PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
COPS3	1	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Min KW (2005), Enchev RI (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	9
BTRC	1	ARIH1	3	affinity chromatography technology, bioid, affinity chromatography technology	Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017)	3
CAND1	2	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
FBXO7	1	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
HSP90AA1	7	FBXW2	0	affinity chromatography technology	Taipale M (2012)	1
PSMA7	1	PSMB4	2	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
SKP1	0	MAGEC2	0	affinity chromatography technology	Hao J (2015)	1
COPS5	0	FBXO22	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
PRKN	1	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2003), Sarraf SA (2013), Huttlin EL (2017)	3
BTRC	1	E2F1	0	enzymatic study	Ohta T (2001)	1
FBXW4	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2012), Lockwood WW (2013), Lockwood WW (2013), Hauri S (2016)	4
SKP2	2	TRIM21	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Sabile A (2006), Sabile A (2006), Sabile A (2006), Sabile A (2006), Sabile A (2006)	5
VCP	6	FAF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, x-ray crystallography, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Haenzelmann P (2011), Song EJ (2005), Song EJ (2005), Shin HY (2010), Haenzelmann P (2011), Haenzelmann P (2011), Kang W (2011), Alexandru G (2012), Lee JJ (2013), Lee JJ (2013), Lee JJ (2013), Yu CC (2013), Baron Y (2014), Franz A (2016), Raman M (2015)	17
FBXO44	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Yoshida Y (2011)	2
VCP	6	UBE2M	0	affinity chromatography technology	Yu CC (2013)	1
COPS8	2	COPS7A	0	biochemical, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Luke-Glaser S (2007), Kapelari B (2000), Olma MH (2009), Huang X (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	10
FBXO7	1	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
PSMA4	0	CUL1	7	affinity chromatography technology, affinity chromatography technology	Bloom J (2006), Bennett EJ (2010)	2
CUL3	17	CDC5L	2	affinity chromatography technology	Bennett EJ (2010)	1
MDM2	2	CCND1	1	affinity chromatography technology	Yang P (2016)	1
NFKBIA	0	COPS2	5	affinity chromatography technology	Schweitzer K (2007)	1
RBX1	2	SKP2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Ohta T (2001), Saiga T (2009), Rodier G (2008), Zhou W (2014), Zhou W (2014)	6
DDB1	6	COPS6	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006), Emberley ED (2012), Bennett EJ (2010), Olma MH (2009)	5
SKP1	0	FBXW5	6	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lievens S (2009), Busino L (2012), Watanabe N (2004), Jeong YT (2013), Tian X (2015), Hauri S (2016)	6
CDC34	3	CUL3	17	pull down	Plafker KS (2009)	1
CUL3	17	SF3B3	4	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Cordero-Espinoza L (2013)	2
DCUN1D1	0	COPS3	1	affinity chromatography technology	Bennett EJ (2010)	1
ARIH1	3	FBXW2	0	affinity chromatography technology	Huttlin EL (2017)	1
FBXW2	0	BTRC	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Xu J (2017), Xu J (2017), Xu J (2017), Huttlin EL (2017)	4
GPS1	1	COPS2	5	affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, two hybrid, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Stotland A (2012), Huang X (2005), Sharon M (2009), Kapelari B (2000), Tsuge T (2001), Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	11
CCDC22	1	CUL3	17	affinity chromatography technology	Starokadomskyy P (2013)	1
CUL1	7	COPS9	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Ebina M (2013)	2
CUL1	7	CCNA1	3	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Michel JJ (1998)	2
HSP90AA1	7	VCP	6	affinity chromatography technology, affinity chromatography technology	Vij N (2006), Yu CC (2013)	2
HSP90AA1	7	SKP1	0	pull down	Zhang M (2008)	1
FAF1	1	CUL3	17	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
FBXL2	2	VCP	6	affinity chromatography technology	Kuchay S (2017)	1
COPS6	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
CCNA2	1	SKP1	0	affinity chromatography technology	Hein MY (2015)	1
COPS5	0	FBXO9	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	FBXO7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2017)	3
COPS5	0	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Fang L (2008), Bennett EJ (2010), Oh W (2006), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	11
PSMA2	1	CDC5L	2	affinity chromatography technology	Loescher M (2005)	1
DDB1	6	COPS7B	0	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006)	2
CUL1	7	MAGEC2	0	affinity chromatography technology, imaging technique, affinity chromatography technology	Hao J (2015), Hao J (2015), Hao J (2015)	3
COPS4	0	COPS7B	0	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	7
PSMA7	1	PSMA2	1	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, biochemical, biochemical	Vinayagam A (2011), Claverol S (2002), Apcher GS (2004), Apcher GS (2004), Bousquet-Dubouch MP (2009), Fricke B (2007), Havugimana PC (2012), Froment C (2005), Froment C (2005), Kristensen AR (2012), Wan C (2015)	11
VCP	6	CHEK1	2	affinity chromatography technology	Yu CC (2013)	1
PSMA6	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Bloom J (2006), Bloom J (2006), Bloom J (2006), Bennett EJ (2010)	4
MCL1	1	PRKN	1	affinity chromatography technology, affinity chromatography technology	Hollville E (2014), Hollville E (2014)	2
COPS5	0	FBXW9	3	affinity chromatography technology	Bennett EJ (2010)	1
FBXO34	0	FBXO30	1	affinity chromatography technology	Huttlin EL (2017)	1
GLMN	2	FBXW7	2	pull down	Tron AE (2012)	1
COPS5	0	CKS1B	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	FBXO22	1	affinity chromatography technology	Sowa ME (2009)	1
CDK2	0	CDKN1B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Youn CK (2005), Porter LA (2003), Law BK (2002), Connor MK (2003), Naderi S (2005), Varshochi R (2005), Hsu SP (2008), McAndrew CW (2007), Peiretti A (2003), Peiretti A (2003), Haddad MM (1999), Xu X (1999), Xu X (1999), Radu M (2008), Mori S (1999), Schulman BA (1998), Kokontis JM (1998), Orend G (1998), Wu G (1997), Liu J (1997), Sheaff RJ (1997), Vlach J (1996), Vlach J (1996), Vlach J (1997), Liu S (2009), Rosner M (2004), Ciarallo S (2002), Ciarallo S (2002), Wang Y (2008), Bockstaele L (2006), Chu I (2007), Chu I (2007), Levkau B (1998), Levkau B (1998), Lacy ER (2005), Zhao J (1998), Seo DW (2006), Kossatz U (2006), Grimmler M (2007), Grimmler M (2007), Varjosalo M (2013), Varjosalo M (2013), Montagnoli A (1999), So J (2015), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Lovisa S (2016), Qiu H (2016), Carrasco-Garcia E (2011), Huttlin EL (2017), Hu B (2017)	52
CDC5L	2	UBE2M	0	affinity chromatography technology	Lleres D (2010)	1
COPS5	0	FBXO31	4	affinity chromatography technology	Bennett EJ (2010)	1
HSP90AA1	7	FBXO17	1	affinity chromatography technology	Taipale M (2012)	1
FBXO6	0	COPS5	0	affinity chromatography technology	Liu B (2012)	1
FBXO25	1	CDK9	3	enzymatic study	Teixeira FR (2013)	1
SKP1	0	FBXL5	3	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Winston JT (1999), Vashisht AA (2009), Salahudeen AA (2009), Vinas-Castells R (2013), Moroishi T (2014), Moroishi T (2014), Rolland T (2014), Yu H (2011), Wu WD (2016), Huttlin EL (2017)	10
DDB1	6	COPS2	5	affinity chromatography technology, affinity chromatography technology, pull down	Angers S (2006), Jin J (2006), Emberley ED (2012)	3
RNF7	0	GLMN	2	pull down	Tron AE (2012)	1
FBXO18	0	SKP1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kim J (2002), Kim J (2002), Kim J (2002), Kim JH (2004), Jeong YT (2013), Hauri S (2016)	6
HSP90AA1	7	FBXO9	0	affinity chromatography technology	Taipale M (2012)	1
FZR1	1	CDC25A	2	affinity chromatography technology, pull down, enzymatic study	Gao D (2009), Donzelli M (2002), Donzelli M (2002)	3
CAND1	2	SKP1	0	affinity chromatography technology, affinity chromatography technology	Zheng J (2002), Bennett EJ (2010)	2
VCP	6	PSMA6	1	affinity chromatography technology	Lim PJ (2009)	1
FBXO21	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang C (2015), Zhang C (2015), Hauri S (2016)	3
COPS7A	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uhle S (2003), Bennett EJ (2010), Huang X (2016), Reitsma JM (2017)	4
UBC	7	COPS4	0	affinity chromatography technology	Matsumoto M (2005)	1
CDK9	3	CHEK1	2	genetic interference	Shen JP (2017)	1
VCP	6	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li JM (2013), Riemer A (2014), Zhang Z (2015)	3
COPS5	0	FBXL14	2	affinity chromatography technology	Bennett EJ (2010)	1
FBXO27	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Yoshida Y (2011)	2
FZR1	1	CCND1	1	affinity chromatography technology	Pawar SA (2010)	1
CCDC22	1	UBE2M	0	affinity chromatography technology	Hein MY (2015)	1
PTTG1	0	BTRC	1	affinity chromatography technology	Limon-Mortes MC (2008)	1
DCUN1D1	0	CAND1	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kim AY (2008), Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Bommelje CC (2013), Kim AY (2008), Huang G (2014), Huang G (2014), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016)	11
FBXO32	2	CDC34	3	pull down	Csibi A (2009)	1
FBXW7	2	MCL1	1	enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Min SH (2012), Tong J (2017), Tong J (2017), Ye M (2017), Tong J (2017)	5
DCUN1D2	0	RNF7	0	affinity chromatography technology	Keuss MJ (2016)	1
FBXW4	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2003), Lockwood WW (2013), Chung FZ (2014), Low TY (2014), Reitsma JM (2017)	5
FBXO6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2007), Nelson RF (2007), Glenn KA (2008), Yoshida Y (2011), Liu B (2012), Liu B (2012), Huttlin EL (2015), Huttlin EL (2017), Reitsma JM (2017), Reitsma JM (2017)	10
PRKN	1	FBXO7	1	affinity chromatography technology, pull down, pull down	Burchell VS (2013), Burchell VS (2013), Burchell VS (2013)	3
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
DDB1	6	UBC	7	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Matsumoto M (2005)	2
DCX	5	CUL1	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CRY1	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Busino L (2007), Papp SJ (2015)	2
COMMD1	1	CUL3	17	affinity chromatography technology, pull down, pull down	Mao X (2011), Mao X (2011), Mao X (2011)	3
DCUN1D3	1	CUL3	17	pull down, affinity chromatography technology, pull down, imaging technique, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Monda JK (2013), Meyer-Schaller N (2009), Meyer-Schaller N (2009), Meyer-Schaller N (2009), Meyer-Schaller N (2009), Huang G (2014), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016)	11
BTRC	1	SNRNP70	2	affinity chromatography technology, affinity chromatography technology	Davis M (2002), Davis M (2002)	2
CCNA1	3	CDK2	0	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, imaging technique	Sweeney C (1996), Yang R (1997), Yang R (1997), Mueller-Tidow C (2001), Brown NR (1999), Niida H (2005), Yam CH (2000), Wang H (2009), Narayanan R (2005), Harwell RM (2004), Shen WH (2004), He W (2003), Peiretti A (2003), Peiretti A (2003), Pan ZQ (1993), Kim KS (2002), Lyapina SA (1998), Desai D (1995), Thomas DM (2004), Johnson LN (2002), Rohaly G (2005), Chen TC (2014)	22
FBXL5	3	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
ASB2	1	DCUN1D3	1	affinity chromatography technology	Huttlin EL (2017)	1
FBXL5	3	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
NEDD8	0	COPS2	5	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
VCP	6	SKP1	0	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
HSP90AA1	7	FBXO18	0	affinity chromatography technology	Taipale M (2012)	1
VCP	6	CDKN1B	1	affinity chromatography technology	Yu CC (2013)	1
ASB2	1	UBC	7	enzymatic study, enzymatic study, enzymatic study	Bello NF (2009), Lamsoul I (2011), Heuze ML (2008)	3
ARIH1	3	CUL3	17	affinity chromatography technology	Kelsall IR (2013)	1
CUL1	7	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Cenciarelli C (1999), Sowa ME (2009), Megumi Y (2005), Davis M (2002), Kawakami T (2001), Read MA (2000), Suzuki H (1999), Kumar KG (2007), Schweitzer K (2007), Chua YS (2011), Winston JT (1999), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Latres E (1999), Yoshida Y (2007), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), Chung FZ (2014), Chen ZW (2015), Kim TY (2014), Read MA (2000), Coyaud E (2015), Low TY (2014), Coyaud E (2015), He N (2005), Huttlin EL (2017), Kuang P (2016), Reitsma JM (2017), Reitsma JM (2017)	34
HSP90AA1	7	MCL1	1	genetic interference	Srivas R (2016)	1
DCUN1D1	0	COPS6	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS3	1	COPS7B	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Enchev RI (2010), Olma MH (2009), Havugimana PC (2012), Huttlin EL (2015), Huang X (2016), Huttlin EL (2017)	6
DCUN1D1	0	COPS8	2	affinity chromatography technology	Bennett EJ (2010)	1
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
FZR1	1	DDB1	6	affinity chromatography technology, affinity chromatography technology	Lv XB (2010), Lv XB (2010)	2
COPS6	0	CDK2	0	affinity chromatography technology	Bennett EJ (2010)	1
UBXN1	0	UBC	7	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Wu-Baer F (2010), Fenner BJ (2009), Alexandru G (2008), LaLonde DP (2011), McNeill H (2004), Zhang X (2017)	6
CUL3	17	DDB1	6	affinity chromatography technology	Bennett EJ (2010)	1
FBXW7	2	YBX1	1	affinity chromatography technology	Kourtis N (2015)	1
COPS6	0	COPS9	1	affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Bennett EJ (2010), Rozen S (2015)	3
FBXW7	2	RBX1	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2012), Matsumoto A (2011), Strohmaier H (2001), Ye M (2017)	4
PRKN	1	CUL1	7	affinity chromatography technology, pull down, affinity chromatography technology	Staropoli JF (2003), Staropoli JF (2003), Gong Y (2014)	3
DCUN1D5	0	CUL1	7	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Monda JK (2013), Bommelje CC (2013), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	5
FBXW11	2	CDC34	3	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu K (2010), Chong RA (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014)	5
UBC	7	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Matsumoto M (2005), Bennett EJ (2010), Bish RA (2007), Wu K (2016)	4
FBXW7	2	COPS3	1	genetic interference	Bailey ML (2015)	1
SKP1	0	FBXO33	0	affinity chromatography technology	Hauri S (2016)	1
PSMA6	1	GPS1	1	affinity chromatography technology	Huang X (2005)	1
CUL1	7	SF3B3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Cordero-Espinoza L (2013), Cordero-Espinoza L (2013)	3
FBXO42	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun L (2009), Bennett EJ (2010), Huttlin EL (2017), Reitsma JM (2017)	4
COPS2	5	COPS4	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Huang X (2005), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	8
CCND1	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okabe H (2007), Lin DI (2006), Wei S (2008), Yu ZK (1998)	4
DDB1	6	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Angers S (2006), Jin J (2006), Min KW (2005), Emberley ED (2012), Olma MH (2009)	5
CCDC22	1	COMMD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Starokadomskyy P (2013), Starokadomskyy P (2013), Starokadomskyy P (2013), Hein MY (2015), Huttlin EL (2017)	5
CDC25A	2	CUL3	17	two hybrid	Wang J (2011)	1
HES1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology	Chen F (2017), Chen F (2017)	2
HSP90AA1	7	FZR1	1	genetic interference	Srivas R (2016)	1
SKP1	0	FBXO46	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lievens S (2009), Lievens S (2009), Lockwood WW (2013), Hauri S (2016)	4
CDC5L	2	CHEK1	2	affinity chromatography technology	Lleres D (2010)	1
TSC22D4	1	FBXW11	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL1	7	FBXO3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Shima Y (2008), Reitsma JM (2017)	3
COPS6	0	COPS4	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sharon M (2009), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	14
FBXO6	0	GPS1	1	affinity chromatography technology	Liu B (2012)	1
SKP1	0	FBXO44	0	pull down, two hybrid, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Cenciarelli C (1999), Kumanomidou T (2010), Lievens S (2009), Yoshida Y (2007), Yoshida Y (2007), Glenn KA (2008), Yoshida Y (2011), Rolland T (2014), Huttlin EL (2015), Sjoegren B (2015), Kumanomidou T (2015), Huttlin EL (2017), Hauri S (2016)	14
FBXW4	0	COPS7B	0	affinity chromatography technology	Lockwood WW (2013)	1
SKP2	2	CDKN1B	1	enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Wang W (2003), Sitry D (2002), Fujita N (2002), Ji P (2006), Zancai P (2005), Ji P (2004), Iovine B (2011), Calvisi DF (2009), Spruck C (2001), Bashir T (2010), Bashir T (2010), Li P (2004), Boutonnet C (2010), Rosner M (2004), Rosner M (2004), Carrano AC (1999), Carrano AC (1999), Carrano AC (1999), Wu J (2012), Strohmaier H (2001), Rodier G (2008), Rodier G (2008), Ooi LC (2013), Yumimoto K (2013), Ooi LC (2013), Cen B (2010), Enchev RI (2012), Yumimoto K (2012), Shi P (2011), Lovisa S (2016), Cen B (2009), Chan CH (2013), Ma X (2017)	33
COPS5	0	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Stotland A (2012), Bennett EJ (2010), Oh W (2006), Chun Y (2013), Chun Y (2013), Chun Y (2013), Lingaraju GM (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	11
FBXO9	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Busino L (2007), Hauri S (2016)	2
KDM2B	11	RBX1	2	affinity chromatography technology	Han XR (2016)	1
DCUN1D5	0	RNF7	0	affinity chromatography technology	Keuss MJ (2016)	1
FBXW7	2	COPS6	0	genetic interference	Bailey ML (2015)	1
UBC	7	E2F1	0	affinity chromatography technology	Rizos H (2007)	1
HSP90AA1	7	SF3B3	4	affinity chromatography technology	Taipale M (2012)	1
COPS9	1	COPS8	2	affinity chromatography technology, biochemical	Rozen S (2015), Rozen S (2015)	2
FBXW4	0	COPS2	5	affinity chromatography technology, affinity chromatography technology	Lockwood WW (2013), Lockwood WW (2013)	2
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
CHEK1	2	FZR1	1	genetic interference	Srivas R (2016)	1
UBC	7	NEDD8	0	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Matsumoto M (2005), Bennett EJ (2010), Singh RK (2012), Singh RK (2012)	4
COPS5	0	CAND1	2	biochemical, affinity chromatography technology	Bornstein G (2006), Bennett EJ (2010)	2
CDC34	3	BTRC	1	pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, bioid, affinity chromatography technology	Semplici F (2002), Cenciarelli C (1999), Sowa ME (2009), Fernandez-Sanchez ME (2010), Chong RA (2014), Burrows AC (2012), Coyaud E (2015), Huttlin EL (2017)	8
COPS8	2	COPS3	1	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Min KW (2005), Enchev RI (2010), Sharon M (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	11
CAND1	2	SF3B3	4	affinity chromatography technology	Bennett EJ (2010)	1
MDM2	2	CDK9	3	affinity chromatography technology	Lau J (2009)	1
COPS8	2	COPS2	5	biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Yang X (2002), Huang X (2005), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	9
FZR1	1	PRKN	1	affinity chromatography technology, affinity chromatography technology	Lee SB (2015), Lee SB (2015)	2
E2F1	0	CCNA1	3	pull down, affinity chromatography technology, pull down	Yang R (1999), Yang R (1999), Ji P (2006)	3
GPS1	1	SKP2	2	affinity chromatography technology	Lyapina S (2001)	1
NEDD8	0	COPS8	2	affinity chromatography technology	Bennett EJ (2010)	1
SKP2	2	DCUN1D3	1	affinity chromatography technology	Zhang S (2016)	1
UBC	7	CDKN1B	1	affinity chromatography technology	Huang G (2014)	1
DCUN1D1	0	CUL1	7	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Wu K (2011), Bennett EJ (2010), Huang G (2011), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Huang G (2014), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	16
COMMD1	1	PRKN	1	pull down	Vonk WI (2014)	1
FBXO6	0	TRIM21	0	affinity chromatography technology	Liu B (2012)	1
FBXW11	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Fuchs SY (1999), Tan P (1999), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Chen TC (2014), Reitsma JM (2017)	14
PSMB4	2	FBXO7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Vingill S (2016), Huttlin EL (2017)	3
COPS4	0	FBXO17	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	3
RICTOR	4	FBXW7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guo Z (2012), Koo J (2015), Koo J (2015)	3
FBXO7	1	HSP90AA1	7	affinity chromatography technology	Teixeira FR (2016)	1
VCP	6	FBXW11	2	affinity chromatography technology	Li JM (2013)	1
HSP90AA1	7	FBXO28	2	affinity chromatography technology	Taipale M (2012)	1
FBXL2	2	CDC34	3	pull down	Kuchay S (2013)	1
COPS6	0	CKS1B	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
MDM2	2	PSMA7	1	biochemical, affinity chromatography technology, affinity chromatography technology	Kulikov R (2010), Kulikov R (2010), Sdek P (2005)	3
COPS2	5	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Huang X (2005), Bennett EJ (2010), Olma MH (2009), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	6
CDKN1B	1	CCNA1	3	pull down, affinity chromatography technology	Ji P (2006), Thomas DM (2004)	2
PSMA4	0	PSMB4	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Nandi D (1997), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
UBXN7	3	SKP1	0	affinity chromatography technology	Alexandru G (2008)	1
MCL1	1	FBXW11	2	affinity chromatography technology, affinity chromatography technology, unspecified method	Ding Q (2007), Ding Q (2007), Ding Q (2007)	3
ZC3HC1	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, pull down	Bassermann F (2007), Bassermann F (2005), Bassermann F (2005)	3
FBXO25	1	RBX1	2	affinity chromatography technology	Maragno AL (2006)	1
CAND1	2	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
BTRC	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Strack P (2000), Margottin F (1998), Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Watanabe N (2004), Wu G (2003), Kawakami T (2001), Hattori K (1999), Hattori K (1999), Hattori K (1999), Kitagawa M (1999), Hart M (1999), Su Y (2008), Banerjee S (2010), Winston JT (1999), Winston JT (1999), Estrabaud E (2007), Latres E (1999), Latres E (1999), Liu J (2004), Lievens S (2009), Yoshida Y (2007), Yoshida Y (2007), Busino L (2012), Li T (2005), da Silva Almeida AC (2013), Sahasrabuddhe AA (2014), Choi BH (2014), Chong RA (2014), Kim TY (2014), Coyaud E (2015), Deng W (2015), Coyaud E (2015), Liu YQ (2015), He N (2005), Kuchay S (2017), Hauri S (2016)	40
COPS3	1	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, far western blotting, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Yang X (2002), Enchev RI (2010), Huang X (2005), Kapelari B (2000), Kapelari B (2000), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Rozen S (2015), Huttlin EL (2017)	13
COPS6	0	FBXL12	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	FBXO10	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Jeong YT (2013), Reitsma JM (2017)	3
COPS3	1	HSP90AA1	7	affinity chromatography technology	Min KW (2005)	1
FBXO32	2	SKP1	0	pull down, affinity chromatography technology	Gomes MD (2001), Al-Yacoub N (2016)	2
FBXO42	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun L (2009), Huttlin EL (2017), Hauri S (2016)	3
NEDD8	0	COPS7B	0	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	COPS7B	0	affinity chromatography technology	Bennett EJ (2010)	1
MCL1	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Bewley MA (2011), Stankiewicz AR (2009)	2
HSP90AA1	7	FBXL12	1	affinity chromatography technology	Taipale M (2012)	1
SKP1	0	FBXL15	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lievens S (2009), Cui Y (2011), Huttlin EL (2015), Busino L (2007), Huttlin EL (2017), Hauri S (2016)	6
FZR1	1	ZC3HC1	1	enzymatic study, affinity chromatography technology	von Klitzing C (2011), von Klitzing C (2011)	2
COPS5	0	SNRNP70	2	affinity chromatography technology	Bennett EJ (2010)	1
HSP90AA1	7	FBXO34	0	affinity chromatography technology	Taipale M (2012)	1
COPS6	0	FBXO21	2	affinity chromatography technology	Bennett EJ (2010)	1
FBXO6	0	COPS7B	0	affinity chromatography technology	Liu B (2012)	1
PRKN	1	PTTG1	0	enzymatic study	Lee SB (2015)	1
CDC34	3	FBXO7	1	enzymatic study, pull down	Cenciarelli C (1999), Vingill S (2016)	2
ASB2	1	RNF7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kohroki J (2005), Bello NF (2009), Zakaria R (2013)	3
FBXO17	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017), Reitsma JM (2017)	5
CDC5L	2	FAF1	1	affinity chromatography technology	Lleres D (2010)	1
CUL3	17	GLMN	2	affinity chromatography technology	Tron AE (2012)	1
COPS6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Reitsma JM (2017)	7
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
SKP2	2	RICTOR	4	affinity chromatography technology	Huttlin EL (2017)	1
PRKN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2003), Taipale M (2012), Zanon A (2013)	3
FBXO7	1	FBXW2	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
NEDD8	0	FBXW11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Kim TY (2014), Coyaud E (2015)	3
DCUN1D5	0	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bommelje CC (2013), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016)	4
TRIM21	0	UBC	7	enzymatic study	McEwan WA (2013)	1
FZR1	1	PTTG1	0	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Pfleger CM (2001), Jin L (2008), Tian W (2012), He J (2013), Wang W (2013), Van Voorhis VA (2014), Gmachl M (2000), Wu T (2010), Vodermaier HC (2003), Jeganathan KB (2006), Yamaguchi M (2015), Brown NG (2015), Williamson A (2011), Qiao R (2016), Brown NG (2016)	15
FBXW8	2	FBXO4	0	affinity chromatography technology	Ponyeam W (2012)	1
E2F1	0	CCNA2	1	affinity chromatography technology, pull down, affinity chromatography technology	Xu M (1994), Xu M (1994), Schulman BA (1998)	3
UBE2M	0	CUL3	17	enzymatic study, pull down	Huang G (2011), Schumacher FR (2015)	2
COPS5	0	FBXL18	5	affinity chromatography technology	Bennett EJ (2010)	1
SKP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Kumar R (2005), Wang W (2004), Ohta T (2001), Oshikawa K (2003), Liu J (2002), Li X (2003), Zhou W (2014), Zhou W (2014), Hao J (2015), Hauri S (2016)	11
FAF1	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Zhang L (2012), Zhang L (2012)	4
SENP3	1	CUL1	7	affinity chromatography technology, affinity chromatography technology	Wang M (2016), Wang M (2016)	2
CDK2	0	TRIM21	0	affinity chromatography technology	Neganova I (2011)	1
COPS5	0	MDM2	2	affinity chromatography technology, pull down	Zhang XC (2008), Zhang XC (2008)	2
SKP1	0	PSMA6	1	affinity chromatography technology	Hauri S (2016)	1
CUL1	7	FBXO30	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Reitsma JM (2017)	2
NEDD8	0	COPS7A	0	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
UBC	7	PSMA6	1	affinity chromatography technology	Matsumoto M (2005)	1
DCUN1D1	0	SNRNP70	2	affinity chromatography technology	Bennett EJ (2010)	1
FBXO11	14	RBX1	2	affinity chromatography technology	Abida WM (2007)	1
CUL3	17	VCP	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Besten Wd (2012)	2
DCUN1D4	0	CUL1	7	pull down, enzymatic study, affinity chromatography technology	Monda JK (2013), Monda JK (2013), Keuss MJ (2016)	3
RNF7	0	SKP2	2	affinity chromatography technology, affinity chromatography technology	Duan H (2001), Duan H (2001)	2
NFKBIA	0	COPS3	1	affinity chromatography technology	Lee JH (2013)	1
MDM2	2	DDB1	6	affinity chromatography technology, affinity chromatography technology	Latini P (2011), Jacob AG (2014)	2
BTRC	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down	Inuzuka H (2010), Inuzuka H (2010), Inuzuka H (2010)	3
CDC5L	2	SENP3	1	affinity chromatography technology, affinity chromatography technology	Lleres D (2010), Wang M (2016)	2
CCNF	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2011), Jeong YT (2013), Choudhury R (2017), Reitsma JM (2017)	4
HSPA4	3	CAND1	2	biochemical	Kristensen AR (2012)	1
UBXN1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Hu Y (2017), Hu Y (2017)	4
SKP2	2	FBXL18	5	affinity chromatography technology	Huttlin EL (2017)	1
COPS5	0	FBXO44	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	SF3B3	4	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	GLMN	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tron AE (2012), Tron AE (2012), Duda DM (2012), Tron AE (2012), Huttlin EL (2017)	5
UBC	7	PSMA7	1	affinity chromatography technology	Matsumoto M (2005)	1
FBXW4	0	COPS3	1	affinity chromatography technology	Lockwood WW (2013)	1
PSMA2	1	YBX1	1	biochemical	Havugimana PC (2012)	1
NEDD8	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
FBXL2	2	SKP1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe T (2012), Ilyin GP (1999), Kuchay S (2013), Winston JT (1999), Li LQ (2016), Kuchay S (2017), Hauri S (2016)	7
RBX1	2	CCND1	1	affinity chromatography technology	Maeda I (2001)	1
DCUN1D2	0	CAND1	2	affinity chromatography technology, affinity chromatography technology, pull down	Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016)	3
FBXO6	0	NEDD8	0	affinity chromatography technology	Liu B (2012)	1
PSMA4	0	YBX1	1	biochemical	Havugimana PC (2012)	1
DDB1	6	FBXW8	2	affinity chromatography technology	He YJ (2006)	1
HSP90AA1	7	CHEK1	2	affinity chromatography technology, pull down, affinity chromatography technology	Ha K (2011), Arlander SJ (2006), Taipale M (2012)	3
FBXW11	2	KDR	4	two hybrid, affinity chromatography technology	Vinayagam A (2011), Shaik S (2012)	2
FBXO6	0	COPS6	0	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015)	2
COPS7A	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Hein MY (2015)	2
DCUN1D5	0	DDB1	6	affinity chromatography technology	Keuss MJ (2016)	1
MCL1	1	SKP1	0	affinity chromatography technology, affinity chromatography technology	Ye M (2017), Feng C (2017)	2
HSPA4	3	VCP	6	affinity chromatography technology, affinity chromatography technology	Vij N (2006), Yu CC (2013)	2
FBXO11	14	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Abida WM (2007), Duan S (2011), Rossi M (2013), Rolland T (2014), Kuchay S (2017), Hauri S (2016)	6
COPS6	0	UBE2M	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
COPS3	1	SKP1	0	affinity chromatography technology	Olma MH (2009)	1
FBXO7	1	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
SKP2	2	CCNA2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marti A (1999), Bashir T (2010), Rosner M (2009), Rosner M (2004), Zhang H (1995), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	8
NEDD8	0	PSMA2	1	affinity chromatography technology	Norman JA (2006)	1
FBXO44	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2007), Glenn KA (2008), Yoshida Y (2011), Bennett EJ (2010), Huttlin EL (2015), Sjoegren B (2015), Huttlin EL (2017), Reitsma JM (2017)	8
COPS5	0	CDKN1B	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Caballero OL (2002), Kouvaraki MA (2006), Kouvaraki MA (2006), Kouvaraki MA (2006), Hsieh YH (2007), Hwang CY (2004), Hwang CY (2004), Pan Y (2012), Wang Y (2008), Wang Y (2008), Yamaguchi F (2008), Wang Y (2014), Zhang H (2017), Zhang H (2017)	14
CUL3	17	SKP1	0	affinity chromatography technology	Bennett EJ (2010)	1
FBXW4	0	PSMA2	1	affinity chromatography technology	Lockwood WW (2013)	1
CUL1	7	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Min KW (2005), Lee JE (2011), Bennett EJ (2010), Lyapina S (2001), Reitsma JM (2017)	6
CUL3	17	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huang X (2016), Huttlin EL (2017)	3
UBXN7	3	FAF1	1	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015)	2
FBXO32	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Al-Yacoub N (2016), Al-Yacoub N (2016), Reitsma JM (2017)	3
FBXO25	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teixeira FR (2010), Teixeira FR (2010), Hagens O (2006), Maragno AL (2006)	4
DCUN1D1	0	COPS2	5	affinity chromatography technology	Bennett EJ (2010)	1
FBXL15	0	RBX1	2	affinity chromatography technology	Cui Y (2011)	1
NFKBIA	0	FBXW8	2	affinity chromatography technology	Keutgens A (2010)	1
NEDD8	0	ARIH1	3	affinity chromatography technology, pull down, pull down	Bennett EJ (2010), Kelsall IR (2013), Dove KK (2017)	3
COPS2	5	FBXO7	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lyapina S (2001), Huttlin EL (2017)	3
TRIM21	0	CDKN1B	1	affinity chromatography technology	Sabile A (2006)	1
CDC5L	2	TRIM21	0	affinity chromatography technology	Lleres D (2010)	1
FBXO7	1	PSMA2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Vingill S (2016), Vingill S (2016), Vingill S (2016), Vingill S (2016), Vingill S (2016), Vingill S (2016), Teixeira FR (2016)	7
SF3B3	4	SKP2	2	affinity chromatography technology	Cordero-Espinoza L (2013)	1
NEDD8	0	COPS4	0	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
HSP90AA1	7	SKP2	2	affinity chromatography technology	Taipale M (2012)	1
NEDD8	0	PSMA6	1	affinity chromatography technology	Norman JA (2006)	1
CUL1	7	FBXL17	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Tan MK (2013), Raducu M (2016), Reitsma JM (2017)	4
FBXW7	2	CDC34	3	pull down	Klotz K (2009)	1
SNRNP70	2	SKP1	0	affinity chromatography technology	Davis M (2002)	1
COPS6	0	FBXO44	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
PSMA4	0	VCP	6	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
FBXL2	2	FBXO3	0	affinity chromatography technology	Krzysiak TC (2016)	1
FBXW11	2	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Suzuki H (2000), Tan P (1999), Suzuki H (1999), Suzuki H (1999), Herter JR (2002), Chong RA (2014), Herter JR (2002), Huttlin EL (2015), Huttlin EL (2017), Gazdoiu S (2007)	10
RICTOR	4	DDB1	6	affinity chromatography technology, affinity chromatography technology	Hussain S (2013), Hussain S (2013)	2
COMMD1	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology	van de Sluis B (2009), van de Sluis B (2009)	2
COPS7B	0	BTRC	1	affinity chromatography technology	Huang X (2016)	1
COPS5	0	FBXO3	0	affinity chromatography technology	Bennett EJ (2010)	1
TRIM21	0	CUL1	7	affinity chromatography technology, biochemical, pull down	Sabile A (2006), Sabile A (2006), Sabile A (2006)	3
FBXW4	0	COPS7A	0	affinity chromatography technology	Lockwood WW (2013)	1
UBC	7	SKP1	0	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
FBXO25	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teixeira FR (2010), Teixeira FR (2010), Hagens O (2006), Maragno AL (2006)	4
UBE2M	0	PRKN	1	enzymatic study	Choo YS (2012)	1
CUL1	7	COPS8	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Menon S (2008), Bennett EJ (2010), Enchev RI (2012), Reitsma JM (2017)	4
COPS3	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Bennett EJ (2010), Olma MH (2009), Reitsma JM (2017)	4
COPS5	0	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Fang L (2008), Bennett EJ (2010), Oh W (2006), Olma MH (2009), Olma MH (2009), Kotiguda GG (2012), Kristensen AR (2012), Huttlin EL (2015), Bhansali M (2014), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	13
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
CUL1	7	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lyapina SA (1998), Huttlin EL (2015), Huttlin EL (2017)	4
FBXO7	1	PSMA6	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Vingill S (2016), Teixeira FR (2016)	3
FBXW11	2	TRIM21	0	pull down, affinity chromatography technology	Sabile A (2006), Sabile A (2006)	2
CDK9	3	CUL1	7	affinity chromatography technology, affinity chromatography technology	Kiernan RE (2001), Garriga J (2003)	2
HSP90AA1	7	ASB2	1	affinity chromatography technology	Taipale M (2012)	1
FBXW7	2	MAGEC2	0	affinity chromatography technology	Hao J (2015)	1
FBXW4	0	COPS6	0	affinity chromatography technology	Lockwood WW (2013)	1
HSP90AA1	7	BTRC	1	affinity chromatography technology	Taipale M (2012)	1
PSMA6	1	CAND2	7	biochemical	Wan C (2015)	1
FBXO33	0	YBX1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lutz M (2006), Lutz M (2006), Lutz M (2006)	3
PSMA2	1	VCP	6	affinity chromatography technology, biochemical	Bousquet-Dubouch MP (2009), Havugimana PC (2012)	2
IDS	0	FBXO21	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS6	0	FBXL14	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
SKP2	2	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marti A (1999), Yam CH (1999), Calvisi DF (2009), Gao D (2009), Bashir T (2010), Yao ZP (2006), Rosner M (2009), Lyapina SA (1998), Zhang H (1995), Zhang H (1995), Inuzuka H (2012), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	17
COPS2	5	COPS7B	0	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	7
DDB1	6	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006), Olma MH (2009)	3
HSP90AA1	7	FBXO3	0	affinity chromatography technology	Taipale M (2012)	1
RNF7	0	CUL3	17	enzymatic study	Huang DT (2009)	1
CDC34	3	NFKBIA	0	enzymatic study	Wu K (2010)	1
FBXW7	2	FBXW2	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS8	2	GPS1	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Stotland A (2012), Sharon M (2009), Sun Y (2002), Kristensen AR (2012), Lingaraju GM (2014), Lyapina S (2001), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	10
SKP2	2	SKP1	0	affinity chromatography technology, pull down, pull down, two hybrid, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Strack P (2000), Ng RW (1998), Ng RW (1998), Schulman BA (2000), Cenciarelli C (1999), Marti A (1999), Sabile A (2006), Ji P (2004), Wang W (2004), Tokarz S (2004), Watanabe N (2004), Lin HK (2009), Lin HK (2009), Lin HK (2009), Price CT (2009), Huang Z (2004), Wu J (2012), Bashir T (2010), Saiga T (2009), Li T (2005), Carrano AC (1999), Wu J (2012), Wu L (2012), Rodier G (2008), Swarnalatha M (2013), Yumimoto K (2013), Zhou W (2014), Zhou W (2014), Yumimoto K (2012), Tian X (2015), Liu YQ (2015), Kuchay S (2017), Chan CH (2013), Chan CH (2013), Hauri S (2016), Ma X (2017)	37
COPS6	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	CCNA2	1	affinity chromatography technology	Bennett EJ (2010)	1
TRIM21	0	CDC34	3	pull down	Wada K (2006)	1
FBXO42	0	RBX1	2	affinity chromatography technology	Sun L (2009)	1
GPS1	1	SKP1	0	affinity chromatography technology	Lyapina S (2001)	1
FBXW8	2	BTRC	1	affinity chromatography technology	Ponyeam W (2012)	1
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
BTRC	1	COPS6	0	affinity chromatography technology	Fang L (2015)	1
SF3B3	4	SKP1	0	affinity chromatography technology	Cordero-Espinoza L (2013)	1
CUL1	7	FBXL20	0	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Xiao J (2015), Reitsma JM (2017)	3
FBXO18	0	UBC	7	enzymatic study	Kim JH (2015)	1
CDK2	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Fogeron ML (2013)	2
FBXW2	0	SKP1	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Busino L (2012), Saiga T (2009), Watanabe N (2004), Winston JT (1999), Tian X (2015), Hauri S (2016)	9
FBXO11	14	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abida WM (2007), Duan S (2011), Bennett EJ (2010), Jeong YT (2013), Reitsma JM (2017), Reitsma JM (2017)	6
BTRC	1	NEDD8	0	affinity chromatography technology, affinity chromatography technology, bioid	Schweitzer K (2007), Schweitzer K (2007), Coyaud E (2015)	3
NEDD8	0	HSPA4	3	affinity chromatography technology	Bennett EJ (2010)	1
GPS1	1	RBX1	2	affinity chromatography technology	Lyapina S (2001)	1
UBXN7	3	RBX1	2	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Bandau S (2012)	2
UBE2M	0	COPS5	0	affinity chromatography technology	Huttlin EL (2017)	1
RBX1	2	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Furukawa M (2005), Hu J (2004), Furukawa M (2002), Ichikawa T (2009), Ichikawa T (2009), Lee DF (2009), Tron AE (2012), Oshikawa K (2003), Plafker KS (2009), Lu A (2013), Meyer-Schaller N (2009), Theurillat JP (2014), Huang DT (2009), Ibeawuchi SR (2015), Schumacher FR (2015), Kasahara K (2014), Kasahara K (2014)	18
NFKBIA	0	PSMA2	1	pull down	Alvarez-Castelao B (2005)	1
COPS5	0	CDK2	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Chun Y (2013)	2
SF3B3	4	YBX1	1	biochemical	Havugimana PC (2012)	1
CAND1	2	SNRNP70	2	affinity chromatography technology	Bennett EJ (2010)	1
NFKBIA	0	GPS1	1	affinity chromatography technology	Lee JH (2013)	1
RBX1	2	DCUN1D3	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meyer-Schaller N (2009), Huang G (2014), Keuss MJ (2016), Keuss MJ (2016)	4
FBXO31	4	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kumar R (2005), Kumar R (2005), Vadhvani M (2013), Jeffery JM (2017)	4
FBXW4	0	COPS5	0	affinity chromatography technology, affinity chromatography technology	Lockwood WW (2013), Lockwood WW (2013)	2
FBXO6	0	ARIH1	3	affinity chromatography technology	Liu B (2012)	1
DCUN1D1	0	COPS7A	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	PSMA7	1	affinity chromatography technology	Shen H (2007)	1
CDK2	0	SF3B3	4	affinity chromatography technology	Neganova I (2011)	1
FBXO27	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Yoshida Y (2011)	2
FBXO8	1	SKP1	0	affinity chromatography technology, pull down	Yano H (2008), Winston JT (1999)	2
UBE2M	0	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
DCUN1D4	0	RNF7	0	affinity chromatography technology	Keuss MJ (2016)	1
CCND1	1	BTRC	1	affinity chromatography technology, affinity chromatography technology, pull down	Wei S (2008), Wei S (2008), Wei S (2008)	3
COPS5	0	FBXO46	1	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D5	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bommelje CC (2013), Keuss MJ (2016), Keuss MJ (2016)	3
FBXO17	1	FBXW2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DCUN1D3	1	CUL1	7	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Monda JK (2013), Meyer-Schaller N (2009), Huang G (2014), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016), Zhang S (2016), Zhang S (2016)	8
FBXL15	0	ARIH1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2M	0	DCUN1D3	1	pull down, pull down, pull down	Monda JK (2013), Meyer-Schaller N (2009), Keuss MJ (2016)	3
DDB1	6	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down	Wang H (2006), Kapetanaki MG (2006), Hu J (2004), Ahn J (2010), Fischer ES (2011), Groisman R (2006)	6
FBXO6	0	COPS8	2	affinity chromatography technology	Liu B (2012)	1
CKS1B	0	HSP90AA1	7	pull down	Radulovic M (2010)	1
HES1	0	HSPA4	3	affinity chromatography technology	Tremblay CS (2008)	1
FBXO6	0	FBXW2	0	affinity chromatography technology	Liu B (2012)	1
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
VCP	6	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dai RM (1998), Dai RM (1998), Gao Y (2000), Hotta K (2013), Yu CC (2013), Li JM (2013), Li JM (2013), Schweitzer K (2016)	8
COPS5	0	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Fang L (2008), Huang X (2005), Bennett EJ (2010), Kapelari B (2000), Oh W (2006), Olma MH (2009), Havugimana PC (2012), Christmann M (2013), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Scherer PC (2016), Huttlin EL (2017), Boldt K (2016)	15
CDC5L	2	COPS5	0	affinity chromatography technology	Lleres D (2010)	1
CDC5L	2	DDB1	6	affinity chromatography technology	Lleres D (2010)	1
COPS6	0	CDKN1B	1	affinity chromatography technology	Choi HH (2015)	1
FBXL3	1	CRY1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2007), Busino L (2007), Busino L (2007), Yumimoto K (2013), Huttlin EL (2015), Papp SJ (2015), Papp SJ (2015), Huttlin EL (2017)	8
VCP	6	UBXN7	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down	Alexandru G (2008), Alexandru G (2008), Alexandru G (2008), Alexandru G (2008), Alexandru G (2008), Besten Wd (2012), Raman M (2015), Li ZH (2017), Li ZH (2017)	9
CCNA2	1	CCNA1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS5	0	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Cayli S (2009), Cayli S (2009), Cayli S (2009), Cayli S (2009), Bennett EJ (2010)	5
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
CCND1	1	SKP1	0	affinity chromatography technology, affinity chromatography technology	Okabe H (2007), Lin DI (2006)	2
RBX1	2	FBXO18	0	affinity chromatography technology, pull down	Kim J (2002), Kim JH (2004)	2
CUL1	7	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inuzuka H (2010), Inuzuka H (2010), He Y (2014)	3
BTRC	1	COPS4	0	affinity chromatography technology	Sowa ME (2009)	1
SKP1	0	PSMA4	0	affinity chromatography technology	Hauri S (2016)	1
FBXO7	1	NEDD8	0	affinity chromatography technology	Teixeira FR (2016)	1
COPS5	0	FBXO21	2	affinity chromatography technology	Bennett EJ (2010)	1
FBXO6	0	SF3B3	4	affinity chromatography technology	Liu B (2012)	1
RBX1	2	FBXO22	1	affinity chromatography technology	Dias DC (2002)	1
RBX1	2	UBE2M	0	pull down, pull down, pull down, pull down, x-ray crystallography, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, enzymatic study, pull down	Okuda H (2001), Yoshida Y (2005), Choi YS (2010), Calabrese MF (2011), Calabrese MF (2011), Kim AY (2008), Scott DC (2014), Markson G (2009), Sufan RI (2006), Huang DT (2009), Morimoto M (2003), Ohki Y (2009), Ohki Y (2009), Wang X (2015)	14
FBXO3	0	SKP1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Shima Y (2008), Yu H (2011), Cloutier P (2017), Hauri S (2016)	4
CUL1	7	SENP8	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Gastaldello S (2010), Gastaldello S (2010), Christmann M (2013), Gastaldello S (2010)	4
COPS3	1	FBXO17	1	affinity chromatography technology	Olma MH (2009)	1
UBE2M	0	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
COPS5	0	PSMA7	1	affinity chromatography technology	Bennett EJ (2010)	1
SKP2	2	CDC34	3	pull down, enzymatic study, pull down	Cen B (2010), Umanskaya K (2007), Ji P (2006)	3
COPS6	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
COPS7A	0	BTRC	1	affinity chromatography technology	Huang X (2016)	1
FBXO25	1	DCX	5	enzymatic study	Teixeira FR (2013)	1
DCUN1D4	0	CUL3	17	pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study	Monda JK (2013), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016)	5
HSP90AA1	7	FBXL15	0	affinity chromatography technology	Taipale M (2012)	1
FBXO6	0	COPS7A	0	affinity chromatography technology	Liu B (2012)	1
CDC34	3	FBXW2	0	enzymatic study	Cenciarelli C (1999)	1
SKP1	0	FBXW9	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Lievens S (2009), Lievens S (2009), Hauri S (2016)	3
DCUN1D1	0	COPS4	0	affinity chromatography technology	Bennett EJ (2010)	1
FBXW8	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Okabe H (2007), Litterman N (2011), Busino L (2012), Watanabe N (2004), Ponyeam W (2012), Tian X (2015), Xu X (2008), Hauri S (2016)	9
FAF1	1	FBXW11	2	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Zhang L (2012)	2
UBE2M	0	CUL1	7	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Huang G (2011), Huang G (2011), Kim AY (2008), Ponyeam W (2012), Ohki Y (2009), Zhou W (2017), Mo Z (2016)	7
ARIH1	3	UBC	7	pull down, x-ray crystallography	Dove KK (2017), Dove KK (2017)	2
COPS3	1	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
CUL1	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
CUL3	17	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huang X (2016), Huttlin EL (2017)	5
PSMA6	1	CCNF	2	affinity chromatography technology	Sharma SS (2011)	1
GPS1	1	SENP8	0	far western blotting, far western blotting	Christmann M (2013), Christmann M (2013)	2
SENP3	1	VCP	6	affinity chromatography technology	Wang M (2016)	1
COPS3	1	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, two hybrid, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Min KW (2005), Enchev RI (2010), Stotland A (2012), Sharon M (2009), Kapelari B (2000), Tsuge T (2001), Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	12
SKP1	0	CCNF	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2007), DAngiolella V (2012), Yoshida Y (2011), Kuchay S (2017), Choudhury R (2017)	5
COPS7A	0	COPS2	5	affinity chromatography technology, far western blotting, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uhle S (2003), Kapelari B (2000), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	10
CUL1	7	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Oshikawa K (2003), Bennett EJ (2010)	2
TSC22D4	1	CUL1	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDC5L	2	HSP90AA1	7	affinity chromatography technology	Lleres D (2010)	1
NEDD8	0	COPS3	1	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
CUL1	7	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Min KW (2005), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Reitsma JM (2017)	6
CDC34	3	FBXO4	0	enzymatic study	Cenciarelli C (1999)	1
ING3	3	CUL1	7	affinity chromatography technology, affinity chromatography technology	Chen G (2010), Chen G (2010)	2
FBXO17	1	COPS2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL1	7	CCDC22	1	affinity chromatography technology, affinity chromatography technology	Starokadomskyy P (2013), Starokadomskyy P (2013)	2
CUL3	17	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	5
FBXO7	1	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
FBXL14	2	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
TSC22D4	1	BTRC	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SKP1	0	FBXO10	3	affinity chromatography technology	Hauri S (2016)	1
CUL3	17	FBXW5	6	affinity chromatography technology	Wimuttisuk W (2014)	1
DDB1	6	SKP2	2	affinity chromatography technology	Bondar T (2006)	1
PRKN	1	CDC34	3	pull down	Kazlauskaite A (2014)	1
SENP3	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yan S (2010), Yan S (2010), Wang M (2016)	3
CUL1	7	FBXL8	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Reitsma JM (2017)	2
CRY1	0	BTRC	1	affinity chromatography technology	Busino L (2007)	1
CUL1	7	FBXL14	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017), Reitsma JM (2017)	3
COPS6	0	FBXL15	0	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012)	4
HSP90AA1	7	FBXO10	3	affinity chromatography technology	Taipale M (2012)	1
FBXW5	6	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hu J (2008), He YJ (2006), Kanei-Ishii C (2012)	3
HSP90AA1	7	CDKN1B	1	genetic interference	Srivas R (2016)	1
PSMA7	1	CUL1	7	pull down, affinity chromatography technology	Bloom J (2006), Bennett EJ (2010)	2
CUL1	7	ARIH1	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Bennett EJ (2010), Kelsall IR (2013), Kelsall IR (2013), Huttlin EL (2017)	4
FBXO31	4	MDM2	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Malonia SK (2015), Malonia SK (2015), Malonia SK (2015)	3
COPS6	0	FBXL18	5	affinity chromatography technology	Bennett EJ (2010)	1
SKP1	0	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down	Hattori K (1999), Tan P (1999), Suzuki H (1999), Winston JT (1999), Surjit M (2012), Chong RA (2014)	6
DCUN1D1	0	GPS1	1	affinity chromatography technology	Bennett EJ (2010)	1
FBXL5	3	ARIH1	3	affinity chromatography technology	Huttlin EL (2017)	1
CDK2	0	NEDD8	0	affinity chromatography technology	Ewing RM (2007)	1
DDB1	6	GPS1	1	affinity chromatography technology, pull down, fluorescent resonance energy transfe	Jin J (2006), Emberley ED (2012), Cavadini S (2016)	3
CDKN1B	1	CCND1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin J (2001), Guidoboni M (2005), Vlach J (1996), Vlach J (1997), Tsai CH (2009), Ciarallo S (2002), Bindra RS (2002), Kossatz U (2006), Grimmler M (2007), Rolland T (2014), Hein MY (2015), Barbash O (2009), Huttlin EL (2017)	13
PRKN	1	PSMB4	2	affinity chromatography technology	Sarraf SA (2013)	1
PSMB4	2	YBX1	1	biochemical	Havugimana PC (2012)	1
HSP90AA1	7	FBXL2	2	affinity chromatography technology	Taipale M (2012)	1
HSP90AA1	7	FBXW11	2	affinity chromatography technology	Taipale M (2012)	1
FAF1	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Lee JJ (2012), Kim HJ (2005), Kim HJ (2005), Lee JJ (2013), Lee JJ (2013), Kristensen AR (2012)	6
COPS6	0	FBXW9	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
PSMA6	1	CDK2	0	affinity chromatography technology, affinity chromatography technology	Sharma SS (2011), Neganova I (2011)	2
UBXN1	0	DDB1	6	affinity chromatography technology	Alexandru G (2008)	1
COPS8	2	COPS7B	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	5
PSMA2	1	FBXW7	2	affinity chromatography technology	Bousquet-Dubouch MP (2009)	1
FBXL14	2	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
PSMA4	0	PSMA6	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical	Bloom J (2006), Apcher GS (2004), Apcher GS (2004), Nandi D (1997), Fricke B (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	8
FBXL5	3	RBX1	2	affinity chromatography technology, biochemical	Salahudeen AA (2009), Vinas-Castells R (2013)	2
FBXW7	2	CDK2	0	affinity chromatography technology, affinity chromatography technology	Zhang W (2012), Zhang W (2012)	2
CUL1	7	FZR1	1	affinity chromatography technology, affinity chromatography technology	Fukushima H (2013), Fukushima H (2013)	2
CDC25A	2	CCNA2	1	affinity chromatography technology	Li X (2016)	1
NEDD8	0	FBXO3	0	affinity chromatography technology	Bennett EJ (2010)	1
CRY1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2007), Papp SJ (2015), Huttlin EL (2017)	3
CCNA2	1	CDKN1B	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joaquin M (2003), Schulman BA (1998), Datta NS (1998), Vlach J (1997), Levkau B (1998), Grimmler M (2007), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
FBXO6	0	PSMA4	0	affinity chromatography technology	Liu B (2012)	1
COPS5	0	FBXW11	2	affinity chromatography technology	Bennett EJ (2010)	1
CCNA1	3	CDC25A	2	affinity chromatography technology, affinity chromatography technology	Liu D (2000), Li X (2016)	2
CHEK1	2	CDC25A	2	pull down, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Goloudina A (2003), Sanchez Y (1997), Sanchez Y (1997), Zhao H (2002), Jin J (2008), Hassepass I (2003), Sorensen CS (2003), Li X (2016)	8
MCL1	1	CUL1	7	affinity chromatography technology, affinity chromatography technology	Ye M (2017), Feng C (2017)	2
FBXO25	1	CAND1	2	affinity chromatography technology, affinity chromatography technology	Teixeira FR (2010), Teixeira FR (2010)	2
FBXO4	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Li Y (2010), Li Y (2010), Hagens O (2006), Lee EK (2013), Tian X (2015), Huttlin EL (2017), Qie S (2017), Hauri S (2016)	12
FZR1	1	CCNA1	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sorensen CS (2001), Sorensen CS (2001), Gao D (2009), Fukushima H (2013)	4
DCUN1D1	0	COPS5	0	affinity chromatography technology	Bennett EJ (2010)	1
YBX1	1	CUL1	7	affinity chromatography technology, affinity chromatography technology	Lutz M (2006), Bennett EJ (2010)	2
CHEK1	2	FBXO6	0	affinity chromatography technology	Tu Y (2017)	1
UBXN7	3	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
COPS6	0	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Enchev RI (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	11
SKP2	2	CKS1B	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe, pull down, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Wang W (2003), Wang W (2003), Sitry D (2002), Sitry D (2002), Ganoth D (2001), Calvisi DF (2008), Xu S (2007), Ungermannova D (2005), Spruck C (2001), Yao ZP (2006), Seeliger MA (2005), Huang KS (2005), Rodier G (2008), Ungermannova D (2013), Radulovic M (2010), Huttlin EL (2017)	16
COPS5	0	SKP1	0	affinity chromatography technology	Bennett EJ (2010)	1
DDB1	6	COPS8	2	affinity chromatography technology, pull down	Angers S (2006), Emberley ED (2012)	2
DCUN1D3	1	RNF7	0	affinity chromatography technology	Keuss MJ (2016)	1
HSP90AA1	7	FBXW7	2	affinity chromatography technology	Taipale M (2012)	1
CUL1	7	CUL1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao X (2011), Lee JE (2011), Bennett EJ (2010), Chew EH (2007)	4
CKS1B	0	SKP1	0	pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology	Yao ZP (2006), Seeliger MA (2005), Radulovic M (2010), Ungermannova D (2013), Hauri S (2016)	5
UBXN7	3	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
COPS5	0	FBXO7	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
IDS	0	FBXO3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VCP	6	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012), Zhang Z (2015)	3
SKP1	0	FBXL8	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Lievens S (2009), Rolland T (2014), Hein MY (2015), Hauri S (2016)	4
RBX1	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, bioid	Tan M (2010), Oshikawa K (2003), Coyaud E (2015)	3
CDC25A	2	CDK2	0	pull down, enzymatic study, affinity chromatography technology	Xu X (1996), Cheng A (2005), Li X (2016)	3
CDK9	3	YBX1	1	affinity chromatography technology	Jeronimo C (2007)	1
DCUN1D5	0	CUL3	17	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Monda JK (2013), Bommelje CC (2013), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016)	7
FBXW2	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Saiga T (2009), Xu J (2017)	2
DCUN1D1	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
FBXO2	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wen H (2010), Glenn KA (2008), Jeong YT (2013), Reitsma JM (2017)	4
CUL1	7	CKS1B	0	affinity chromatography technology, pull down, affinity chromatography technology	Bennett EJ (2010), Radulovic M (2010), Huttlin EL (2017)	3
DDB1	6	COPS4	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Angers S (2006), Jin J (2006), Emberley ED (2012), Olma MH (2009)	4
FAF1	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Zhang L (2012), Zhang L (2012)	3
COPS6	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	6
CUL1	7	DDB1	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Gastaldello S (2012)	2
COPS6	0	FBXO17	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
MDM2	2	UBE2M	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Xirodimas DP (2004), Batuello CN (2015), Batuello CN (2015), Batuello CN (2015)	4
VCP	6	ARIH1	3	affinity chromatography technology	Yu CC (2013)	1
CUL1	7	8847	0	affinity chromatography technology, unspecified method	Li W (2017), Li W (2017)	2
PRKN	1	ARIH1	3	affinity chromatography technology	Parelkar SS (2012)	1
COMMD1	1	NFKBIA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganesh L (2003), Zoubeidi A (2010), de Bie P (2006), Taura M (2015)	4
FBXO25	1	ING3	3	enzymatic study	Teixeira FR (2013)	1
HES1	0	HSP90AA1	7	affinity chromatography technology	Tremblay CS (2008)	1
SKP2	2	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
MDM2	2	HSPA4	3	affinity chromatography technology	Lu TL (2010)	1
CUL1	7	FBXL12	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Kim M (2008), Postow L (2013), Nishiyama M (2015), Reitsma JM (2017)	5
CUL3	17	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Oshikawa K (2003), Bennett EJ (2010)	2
CUL1	7	CHEK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu S (2009), Huh J (2013), Zhang YW (2005)	3
FBXW7	2	PSMA4	0	affinity chromatography technology	Kourtis N (2015)	1
FBXW11	2	RBX1	2	affinity chromatography technology	Tan P (1999)	1
COPS5	0	COPS9	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bennett EJ (2010), Ebina M (2013), Ebina M (2013), Rozen S (2015), Rozen S (2015)	5
SENP3	1	MDM2	2	affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Nishida T (2011), Nishida T (2011), Nishida T (2011), Nishida T (2011)	4
FBXW8	2	CCND1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Okabe H (2007), Okabe H (2007), Wei S (2008)	3
COPS8	2	COPS5	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Sowa ME (2009), Fang L (2008), Bennett EJ (2010), Olma MH (2009), Asare Y (2013), Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	9
CDC34	3	FBXL3	1	enzymatic study	Cenciarelli C (1999)	1
FBXL12	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim M (2008), Postow L (2013), Postow L (2013), Nishiyama M (2015), Hauri S (2016)	5
GPS1	1	COPS7A	0	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Wan C (2015), Hein MY (2015), Huang X (2016)	6
DDB1	6	COPS5	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Angers S (2006), Jin J (2006), Emberley ED (2012), Bennett EJ (2010), Olma MH (2009), He F (2013)	6
CDK2	0	CAND1	2	affinity chromatography technology	Neganova I (2011)	1
FBXO31	4	RBX1	2	affinity chromatography technology, affinity chromatography technology	Kumar R (2005), Jeffery JM (2017)	2
NEDD8	0	YBX1	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	CCNA1	3	affinity chromatography technology	Bennett EJ (2010)	1
CAND1	2	UBE2M	0	pull down	Kim AY (2008)	1
CUL3	17	YBX1	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	FBXL17	4	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	PSMB4	2	affinity chromatography technology, two hybrid	Bennett EJ (2010), Lyapina SA (1998)	2
COPS5	0	FBXO10	3	affinity chromatography technology	Bennett EJ (2010)	1
PSMA6	1	COPS5	0	affinity chromatography technology	Huang X (2005)	1
CDC34	3	CUL1	7	pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology	Block K (2005), Wirbelauer C (2000), Saha A (2008), Sandoval D (2014), Wu K (2016)	5
UBC	7	FBXO44	0	pull down	Nathan JA (2013)	1
PSMA6	1	CCND1	1	affinity chromatography technology	Sharma SS (2011)	1
DCUN1D1	0	CUL3	17	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Monda JK (2013), Wan C (2015), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Huttlin EL (2017)	19
FBXO7	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Kirk R (2008), Hsu JM (2004), Hagens O (2006), Bennett EJ (2010), Hein MY (2015), Vingill S (2016), Huttlin EL (2017), Teixeira FR (2016), Reitsma JM (2017), Reitsma JM (2017)	11
CCNA1	3	SKP2	2	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ji P (2006), Ji P (2006), Ji P (2006), Yam CH (2000), Gao D (2009), Ji P (2007)	6
CDC5L	2	SF3B3	4	biochemical, affinity chromatography technology	Wan C (2015), Lleres D (2010)	2
CDCA3	0	FZR1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
E2F1	0	FZR1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Budhavarapu VN (2012), Budhavarapu VN (2012), Budhavarapu VN (2012), Singh RK (2017)	4
COPS5	0	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Fang L (2008), Enchev RI (2010), Bennett EJ (2010), Oh W (2006), Olma MH (2009), Olma MH (2009), Asare Y (2013), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	13
PRKN	1	PSMA2	1	affinity chromatography technology	Sarraf SA (2013)	1
COPS6	0	COPS7A	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sharon M (2009), Bennett EJ (2010), Luke-Glaser S (2007), Kapelari B (2000), Olma MH (2009), Olma MH (2009), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	15
FAF1	1	BTRC	1	affinity chromatography technology, affinity chromatography technology	Zhang L (2012), Zhang L (2012)	2
UBXN1	0	RBX1	2	affinity chromatography technology	Hu Y (2017)	1
CDCA3	0	SKP1	0	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical	Ayad NG (2003), Ayad NG (2003), Lievens S (2009), Watanabe N (2004), Ayad NG (2003)	5
FBXW11	2	COPS7A	0	affinity chromatography technology	Kim TY (2014)	1
CUL3	17	COPS8	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Schumacher FR (2015)	2
PTTG1	0	CUL1	7	affinity chromatography technology, pull down	Molina-Jimenez F (2010), Molina-Jimenez F (2010)	2
BTRC	1	CCDC22	1	affinity chromatography technology	Starokadomskyy P (2013)	1
ING3	3	RBX1	2	affinity chromatography technology, affinity chromatography technology	Chen G (2010), Chen G (2010)	2
SENP8	0	NEDD8	0	pull down, x-ray crystallography, enzymatic study, x-ray crystallography, enzymatic study	Wu K (2003), Shen LN (2005), Engels IH (2009), Reverter D (2005), Shen LN (2005)	5
FBXO32	2	RBX1	2	affinity chromatography technology	Al-Yacoub N (2016)	1
DCUN1D1	0	UBC	7	affinity chromatography technology, pull down, affinity chromatography technology	Bennett EJ (2010), Huang G (2014), Huang G (2014)	3
FBXL14	2	SKP1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
CCNF	2	FZR1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Choudhury R (2016), Choudhury R (2016), Choudhury R (2016)	3
DCUN1D4	0	RBX1	2	affinity chromatography technology	Keuss MJ (2016)	1
PRKN	1	PSMA4	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hampe C (2006), Daechsel JC (2005), Daechsel JC (2005), Daechsel JC (2005), Sarraf SA (2013)	5
HSP90AA1	7	FBXL14	2	affinity chromatography technology	Taipale M (2012)	1
SENP3	1	CUL3	17	affinity chromatography technology, affinity chromatography technology	Wang M (2016), Wang M (2016)	2
FBXW11	2	YBX1	1	affinity chromatography technology	Low TY (2014)	1
SKP1	0	FBXO2	0	x-ray crystallography, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, two hybrid, affinity chromatography technology	Mizushima T (2007), Lievens S (2009), Nelson RF (2007), Henzl MT (2004), Henzl MT (2004), Glenn KA (2008), Tan A (2008), Erhardt JA (1998), Winston JT (1999), Rolland T (2014), Hauri S (2016)	11
PRKN	1	FBXO4	0	affinity chromatography technology	Gong Y (2014)	1
CUL3	17	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
VCP	6	COPS7A	0	affinity chromatography technology	Yu CC (2013)	1
COPS8	2	COPS6	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	10
RNF7	0	UBE2M	0	pull down	Huang DT (2009)	1
UBC	7	FBXO7	1	affinity chromatography technology	Matsumoto M (2005)	1
UBXN7	3	DDB1	6	affinity chromatography technology	Alexandru G (2008)	1
CDC25A	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2003), Donzelli M (2004), Busino L (2003), Donzelli M (2002), He N (2005), Li X (2016)	6
CUL1	7	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Min KW (2005), Min KW (2005), Yang X (2002), Yang X (2002), Huang X (2005), Bennett EJ (2010), Scherer PC (2016), Scherer PC (2016), Reitsma JM (2017)	9
FBXW8	2	FBXW2	0	affinity chromatography technology	Ponyeam W (2012)	1
UBC	7	FBXL15	0	pull down	Zhang X (2017)	1
DCUN1D2	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Keuss MJ (2016), Keuss MJ (2016)	2
DCUN1D1	0	DDB1	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Keuss MJ (2016)	2
FBXO7	1	SF3B3	4	affinity chromatography technology	Teixeira FR (2016)	1
FBXL3	1	SKP1	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Yumimoto K (2013), Kuchay S (2017)	5
GPS1	1	COPS7B	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Stotland A (2012), Havugimana PC (2012), Huang X (2016), Huttlin EL (2017)	4
FBXO31	4	CCND1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Santra MK (2009), Santra MK (2009), Santra MK (2009), Yumimoto K (2013), Johansson P (2014)	5
CDC5L	2	CDK9	3	affinity chromatography technology	Lleres D (2010)	1
COPS5	0	SKP2	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
COPS5	0	FBXO17	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
DCUN1D1	0	NEDD8	0	affinity chromatography technology	Bennett EJ (2010)	1
SKP1	0	MED6	0	affinity chromatography technology	Ang K (2012)	1
COPS4	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
CDC5L	2	ZC3HC1	1	affinity chromatography technology	Lleres D (2010)	1
MDM2	2	E2F1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Zhang Z (2005), Zhang Z (2005), Stevens C (2008), Stevens C (2008)	4
DCUN1D1	0	COPS9	1	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	UBE2M	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li T (2006), Norman JA (2006), Huttlin EL (2017)	3
RBX1	2	RICTOR	4	affinity chromatography technology, affinity chromatography technology	Gao D (2010), Gao D (2010)	2
FBXO31	4	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kumar R (2005), Bennett EJ (2010), Vadhvani M (2013), Jeong YT (2013), Hein MY (2015), Malonia SK (2015), Jeffery JM (2017), Reitsma JM (2017)	8
COPS5	0	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Neuss H (2007), Fang L (2008), Orel L (2010), Uhle S (2003), Bennett EJ (2010), Luke-Glaser S (2007), Kapelari B (2000), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	17
FBXO6	0	YBX1	1	affinity chromatography technology	Liu B (2012)	1
CDKN1B	1	DDB1	6	affinity chromatography technology	Iovine B (2011)	1
SKP1	0	FBXO30	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Tian X (2015), Hauri S (2016)	3
SKP1	0	PSMB4	2	affinity chromatography technology	Hauri S (2016)	1
FBXW8	2	SKP2	2	affinity chromatography technology	Ponyeam W (2012)	1
FBXL17	4	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tan MK (2013), Raducu M (2016), Raducu M (2016), Hauri S (2016)	4
CCND1	1	CDK2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sweeney KJ (1997), Higashi H (1996), Higashi H (1996), Varjosalo M (2013), Hein MY (2015), Huttlin EL (2017)	6
FBXL14	2	HES1	0	affinity chromatography technology, affinity chromatography technology	Chen F (2017), Chen F (2017)	2
CUL1	7	FBXL15	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Cui Y (2011), Huttlin EL (2015), Huttlin EL (2017), Reitsma JM (2017)	5
DCUN1D3	1	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Huang G (2014), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Zhang S (2016), Zhang S (2016)	6
HSPA4	3	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Moore DJ (2008), Hampe C (2006), Tsai YC (2003), Morishima Y (2008), Kalia SK (2004), Kalia SK (2004), Imai Y (2003), Imai Y (2003)	8
FBXO17	1	RBX1	2	affinity chromatography technology	Glenn KA (2008)	1
BTRC	1	KDR	4	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Meyer RD (2011), Meyer RD (2011), Shaik S (2012), Shaik S (2012)	4
FBXO44	0	DDB1	6	affinity chromatography technology	Sjoegren B (2015)	1
RBX1	2	NEDD8	0	affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Norman JA (2006)	2
MDM2	2	HSP90AA1	7	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, biochemical, unspecified method, affinity chromatography technology	Lu TL (2010), Burch L (2004), Burch L (2004), Burch L (2004), Burch L (2004), Burch LR (2004), Okoro DR (2013)	7
FBXW7	2	SNRNP70	2	genetic interference	Bailey ML (2015)	1
FBXW7	2	CUL1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu G (2001), Tron AE (2012), Busino L (2012), Busino L (2012), Busino L (2012), Matsumoto A (2011), Bennett EJ (2010), Strohmaier H (2001), Davis MA (2013), JunGang Z (2012), Busino L (2003), Pierce NW (2013), Chung FZ (2014), Yumimoto K (2012), Low TY (2014), Kourtis N (2015), Gorelik M (2016), Gorelik M (2016), Huttlin EL (2017), Reiterer V (2017), Reiterer V (2017), Ye M (2017), Reitsma JM (2017)	23
COPS6	0	GPS1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Stotland A (2012), Sharon M (2009), Bennett EJ (2010), Lingaraju GM (2014), Huttlin EL (2015), Huttlin EL (2017)	7
CUL1	7	FBXO33	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Reitsma JM (2017)	2
FBXW11	2	ARIH1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Kim TY (2014), Low TY (2014), Huttlin EL (2017)	4
FAF1	1	UBC	7	pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Song EJ (2005), Lee JJ (2012), Song J (2009), Song J (2009), Song J (2009), Lee JJ (2013), Lee JJ (2013), Nathan JA (2013), Baron Y (2014), Alexandru G (2008), Lee JJ (2012)	11
COPS6	0	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
FBXO21	2	RBX1	2	affinity chromatography technology	Watanabe K (2015)	1
FBXL12	1	RBX1	2	affinity chromatography technology	Kim M (2008)	1
CDK9	3	SKP1	0	pull down, affinity chromatography technology	Kiernan RE (2001), Kiernan RE (2001)	2
DCUN1D2	0	CUL1	7	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Monda JK (2013), Meyer-Schaller N (2009), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	5
CUL1	7	KDR	4	affinity chromatography technology, affinity chromatography technology	Shaik S (2012), Shaik S (2012)	2
SNRNP70	2	CUL1	7	affinity chromatography technology, affinity chromatography technology	Davis M (2002), Bennett EJ (2010)	2
E2F1	0	DDB1	6	affinity chromatography technology	Hayes S (1998)	1
UBXN1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
CDK2	0	CDC5L	2	enzymatic study	Boudrez A (2000)	1
COPS7B	0	COPS7A	0	biochemical, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2017)	2
PRKN	1	PSMA6	1	affinity chromatography technology	Sarraf SA (2013)	1
FBXO4	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Cenciarelli C (1999), Hagens O (2006), Choo YY (2011), Liu B (2012), Jeong YT (2013), Huttlin EL (2017), Reitsma JM (2017)	8
UBE2M	0	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS5	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
CDK2	0	CKS1B	0	x-ray crystallography, affinity chromatography technology, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Bourne Y (1996), Xu S (2007), Yao ZP (2006), Seeliger MA (2005), Varjosalo M (2013), Radulovic M (2010), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	12
PSMA6	1	PSMB4	2	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
COPS5	0	COPS6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Fang L (2008), Sharon M (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Choi HH (2011), Kristensen AR (2012), Birol M (2014), Birol M (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	18
DCUN1D1	0	UBE2M	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, unspecified method, affinity chromatography technology	Kim AY (2008), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Kim AY (2008), Scott DC (2011), Huang G (2014), Huang G (2014), Keuss MJ (2016), Huttlin EL (2017), Zhou H (2017), Zhou H (2017), Zhou H (2017)	13
SKP1	0	FBXL20	0	affinity chromatography technology	Hauri S (2016)	1
HSP90AA1	7	FBXO25	1	affinity chromatography technology	Taipale M (2012)	1
RNF7	0	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Tan M (2010), Kuang P (2016), Kuang P (2016), Kuang P (2016)	4
PSMA2	1	RBX1	2	affinity chromatography technology	Bousquet-Dubouch MP (2009)	1
FBXW2	0	SKP2	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Xu J (2017), Xu J (2017), Xu J (2017)	3
ZC3HC1	1	SKP1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bassermann F (2007), Bassermann F (2005), Bassermann F (2005), Bassermann F (2005), von Klitzing C (2011), Liu YQ (2015), Liu YQ (2015)	7
CDK2	0	UBE2M	0	affinity chromatography technology	Ewing RM (2007)	1
CUL1	7	CCNA2	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Hein MY (2015)	2
UBE2M	0	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
DCUN1D2	0	CUL3	17	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Monda JK (2013), Meyer-Schaller N (2009), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016)	7
BTRC	1	MCL1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study	Dehan E (2009), Ding Q (2007), Ding Q (2007), Ding Q (2007), Ding Q (2007)	5
BTRC	1	CDC25A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Ray D (2005), Jin J (2003), Jin J (2003), Honaker Y (2010), Honaker Y (2010), Gao D (2009), Donzelli M (2004), Donzelli M (2004), Jin J (2005), Busino L (2003), Busino L (2003), Busino L (2003), Busino L (2003), Kim TY (2014), Jin J (2003), Coyaud E (2015), Loveless TB (2015), Coyaud E (2015), He N (2005), He N (2005), St-Denis N (2016), Huttlin EL (2017)	23
E2F1	0	CDK2	0	pull down, enzymatic study, affinity chromatography technology, enzymatic study	Xu M (1994), Dynlacht BD (1997), Dynlacht BD (1997), Ohta T (2001)	4
CKS1B	0	CCNA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jackman M (2002), Wolthuis R (2008), Mateo F (2009), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
PSMA4	0	PSMA7	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, two hybrid, biochemical, biochemical, biochemical	Apcher GS (2004), Apcher GS (2004), Apcher GS (2004), Apcher GS (2004), Jayarapu K (2004), Nandi D (1997), Fricke B (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	10
PSMA6	1	RBX1	2	affinity chromatography technology	Bloom J (2006)	1
FBXO7	1	SKP1	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Hsu JM (2004), Nelson DE (2011), Hagens O (2006), Kang J (2014), Winston JT (1999), Hein MY (2015), Hein MY (2015), Vingill S (2016), Vingill S (2016), Huttlin EL (2017), Teixeira FR (2016), Teixeira FR (2016), Hauri S (2016)	16
COPS4	0	COPS7A	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Sharon M (2009), Luke-Glaser S (2007), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huang X (2016)	13
DDB1	6	BTRC	1	affinity chromatography technology	He YJ (2006)	1
SKP2	2	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
ZC3HC1	1	RBX1	2	affinity chromatography technology	Bassermann F (2005)	1
COPS3	1	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	5
CDC34	3	CDKN1B	1	enzymatic study, unspecified method	Ryu KS (2008), Duda DM (2012)	2
GPS1	1	COPS4	0	affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical	Stotland A (2012), Tsuge T (2001), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Wan C (2015)	7
VCP	6	COPS3	1	affinity chromatography technology	Yu CC (2013)	1
RBX1	2	CDC34	3	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Wu K (2002), Block K (2005), Block K (2005), Chen A (2000), Cen B (2010), Cen B (2009), DAngiolella V (2010), Spruck C (2001), Shaik S (2012), Kruiswijk F (2012), Tan M (2010), Bashir T (2010), Higa LA (2003), Kanayama A (2004), Lan L (2012), Welcker M (2011), Banks D (2006), Kumar KG (2003), Higa LA (2006), Saha A (2008), Jin J (2005), Cen B (2009), Tedesco D (2002), Choi YS (2010), Duan S (2011), Li X (2003), Wang W (2003), Gallegos JR (2008), Peschiaroli A (2009), Banerjee S (2010), Duan S (2011), Wang F (2011), Chen H (2013), Rodier G (2008), Rossi M (2013), Ungermannova D (2013), Ooi LC (2013), Ziemba A (2013), Huang H (2014), Herrero-Ruiz J (2014), Kim J (2014), Min SH (2012), Watanabe M (2011), Gao D (2010), Zhou W (2014), Canettieri G (2010), Morimoto M (2003), Chen A (2002), Pashkova N (2010), Read MA (2000), Bassermann F (2005), Duda DM (2008), Enchev RI (2012), Fukushima H (2013), Tintignac LA (2005), Ungermannova D (2005), Low TY (2014), Walter D (2016), Gao J (2015), Orthwein A (2015), Wu K (2016), Wu K (2016), Nateri AS (2004), Pierce NW (2009), Kim JH (2015), Shimizu K (2017), Gschweitl M (2016), Ibarra R (2016), Kuang P (2016), Kuang P (2016), Kuang P (2016), Ferretti LP (2016), Kuchay S (2017), Gazdoiu S (2007), Dai X (2017)	75
FBXW8	2	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Okabe H (2007), Xu X (2008)	3
FBXO46	1	CUL1	7	affinity chromatography technology, affinity chromatography technology	Jeong YT (2013), Reitsma JM (2017)	2
PRKN	1	PSMA7	1	affinity chromatography technology	Sarraf SA (2013)	1
COPS5	0	YBX1	1	affinity chromatography technology	Bennett EJ (2010)	1
PRKN	1	FAF1	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Sul JW (2013), Sul JW (2013), Sul JW (2013), Sul JW (2013), Sul JW (2013)	5
COPS6	0	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	9
UBXN1	0	FAF1	1	affinity chromatography technology	Raman M (2015)	1
CDK9	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mak AB (2010), Taipale M (2012), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	5
COPS2	5	COPS9	1	affinity chromatography technology	Rozen S (2015)	1
SKP1	0	FBXL18	5	affinity chromatography technology	Hauri S (2016)	1
COPS5	0	FBXO11	14	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
ASB2	1	CUL1	7	affinity chromatography technology, affinity chromatography technology	Nie L (2011), Nie L (2011)	2
CHEK1	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leung-Pineda V (2009), Leung-Pineda V (2009), Huh J (2013), Williamson EA (2014)	4
CDK2	0	SKP1	0	x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao ZP (2006), Lyapina SA (1998), Zhang H (1995), Varjosalo M (2013), So J (2015), Hein MY (2015)	6
CDK9	3	SKP2	2	affinity chromatography technology	Kiernan RE (2001)	1
SKP2	2	BTRC	1	affinity chromatography technology, pull down, affinity chromatography technology	Wei S (2012), Wei S (2012), Wei S (2012)	3
CDKN1B	1	SKP1	0	unspecified method, unspecified method	Carrano AC (1999), Ooi LC (2013)	2
UBE2M	0	DCUN1D2	0	pull down, x-ray crystallography, affinity chromatography technology, pull down	Monda JK (2013), Monda JK (2013), Meyer-Schaller N (2009), Keuss MJ (2016)	4
DCUN1D1	0	DCUN1D2	0	affinity chromatography technology	Bennett EJ (2010)	1
FBXW11	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Watanabe N (2004), Fuchs SY (1999), Tan P (1999), Herter JR (2002), Lievens S (2009), Lievens S (2009), DAnnibale S (2014), Kim TY (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Hein MY (2015), Liu X (2017), Hauri S (2016)	16
CAND1	2	CDC5L	2	affinity chromatography technology	Bennett EJ (2010)	1
PSMA2	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bloom J (2006), Bousquet-Dubouch MP (2009), Bennett EJ (2010)	3
RICTOR	4	HSPA4	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Pearce LR (2007), Martin J (2008), Martin J (2008), Martin J (2008)	4
UBE2M	0	DCUN1D4	0	pull down, pull down	Monda JK (2013), Keuss MJ (2016)	2
UBC	7	BRAP	0	affinity chromatography technology, two hybrid, pull down, pull down, enzymatic study	Bish RA (2007), Fatima S (2015), Zhang X (2017), Shoji S (2017), Shoji S (2017)	5
FBXO8	1	CUL1	7	affinity chromatography technology, affinity chromatography technology	Yano H (2008), Yano H (2008)	2
ASB2	1	SKP2	2	affinity chromatography technology, affinity chromatography technology	Nie L (2011), Nie L (2011)	2
FBXW11	2	CDC25A	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Ray D (2005), Ray D (2005), Jin J (2003), Jin J (2005), Gao D (2011), Busino L (2003), Busino L (2003), Kim TY (2014), Jin J (2003), Coyaud E (2015), Low TY (2014), St-Denis N (2016), Li X (2016), Huttlin EL (2017), Liu X (2017), Liu X (2017), Yadav L (2017), Yadav L (2017)	18
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
SKP2	2	FZR1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Calvisi DF (2009), Cen B (2010), Bashir T (2004), Bashir T (2004), Hu D (2011), Fukushima H (2013), Gao D (2009), Gao D (2009), Inuzuka H (2012), Inuzuka H (2012), Inuzuka H (2012), Huttlin EL (2017)	12
CUL1	7	RICTOR	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Gao D (2010), Gao D (2010), Gao D (2010), Gao D (2010)	4
PRKN	1	FBXW7	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Staropoli JF (2003), Staropoli JF (2003), Staropoli JF (2003), Gong Y (2014)	4
UBC	7	UBXN7	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Kelsall IR (2013), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
RNF7	0	CUL1	7	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Ohta T (1999), Kawakami T (2001), Tan M (2010), Swaroop M (2001), Huang DT (2009), Kuang P (2016), Zhou W (2017)	7
HSP90AA1	7	FBXO27	0	affinity chromatography technology	Taipale M (2012)	1
FBXW11	2	MDM2	2	affinity chromatography technology	Inuzuka H (2010)	1
FBXW8	2	HSP90AA1	7	affinity chromatography technology	Ponyeam W (2012)	1
CCNA2	1	FZR1	1	pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Mateo F (2009), Jin L (2008), Mateo F (2009), Mateo F (2009), Huttlin EL (2015), Williamson A (2011), Huttlin EL (2017), Choudhury R (2016)	8
UBC	7	BTRC	1	affinity chromatography technology, enzymatic study	Matsumoto M (2005), Kumar KG (2007)	2
NEDD8	0	GPS1	1	affinity chromatography technology	Bennett EJ (2010)	1
CAND1	2	FBXL3	1	affinity chromatography technology	Pierce NW (2013)	1
UBE2M	0	DCUN1D5	0	pull down, affinity chromatography technology, pull down, pull down	Monda JK (2013), Bommelje CC (2013), Monda JK (2013), Keuss MJ (2016)	4
UBE2M	0	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
FBXW7	2	MED6	0	affinity chromatography technology, affinity chromatography technology	Davis MA (2013), Kourtis N (2015)	2
RBX1	2	FBXO3	0	affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Shima Y (2008)	2
FBXO34	0	SKP1	0	two hybrid, two hybrid, affinity chromatography technology	Stelzl U (2005), Stelzl U (2005), Tian X (2015)	3
FBXW7	2	TSC22D4	1	two hybrid	Daakour S (2016)	1
VCP	6	UBXN1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), McNeill H (2004), LaLonde DP (2011), LaLonde DP (2011), LaLonde DP (2011), LaLonde DP (2011), Rolland T (2014), McNeill H (2004), Raman M (2015), Park ES (2017)	11
HSP90AA1	7	FBXL18	5	affinity chromatography technology	Taipale M (2012)	1
CDC5L	2	SNRNP70	2	affinity chromatography technology, affinity chromatography technology	Lleres D (2010), Huttlin EL (2017)	2
PSMA4	0	NFKBIA	0	affinity chromatography technology, affinity chromatography technology	Petropoulos L (1998), Petropoulos L (1998)	2
HSP90AA1	7	FBXW5	6	affinity chromatography technology	Taipale M (2012)	1
FBXO17	1	COPS7B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SKP1	0	CCDC22	1	affinity chromatography technology	Starokadomskyy P (2013)	1
CAND1	2	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Kim AY (2008), Zheng J (2002), Zheng J (2002), Liu J (2002), Liu J (2002)	7
COPS5	0	HSPA4	3	affinity chromatography technology	Bennett EJ (2010)	1
CKS1B	0	CCNA1	3	pull down	Radulovic M (2010)	1
VCP	6	RNF7	0	affinity chromatography technology	Yu CC (2013)	1
FBXO22	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2007), Hein MY (2015), Tian X (2015), Hauri S (2016)	4
BRAP	0	FBXO2	0	two hybrid	Fatima S (2015)	1
FBXO6	0	COPS3	1	affinity chromatography technology	Liu B (2012)	1
CDC34	3	UBC	7	pull down, x-ray crystallography, enzymatic study, enzymatic study, x-ray crystallography, pull down, fluorescent resonance energy transfe, affinity chromatography technology, enzymatic study, enzymatic study	Choi YS (2010), Choi YS (2010), Sheng Y (2012), Enchev RI (2012), Huang H (2014), Huang H (2014), Huang H (2014), Bish RA (2007), Chong RA (2014), Phillips AH (2013)	10
NEDD8	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Hauri S (2016)	3
BTRC	1	FZR1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Fukushima H (2013), Fukushima H (2013), Fukushima H (2013)	3
FBXO17	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Yoshida Y (2011), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	6
PSMA7	1	VCP	6	two hybrid	Wang J (2011)	1
NFKBIA	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kawakami T (2001), Read MA (2000), Suzuki H (1999), Surjit M (2012), Furukawa M (2000), Furukawa M (2000)	6
UBXN1	0	UBXN7	3	affinity chromatography technology	Raman M (2015)	1
FBXO6	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Taipale M (2012)	2
ASB2	1	CAND1	2	affinity chromatography technology	Andresen CA (2014)	1
FBXO6	0	COPS4	0	affinity chromatography technology	Liu B (2012)	1
NEDD8	0	COPS9	1	affinity chromatography technology	Bennett EJ (2010)	1
CCNA2	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Naderi S (2005), Varshochi R (2005), Di Fiore B (2010), Mateo F (2009), Abbas T (2007), Schulman BA (1998), Datta NS (1998), Wu G (1997), Sebastian B (1993), Liu S (2009), Ciarallo S (2002), Wolthuis R (2008), Vicent GP (2011), Zhang H (1995), Sayle KL (2003), Jeffrey PD (1995), Davies TG (2001), Cook A (2002), Pevarello P (2006), Levkau B (1998), Poon RY (1996), OConnor PM (1993), Davies TG (2002), Kontopidis G (2003), Andrews MJ (2004), Pevarello P (2004), Pevarello P (2005), Varjosalo M (2013), Varjosalo M (2013), Kikuchi R (2014), Kikuchi R (2014), Mateo F (2009), So J (2015), Okamoto K (2002), Song MS (2011), Huttlin EL (2015), Di Fiore B (2015), Pan ZQ (1993), Pan ZQ (1993), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	43
PRKN	1	CCNA1	3	affinity chromatography technology	Staropoli JF (2003)	1
PSMA2	1	SKP1	0	affinity chromatography technology, affinity chromatography technology	Bousquet-Dubouch MP (2009), Hauri S (2016)	2
RNF7	0	CDC34	3	pull down, pull down	He H (2007), Tan M (2010)	2
COPS5	0	CHEK1	2	affinity chromatography technology	Bennett EJ (2010)	1
FBXO28	2	CUL1	7	affinity chromatography technology, affinity chromatography technology	Kratz AS (2016), Reitsma JM (2017)	2
NEDD8	0	PSMA4	0	affinity chromatography technology	Norman JA (2006)	1
COPS6	0	SNRNP70	2	affinity chromatography technology	Bennett EJ (2010)	1
FBXO25	1	FBXO32	2	affinity chromatography technology	Teixeira FR (2010)	1
FBXW4	0	GPS1	1	affinity chromatography technology	Lockwood WW (2013)	1
PSMA6	1	PSMA7	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, biochemical, biochemical, biochemical, pull down	Apcher GS (2004), Apcher GS (2004), Apcher GS (2004), Apcher GS (2004), Jayarapu K (2004), Fricke B (2007), Fricke B (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Ishii K (2015)	11
CUL1	7	FBXL5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vashisht AA (2009), Salahudeen AA (2009), Liu B (2012), Vinas-Castells R (2013), Moroishi T (2014), Moroishi T (2014), Chen ZW (2015), Wu WD (2016), Huttlin EL (2017)	9
FBXO7	1	UBE2M	0	enzymatic study	Teixeira FR (2016)	1
FBXL14	2	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
FBXL14	2	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
SKP1	0	FBXW7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Wu G (2001), Wu G (2001), Wu G (2001), Hao B (2007), Schuelein C (2011), Busino L (2012), Busino L (2012), Busino L (2012), Matsumoto A (2011), Watanabe N (2004), Strohmaier H (2001), Choi BH (2014), Yumimoto K (2012), Kourtis N (2015), Kourtis N (2015), Hao J (2015), Tian X (2015), Liu YQ (2015), Gorelik M (2016), Gorelik M (2016), Gorelik M (2016), Yeh CH (2016), Reiterer V (2017), Reiterer V (2017), Reiterer V (2017), Kuchay S (2017), Ye M (2017)	28
HSP90AA1	7	FBXO4	0	affinity chromatography technology	Taipale M (2012)	1
RBX1	2	GLMN	2	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, pull down, pull down	Tron AE (2012), Tron AE (2012), Duda DM (2012), Duda DM (2012), Tron AE (2012), Tron AE (2012)	6
CUL1	7	FBXL18	5	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Reitsma JM (2017)	2
DDB1	6	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Norman JA (2006), Bennett EJ (2010)	3
COPS5	0	FBXL5	3	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
BTRC	1	CAND1	2	affinity chromatography technology	Coyaud E (2015)	1
FBXO6	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2007), Yoshida Y (2007), Nelson RF (2007), Glenn KA (2008), Yoshida Y (2011), Liu B (2012), Liu B (2012), Tian X (2015), Hauri S (2016)	9
CUL3	17	COPS9	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Ebina M (2013)	2
CDK2	0	HSPA4	3	affinity chromatography technology	Neganova I (2011)	1
PSMA2	1	PSMB4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Claverol S (2002), Loescher M (2005), Bousquet-Dubouch MP (2009), Havugimana PC (2012), Froment C (2005), Froment C (2005), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	10
COPS6	0	FBXO11	14	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
HSP90AA1	7	FBXL3	1	affinity chromatography technology	Taipale M (2012)	1
CDC25A	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Donzelli M (2004), Busino L (2003), Donzelli M (2002), He N (2005), Li X (2016), Yadav L (2017), Yadav L (2017)	7
FBXO2	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Yoshida Y (2005), Yoshida Y (2005)	2
COPS2	5	PSMA6	1	affinity chromatography technology, affinity chromatography technology	Kob R (2009), Kob R (2009)	2
CUL3	17	FBXO3	0	affinity chromatography technology	Bennett EJ (2010)	1
MDM2	2	SF3B3	4	affinity chromatography technology	Jacob AG (2014)	1
COPS6	0	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huang X (2005), Bennett EJ (2010), Kapelari B (2000), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	11
PSMA2	1	CAND1	2	affinity chromatography technology	Bousquet-Dubouch MP (2009)	1
FBXW4	0	COPS4	0	affinity chromatography technology	Lockwood WW (2013)	1
BRAP	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology	Takashima O (2013), Takashima O (2013)	2
COPS3	1	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	10
FBXO25	1	KDR	4	enzymatic study	Teixeira FR (2013)	1
COPS6	0	SKP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2017)	3
MCL1	1	FBXO4	0	affinity chromatography technology	Feng C (2017)	1
CDCA3	0	CUL1	7	affinity chromatography technology, pull down	Ayad NG (2003), Ayad NG (2003)	2
DCUN1D4	0	CAND1	2	affinity chromatography technology, pull down	Keuss MJ (2016), Keuss MJ (2016)	2
HSP90AA1	7	FBXL8	0	affinity chromatography technology	Taipale M (2012)	1
TRIM21	0	SKP1	0	affinity chromatography technology, biochemical	Sabile A (2006), Sabile A (2006)	2
FBXW8	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okabe H (2007), Ponyeam W (2012), Litterman N (2011), Bennett EJ (2010), Liu B (2012), Low TY (2014), Reitsma JM (2017)	7
VCP	6	MDM2	2	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Okoro DR (2013)	2
CUL1	7	FBXO22	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Liu B (2012), Reitsma JM (2017)	3
VCP	6	COMMD1	1	affinity chromatography technology	Yu CC (2013)	1
PSMA2	1	PSMA6	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, biochemical	Bloom J (2006), Claverol S (2002), Jayarapu K (2004), Bousquet-Dubouch MP (2009), Havugimana PC (2012), Froment C (2005), Froment C (2005), Kristensen AR (2012), Wan C (2015)	9
FBXL5	3	COPS6	0	affinity chromatography technology	Huttlin EL (2017)	1
RBX1	2	MAGEC2	0	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Hao J (2015), Hao J (2015), Hao J (2015), Hao J (2015)	4
FBXO6	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Yoshida Y (2011)	2
FBXL3	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Liu B (2012), Yumimoto K (2013), Reitsma JM (2017)	4
FBXW4	0	COPS8	2	affinity chromatography technology	Lockwood WW (2013)	1
COPS2	5	SENP8	0	affinity chromatography technology, far western blotting	Christmann M (2013), Christmann M (2013)	2
KDM2B	11	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koyama-Nasu R (2007), Han XR (2016), Han XR (2016)	3
FBXO6	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Yoshida Y (2005), Yoshida Y (2005)	2
UBC	7	PSMA2	1	affinity chromatography technology	Matsumoto M (2005)	1
UBXN7	3	NEDD8	0	affinity chromatography technology, affinity chromatography technology, pull down	Bandau S (2012), Besten Wd (2012), Kelsall IR (2013)	3
RBX1	2	CDKN1B	1	enzymatic study	Duda DM (2008)	1
CKS1B	0	CDKN1B	1	enzymatic study, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology	Wang W (2003), Sitry D (2002), Zhou W (2009), Ooi LC (2013), Huttlin EL (2017)	5
PRKN	1	CCND1	1	affinity chromatography technology, enzymatic study	Gong Y (2014), Gong Y (2014)	2
FBXO7	1	PSMA4	0	affinity chromatography technology	Teixeira FR (2016)	1
NEDD8	0	PSMA7	1	affinity chromatography technology	Norman JA (2006)	1
CDK2	0	FZR1	1	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Sorensen CS (2001), Fukushima H (2013), Lau AW (2013), Chang L (2015), Huttlin EL (2017)	5
CUL1	7	FBXO21	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Watanabe K (2015), Zhang C (2015), Zhang C (2015), Reitsma JM (2017)	5
CUL1	7	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Min KW (2003), Menon S (2008), Chew EH (2007), Min KW (2005), Min KW (2005), Min KW (2005), Hwang JW (2003), Hwang JW (2003), Mao X (2011), Chua YS (2011), Chua YS (2011), Tron AE (2012), Zheng J (2002), Zheng J (2002), Bornstein G (2006), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), He YJ (2006), Emberley ED (2012), Choo YY (2011), Jonason JH (2007), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Liu J (2002), Liu J (2002), Liu J (2002), Liu J (2002), Korzeniewski N (2012), Pierce NW (2013), Kim AY (2008), Zhang S (2016), Tikhmyanova N (2017), Tikhmyanova N (2017), Reitsma JM (2017), Reitsma JM (2017)	41
FBXW2	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Saiga T (2009), Bennett EJ (2010), Busino L (2003), Liu B (2012), Low TY (2014), Xu J (2017), Reitsma JM (2017)	8
CUL1	7	MED6	0	affinity chromatography technology, affinity chromatography technology	Ang K (2012), Ang K (2012)	2
SKP2	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2003), Min KW (2003), Lisztwan J (1998), Lisztwan J (1998), Marti A (1999), Zheng N (2002), Menon S (2008), Chew EH (2007), Chew EH (2007), Ji P (2006), Sabile A (2006), Tan P (1999), Lin HK (2009), Nie L (2011), Chua YS (2011), Huang Z (2004), Wu J (2012), Koyama-Nasu R (2007), Bashir T (2010), Saiga T (2009), Choo YY (2011), Jonason JH (2007), Jonason JH (2007), Bennett EJ (2010), Michel JJ (1998), Carrano AC (1999), Lyapina SA (1998), Lyapina SA (1998), Wu J (2012), Yu ZK (1998), Yu ZK (1998), Rodier G (2008), Swarnalatha M (2013), Cordero-Espinoza L (2013), Yumimoto K (2013), Chung FZ (2014), Zhou W (2014), Zhou W (2014), Yumimoto K (2012), Zhang S (2016), Zhang S (2016), Huttlin EL (2017), Kuchay S (2017), Reitsma JM (2017), Reitsma JM (2017), Ma X (2017)	46
FBXO7	1	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
SKP2	2	E2F1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marti A (1999), Marti A (1999), Zhang Z (2005), Farhana L (2002), Salon C (2007), Swarnalatha M (2013)	6
DCUN1D1	0	RBX1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Kim AY (2008), Bommelje CC (2013), Meyer-Schaller N (2009), Huang G (2014), Huang G (2014), Keuss MJ (2016), Keuss MJ (2016)	9
COPS5	0	CCNA2	1	affinity chromatography technology	Bennett EJ (2010)	1
FZR1	1	CKS1B	0	affinity chromatography technology	Bashir T (2004)	1
FBXW8	2	HSPA4	3	affinity chromatography technology	Ponyeam W (2012)	1
COPS6	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009)	2
IDS	0	CUL1	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCNF	2	RBX1	2	affinity chromatography technology	Yoshida Y (2011)	1
CDK9	3	CDC34	3	pull down, affinity chromatography technology	Kiernan RE (2001), Kiernan RE (2001)	2
CDK2	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Varjosalo M (2013)	2
FBXO18	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim J (2002), Kim J (2002), Kim JH (2004), Bennett EJ (2010), Jeong YT (2013), Jeong YT (2013), Reitsma JM (2017)	7
FBXO7	1	PSMA7	1	affinity chromatography technology	Teixeira FR (2016)	1
VCP	6	TRIM21	0	affinity chromatography technology	Yu CC (2013)	1
FBXO27	0	CUL1	7	affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Yoshida Y (2011)	2
SKP1	0	PSMA7	1	affinity chromatography technology	Hauri S (2016)	1
FBXO34	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2017), Reitsma JM (2017)	3
SKP1	0	FBXO28	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Hauri S (2016), Kratz AS (2016)	3
COMMD1	1	CUL1	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Mao X (2011), Mao X (2011), Mao X (2011), Malek E (2017)	4
GLMN	2	SKP1	0	pull down	Tron AE (2012)	1
PSMA2	1	PSMA4	0	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, biochemical, biochemical	Claverol S (2002), Apcher GS (2004), Apcher GS (2004), Jayarapu K (2004), Jayarapu K (2004), Nandi D (1997), Bousquet-Dubouch MP (2009), Fricke B (2007), Havugimana PC (2012), Froment C (2005), Froment C (2005), Kristensen AR (2012), Wan C (2015)	13
CUL1	7	BRAP	0	affinity chromatography technology, affinity chromatography technology	Takashima O (2013), Takashima O (2013)	2
COPS4	0	SKP1	0	affinity chromatography technology	Olma MH (2009)	1
FBXO6	0	COPS2	5	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015)	2
COPS5	0	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
COPS3	1	COPS9	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology	Huttlin EL (2015), Rozen S (2015), Rozen S (2015), Rozen S (2015), Rozen S (2015), Huttlin EL (2017)	6
CUL3	17	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Chua YS (2011), Chua YS (2011), Tron AE (2012), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Schumacher FR (2015), Schumacher FR (2015), Lo SC (2006), Lo SC (2006)	12
COPS5	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
CUL1	7	FBXW9	3	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Reitsma JM (2017)	2
BTRC	1	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, bioid, enzymatic study, protein complementation assay	Suzuki H (2000), Spencer E (1999), Spencer E (1999), Spencer E (1999), Suzuki H (1999), Suzuki H (1999), Kroll M (1999), Kroll M (1999), Yaron A (1998), Choi YS (2010), Banerjee S (2010), Banerjee S (2010), Banerjee S (2010), Da Silva-Ferrada E (2011), Tsuchiya Y (2010), Tsuchiya Y (2010), Keutgens A (2010), Winston JT (1999), Winston JT (1999), Winston JT (1999), Winston JT (1999), Surjit M (2012), Busino L (2012), Evrard-Todeschi N (2008), Furukawa M (2000), Kovacev J (2014), Chong RA (2014), Chong RA (2014), Shi M (2014), Shirane M (1999), Read MA (2000), Tan M (2010), Coyaud E (2015), Coyaud E (2015), Wu K (2016), Villalobos V (2010)	36
FBXO7	1	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vingill S (2016), Teixeira FR (2016), Teixeira FR (2016)	3
CCND1	1	FBXO4	0	affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Lin DI (2006), Lin DI (2006), Barbash O (2011), Lin DI (2006), Lin DI (2006), Lee EK (2013), Barbash O (2009), Qie S (2017), Qie S (2017), Gong Y (2014)	10
CUL1	7	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huang X (2016), Reitsma JM (2017)	3
DDB1	6	CAND1	2	affinity chromatography technology	Hu J (2004)	1
COPS5	0	CCNA1	3	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
NEDD8	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Wimuttisuk W (2007)	4
CUL1	7	FBXW5	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Busino L (2003), Jeong YT (2013), Chung FZ (2014), Low TY (2014), Reitsma JM (2017)	6
COPS8	2	COPS4	0	biochemical, affinity chromatography technology, biochemical, biochemical, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Olma MH (2009), Havugimana PC (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	9
FBXL2	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe T (2012), Li LQ (2016), Kuchay S (2017), Reitsma JM (2017)	4
FBXO2	0	RBX1	2	affinity chromatography technology	Glenn KA (2008)	1
BRAP	0	SKP2	2	pull down, affinity chromatography technology	Lanctot AA (2017), Lanctot AA (2017)	2
KDM2B	11	SKP1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gearhart MD (2006), Koyama-Nasu R (2007), Inagaki T (2015), Inagaki T (2015), Busino L (2007), Han XR (2016), Kuchay S (2017), Hauri S (2016)	8
CUL1	7	FBXO9	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Reitsma JM (2017), Reitsma JM (2017)	3
CAND1	2	YBX1	1	affinity chromatography technology	Bennett EJ (2010)	1
PSMA6	1	CCNA2	1	affinity chromatography technology	Sharma SS (2011)	1
CUL1	7	CDC5L	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lleres D (2010)	2
CUL1	7	CAND2	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee JE (2011), Cordero-Espinoza L (2013), Reitsma JM (2017)	3
COPS6	0	FBXO42	0	affinity chromatography technology	Bennett EJ (2010)	1
CDC25A	2	VCP	6	affinity chromatography technology	Riemer A (2014)	1
HES1	0	SKP1	0	affinity chromatography technology	Chen F (2017)	1
ING3	3	SKP2	2	affinity chromatography technology, affinity chromatography technology	Chen G (2010), Chen G (2010)	2
FBXO4	0	NEDD8	0	affinity chromatography technology	Ewing RM (2007)	1
COPS9	1	GPS1	1	affinity chromatography technology, biochemical	Rozen S (2015), Rozen S (2015)	2
CDKN1B	1	CUL1	7	unspecified method, pull down	Carrano AC (1999), Enchev RI (2012)	2
CUL1	7	E2F1	0	affinity chromatography technology, pull down	Marti A (1999), Marti A (1999)	2
CUL3	17	SNRNP70	2	affinity chromatography technology	Bennett EJ (2010)	1