PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PARD6G	0	WDR83	1	two hybrid, affinity chromatography technology	Hayase J (2013), Hayase J (2013)	2
PARD6B	0	CDC42	3	pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Joberty G (2000), Joberty G (2000), Joberty G (2000), Noda Y (2001), Noda Y (2001), Bandyopadhyay S (2010), Brajenovic M (2004), Hayase J (2013), Hayase J (2013), Hayase J (2013), Rolland T (2014)	11
YWHAH	0	PARD6G	0	affinity chromatography technology	Brajenovic M (2004)	1
PARD3	5	YWHAH	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004), Hein MY (2015)	3
PARD6G	0	PNMA2	0	affinity chromatography technology	Brajenovic M (2004)	1
PARD6G	0	YWHAE	0	affinity chromatography technology	Brajenovic M (2004)	1
PARD3	5	PRKCI	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kohjima M (2002), Kohjima M (2002), Brajenovic M (2004), Brajenovic M (2004), Yang Z (2012)	5
RHOJ	0	PARD6G	0	affinity chromatography technology	Huttlin EL (2017)	1
PARD6G	0	LLGL1	9	affinity chromatography technology	Brajenovic M (2004)	1
PARD6G	0	PNMA8A	2	affinity chromatography technology	Brajenovic M (2004)	1
PARD6G	0	BRINP1	5	affinity chromatography technology	Brajenovic M (2004)	1
RHOJ	0	PRKCI	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PARD6G	0	PARD6B	0	affinity chromatography technology	Brajenovic M (2004)	1
PARD6B	0	PRKCI	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004), Waaijers S (2013), Waaijers S (2013), Hayase J (2013), Rolland T (2014), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	10
PARD6G	0	PRKCZ	5	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Noda Y (2001), Brajenovic M (2004), So J (2015), Huttlin EL (2017)	4
YWHAH	0	PRKCI	1	affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004)	2
PRKCZ	5	PRKCI	1	affinity chromatography technology, affinity chromatography technology	So J (2015), Huttlin EL (2017)	2
PARD6B	0	RAC1	7	two hybrid, pull down	Noda Y (2001), Noda Y (2001)	2
PARD3	5	LLGL1	9	affinity chromatography technology	Brajenovic M (2004)	1
MARK2	6	PRKCI	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Suzuki A (2004)	2
YWHAH	0	PARD6B	0	affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Hein MY (2015)	2
MARK2	6	YWHAH	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Brajenovic M (2004), Brajenovic M (2004), Brajenovic M (2004)	4
PRKCZ	5	YWHAH	0	affinity chromatography technology	Van Der Hoeven PC (2000)	1
PARD6B	0	PRKCZ	5	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Noda Y (2001), Noda Y (2001), Brajenovic M (2004), Wilson MI (2003), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	7
PARD3	5	PNMA2	0	affinity chromatography technology	Brajenovic M (2004)	1
PRKCZ	5	LLGL2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	So J (2015), Hauri S (2013), Huttlin EL (2017)	3
PARD6G	0	PNMA3	0	affinity chromatography technology	Brajenovic M (2004)	1
BRINP1	5	RAC1	7	two hybrid	Wang J (2011)	1
PRKCI	1	LLGL1	9	affinity chromatography technology, biochemical, affinity chromatography technology	Brajenovic M (2004), Wan C (2015), Hein MY (2015)	3
PARD6B	0	LLGL2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Hutchins JR (2010), Huttlin EL (2015), Hauri S (2013), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
PARD3	5	MARK2	6	affinity chromatography technology	Yang Z (2012)	1
PARD6G	0	CDC42	3	pull down, affinity chromatography technology	Noda Y (2001), Brajenovic M (2004)	2
PARD6G	0	MARK2	6	affinity chromatography technology	Brajenovic M (2004)	1
PRKCZ	5	LLGL1	9	affinity chromatography technology, affinity chromatography technology	So J (2015), Huttlin EL (2017)	2
PARD6B	0	LLGL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	5
YWHAE	0	PRKCI	1	affinity chromatography technology	Gloeckner CJ (2007)	1
YWHAE	0	PARD3	5	affinity chromatography technology	Gloeckner CJ (2007)	1
PARD6G	0	RAC1	7	pull down	Noda Y (2001)	1
PARD6G	0	LLGL2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Hauri S (2013), Huttlin EL (2017)	3
PARD6G	0	HSPA4	3	affinity chromatography technology	Brajenovic M (2004)	1
YWHAE	0	YWHAH	0	two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Bandyopadhyay S (2010), Gloeckner CJ (2007), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	5
PARD6G	0	PRKCI	1	affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004)	2
RHOJ	0	PARD6B	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
PARD3	5	PARD6G	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kohjima M (2002), Brajenovic M (2004), Brajenovic M (2004)	3
PRKCI	1	LLGL2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Hutchins JR (2010), Hauri S (2013), Hein MY (2015), Huttlin EL (2017)	5
PARD3	5	PARD6B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kohjima M (2002), Brajenovic M (2004), Brajenovic M (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
PARD3	5	PRKCZ	5	affinity chromatography technology	Kohjima M (2002)	1
MARK2	6	YWHAE	0	affinity chromatography technology, affinity chromatography technology	Goeransson O (2006), Gloeckner CJ (2007)	2
PARD6B	0	WDR83	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Hayase J (2013), Hayase J (2013), Hayase J (2013), Hayase J (2013)	4