PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MCM2	3	TTN	102	affinity chromatography technology	Drissi R (2015)	1
MYPN	7	ACTN3	2	two hybrid	Bang ML (2001)	1
MCM2	3	CAPZA2	1	affinity chromatography technology	Drissi R (2015)	1
MCM2	3	TRIM25	5	affinity chromatography technology	Drissi R (2015)	1
TRIM25	5	CAPZA2	1	affinity chromatography technology	Choudhury NR (2017)	1
MCM2	3	MYPN	7	affinity chromatography technology	Drissi R (2015)	1
MYPN	7	TTN	102	two hybrid	Miller MK (2003)	1
CAPZA2	1	GTSE1	3	affinity chromatography technology	Hein MY (2015)	1
DENND2D	2	MYPN	7	biochemical	Havugimana PC (2012)	1
XPO1	8	MYPN	7	affinity chromatography technology	Kirli K (2015)	1
ACTN3	2	NEBL	4	two hybrid	Rolland T (2014)	1
ANKRD23	1	MYPN	7	two hybrid, two hybrid	Miller MK (2003), Miller MK (2003)	2
MYPN	7	NEBL	4	two hybrid	Bang ML (2001)	1
TRIM25	5	MYPN	7	affinity chromatography technology	Choudhury NR (2017)	1
XPO1	8	GTSE1	3	affinity chromatography technology	Kirli K (2015)	1
TRIM25	5	XPO1	8	affinity chromatography technology	Choudhury NR (2017)	1
ANKRD1	0	MYPN	7	two hybrid, two hybrid, two hybrid, pull down	Miller MK (2003), Miller MK (2003), Bang ML (2001), Bang ML (2001)	4
GTSE1	3	MYPN	7	affinity chromatography technology	Hein MY (2015)	1
TTN	102	ANKRD1	0	two hybrid, pull down, two hybrid	Miller MK (2003), Miller MK (2003), Miller MK (2003)	3
BAG6	2	MYPN	7	affinity chromatography technology	Hein MY (2015)	1
DHX8	3	MYPN	7	biochemical	Havugimana PC (2012)	1
MCM2	3	NEB	21	affinity chromatography technology	Drissi R (2015)	1
CAPZA2	1	MYPN	7	affinity chromatography technology	Hein MY (2015)	1
MCM2	3	XPO1	8	affinity chromatography technology	Drissi R (2015)	1
MYPN	7	ACTN2	2	two hybrid, two hybrid	Bang ML (2001), Bang ML (2001)	2
TTN	102	ANKRD23	1	two hybrid, pull down, two hybrid	Miller MK (2003), Miller MK (2003), Miller MK (2003)	3
NEB	21	MYPN	7	two hybrid, pull down, pull down	Bang ML (2001), Bang ML (2001), Ma K (2002)	3
MYPN	7	MTA2	1	biochemical	Wan C (2015)	1
ACTN3	2	ACTN2	2	far western blotting, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Chan Y (1998), Chan Y (1998), Chan Y (1998), Chan Y (1998), Chan Y (1998), Chan Y (1998)	6
TRIM25	5	BAG6	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	DHX8	3	affinity chromatography technology	Choudhury NR (2017)	1