PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LLGL2	4	MKNK1	0	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	MSANTD4	0	affinity chromatography technology	Hein MY (2015)	1
PPP1CA	3	TP53BP2	5	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Esteves SL (2012), Liu CY (2011), Colland F (2004), Huttlin EL (2015), Hauri S (2013), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017), Yadav L (2017)	9
PARD6B	0	DLGAP4	4	affinity chromatography technology	Hein MY (2015)	1
PARD6G	0	WDR83	1	two hybrid, affinity chromatography technology	Hayase J (2013), Hayase J (2013)	2
WDR83	1	CRB3	0	affinity chromatography technology, pull down	Hayase J (2013), Hayase J (2013)	2
PARD6B	0	MRPL55	0	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	CDC42	3	pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Joberty G (2000), Joberty G (2000), Joberty G (2000), Noda Y (2001), Noda Y (2001), Bandyopadhyay S (2010), Brajenovic M (2004), Hayase J (2013), Hayase J (2013), Hayase J (2013), Rolland T (2014)	11
PARD6A	0	RHOQ	0	two hybrid	Joberty G (2000)	1
PRKCZ	5	NPM1	0	affinity chromatography technology, affinity chromatography technology	Chen R (2013), Chen R (2013)	2
GOLGA2	2	PARD6B	0	two hybrid	Rolland T (2014)	1
YWHAH	0	PARD6G	0	affinity chromatography technology	Brajenovic M (2004)	1
PARD6B	0	IFT22	0	affinity chromatography technology	Hein MY (2015)	1
CCNK	1	CEP76	1	two hybrid	Rual JF (2005)	1
PARD6B	0	PSMD5	0	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	CLPTM1	4	affinity chromatography technology	Hein MY (2015)	1
PARD3	5	YWHAH	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004), Hein MY (2015)	3
MKNK1	0	APP	1	pull down	Olah J (2011)	1
NPM1	0	PTPN14	5	affinity chromatography technology	Chen R (2013)	1
RHOQ	0	PARD6B	0	two hybrid, pull down, two hybrid	Neudauer CL (2001), Joberty G (2000), Joberty G (2000)	3
PARD6A	0	WDR83	1	two hybrid, affinity chromatography technology	Hayase J (2013), Hayase J (2013)	2
PARD6B	0	RNF170	1	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	LRCH3	2	affinity chromatography technology	Hein MY (2015)	1
YWHAH	0	RASSF8	2	affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Hein MY (2015)	2
PARD3	5	PRKCI	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kohjima M (2002), Kohjima M (2002), Brajenovic M (2004), Brajenovic M (2004), Yang Z (2012)	5
RHOJ	0	PARD6G	0	affinity chromatography technology	Huttlin EL (2017)	1
PARD6B	0	EPB41L4B	2	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	MKNK1	0	affinity chromatography technology	Hein MY (2015)	1
YWHAH	0	PPP1CA	3	biochemical	Kristensen AR (2012)	1
LLGL2	4	EPB41L4B	2	affinity chromatography technology	Hein MY (2015)	1
PRKCI	1	4651	0	affinity chromatography technology	Brajenovic M (2004)	1
KBTBD7	3	PRKCI	1	affinity chromatography technology	Huttlin EL (2017)	1
PARD6B	0	ARL10	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PARD6B	0	4651	0	affinity chromatography technology	Hein MY (2015)	1
PARD6A	0	RAC1	7	pull down, affinity chromatography technology, two hybrid, pull down	Qiu RG (2000), Qiu RG (2000), Noda Y (2001), Noda Y (2001)	4
ZZEF1	5	HECTD3	8	biochemical	Kristensen AR (2012)	1
PARD6B	0	ICAM5	0	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	ZZEF1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PARD6G	0	LLGL1	9	affinity chromatography technology	Brajenovic M (2004)	1
PARD6B	0	RBM10	1	affinity chromatography technology	Hein MY (2015)	1
EME1	3	APP	1	pull down, affinity chromatography technology	Olah J (2011), Huttlin EL (2017)	2
RHOJ	0	PRKCI	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PARD6B	0	RASSF8	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015)	2
PARD6B	0	PPP1CA	3	affinity chromatography technology	Hein MY (2015)	1
CDC42	3	SF1	9	affinity chromatography technology	Hein MY (2015)	1
APP	1	PARD6A	0	pull down	Virok DP (2011)	1
PARD6G	0	PARD6B	0	affinity chromatography technology	Brajenovic M (2004)	1
PARD3	5	PARD6A	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kohjima M (2002), Brajenovic M (2004), Suzuki A (2001), Yang Z (2012), Hein MY (2015)	5
YWHAQ	0	NPM1	0	affinity chromatography technology, pull down, affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Meek SE (2004), Pozuelo-Rubio M (2010), Pozuelo-Rubio M (2010)	4
PARD6B	0	SLF1	2	affinity chromatography technology	Hein MY (2015)	1
RASSF8	2	APP	1	pull down	Olah J (2011)	1
PARD6B	0	PRKCI	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004), Waaijers S (2013), Waaijers S (2013), Hayase J (2013), Rolland T (2014), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	10
PARD6B	0	AGGF1	2	affinity chromatography technology	Hein MY (2015)	1
HNRNPA1	1	CDC42	3	biochemical	Wan C (2015)	1
PARD6B	0	KIFC1	0	affinity chromatography technology	Hein MY (2015)	1
KBTBD7	3	KBTBD6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Genau HM (2015), Genau HM (2015), Hein MY (2015), Huttlin EL (2017)	5
HNRNPA1	1	APP	1	pull down	Olah J (2011)	1
PARD6G	0	PRKCZ	5	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Noda Y (2001), Brajenovic M (2004), So J (2015), Huttlin EL (2017)	4
PARD6B	0	PTPN14	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PARD6A	0	LLGL2	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Hutchins JR (2010), Wan C (2015), Hein MY (2015), Hein MY (2015)	5
PSMD5	0	APP	1	pull down	Olah J (2011)	1
PARD6A	0	CDC42	3	two hybrid, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Joberty G (2000), Qiu RG (2000), Qiu RG (2000), Noda Y (2001), Noda Y (2001), Brajenovic M (2004)	6
NPM1	0	PARD6B	0	affinity chromatography technology	Chen R (2013)	1
YWHAH	0	PARD6A	0	affinity chromatography technology	Brajenovic M (2004)	1
YWHAH	0	PRKCI	1	affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004)	2
PRKCZ	5	PRKCI	1	affinity chromatography technology, affinity chromatography technology	So J (2015), Huttlin EL (2017)	2
WWC1	5	PRKCZ	5	two hybrid, pull down, enzymatic study, affinity chromatography technology	Buether K (2004), Buether K (2004), Buether K (2004), Huttlin EL (2017)	4
CDC42	3	EPB41L4B	2	affinity chromatography technology	Hein MY (2015)	1
NPM1	0	LLGL1	9	affinity chromatography technology	Chen R (2013)	1
PARD6B	0	PLPBP	4	affinity chromatography technology	Hein MY (2015)	1
LLGL2	4	KBTBD7	3	affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Huttlin EL (2017)	2
YWHAQ	0	TP53BP2	5	pull down	Meek SE (2004)	1
YWHAQ	0	YWHAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
PARD6B	0	RAC1	7	two hybrid, pull down	Noda Y (2001), Noda Y (2001)	2
LLGL2	4	KBTBD6	0	affinity chromatography technology	Huttlin EL (2017)	1
PARD6B	0	PTPN21	10	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PARD6B	0	GNS	3	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	ROBO2	2	affinity chromatography technology	Hein MY (2015)	1
PARD3	5	LLGL1	9	affinity chromatography technology	Brajenovic M (2004)	1
PARD6B	0	ATAD3C	4	affinity chromatography technology	Huttlin EL (2015)	1
PARD6B	0	KBTBD7	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PARD6B	0	INPP5B	2	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	YWHAQ	0	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	HNRNPA1	1	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	GOLIM4	1	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	AGPS	1	affinity chromatography technology	Hein MY (2015)	1
YWHAH	0	PARD6B	0	affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Hein MY (2015)	2
PARD6A	0	LRCH3	2	affinity chromatography technology	Hein MY (2015)	1
GMCL1	0	PARD6B	0	two hybrid	Rolland T (2014)	1
GOLGA2	2	VPS28	2	two hybrid	Rolland T (2014)	1
PARD6B	0	KBTBD6	0	affinity chromatography technology	Huttlin EL (2015)	1
PARD6B	0	TP53BP2	5	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	CDCA3	0	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	PDF	0	affinity chromatography technology	Hein MY (2015)	1
PLPBP	4	HNRNPA1	1	biochemical	Wan C (2015)	1
PARD6B	0	HECTD3	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NPM1	0	GOLGA2	2	affinity chromatography technology	Chen R (2013)	1
WWC1	5	YWHAQ	0	affinity chromatography technology	Hauri S (2013)	1
RASSF8	2	PRKCI	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKCI	1	APP	1	pull down	Olah J (2011)	1
IARS2	2	APP	1	pull down	Olah J (2011)	1
PARD6B	0	DMBT1	4	affinity chromatography technology	Brajenovic M (2004)	1
PARD6B	0	PHKA1	0	affinity chromatography technology	Hein MY (2015)	1
PRKCZ	5	YWHAH	0	affinity chromatography technology	Van Der Hoeven PC (2000)	1
PARD6B	0	TMEM92	0	affinity chromatography technology	Hein MY (2015)	1
WWC1	5	YWHAH	0	affinity chromatography technology	Hauri S (2013)	1
PARD6B	0	EEFSEC	0	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	PRKCZ	5	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Noda Y (2001), Noda Y (2001), Brajenovic M (2004), Wilson MI (2003), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	7
PARD6B	0	FOXM1	3	affinity chromatography technology	Hein MY (2015)	1
YWHAQ	0	HNRNPA1	1	pull down, affinity chromatography technology	Meek SE (2004), Roy R (2014)	2
NPM1	0	APP	1	pull down	Olah J (2011)	1
PSMD5	0	P4HA1	1	biochemical	Wan C (2015)	1
RASSF8	2	TP53BP2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hauri S (2013), Hauri S (2013), Hein MY (2015), Huttlin EL (2017)	5
PARD6B	0	EME1	3	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	CRB3	0	affinity chromatography technology, pull down, affinity chromatography technology	Hayase J (2013), Hayase J (2013), Hayase J (2013)	3
PTPN14	5	YWHAH	0	affinity chromatography technology	Li X (2016)	1
PARD6B	0	IARS2	2	affinity chromatography technology	Hein MY (2015)	1
PRKCZ	5	LLGL2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	So J (2015), Hauri S (2013), Huttlin EL (2017)	3
PARD6B	0	AVL9	0	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	KIAA2013	0	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	DR1	1	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	PARD6A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004), Hein MY (2015)	3
KIFC1	0	APP	1	pull down	Olah J (2011)	1
PRKCI	1	LLGL1	9	affinity chromatography technology, biochemical, affinity chromatography technology	Brajenovic M (2004), Wan C (2015), Hein MY (2015)	3
CDC42	3	GOLIM4	1	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	LLGL2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Hutchins JR (2010), Huttlin EL (2015), Hauri S (2013), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
PTPN21	10	WWC1	5	affinity chromatography technology, affinity chromatography technology	Li X (2016), Li X (2016)	2
SF1	9	WDR83	1	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
PARD6G	0	CDC42	3	pull down, affinity chromatography technology	Noda Y (2001), Brajenovic M (2004)	2
PARD6B	0	APP	1	pull down	Olah J (2011)	1
INPP5B	2	APP	1	pull down	Olah J (2011)	1
TP53BP2	5	PARD3	5	affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Hauri S (2013), Gen Y (2017), Gen Y (2017), Gen Y (2017)	4
YWHAQ	0	IARS2	2	pull down	Meek SE (2004)	1
PARD6B	0	UBR2	8	affinity chromatography technology	Hein MY (2015)	1
YWHAH	0	TP53BP2	5	affinity chromatography technology	Hein MY (2015)	1
PRKCZ	5	LLGL1	9	affinity chromatography technology, affinity chromatography technology	So J (2015), Huttlin EL (2017)	2
PARD6B	0	LLGL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	5
PARD6A	0	TP53BP2	5	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	WWC1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PARD6B	0	LTN1	8	affinity chromatography technology	Hein MY (2015)	1
PARD6G	0	RAC1	7	pull down	Noda Y (2001)	1
LLGL2	4	SF1	9	affinity chromatography technology	Hein MY (2015)	1
KBTBD7	3	LLGL1	9	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Huttlin EL (2017)	2
PARD6G	0	LLGL2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Hauri S (2013), Huttlin EL (2017)	3
PARD6G	0	PRKCI	1	affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004)	2
PARD6A	0	RASSF8	2	affinity chromatography technology	Hein MY (2015)	1
RBM10	1	SF1	9	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
PPP1CA	3	PARD3	5	affinity chromatography technology, affinity chromatography technology, bioid	Lv XB (2015), Yadav L (2017), Yadav L (2017)	3
PARD6B	0	P4HA1	1	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	SF1	9	affinity chromatography technology	Hein MY (2015)	1
PRKCI	1	PARD6A	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Brajenovic M (2004), Suzuki A (2001), Suzuki A (2001), Suzuki A (2001), Lamark T (2003), Lamark T (2003), Lamark T (2003), Lamark T (2003), Erdogan E (2006), Rolland T (2014), Yu H (2011), Hein MY (2015)	13
RAC1	7	PDF	0	affinity chromatography technology	Boldt K (2016)	1
PARD6A	0	LLGL1	9	affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Hein MY (2015)	2
HNRNPA1	1	UBR2	8	affinity chromatography technology	Jeronimo C (2007)	1
RHOJ	0	PARD6B	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
PARD6B	0	ROBO1	5	affinity chromatography technology	Hein MY (2015)	1
PARD3	5	PARD6G	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kohjima M (2002), Brajenovic M (2004), Brajenovic M (2004)	3
PPP1CA	3	RASSF8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), Hauri S (2013), Huttlin EL (2017), Yadav L (2017), Yadav L (2017)	5
PRKCI	1	LLGL2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Hutchins JR (2010), Hauri S (2013), Hein MY (2015), Huttlin EL (2017)	5
RASSF8	2	GOLGA2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PARD6B	0	VPS28	2	affinity chromatography technology	Hein MY (2015)	1
PARD3	5	PARD6B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kohjima M (2002), Brajenovic M (2004), Brajenovic M (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
WWC1	5	PRKCI	1	affinity chromatography technology	Toloczko A (2017)	1
PARD3	5	PRKCZ	5	affinity chromatography technology	Kohjima M (2002)	1
CDCA3	0	APP	1	pull down	Olah J (2011)	1
PRKCZ	5	YWHAQ	0	affinity chromatography technology, pull down, enzymatic study	Van Der Hoeven PC (2000), Van Der Hoeven PC (2000), Van Der Hoeven PC (2000)	3
PARD3	5	RASSF8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
PARD6B	0	RECQL5	3	affinity chromatography technology	Hein MY (2015)	1
PRKCZ	5	PARD6A	0	two hybrid, pull down, two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Rual JF (2005), Liu XF (2004), Noda Y (2001), Brajenovic M (2004), Lamark T (2003), Lamark T (2003), So J (2015), Huttlin EL (2017), Tobias IS (2016), Tobias IS (2016)	10
PTPN14	5	WWC1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang W (2012), Wilson KE (2014), Wilson KE (2014), Hauri S (2013), Li X (2016), Toloczko A (2017)	6
PARD6B	0	CCNK	1	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	WDR83	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Hayase J (2013), Hayase J (2013), Hayase J (2013), Hayase J (2013)	4
CEP76	1	PARD6B	0	two hybrid	Rolland T (2014)	1
NPM1	0	PRKCI	1	affinity chromatography technology	Chen R (2013)	1