PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KMT5C	1	CBX3	1	affinity chromatography technology	Schotta G (2004)	1
KMT5C	1	PSTPIP1	3	affinity chromatography technology	Zhao Z (2016)	1
HIST1H4A	0	CBX3	1	pull down	Shiio Y (2003)	1
CBX1	0	CBX3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Rosnoblet C (2011), Hauri S (2016), Hauri S (2016)	8
KMT5C	1	HIST1H4A	0	enzymatic study	Schotta G (2004)	1
HIST1H4A	0	MCM7	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saade E (2009), Saade E (2009), Huttlin EL (2017)	3
KMT5C	1	HSPA4	3	affinity chromatography technology	Souza PP (2009)	1
CBX1	0	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Mateos-Langerak J (2007), Rosnoblet C (2011), Nozawa RS (2010), Hauri S (2016), Hauri S (2016)	10
KMT5C	1	CBX1	0	affinity chromatography technology, pull down, affinity chromatography technology	Souza PP (2009), Souza PP (2009), Schotta G (2004)	3
KMT5C	1	CBX5	3	affinity chromatography technology, pull down, affinity chromatography technology	Souza PP (2009), Souza PP (2009), Schotta G (2004)	3
KMT5C	1	TUB	5	affinity chromatography technology	Souza PP (2009)	1
KMT5C	1	EEF1A1	0	affinity chromatography technology	Souza PP (2009)	1
CBX3	1	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Quivy JP (2004), Quivy JP (2004), Quivy JP (2004), Kiyomitsu T (2010), Rosnoblet C (2011), Nozawa RS (2010), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016), Hauri S (2016)	15
KMT5C	1	MCM7	5	affinity chromatography technology	Souza PP (2009)	1
EEF1A1	0	GTF2I	1	biochemical	Havugimana PC (2012)	1
KMT5C	1	NEDD4	2	affinity chromatography technology	Zhao Z (2016)	1
KMT5C	1	GTF2I	1	affinity chromatography technology	Souza PP (2009)	1