PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FHL2	0	SRF	1	pull down, affinity chromatography technology, affinity chromatography technology	Philippar U (2004), Philippar U (2004), Philippar U (2004)	3
TRIM63	0	USP4	3	enzymatic study	Loch CM (2012)	1
TRIM63	0	HIBADH	1	two hybrid	Witt SH (2005)	1
TRIM63	0	PDHB	1	two hybrid, two hybrid	Hirner S (2008), Witt SH (2005)	2
PSMD4	1	CKM	0	affinity chromatography technology	Weekes J (2003)	1
EEF1G	0	PSMD4	1	genetic interference	Horlbeck MA (2018)	1
USP28	3	USP33	1	enzymatic study	Loch CM (2012)	1
USP7	14	SUMO2	0	enzymatic study	Lecona E (2016)	1
TRIM63	0	SENP3	1	enzymatic study	Loch CM (2012)	1
USP28	3	OTUB2	0	enzymatic study	Loch CM (2012)	1
USP5	2	APP	1	pull down	Olah J (2011)	1
TRIM54	1	YOD1	0	enzymatic study	Loch CM (2012)	1
UBE2I	0	TRIM63	0	two hybrid	McElhinny AS (2002)	1
USP28	3	JOSD1	1	enzymatic study	Loch CM (2012)	1
TRIM54	1	USP33	1	enzymatic study	Loch CM (2012)	1
TRIM63	0	YOD1	0	enzymatic study	Loch CM (2012)	1
DES	1	EHHADH	1	two hybrid	Rolland T (2014)	1
TRIM63	0	ATXN3L	0	enzymatic study	Loch CM (2012)	1
TRIM63	0	UCHL3	1	enzymatic study	Loch CM (2012)	1
PKM	1	MYL2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Jiang Y (2014), Jiang Y (2014), Jiang Y (2014), Jiang Y (2014), Jiang Y (2014)	5
SUMO2	0	SENP2	3	two hybrid, pull down	Rolland T (2014), Ouyang J (2009)	2
TRIM54	1	USP5	2	enzymatic study	Loch CM (2012)	1
TTN	102	TRIM63	0	two hybrid, pull down, two hybrid, x-ray crystallography, pull down, two hybrid	Centner T (2001), Centner T (2001), Witt SH (2005), Mrosek M (2007), Bogomolovas J (2014), Witt CC (2008)	6
TNNC1	2	TNNI1	0	pull down, x-ray crystallography, two hybrid, two hybrid	Lindhout DA (2002), Julien O (2008), Mogensen J (2004), Wang J (2011)	4
USP5	2	UCHL3	1	biochemical	Havugimana PC (2012)	1
TRIM63	0	NEBL	4	two hybrid	Witt CC (2008)	1
TRIM63	0	SUMO2	0	two hybrid, pull down	Dai KS (2001), Dai KS (2001)	2
UXT	0	APP	1	pull down	Olah J (2011)	1
ATXN3	2	USP13	2	affinity chromatography technology	Sowa ME (2009)	1
PKM	1	ALDOA	0	biochemical	Wan C (2015)	1
SENP2	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
TRIM55	2	TCAP	0	two hybrid	Witt CC (2008)	1
TRIM54	1	UCHL1	1	enzymatic study	Loch CM (2012)	1
UBE2I	0	TRIM54	1	two hybrid	McElhinny AS (2002)	1
TRIM63	0	SENP2	3	enzymatic study	Loch CM (2012)	1
TRIM63	0	ACTA1	1	enzymatic study, pull down, biochemical, two hybrid	Polge C (2011), Polge C (2011), Polge C (2011), Witt CC (2008)	4
TRIM54	1	USP7	14	enzymatic study	Loch CM (2012)	1
MYOT	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
USP21	2	USP28	3	enzymatic study, enzymatic study	Loch CM (2012), Loch CM (2012)	2
TRIM63	0	HSPA4	3	affinity chromatography technology	Kawaguchi Y (2017)	1
TRIM63	0	PIAS2	2	two hybrid	Witt CC (2008)	1
TRIM63	0	THRA	2	affinity chromatography technology, pull down, enzymatic study	Wadosky KM (2016), Wadosky KM (2016), Wadosky KM (2016)	3
TRIM63	0	ALDOA	0	two hybrid	Witt SH (2005)	1
TRIM63	0	EIF3E	1	two hybrid	Witt CC (2008)	1
SUMO2	0	ALDOA	0	biochemical	Wan C (2015)	1
UBE2I	0	TRIM55	2	two hybrid, affinity chromatography technology	McElhinny AS (2002), Lange S (2005)	2
UBE2I	0	APP	1	enzymatic study	Gocke CB (2005)	1
TRIM55	2	MRPL19	0	two hybrid	Witt CC (2008)	1
SUMO2	0	EEF1G	0	pull down	Ouyang J (2009)	1
MRPL19	0	APP	1	pull down	Olah J (2011)	1
TRIM55	2	OTUB1	0	enzymatic study	Loch CM (2012)	1
UCHL5	1	PKM	1	pull down	Fang Y (2011)	1
TRIM55	2	ESPL1	2	enzymatic study	Loch CM (2012)	1
TRIM63	0	TRIM54	1	two hybrid, pull down	Centner T (2001), Centner T (2001)	2
SUMO2	0	UBE2I	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Li T (2006), Knipscheer P (2007), Boutell C (2011), Hecker CM (2006), Hecker CM (2006), Zilio N (2013), Tatham MH (2001), Knipscheer P (2007), Ullmann R (2012), Matic I (2008), Xu Y (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	14
TRIM63	0	USP2	0	enzymatic study	Loch CM (2012)	1
TRIM63	0	SRF	1	two hybrid	Lange S (2005)	1
TRIM63	0	EHHADH	1	two hybrid	Witt CC (2008)	1
TRIM63	0	UQCRC1	1	two hybrid, two hybrid	Witt SH (2005), Witt CC (2008)	2
TRIM63	0	MRPL41	2	two hybrid, pull down	Witt CC (2008), Witt CC (2008)	2
OTUB2	0	APP	1	pull down	Olah J (2011)	1
TRIM63	0	GFM1	0	two hybrid, pull down	Witt CC (2008), Witt CC (2008)	2
USP15	4	USP7	14	enzymatic study	Loch CM (2012)	1
FLNC	8	MYOZ1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Takada F (2001), Takada F (2001), Frey N (2002), Faulkner G (2000)	4
TRIM63	0	CKM	0	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Koyama S (2008), Koyama S (2008), Witt SH (2005), Witt CC (2008)	4
TRIM55	2	FLNC	8	two hybrid	Witt CC (2008)	1
ALDOA	0	CKB	1	biochemical	Wan C (2015)	1
TRIM63	0	MYOT	0	two hybrid, two hybrid	Witt SH (2005), Witt CC (2008)	2
ENO3	4	APP	1	pull down	Olah J (2011)	1
HSPD1	0	HSPA4	3	biochemical	Wan C (2015)	1
SQSTM1	0	UBE2D3	1	two hybrid, affinity chromatography technology, pull down, enzymatic study, pull down	Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017)	5
AK1	2	APP	1	pull down	Olah J (2011)	1
TRIM55	2	NDUFA1	0	two hybrid	Witt CC (2008)	1
TRIM55	2	TTN	102	two hybrid	Witt CC (2008)	1
USP21	2	UCHL3	1	enzymatic study	Loch CM (2012)	1
USP21	2	ESPL1	2	enzymatic study	Loch CM (2012)	1
TRIM55	2	GMEB1	4	two hybrid	Witt CC (2008)	1
USP21	2	BAP1	4	enzymatic study	Loch CM (2012)	1
TRIM63	0	USP33	1	enzymatic study	Loch CM (2012)	1
FHL2	0	AK1	2	pull down	Lange S (2002)	1
TRIM63	0	BAP1	4	enzymatic study	Loch CM (2012)	1
PIAS2	2	PIAS1	4	imaging technique	Chen TC (2014)	1
APP	1	UCHL1	1	affinity chromatography technology	Zhang M (2014)	1
USP28	3	UCHL3	1	enzymatic study	Loch CM (2012)	1
USP21	2	ATXN3	2	enzymatic study	Loch CM (2012)	1
TRIM54	1	STAM	3	enzymatic study	Loch CM (2012)	1
TRIM55	2	SQSTM1	0	affinity chromatography technology, two hybrid	Lange S (2005), Witt CC (2008)	2
USP21	2	OTUB2	0	enzymatic study	Loch CM (2012)	1
USP7	14	PKM	1	affinity chromatography technology, affinity chromatography technology	Park JJ (2015), Park JJ (2015)	2
PDHB	1	FHL2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM54	1	USP8	7	enzymatic study	Loch CM (2012)	1
TRIM55	2	USP5	2	enzymatic study	Loch CM (2012)	1
USP15	4	YOD1	0	enzymatic study	Loch CM (2012)	1
USP15	4	SENP3	1	enzymatic study	Loch CM (2012)	1
USP28	3	ESPL1	2	enzymatic study	Loch CM (2012)	1
TRIM63	0	ANKRD1	0	two hybrid, pull down	Witt CC (2008), Witt CC (2008)	2
USP15	4	USP33	1	enzymatic study	Loch CM (2012)	1
TRIM63	0	TNNI3	0	two hybrid, enzymatic study	Witt CC (2008), Kim HT (2007)	2
USP28	3	BAP1	4	enzymatic study	Loch CM (2012)	1
UBE2J1	1	TRIM63	0	two hybrid	van Wijk SJ (2009)	1
USP28	3	STAM	3	enzymatic study	Loch CM (2012)	1
USP21	2	USP7	14	enzymatic study	Loch CM (2012)	1
THRA	2	HSPA4	3	affinity chromatography technology	Jeyakumar M (2007)	1
SUMO2	0	PIAS1	4	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Gocke CB (2008), Stehmeier P (2009), Stehmeier P (2009), Ullmann R (2012), Hecker CM (2006), Hecker CM (2006), Ullmann R (2012), Ullmann R (2012), Ouyang J (2009)	9
PSMD4	1	APP	1	pull down	Olah J (2011)	1
TRIM54	1	JOSD1	1	enzymatic study	Loch CM (2012)	1
ATP5B	0	UQCRC1	1	biochemical	Havugimana PC (2012)	1
TRIM63	0	USP8	7	enzymatic study	Loch CM (2012)	1
CKB	1	CKM	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM54	1	ATXN3	2	enzymatic study	Loch CM (2012)	1
UBE2I	0	PIAS3	2	two hybrid, two hybrid	Bandyopadhyay S (2010), Wang J (2011)	2
TRIM63	0	NEB	21	two hybrid, two hybrid	Witt SH (2005), Witt CC (2008)	2
TRIM63	0	ATXN3	2	enzymatic study	Loch CM (2012)	1
UCHL5	1	APP	1	pull down	Olah J (2011)	1
TRIM63	0	TRIM63	0	two hybrid, pull down, enzymatic study, enzymatic study, two hybrid, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Centner T (2001), Centner T (2001), Bosanac I (2011), Uchiki T (2009), Lange S (2005), Mrosek M (2008), Mrosek M (2008), Marblestone JG (2012), Kenten JH (2005), Thom CS (2014), Wadosky KM (2016), Kim HT (2007), Eddins MJ (2011)	13
MYOZ1	1	TRIM63	0	two hybrid, two hybrid, pull down	Moriscot AS (2010), Witt CC (2008), Witt CC (2008)	3
TRIM63	0	EEF1G	0	two hybrid, pull down	Witt CC (2008), Witt CC (2008)	2
OTUB1	0	UBE2N	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Nakada S (2010), Nakada S (2010), Sato Y (2012), Sato Y (2012), Sato Y (2012), Wiener R (2012), Herhaus L (2013), Herhaus L (2015), Scholz CC (2016), Boldt K (2016), Weber E (2017)	12
TRIM63	0	PSMD4	1	enzymatic study, enzymatic study	Uchiki T (2009), Kim HT (2012)	2
USP28	3	USP4	3	enzymatic study	Loch CM (2012)	1
ATXN3	2	SQSTM1	0	affinity chromatography technology, pull down	Zhou L (2014), Zhou L (2014)	2
MYOZ1	1	APP	1	pull down	Olah J (2011)	1
TRIM63	0	UXT	0	two hybrid	Witt CC (2008)	1
TRIM63	0	PDK4	0	two hybrid	Hirner S (2008)	1
UBE2K	0	UBE2N	1	biochemical	Wan C (2015)	1
TRIM55	2	MYOZ1	1	two hybrid	Witt CC (2008)	1
TRIM54	1	USP15	4	enzymatic study	Loch CM (2012)	1
TRIM55	2	ANKRD1	0	two hybrid, pull down	Witt CC (2008), Witt CC (2008)	2
TRIM63	0	NRAP	3	two hybrid	Witt SH (2005)	1
TRIM55	2	PIAS2	2	two hybrid	Witt CC (2008)	1
USP4	3	USP15	4	affinity chromatography technology, enzymatic study, affinity chromatography technology	Zhang L (2012), Loch CM (2012), Das T (2017)	3
TNNC1	2	TNNT1	0	two hybrid	Stefancsik R (1998)	1
TRIM63	0	UBE2D1	0	pull down, pull down, pull down	Bosanac I (2011), Uchiki T (2009), Kim HT (2007)	3
TRIM63	0	ATP5B	0	two hybrid, enzymatic study	Witt CC (2008), Rubel CE (2013)	2
HSPD1	0	APP	1	affinity chromatography technology, pull down	Kumar P (2007), Olah J (2011)	2
PSMD4	1	SQSTM1	0	affinity chromatography technology	Seibenhener ML (2004)	1
TRIM55	2	UCHL5	1	enzymatic study	Loch CM (2012)	1
ENO3	4	PKM	1	biochemical	Havugimana PC (2012)	1
USP15	4	UCHL3	1	enzymatic study	Loch CM (2012)	1
TRIM63	0	FHL2	0	two hybrid	Witt CC (2008)	1
UBE2D1	0	TRIM55	2	two hybrid	Markson G (2009)	1
USP21	2	SENP3	1	enzymatic study	Loch CM (2012)	1
TRIM55	2	USP7	14	enzymatic study	Loch CM (2012)	1
TRIM55	2	ATP5B	0	two hybrid	Witt CC (2008)	1
USP21	2	JOSD1	1	enzymatic study	Loch CM (2012)	1
TRIM54	1	UBE2D3	1	pull down	Loch CM (2012)	1
TRIM54	1	USP4	3	enzymatic study	Loch CM (2012)	1
UBE2D2	0	TRIM55	2	two hybrid	Markson G (2009)	1
TRIM63	0	PIAS3	2	two hybrid	Witt CC (2008)	1
NEB	21	DES	1	two hybrid	Bang ML (2001)	1
LMCD1	0	APP	1	pull down	Olah J (2011)	1
USP21	2	USP33	1	enzymatic study	Loch CM (2012)	1
UBE2D3	1	OTUB1	0	two hybrid, enzymatic study, pull down, affinity chromatography technology	Rolland T (2014), Li Y (2014), Li Y (2014), Scholz CC (2016)	4
USP7	14	UBE2D3	1	enzymatic study	Zhang ZM (2015)	1
USP21	2	USP15	4	enzymatic study, enzymatic study	Loch CM (2012), Loch CM (2012)	2
TRIM55	2	USP4	3	enzymatic study	Loch CM (2012)	1
UBE2U	0	TRIM63	0	two hybrid	van Wijk SJ (2009)	1
TRIM55	2	ACTA1	1	two hybrid	Witt CC (2008)	1
TRIM55	2	UCHL3	1	enzymatic study	Loch CM (2012)	1
UBE2D3	1	TRIM55	2	two hybrid, pull down	Markson G (2009), Loch CM (2012)	2
USP2	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
TRIM55	2	EEF1G	0	two hybrid, pull down	Witt CC (2008), Witt CC (2008)	2
FHL2	0	APP	1	pull down	Olah J (2011)	1
TRIM63	0	ENO3	4	two hybrid	Hirner S (2008)	1
TCAP	0	TTN	102	two hybrid, enzymatic study, biochemical, two hybrid, pull down, two hybrid, enzymatic study	Gregorio CC (1998), Mayans O (1998), Zou P (2003), Zou P (2003), Mues A (1998), Mues A (1998), Lange S (2005)	7
TRIM63	0	JOSD1	1	enzymatic study	Loch CM (2012)	1
TRIM63	0	UBE2N	1	pull down	Kim HT (2007)	1
TRIM63	0	UBE2D3	1	pull down, pull down, pull down	Loch CM (2012), Thom CS (2014), Rubel CE (2013)	3
USP15	4	STAM	3	enzymatic study	Loch CM (2012)	1
OTUB1	0	UBE2D2	0	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Nakada S (2010), Juang YC (2012), Ernst A (2013), Juang YC (2012), Huttlin EL (2015), Scholz CC (2016), Huttlin EL (2017)	8
TRIM55	2	OTUB2	0	enzymatic study	Loch CM (2012)	1
TRIM63	0	PIAS1	4	two hybrid	Witt CC (2008)	1
USP28	3	USP15	4	enzymatic study	Loch CM (2012)	1
USP15	4	ALDOA	0	affinity chromatography technology	Sowa ME (2009)	1
EHHADH	1	TRIM54	1	two hybrid	Rolland T (2014)	1
USP28	3	OTUB1	0	enzymatic study	Loch CM (2012)	1
TRIM63	0	PKM	1	two hybrid, two hybrid	Hirner S (2008), Witt SH (2005)	2
TRIM63	0	FLNC	8	two hybrid	Witt CC (2008)	1
TRIM54	1	SENP3	1	enzymatic study	Loch CM (2012)	1
PSMD4	1	ALDOA	0	affinity chromatography technology	Weekes J (2003)	1
TRIM55	2	EIF3E	1	two hybrid	Witt CC (2008)	1
USP8	7	OTUB1	0	affinity chromatography technology	Soares L (2004)	1
USP15	4	CKB	1	affinity chromatography technology	Sowa ME (2009)	1
UBE2I	0	UBE2K	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, biochemical	Knipscheer P (2008), Gruenwald M (2011), Pichler A (2005), Galisson F (2011), Wan C (2015)	5
SUMO2	0	SENP3	1	two hybrid, pull down	Nishida T (2000), Ouyang J (2009)	2
TRIM55	2	MYBPC1	4	two hybrid	Witt CC (2008)	1
UBE2U	0	TRIM54	1	two hybrid	van Wijk SJ (2009)	1
TRIM63	0	PYGM	0	two hybrid	Hirner S (2008)	1
USP28	3	USP5	2	enzymatic study	Loch CM (2012)	1
TRIM54	1	UCHL5	1	enzymatic study	Loch CM (2012)	1
HSPA4	3	APP	1	affinity chromatography technology	Kumar P (2007)	1
TRIM63	0	MRPL19	0	two hybrid	Witt CC (2008)	1
ACTA1	1	NRAP	3	pull down	Luo G (1999)	1
MYOT	0	FLNC	8	affinity chromatography technology	van der Ven PF (2000)	1
TRIM63	0	OTUB2	0	enzymatic study	Loch CM (2012)	1
TRIM63	0	MYL2	1	two hybrid	Witt SH (2005)	1
TRIM54	1	OTUB2	0	enzymatic study, two hybrid	Loch CM (2012), Rolland T (2014)	2
TRIM55	2	ATXN3L	0	enzymatic study	Loch CM (2012)	1
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
TTN	102	ANKRD1	0	two hybrid, pull down, two hybrid	Miller MK (2003), Miller MK (2003), Miller MK (2003)	3
FHL2	0	CKM	0	pull down	Lange S (2002)	1
OTUB1	0	UBE2D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sun XX (2011), Herhaus L (2013), Li Y (2014), Scholz CC (2016)	4
TRIM55	2	MYOT	0	two hybrid	Witt CC (2008)	1
UCHL5	1	PSMD4	1	affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Qiu XB (2006), Yao T (2008), Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	6
SQSTM1	0	HSPA4	3	pull down, affinity chromatography technology	Pridgeon JW (2004), Pridgeon JW (2004)	2
UBE2I	0	THRA	2	enzymatic study	Liu YY (2012)	1
TRIM63	0	TRIM55	2	two hybrid, two hybrid	Centner T (2001), Witt CC (2008)	2
TRIM63	0	OTUB1	0	enzymatic study	Loch CM (2012)	1
TRIM63	0	DCAF6	0	two hybrid	Witt CC (2008)	1
SUMO2	0	PIAS2	2	two hybrid, two hybrid, pull down, pull down, pull down	Stehmeier P (2009), Hecker CM (2006), Hecker CM (2006), Ullmann R (2012), Ouyang J (2009)	5
SUMO2	0	PIAS3	2	two hybrid, two hybrid, pull down	Stehmeier P (2009), Hecker CM (2006), Hecker CM (2006)	3
TRIM55	2	EHHADH	1	two hybrid	Witt CC (2008)	1
TRIM63	0	NOMO1	2	two hybrid	Witt CC (2008)	1
HSPD1	0	GFM1	0	affinity chromatography technology	Huttlin EL (2017)	1
TRIM63	0	LMCD1	0	two hybrid	Witt CC (2008)	1
TRIM63	0	UBE2D2	0	pull down	Polge C (2011)	1
USP21	2	USP8	7	enzymatic study	Loch CM (2012)	1
TRIM63	0	NDUFA1	0	two hybrid	Witt CC (2008)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
TRIM63	0	UBE2K	0	pull down	Kim HT (2007)	1
TRIM63	0	TNNI2	2	two hybrid, two hybrid	Witt SH (2005), Witt CC (2008)	2
TRIM63	0	USP28	3	enzymatic study	Loch CM (2012)	1
PSMD4	1	ATP5B	0	affinity chromatography technology	Weekes J (2003)	1
TRIM55	2	LMCD1	0	two hybrid	Witt CC (2008)	1
FLNC	8	TRIM54	1	affinity chromatography technology, two hybrid	Fielitz J (2007), Fielitz J (2007)	2
ALDOA	0	HSPD1	0	biochemical	Havugimana PC (2012)	1
TRIM63	0	TNNI1	0	enzymatic study, two hybrid	Uchiki T (2009), Witt CC (2008)	2
MRPL41	2	MRPL19	0	affinity chromatography technology	Huttlin EL (2017)	1
TRIM55	2	STAM	3	enzymatic study	Loch CM (2012)	1
TRIM54	1	USP21	2	enzymatic study	Loch CM (2012)	1
USP28	3	USP7	14	enzymatic study	Loch CM (2012)	1
USP21	2	USP4	3	enzymatic study	Loch CM (2012)	1
USP15	4	OTUB1	0	enzymatic study	Loch CM (2012)	1
TRIM55	2	GFM1	0	two hybrid, pull down	Witt CC (2008), Witt CC (2008)	2
TRIM55	2	FHL2	0	two hybrid	Witt CC (2008)	1
USP13	2	TRIM63	0	two hybrid	McElhinny AS (2002)	1
TRIM63	0	CKB	1	two hybrid	Witt CC (2008)	1
TRIM55	2	NEB	21	two hybrid	Witt CC (2008)	1
TRIM63	0	ESPL1	2	enzymatic study	Loch CM (2012)	1
TRIM63	0	STAM	3	enzymatic study	Loch CM (2012)	1
TRIM55	2	DES	1	two hybrid	Witt CC (2008)	1
EEF1G	0	FLNC	8	biochemical	Havugimana PC (2012)	1
PKM	1	APP	1	pull down	Olah J (2011)	1
TRIM63	0	DES	1	two hybrid	Witt CC (2008)	1
TRIM55	2	TNNI2	2	two hybrid	Witt CC (2008)	1
TRIM63	0	UCHL5	1	enzymatic study	Loch CM (2012)	1
TRIM54	1	USP2	0	enzymatic study	Loch CM (2012)	1
TRIM63	0	TCAP	0	two hybrid, two hybrid	Witt SH (2005), Witt CC (2008)	2
TRIM63	0	AKR7A2	1	two hybrid	Witt SH (2005)	1
USP5	2	USP13	2	affinity chromatography technology	Sowa ME (2009)	1
USP21	2	OTUB1	0	enzymatic study	Loch CM (2012)	1
TRIM55	2	USP28	3	enzymatic study	Loch CM (2012)	1
MYOZ1	1	TCAP	0	affinity chromatography technology, pull down	Frey N (2002), Faulkner G (2000)	2
USP28	3	USP8	7	enzymatic study	Loch CM (2012)	1
TRIM55	2	NEBL	4	two hybrid	Witt CC (2008)	1
USP15	4	JOSD1	1	enzymatic study	Loch CM (2012)	1
OTUB1	0	HSPA4	3	affinity chromatography technology	Scholz CC (2016)	1
TRIM55	2	USP8	7	enzymatic study	Loch CM (2012)	1
TRIM55	2	MYBPC3	2	two hybrid	Witt CC (2008)	1
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
USP13	2	TRIM55	2	two hybrid	McElhinny AS (2002)	1
UBE2I	0	PIAS2	2	two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down	Rual JF (2005), Lee BH (2003), Bandyopadhyay S (2010), Schmidt D (2002), Wang J (2011), Rolland T (2014), Saul VV (2014), van den Akker E (2005), Schmidt D (2002)	9
ATXN3	2	OTUB2	0	affinity chromatography technology	Sowa ME (2009)	1
USP21	2	YOD1	0	enzymatic study	Loch CM (2012)	1
TRIM63	0	TNNC1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Kedar V (2004), Kedar V (2004), Kedar V (2004), Kedar V (2004), Kedar V (2004)	5
UBE2I	0	USP8	7	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
USP15	4	UCHL1	1	enzymatic study	Loch CM (2012)	1
ATXN3	2	APP	1	pull down	Olah J (2011)	1
SENP2	3	USP28	3	affinity chromatography technology	Huttlin EL (2017)	1
UCHL1	1	UBE2I	0	two hybrid	Caballero OL (2002)	1
USP21	2	UCHL1	1	affinity chromatography technology, enzymatic study	Sowa ME (2009), Loch CM (2012)	2
USP28	3	ATXN3L	0	enzymatic study	Loch CM (2012)	1
TNNT1	0	UBE2D1	0	two hybrid	Vinayagam A (2011)	1
BAP1	4	PSMD4	1	affinity chromatography technology	Hauri S (2016)	1
UCHL5	1	EEF1G	0	pull down	Fang Y (2011)	1
TRIM55	2	ATXN3	2	enzymatic study	Loch CM (2012)	1
UBE2J1	1	YOD1	0	affinity chromatography technology	Claessen JH (2010)	1
TRIM55	2	TNNI3	0	two hybrid	Witt CC (2008)	1
TTN	102	SQSTM1	0	enzymatic study	Lange S (2005)	1
TRIM63	0	USP15	4	enzymatic study	Loch CM (2012)	1
TRIM54	1	OTUB1	0	enzymatic study	Loch CM (2012)	1
USP15	4	USP8	7	enzymatic study	Loch CM (2012)	1
TRIM63	0	USP21	2	enzymatic study	Loch CM (2012)	1
USP2	0	BAP1	4	enzymatic study	Mashtalir N (2014)	1
UBE2I	0	SRF	1	enzymatic study	Matsuzaki K (2003)	1
TRIM63	0	APP	1	pull down	Olah J (2011)	1
FHL2	0	MYBPC1	4	two hybrid, affinity chromatography technology	McGrath MJ (2006), McGrath MJ (2006)	2
TRIM63	0	USP7	14	enzymatic study	Loch CM (2012)	1
TCAP	0	HSPA4	3	affinity chromatography technology	Huttlin EL (2017)	1
USP28	3	UCHL1	1	enzymatic study	Loch CM (2012)	1
TRIM55	2	YOD1	0	enzymatic study	Loch CM (2012)	1
TRIM55	2	UXT	0	two hybrid	Witt CC (2008)	1
USP21	2	USP2	0	enzymatic study	Loch CM (2012)	1
TRIM55	2	TNNI1	0	two hybrid	Witt CC (2008)	1
GMEB1	4	TRIM63	0	two hybrid, pull down, two hybrid	McElhinny AS (2002), McElhinny AS (2002), Witt CC (2008)	3
USP28	3	UCHL5	1	enzymatic study	Loch CM (2012)	1
TRIM63	0	UCHL1	1	enzymatic study	Loch CM (2012)	1
TRIM55	2	MRPL41	2	two hybrid	Witt CC (2008)	1
TRIM55	2	PIAS3	2	two hybrid	Witt CC (2008)	1
DES	1	UBE2I	0	two hybrid	Rolland T (2014)	1
TNNI3	0	TNNC1	2	pull down, pull down, pull down, x-ray crystallography, unspecified method, pull down, pull down	Ward DG (2004), Ward DG (2004), Ward DG (2003), Wang X (2002), Li MX (2002), al-Hillawi E (1994), You B (2009)	7
PSMD4	1	HSPA4	3	affinity chromatography technology	Andersen KM (2009)	1
TRIM55	2	NOMO1	2	two hybrid	Witt CC (2008)	1
SQSTM1	0	UBE2D2	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017)	5
USP15	4	BAP1	4	enzymatic study	Loch CM (2012)	1
TRIM54	1	ATXN3L	0	enzymatic study	Loch CM (2012)	1
MYBPC3	2	TRIM63	0	two hybrid, two hybrid	Mearini G (2010), Witt CC (2008)	2
TRIM54	1	UCHL3	1	enzymatic study	Loch CM (2012)	1
TTN	102	MYBPC3	2	far western blotting	Freiburg A (1996)	1
TRIM63	0	TNNT3	1	two hybrid	Witt SH (2005)	1
TRIM55	2	PIAS1	4	two hybrid	Witt CC (2008)	1
TNNC1	2	TNNI2	2	x-ray crystallography	Grand RJ (1982)	1
TRIM63	0	TNNT1	0	two hybrid	Witt SH (2005)	1
TRIM55	2	CKM	0	two hybrid	Witt CC (2008)	1
SQSTM1	0	TRIM63	0	two hybrid, two hybrid	Lange S (2005), Witt CC (2008)	2
FHL2	0	TTN	102	two hybrid, pull down	Lange S (2002), Lange S (2002)	2
TRIM55	2	DCAF6	0	two hybrid	Witt CC (2008)	1
TRIM63	0	HSPD1	0	enzymatic study	Rubel CE (2013)	1
TNNT1	0	EEF1G	0	two hybrid	Vinayagam A (2011)	1
TRIM63	0	AK1	2	two hybrid	Witt SH (2005)	1
OTUB2	0	UBE2N	1	pull down	Nakada S (2010)	1
UBE2I	0	PIAS1	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Lee BH (2003), Sapetschnig A (2002), Kahyo T (2001), Bandyopadhyay S (2010), Driscoll JJ (2010), Kahyo T (2001), Yin Y (2012), Gocke CB (2005), van den Akker E (2005), Ogawa H (2009), Schmidt D (2002), Gibbs-Seymour I (2015)	12
TRIM63	0	USP5	2	enzymatic study	Loch CM (2012)	1
USP8	7	STAM	3	pull down, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Kato M (2000), Berlin I (2010), Berlin I (2010), Row PE (2006)	4
TRIM63	0	MYBPC1	4	two hybrid	Witt CC (2008)	1
USP28	3	SUMO2	0	affinity chromatography technology, x-ray crystallography, pull down	Sowa ME (2009), Wen Y (2015), Wen Y (2015)	3