PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HIST2H2AC	1	HIST2H2BE	1	pull down	Long L (2014)	1
MYC	2	SQSTM1	0	affinity chromatography technology	Koch HB (2007)	1
IKBKG	0	CDK2	0	pull down, affinity chromatography technology, two hybrid	Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010)	3
FBXO7	1	PARP10	4	affinity chromatography technology	Hein MY (2015)	1
PARP14	2	PARP10	4	pull down	Forst AH (2013)	1
HNRNPL	3	PARP10	4	affinity chromatography technology	Fei T (2017)	1
PARP10	4	MYC	2	affinity chromatography technology, pull down, pull down, imaging technique	Yu M (2005), Yu M (2005), Yu M (2005), Kleine H (2012)	4
HIST2H2AC	1	HIST1H3A	3	pull down, pull down, pull down	Hoffmann A (1996), Hoffmann A (1996), Boenisch C (2012)	3
CDK2	0	PARP10	4	affinity chromatography technology	Hein MY (2015)	1
HIST2H2AC	1	UBC	7	pull down, pull down	Long L (2014), Zhang X (2017)	2
SQSTM1	0	UBC	7	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, affinity chromatography technology, unspecified method, pull down, pull down, pull down, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, imaging technique, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Vinayagam A (2011), Vadlamudi RK (1996), Tanji K (2012), Matsumoto G (2011), Long J (2008), Long J (2008), Najat D (2009), Najat D (2009), Hocking LJ (2004), Boh BK (2011), Long J (2010), Seibenhener ML (2004), Seibenhener ML (2004), Seibenhener ML (2004), Fenner BJ (2009), Nathan JA (2013), Ciani B (2003), Shi J (2013), Goode A (2014), Bish RA (2007), Lu K (2014), Zhou L (2014), Zhou L (2014), Vadlamudi RK (1996), Long J (2008), Cavey JR (2006), Cavey JR (2006), Kirkin V (2009), Nakayasu ES (2013), Nakayasu ES (2013), Lim J (2015), Milan E (2015), Milan E (2015), Ordureau A (2015), Wurzer B (2015), Zhang X (2017), Wang L (2017), Liu X (2017), Peng H (2017), Donohue E (2014), Nibe Y (2017), Nibe Y (2017), Govindaraju VK (2017)	43
CDK2	0	HIST1H4A	0	enzymatic study	Yuan WC (2011)	1
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
PARP10	4	SQSTM1	0	imaging technique, affinity chromatography technology, affinity chromatography technology	Kleine H (2012), Kleine H (2012), Kleine H (2012)	3
CDK2	0	RAN	1	affinity chromatography technology	Neganova I (2011)	1
RASSF8	2	PARP10	4	affinity chromatography technology	Hein MY (2015)	1
PARP10	4	HIST1H3A	3	enzymatic study	Yu M (2005)	1
CDK2	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koundrioukoff S (2000), Zhang H (1993), Neganova I (2011), Wu SM (1998), Chen Z (2002), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	8
HIST2H2BE	1	UBC	7	pull down	Long L (2014)	1
UBC	7	PARP10	4	pull down, pull down	Nicolae CM (2014), Verheugd P (2013)	2
IKBKG	0	PARP14	2	affinity chromatography technology	Verheugd P (2013)	1
CDK2	0	HIST2H2BE	1	affinity chromatography technology	Neganova I (2011)	1
PARP10	4	RAN	1	enzymatic study	Forst AH (2013)	1
HIST1H3A	3	HIST1H4A	0	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Tagami H (2004), Shiio Y (2003), Zippo A (2009), Soldi M (2013), Klement K (2014), Sato K (2012)	6
IKBKG	0	PARP10	4	affinity chromatography technology, enzymatic study	Verheugd P (2013), Verheugd P (2013)	2
HIST1H4A	0	HIST2H2AC	1	pull down, pull down	Shiio Y (2003), Boenisch C (2012)	2
PARP10	4	HIST2H2AC	1	enzymatic study	Yu M (2005)	1
PARP10	4	HIST1H4A	0	enzymatic study	Yu M (2005)	1
PARP10	4	HIST2H2BE	1	enzymatic study	Yu M (2005)	1
MYC	2	CDK2	0	genetic interference, genetic interference	Toyoshima M (2012), Zhou Z (2014)	2
UBC	7	FBXO7	1	affinity chromatography technology	Matsumoto M (2005)	1
IKBKG	0	MYC	2	affinity chromatography technology	Kim BY (2010)	1
PCNA	0	PARP10	4	fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Nicolae CM (2014), Nicolae CM (2014), Nicolae CM (2014), Nicolae CM (2014), Nicolae CM (2014)	5
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
IKBKG	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Martin P (2006), Zotti T (2014)	2
HIST1H4A	0	HIST2H2BE	1	pull down	Shiio Y (2003)	1
GAK	5	PARP10	4	affinity chromatography technology	Hein MY (2015)	1