P (2005), Heilker R (1999), Huang TT (2002), Lee FS (1998), Kim KS (2002), Cappello C (2007), Hong S (2007), Morrison BH (2007), Zandi E (1998), Li Q (2006), Manna SK (2010), Li XH (2001), Poyet JL (2001), Zhang W (2010), Bauer JA (2007), Chan H (2005), Munzert G (2002), Stehlik C (2002), Shambharkar PB (2007), Cui J (2010), Li Q (2006), Bernier M (2006), Mitsuhashi S (2008), Hayashi T (2007), Niu J (2013), Dan HC (2008), Criollo A (2010), Kim Y (2002), Huttlin EL (2015), Liu D (2014), Zhang H (2004), Aggarwal S (2006), Ninomiya-Tsuji J (2003), Huttlin EL (2017)	41
RIPK2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Thome M (1998), Li S (2011)	2
BCL10	0	SQSTM1	0	affinity chromatography technology	Paul S (2012)	1
TRAF1	0	RIPK2	0	affinity chromatography technology	Thome M (1998)	1
TNF	0	TAB2	5	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006)	2
ERC1	0	CHUK	5	biochemical, affinity chromatography technology, affinity chromatography technology	Ducut Sigala JL (2004), Ducut Sigala JL (2004), Ducut Sigala JL (2004)	3
GSK3B	1	NSFL1C	1	two hybrid	Vinayagam A (2011)	1
ATM	9	BCL10	0	enzymatic study, affinity chromatography technology	Zhao H (2014), Zhao H (2014)	2
TRAF1	0	UBC	7	affinity chromatography technology	Greenfeld H (2015)	1
HSP90AA1	7	FGR	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012)	2
IKBKB	1	FKBP5	0	affinity chromatography technology	Li S (2011)	1
TNF	0	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006)	2
NFKBIA	0	MALT1	1	affinity chromatography technology	Carvalho G (2010)	1
MAP3K14	1	TANK	1	affinity chromatography technology	Kanno Y (2010)	1
ATM	9	HIF1A	1	enzymatic study	Cam H (2010)	1
TRAF2	1	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henn IH (2007), Henn IH (2007), Um JW (2012), Im E (2015)	4
GIT2	2	IKBKG	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
FKBP5	0	CHUK	5	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
RIPK2	0	TAB2	5	affinity chromatography technology	Hasegawa M (2008)	1
EGLN3	0	IRAK1	1	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	PPM1B	2	affinity chromatography technology	Rodriguez J (2016)	1
CHUK	5	TNFRSF1A	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008)	3
RBCK1	0	TRAF6	0	affinity chromatography technology	Tian Y (2007)	1
BIRC3	1	IKBKG	0	pull down, affinity chromatography technology	Gyrd-Hansen M (2008), Goncharov T (2013)	2
TNFRSF1A	3	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CREBBP	29	CHUK	5	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Verma UN (2004), Verma UN (2004), Verma UN (2004), Huang WC (2007), Huang WC (2007), Huang WC (2007)	6
TRIM14	1	CDC37	0	bioid	Tan P (2017)	1
USP7	14	ANXA1	1	affinity chromatography technology, affinity chromatography technology, pull down	Park JJ (2015), Park JJ (2015), Park JJ (2015)	3
SHARPIN	1	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology	Keusekotten K (2013), Nakazawa S (2016)	2
MAVS	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Yu H (2011), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	7
EGLN3	0	MAP3K7	2	affinity chromatography technology	Rodriguez J (2016)	1
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
USP7	14	TNIP2	1	affinity chromatography technology	Bhattacharya S (2015)	1
TRAF6	0	TRIM13	1	affinity chromatography technology	Huang B (2017)	1
HIF1A	1	SRC	2	imaging technique, affinity chromatography technology	Gray MJ (2005), Ruas JL (2005)	2
TBK1	1	TANK	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Bouwmeester T (2004), Pomerantz JL (1999), Gatot JS (2007), Li S (2011), Li S (2011), Shen RR (2012), Ryzhakov G (2007), Wang J (2011), Seo S (2013), Saul VV (2014), Richter B (2016), Shostak K (2014)	12
PLK1	0	TANK	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Zhang W (2010), Zhang W (2010), Zhang W (2010), Wang J (2011), Wang J (2011)	5
IKBKG	0	CALB1	0	pull down, affinity chromatography technology, two hybrid	Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010)	3
IKBKG	0	SENP2	3	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study	Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010), Lee MH (2011), Lee MH (2011)	5
HIF1A	1	EGLN3	0	pull down, pull down, affinity chromatography technology, two hybrid, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology	Baek JH (2005), Yoo YG (2008), Yeh IJ (2013), Rolland T (2014), Rantanen K (2013), Barth S (2007), Rodriguez J (2016), Rodriguez J (2016)	8
TBK1	1	TRIM14	1	affinity chromatography technology	Zhou Z (2014)	1
PRKN	1	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, imaging technique	Sarraf SA (2013), Song P (2016), Song P (2016), Song P (2016), Song P (2016), Hou XO (2015), Geisler S (2014)	7
PPM1B	2	KRT18	2	affinity chromatography technology	Ewing RM (2007)	1
BCL10	0	CARD11	4	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bertin J (2001), Bertin J (2001), Bertin J (2001), Kojo S (2009), Welteke V (2009), Oruganti SR (2011), Langel FD (2008), McCully RR (2008), Sommer K (2005), Park Y (2013), Chen J (2015), Qiao Q (2013), Qiao Q (2013), Eitelhuber AC (2011), Yang YK (2016), Liu Y (2012), Bidere N (2009)	17
AKT1	1	IKBKB	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Vandermoere F (2005), Vandermoere F (2005), Chen TC (2014), Busch F (2012)	4
USP7	14	TRAF1	0	pull down	Zapata JM (2001)	1
TNFRSF1A	3	RBCK1	0	affinity chromatography technology	Nakazawa S (2016)	1
TNIP2	1	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, two hybrid	Liu WK (2004), Liu WK (2004), Liu WK (2004), Liu WK (2004), Liu WK (2004), Wang J (2011)	6
TNFAIP3	3	TNIP1	1	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid	Heyninck K (1999), Heyninck K (1999), Bohgaki M (2008), Klinkenberg M (2001), Heyninck K (2003), Wang J (2011), Rodriguez MS (2014), Rolland T (2014)	8
TBK1	1	SQSTM1	0	enzymatic study, enzymatic study	Matsumoto G (2015), Richter B (2016)	2
TRAF6	0	MTOR	14	affinity chromatography technology, enzymatic study	Linares JF (2013), Linares JF (2013)	2
EGFR	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Puliyappadamba VT (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
TNF	0	CHUK	5	affinity chromatography technology, genetic interference	Haas TL (2009), Sahu I (2014)	2
AKT1	1	NFKBIA	0	affinity chromatography technology	Koul D (2001)	1
ATM	9	TRAF6	0	pull down	Hinz M (2010)	1
KRT18	2	KRT8	3	two hybrid, two hybrid	Schnabel J (1998), Wang J (2011)	2
PRKN	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Lin DC (2015), Lin DC (2015)	2
UBC	7	TNIP2	1	unspecified method, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down	Laplantine E (2009), Wagner S (2008), Fenner BJ (2009), Komander D (2009), Lin SM (2017), Lin SM (2017)	6
IKBKG	0	TNFAIP3	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhang SQ (2000), Zhang SQ (2000), Skaug B (2011), Skaug B (2011), Klinkenberg M (2001), Verhelst K (2012), Verhelst K (2012), Wang J (2011), Zilberman-Rudenko J (2016)	9
IRAK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, biochemical	De Nardo D (2005), De Nardo D (2005), De Nardo D (2005)	3
MAVS	1	RIPK2	0	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
IKBKB	1	NFKBIA	0	pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Mercurio F (1999), Cohen L (1998), Woronicz JD (1997), Burke JR (2002), Tsuchiya Y (2010), Tsuchiya Y (2010), Da Silva-Ferrada E (2011), Ducut Sigala JL (2004), Heilker R (1999), Edinger RS (2009), Lee FS (1998), Hai T (2006), Zandi E (1998), Henkler F (2003), Li XH (2001), Byun MS (2006), Mauro C (2003), Zhang W (2010), Munzert G (2002), Shibata Y (2012), Shambharkar PB (2007), Cui J (2010), Li Q (2006), Bernier M (2006), Gao H (2004), Hauenstein AV (2014), Fujita H (2014), Zhang J (2013), Chong RA (2014), Dan HC (2008), Sun L (2004), Criollo A (2010), Liu D (2014), Vincendeau M (2016), Zhang L (2015), Zilberman-Rudenko J (2016), Minassian A (2015), Lindstroem TM (2008), Kim BH (2008), Pandey MK (2008), Joo M (2005), Ninomiya-Tsuji J (2003), Chang YJ (2004), Huang WC (2004), Kim EK (2017), Mei ZZ (2016), Shinohara H (2016), Shkoda A (2012)	48
BCL10	0	CARD10	4	two hybrid, affinity chromatography technology, pull down, biochemical	Wang L (2001), Wang L (2001), Wang L (2001), Stilo R (2004)	4
TRIM40	0	CHUK	5	affinity chromatography technology, affinity chromatography technology	Noguchi K (2011), Noguchi K (2011)	2
TNF	0	TBK1	1	affinity chromatography technology	Kuai J (2004)	1
TBK1	1	SRC	2	affinity chromatography technology	Johnsen IB (2009)	1
CYLD	2	HSP90AA1	7	affinity chromatography technology	Elliott PR (2016)	1
LTBR	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPM1B	2	ANXA1	1	affinity chromatography technology	Ewing RM (2007)	1
CHUK	5	RIPK2	0	enzymatic study	Marinis JM (2012)	1
RIPK2	0	UBC	7	affinity chromatography technology	Park S (2013)	1
SRC	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Funakoshi-Tago M (2005), Funakoshi-Tago M (2005), Lee SH (2012)	3
TNIP1	1	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Gao L (2011)	2
TRAF1	0	CHUK	5	affinity chromatography technology, affinity chromatography technology	Wicovsky A (2009), Henkler F (2003)	2
MAP3K7	2	TAB3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Ishitani T (2003), Ishitani T (2003), Li S (2011), Li S (2011), Mendoza H (2008), Criollo A (2011), Hong S (2007), Minoda Y (2009), Liu R (2014), Shinohara H (2016), Zhang J (2017)	13
TRIM23	3	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Sparrer KMJ (2017), Sparrer KMJ (2017)	2
BIRC3	1	RBCK1	0	affinity chromatography technology	Goncharov T (2013)	1
RNF31	3	PRKN	1	affinity chromatography technology	Khan M (2016)	1
EGFR	5	PPM1B	2	two hybrid	Yao Z (2017)	1
PARP1	3	TRIM29	2	two hybrid, affinity chromatography technology	Ravasi T (2010), Yang H (2015)	2
AKT1	1	CHUK	5	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Ozes ON (1999), Ozes ON (1999), Romashkova JA (1999), Lu Y (2005), Chen TC (2014), Takada Y (2005), Koul D (2001)	7
IKBKE	2	CYLD	2	affinity chromatography technology, affinity chromatography technology	Friedman CS (2008), Zhou AY (2013)	2
EGLN3	0	SQSTM1	0	affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology	Rantanen K (2013), Rantanen K (2013), Rantanen K (2013), Rodriguez J (2016)	4
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
PRKN	1	PLK1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lee SB (2015), Lee SB (2015), Lee SB (2015)	3
NFKBIA	0	BCL10	0	affinity chromatography technology, affinity chromatography technology	Carvalho G (2010), Carvalho G (2010)	2
IKBKB	1	MTOR	14	affinity chromatography technology, affinity chromatography technology, biochemical	Dan HC (2008), Dan HC (2008), Dan HC (2008)	3
TRAF3IP2	0	IKBKB	1	affinity chromatography technology, biochemical, affinity chromatography technology	Leonardi A (2000), Mauro C (2003), Valente AJ (2014)	3
IRAK1	1	RNF31	3	affinity chromatography technology	Yang Y (2014)	1
IKBKG	0	TANK	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Chariot A (2002), Chariot A (2002), Chariot A (2002), Zhang W (2010), Zhang W (2010), Zhao T (2007), Wang J (2011), Wang W (2015), Huttlin EL (2017)	9
CREBBP	29	PARP1	3	enzymatic study, imaging technique	Hassa PO (2005), Chen H (2014)	2
PARP1	3	NFKB1	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Hassa PO (2005), Hassa PO (2005), Amiri KI (2006), Amiri KI (2006), Amiri KI (2006)	5
IKBKB	1	HSP90AA1	7	affinity chromatography technology	Xue J (2010)	1
IFIT5	0	IKBKG	0	affinity chromatography technology, pull down	Zheng C (2015), Zheng C (2015)	2
IKBKB	1	CDC37	0	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen G (2002), Chen G (2002), Li S (2011), Taipale M (2014), Taipale M (2014), Hein MY (2015)	6
EGFR	5	PARP1	3	affinity chromatography technology, affinity chromatography technology	Liccardi G (2014), Yao Z (2017)	2
TRAF6	0	AKT1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yang WL (2009), Mitra S (2011), Mitra S (2011)	3
BIRC3	1	RNF31	3	affinity chromatography technology	Goncharov T (2013)	1
TRAF6	0	KRT8	3	affinity chromatography technology	Dong XM (2016)	1
TNFRSF1A	3	TRAF6	0	affinity chromatography technology	Chang YL (2014)	1
TNFAIP3	3	SRC	2	affinity chromatography technology	Huttlin EL (2017)	1
IKBKG	0	MALT1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Duewel M (2009), Gyrd-Hansen M (2008), Oeckinghaus A (2007), Karim ZA (2015)	4
BIRC2	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Hinz M (2010), Hinz M (2010), Shibata Y (2012), Goncharov T (2013), Fu J (2013)	6
TNFRSF1A	3	SRC	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Narita T (2005), Pincheira R (2008), Darnay BG (1997)	3
TAB2	5	NFKB1	2	pull down, affinity chromatography technology	Baek SH (2002), Baek SH (2002)	2
TAB3	1	TRAF2	1	affinity chromatography technology	Ishitani T (2003)	1
IKBKG	0	USP18	1	affinity chromatography technology, affinity chromatography technology	Yang Z (2015), Yang Z (2015)	2
IRAK1	1	TNFAIP3	3	affinity chromatography technology	Xiong Y (2011)	1
TNFRSF1A	3	TRAF1	0	affinity chromatography technology, pull down, affinity chromatography technology	Hsu H (1996), Mosialos G (1995), Wicovsky A (2009)	3
EPAS1	6	HIF1A	1	affinity chromatography technology	Steunou AL (2012)	1
AKT1	1	IRAK1	1	affinity chromatography technology	Chen BC (2002)	1
EGFR	5	IFIT5	0	affinity chromatography technology	Tong J (2014)	1
RIPK1	2	ANXA1	1	affinity chromatography technology, biochemical, affinity chromatography technology	Bist P (2011), Bist P (2011), Bist P (2011)	3
NCOA3	3	CHUK	5	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique	Wu RC (2002), Wu RC (2002), Wu RC (2002), Jung SY (2005), Wu RC (2004), Park KJ (2005)	6
IKBKG	0	NFKBIB	2	affinity chromatography technology, affinity chromatography technology	Le Page C (2001), Shibata Y (2011)	2
TRAF2	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Huttlin EL (2017)	2
AKT1	1	MTOR	14	pull down, unspecified method, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, imaging technique, enzymatic study, imaging technique	Sekulic A (2000), Cheng SW (2004), Oh WJ (2010), Sarbassov DD (2005), Ikenoue T (2008), Murata H (2011), Martin J (2008), Facchinetti V (2008), Facchinetti V (2008), Chen CH (2011), Xu Y (2013), Glidden EJ (2012), Chen TC (2014), Pitre A (2012), Moon HE (2015)	15
IFIT5	0	MAP3K7	2	affinity chromatography technology	Zheng C (2015)	1
BCL10	0	RNF31	3	affinity chromatography technology, affinity chromatography technology	Yang YK (2016), Yang YK (2016)	2
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
FKBP5	0	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mistafa O (2010), Luo K (2017), Luo K (2017)	3
RACGAP1	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Simon GC (2008), Simon GC (2008)	2
TRAF2	1	MTOR	14	imaging technique	Chen TC (2014)	1
GSK3B	1	BIRC3	1	affinity chromatography technology	Sun M (2009)	1
IKBKB	1	EGLN3	0	affinity chromatography technology, pull down, affinity chromatography technology	Xue J (2010), Xue J (2010), Fu J (2013)	3
IKBKG	0	CNTN2	4	affinity chromatography technology, affinity chromatography technology	Zhao T (2009), Hai T (2006)	2
IKBKB	1	NFKB1	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Heissmeyer V (2001), Heissmeyer V (1999), Beinke S (2002), Beinke S (2002), Beinke S (2002), Chen TC (2014)	6
LTBR	0	TRAF2	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marsters SA (1997), Sanjo H (2010), Sanjo H (2010), Li C (2003), Liu HP (2011), Huttlin EL (2015), Huttlin EL (2017)	7
EGFR	5	TRIM23	3	affinity chromatography technology	Yao Z (2017)	1
HSP90AA1	7	SRC	2	affinity chromatography technology, affinity chromatography technology	Hutchison KA (1992), Tsutsumi S (2012)	2
MAVS	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Wang P (2013), Wang P (2013), Shi Z (2015), Shi Z (2015), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	11
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
IRAK1	1	CDC37	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	De Nardo D (2005), De Nardo D (2005), De Nardo D (2005), De Nardo D (2005)	4
RIPK1	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Li H (2006), Ea CK (2006), Dynek JN (2010), Skaug B (2011), Wagner S (2008), Wu CJ (2006), Legarda-Addison D (2009), Yang Y (2011), Bohgaki M (2008), Lucas PC (2001), Biton S (2011), Zhu G (2007), Zhu G (2007), Keusekotten K (2013), Jeon J (2014), Wu CJ (2006), Vincendeau M (2016), Baratchian M (2016), Zilberman-Rudenko J (2016), Medunjanin S (2016), Bal E (2017), Bal E (2017)	23
TRIM23	3	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sparrer KMJ (2017), Sparrer KMJ (2017), Sparrer KMJ (2017), Sparrer KMJ (2017)	4
LTBR	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PARP1	3	HIF1A	1	affinity chromatography technology	Elser M (2008)	1
HIF1A	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
IKBKB	1	IKBKE	2	enzymatic study, affinity chromatography technology	Heilker R (1999), Zhou AY (2013)	2
CHUK	5	BCL10	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Poyet JL (2001), Poyet JL (2001), Marinis JM (2012), Zhou H (2004)	4
PARP1	3	MACROD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wu Z (2015), Wu Z (2015), Wu Z (2015), Wu Z (2015), Huttlin EL (2017)	5
RIPK1	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim JW (2000), Duan H (1997), Hsu H (1996), Blankenship JW (2009), Newton K (2008), Varfolomeev E (2008), Fearns C (2006), Vince JE (2009), Dynek JN (2010), Kim S (2010), Cheung HH (2009), Tenev T (2011), Mahul-Mellier AL (2011), Won M (2010), Glowacka WK (2012), Fan YH (2011), Cusson-Hermance N (2005), ODonnell MA (2012), Zheng L (2006), Vince JE (2007), Mitsuhashi S (2008), Kim TW (2013), Wertz IE (2004), Liao W (2008), Wang YB (2015), Chang YL (2014), Zilberman-Rudenko J (2016), Zemirli N (2014), Moquin DM (2013), Nakazawa S (2016), Jeong M (2017), Huttlin EL (2017), Elliott PR (2016)	33
RBCK1	0	TAB2	5	affinity chromatography technology, affinity chromatography technology	Tian Y (2007), Tian Y (2007)	2
IKBKG	0	IRAK1	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Conze DB (2008), Conze DB (2008), Windheim M (2008), Windheim M (2008), Ordureau A (2008), Xiong Y (2011), Jeon J (2014), Emmerich CH (2013)	8
RIPK2	0	TNFRSF1A	3	affinity chromatography technology	McCarthy JV (1998)	1
SRC	2	CREBBP	29	pull down, affinity chromatography technology, imaging technique	Whiting RJ (2012), Ruas JL (2005), Ruas JL (2005)	3
TNFRSF1A	3	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Blankenship JW (2009), Vince JE (2009)	2
HSP90AA1	7	RPAP3	1	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down	Gano JJ (2010), Skarra DV (2011), Pal M (2014), Pal M (2014), Pal M (2014)	5
NFKBIA	0	NFKBIB	2	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Pringle LM (2011), Pringle LM (2011), Huttlin EL (2015), Huttlin EL (2017)	4
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
EGLN3	0	EPAS1	6	two hybrid, affinity chromatography technology, pull down	Koeditz J (2007), Steunou AL (2012), Barth S (2007)	3
ZC3H12A	1	HIF1A	1	enzymatic study	Roy A (2013)	1
MAP3K14	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varfolomeev E (2007), Kanno Y (2010), Lee S (2014), Lee S (2014)	4
EGLN3	0	NFKBIA	0	affinity chromatography technology	Rodriguez J (2016)	1
RNF31	3	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Draber P (2015), Nakazawa S (2016), Elliott PR (2016)	3
TRIM14	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique	Zhou Z (2014), Zhou Z (2014), Zhou Z (2014), Tan P (2017), Tan P (2017)	5
TRAF3IP2	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Wu L (2014), Boisson B (2013)	2
RIPK2	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	McCarthy JV (1998), Thome M (1998), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	8
BIRC2	1	TRAF2	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Uren AG (1996), Roy N (1997), Shu HB (1996), Yoneda T (2000), Yoneda T (2000), Li X (2002), Li X (2002), Li X (2002), Behrends C (2010), Samuel T (2006), Samuel T (2006), Samuel T (2006), Silke J (2005), Wu CJ (2005), Vince JE (2009), Csomos RA (2009), Li S (2011), Darding M (2011), Sanjo H (2010), Mace PD (2010), Choi JW (2009), Kanno Y (2010), Jang HD (2001), Rothe M (1995), Rothe M (1995), Cartier J (2011), Varfolomeev E (2006), Varfolomeev E (2006), Shen RR (2012), Shen RR (2012), Goncharov T (2013), Wang J (2011), Marivin A (2013), Shen RR (2012), Park ES (2015), Wang YB (2015), Chen TC (2014), Petersen SL (2015), Huttlin EL (2017), Akhtar N (2016)	41
IKBKG	0	MACROD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Wu Z (2015), Wu Z (2015), Wu Z (2015), Wu Z (2015), Wu Z (2015)	5
EGFR	5	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavictoire SJ (2003), Foerster S (2013), Li J (2013), Li J (2013)	4
MALT1	1	TRAF2	1	pull down, affinity chromatography technology	Sun L (2004), Garrison JB (2009)	2
UBC	7	CHUK	5	pull down	Zhang X (2017)	1
MALT1	1	RBCK1	0	enzymatic study	Klein T (2015)	1
MALT1	1	TRAF6	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun L (2004), Sun L (2004), Garrison JB (2009), Li Y (2013), Oeckinghaus A (2007), Oeckinghaus A (2007), Nie Z (2015), Liu Y (2012), Liu Y (2012)	9
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
NFKB1	2	CHUK	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Heissmeyer V (1999), Beinke S (2002), Beinke S (2002), Beinke S (2002)	4
RBCK1	0	RIPK1	2	affinity chromatography technology	Tian Y (2007)	1
NCOA3	3	CREBBP	29	two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Naltner A (2000), Wu RC (2002), Wu RC (2002), Kamei Y (1996), Naeem H (2007), Naeem H (2007), Torchia J (1997), Torchia J (1997), Torchia J (1997), Torchia J (1997), Takeshita A (1997), Wu RC (2004), Corkery D (2011), Yi P (2005), Ceschin DG (2011)	15
TRAF2	1	IKBKG	0	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Poyet JL (2000), Shen RR (2012), Shen RR (2012), Bal E (2017), Bal E (2017)	6
CYLD	2	BIRC2	1	affinity chromatography technology	Elliott PR (2016)	1
MALT1	1	BCL10	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uren AG (2000), Uren AG (2000), Uren AG (2000), Noels H (2009), Carvalho G (2010), Welteke V (2009), Oruganti SR (2011), Lucas PC (2001), Langel FD (2008), Langel FD (2008), Blonska M (2007), Oeckinghaus A (2007), Park Y (2013), Park Y (2013), Borthakur A (2013), Zhou H (2004), Zhou H (2004), Chen J (2015), Karim ZA (2015), Nie Z (2015), Eitelhuber AC (2011), Paul S (2012), Yang YK (2016), Liu Y (2012), Bidere N (2009), Bidere N (2009), Afonina IS (2016), Howes A (2016)	28
TRAF6	0	USP10	2	affinity chromatography technology	Wang W (2015)	1
RIPK1	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ma Q (2008), Ea CK (2006), Kanayama A (2004), Kanayama A (2004)	4
IKBKG	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Martin P (2006), Zotti T (2014)	2
IKBKB	1	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Huang WC (2003), Huang WC (2003), Funakoshi-Tago M (2005), Chang YJ (2004)	4
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
TAB3	1	IKBKG	0	pull down, pull down	Kanayama A (2004), Emmerich CH (2013)	2
FKBP5	0	HSP90AA1	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Nair SC (1997), Nair SC (1997), Li J (2011), Schuelke JP (2010), Gano JJ (2010), Skarra DV (2011), Horibe T (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Graumann K (2000), Ni L (2010), Luo K (2017)	13
EGLN3	0	RPAP3	1	affinity chromatography technology	Rodriguez J (2016)	1
TRIM14	1	PARP1	3	bioid	Tan P (2017)	1
EGLN3	0	RACGAP1	2	affinity chromatography technology	Rodriguez J (2016)	1
TRAF6	0	CARD11	4	affinity chromatography technology	McCully RR (2008)	1
IKBKG	0	TNIP1	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Ashida H (2010), Wagner S (2008), Wang J (2011)	3
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
IKBKB	1	CHUK	5	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Zandi E (1997), Chen G (2002), Otsuki T (2002), May MJ (2000), May MJ (2000), Woronicz JD (1997), Woronicz JD (1997), Deng L (2000), Yeung KC (2001), Mercurio F (1997), Mercurio F (1997), Rothwarf DM (1998), Wu ZH (2010), Li S (2011), Li S (2011), May MJ (2002), Heilker R (1999), Leotoing L (2011), McKenzie FR (2000), Zandi E (1998), Lee DF (2007), Li XH (2001), Yeh PY (2011), Yeh PY (2011), Stehlik C (2002), Li Q (2006), So J (2015), Chen TC (2014), Karim ZA (2015), Huttlin EL (2017)	30
IKBKG	0	USP7	14	affinity chromatography technology, affinity chromatography technology	Daubeuf S (2009), Li T (2014)	2
GIT2	2	KRT18	2	two hybrid	Wang J (2011)	1
IKBKG	0	KRT18	2	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
EGLN3	0	DYNC1LI1	1	affinity chromatography technology	Rodriguez J (2016)	1
MAP3K7	2	CDC37	0	affinity chromatography technology	Liu XY (2008)	1
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
UBC	7	NSFL1C	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Fenner BJ (2009), Shibata Y (2012), Alexandru G (2008), Raasi S (2005), Zhang X (2017)	5
GIT2	2	TRAF1	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
NCOA3	3	IKBKG	0	affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology	Wu RC (2002), Wu RC (2002), Wu RC (2002), Wu RC (2002), Jung SY (2005)	5
TNFRSF1A	3	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahmad R (2007), Fan YH (2011), Cusson-Hermance N (2005), Blonska M (2005), Mitsuhashi S (2008)	5
PPM1B	2	CHUK	5	affinity chromatography technology, affinity chromatography technology, imaging technique	Prajapati S (2004), Prajapati S (2004), Chen TC (2014)	3
BIRC3	1	BCL10	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Yoneda T (2000), Hu S (2006), Yui D (2001), Hu S (2006), Hu S (2006), Hu S (2006), Hu S (2006)	7
IKBKG	0	MAP3K14	1	affinity chromatography technology, affinity chromatography technology	Li Y (1999), Huttlin EL (2017)	2
LTBR	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TAB2	5	IKBKB	1	enzymatic study	Niu J (2011)	1
TRAF1	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, two hybrid	Hsu H (1996), Wicovsky A (2009), Rolland T (2014)	3
PPM1B	2	CDK2	0	enzymatic study, biochemical	Cheng A (2000), Cheng A (2000)	2
SQSTM1	0	IRAK1	1	affinity chromatography technology	Sanz L (2000)	1
NFKBIA	0	MAP3K14	1	pull down	Cohen L (1998)	1
MALT1	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Oeckinghaus A (2007), Karim ZA (2015)	2
TRAF6	0	IKBKB	1	affinity chromatography technology	Bidere N (2006)	1
CHUK	5	IKBKE	2	enzymatic study	Heilker R (1999)	1
IKBKG	0	EGLN3	0	affinity chromatography technology, affinity chromatography technology, pull down	Fu J (2013), Fu J (2013), Fu J (2013)	3
NCOA3	3	IKBKB	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Wu RC (2002), Wu RC (2002), Wu RC (2002), Wu RC (2002), Wu RC (2002), Wu RC (2002), Jung SY (2005)	7
TNF	0	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Tokunaga F (2012), Verhelst K (2012), Keusekotten K (2013), Fu J (2013), Schaeffer V (2014), Draber P (2015)	7
IKBKG	0	ZC3H12A	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Niu J (2013), Niu J (2013), Wang W (2015)	3
CHUK	5	TRAF2	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Regnier CH (1997), Devin A (2001), Li S (2009), Shen RR (2012), Zhang W (2010), Chen TC (2014)	6
AKT1	1	TBK1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Joung SM (2011), Joung SM (2011), Joung SM (2011)	3
RNF31	3	TRAF6	0	enzymatic study	Kliza K (2017)	1
UBC	7	SHARPIN	1	pull down	Zhang X (2017)	1
ATM	9	PARP1	3	pull down	Haince JF (2007)	1
MAP3K7	2	BCL10	0	affinity chromatography technology	Blonska M (2007)	1
EGLN3	0	TAB2	5	affinity chromatography technology	Rodriguez J (2016)	1
IKBKB	1	IKBKG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, biochemical, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, pull down, affinity chromatography technology	Chen G (2002), Chen G (2002), Chariot A (2002), Wu RC (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010), Lee KY (2005), Rothwarf DM (1998), Ea CK (2006), Thurston TL (2009), Orel L (2010), Wu ZH (2010), Napolitano G (2009), Liu J (2009), Skaug B (2011), Li S (2011), Li S (2011), Kensche T (2012), Chiaravalli J (2011), Wu CJ (2006), Wu ZH (2006), Ahmad R (2007), Ahmad R (2007), Palkowitsch L (2008), Palkowitsch L (2008), Lo YC (2008), Mabb AM (2006), Baima ET (2010), Tegethoff S (2003), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), Lee DF (2007), Rottenberg S (2002), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Funakoshi-Tago M (2005), Ivins FJ (2009), Shibata Y (2012), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Wu ZH (2008), Mitsuhashi S (2008), Fujita H (2014), Golden MS (2013), Lee SH (2012), Cote SM (2013), Kim HJ (2014), Jackson SS (2014), Liao W (2008), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), So J (2015), Liu D (2014), Guo B (2014), Guo B (2014), Guo B (2014), Zhou L (2014), Zhou L (2014), Hein MY (2015), Bagneris C (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Rushe M (2008), Hauenstein AV (2017), Bal E (2017)	78
TNFAIP3	3	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Gao L (2011), Saitoh T (2005)	3
SHARPIN	1	IKBKB	1	affinity chromatography technology	Tokunaga F (2011)	1
GIT2	2	TNFAIP3	3	two hybrid	Wang J (2011)	1
EGFR	5	DYNC1LI1	1	affinity chromatography technology	Tong J (2014)	1
IKBKG	0	NSFL1C	1	affinity chromatography technology, affinity chromatography technology	Shibata Y (2012), Medunjanin S (2016)	2
CDK2	0	ANXA1	1	affinity chromatography technology	Neganova I (2011)	1
BIRC3	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
RIPK1	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao L (2015), Ding Z (2015), Varfolomeev E (2015)	3
EGFR	5	TBK1	1	affinity chromatography technology	Tong J (2014)	1
CDK2	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Varjosalo M (2013)	2
EGFR	5	MTOR	14	affinity chromatography technology	Foerster S (2013)	1
MAP3K7	2	CYLD	2	affinity chromatography technology, affinity chromatography technology	Koga T (2008), Elliott PR (2016)	2
RNF31	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Niu J (2011), Fujita H (2014), Tokunaga F (2011), Tokunaga F (2011), Xia ZP (2009), Fu J (2013), Emmerich CH (2013), Chen Y (2015), Bal E (2017)	11
TNFAIP3	3	RBCK1	0	affinity chromatography technology, two hybrid	Verhelst K (2012), Hayes SD (2012)	2
IKBKB	1	TRAF1	0	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid	Sughra K (2010), Sughra K (2010), Sughra K (2010), Henkler F (2003)	4
CYLD	2	PLK1	0	affinity chromatography technology, affinity chromatography technology	Stegmeier F (2007), Stegmeier F (2007)	2
TRAF1	0	TRAF6	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Wang J (2011), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	4
PARP1	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology, pull down	Wu Z (2015), Wu Z (2015), Wu Z (2015)	3
MTOR	14	IKBKG	0	affinity chromatography technology, biochemical	Dan HC (2008), Dan HC (2008)	2
EGLN3	0	CREBBP	29	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	GSK3B	1	affinity chromatography technology	Rodriguez J (2016)	1
TAB2	5	TANK	1	affinity chromatography technology	Kanayama A (2004)	1
IKBKG	0	TRIM29	2	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ravasi T (2010), Xing J (2016), Xing J (2016), Xing J (2016)	4
NFKB1	2	PPP4C	0	affinity chromatography technology	Hu MC (1998)	1
BIRC2	1	TNFAIP3	3	affinity chromatography technology	Yamaguchi N (2013)	1
RBCK1	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Donley C (2013), Donley C (2013)	2
IKBKG	0	DYNC1LI1	1	far western blotting, fluorescent resonance energy transfe	Horgan CP (2010), Horgan CP (2010)	2
RIPK1	2	TNFAIP3	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Shembade N (2009), Wertz IE (2004), Wertz IE (2004), Wertz IE (2004), Shembade N (2008), Bellail AC (2012)	6
GSK3B	1	IKBKG	0	imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), Medunjanin S (2016), Medunjanin S (2016), Medunjanin S (2016)	4
TAB3	1	CARD11	4	affinity chromatography technology	Shinohara H (2016)	1
TNF	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Fritsch J (2014)	2
PPM1B	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Prajapati S (2004), Prajapati S (2004)	2