PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RBPMS	0	FAM103A1	0	two hybrid	Rual JF (2005)	1
DVL2	5	CCDC33	3	two hybrid	Rual JF (2005)	1
SUMO1	0	DTX2	3	two hybrid	Rolland T (2014)	1
FAM103A1	0	RHOXF2	0	two hybrid	Rual JF (2005)	1
ATXN1	2	RBPMS	0	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
UBE2I	0	MED7	1	enzymatic study	Jakobs A (2007)	1
RHOXF2	0	FBF1	2	two hybrid	Rual JF (2005)	1
TRIP13	0	RBPMS	0	two hybrid	Rual JF (2005)	1
LZTS2	4	RHOXF2	0	two hybrid	Rual JF (2005)	1
FAM103A1	0	LZTS2	4	two hybrid	Rolland T (2014)	1
TMCC2	1	FBF1	2	two hybrid	Rolland T (2014)	1
ATXN1	2	ARID5A	4	two hybrid, two hybrid	Lim J (2006), Suter B (2013)	2
PLOD3	5	RHOXF2	0	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
TRIP13	0	DTX2	3	two hybrid	Rual JF (2005)	1
LSM4	1	RHOXF2	0	two hybrid	Lehner B (2004)	1
RHOXF2	0	LENG8	2	two hybrid	Rual JF (2005)	1
NANOG	0	RHOXF2	0	two hybrid	Ravasi T (2010)	1
ATXN1	2	RHOXF2	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
MAGED1	0	RBPMS	0	two hybrid	Rolland T (2014)	1
ATN1	2	EFEMP2	0	two hybrid	Lim J (2006)	1
ATN1	2	AES	2	two hybrid	Lim J (2006)	1
DAB1	1	ARID5A	4	two hybrid	Rolland T (2014)	1
RBPMS	0	FBF1	2	two hybrid	Rolland T (2014)	1
ATN1	2	LENG8	2	two hybrid	Lim J (2006)	1
RBPMS	0	EFEMP2	0	two hybrid	Rolland T (2014)	1
FBF1	2	LASP1	1	bioid	Gupta GD (2015)	1
MAGED1	0	DAZAP2	1	two hybrid	Yu H (2011)	1
RBFOX1	1	DAB1	1	two hybrid	Corominas R (2014)	1
ATXN1	2	TOLLIP	3	two hybrid	Lim J (2006)	1
AES	2	RBPMS	0	two hybrid	Rolland T (2014)	1
UPF1	8	RHOXF2	0	two hybrid	Lehner B (2004)	1
RHOXF2	0	ARMCX2	0	two hybrid	Yu H (2011)	1
MVP	1	AES	2	two hybrid	Corominas R (2014)	1
RHOXF2	0	DEDD2	1	two hybrid	Ravasi T (2010)	1
RBPMS	0	RBFOX2	5	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Huttlin EL (2015), Huttlin EL (2017)	3
LASP1	1	LZTS2	4	two hybrid	Rolland T (2014)	1
TOLLIP	3	RBFOX2	5	two hybrid	Bandyopadhyay S (2010)	1
VAC14	5	KRTAP19-7	0	two hybrid	Rolland T (2014)	1
RBPMS	0	NEU4	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
SUMO1	0	FBF1	2	two hybrid	Rolland T (2014)	1
AES	2	RHOXF2	0	two hybrid	Rolland T (2014)	1
CRYBA1	0	RBPMS	0	two hybrid	Rolland T (2014)	1
DAB1	1	MAGED1	0	two hybrid	Rolland T (2014)	1
DAB1	1	RHOXF2	0	two hybrid	Rolland T (2014)	1
ATXN1	2	UBE2I	0	two hybrid	Lim J (2006)	1
DAB1	1	RBFOX2	5	two hybrid	Rolland T (2014)	1
CCDC33	3	RHOXF2	0	two hybrid	Xin X (2009)	1
RBFOX1	1	ATXN1	2	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
RBPMS	0	RHOXF2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
DAB1	1	SERF2	0	two hybrid	Rolland T (2014)	1
ATN1	2	EWSR1	2	two hybrid, bioid	Lim J (2006), Elzi DJ (2014)	2
DAB1	1	HNRNPLL	1	two hybrid	Rolland T (2014)	1
CCNK	1	EFEMP2	0	two hybrid	Rual JF (2005)	1
DAZAP2	1	RHOXF2	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
MED7	1	RBFOX2	5	two hybrid	Ravasi T (2010)	1
RBM11	0	RHOXF2	0	two hybrid	Rual JF (2005)	1
HOXC13	0	RHOXF2	0	two hybrid	Ravasi T (2010)	1
RBFOX1	1	MAGED1	0	two hybrid, two hybrid	Lim J (2006), Corominas R (2014)	2
DAB1	1	TOLLIP	3	two hybrid	Rolland T (2014)	1
CLASRP	1	RHOXF2	0	two hybrid	Rual JF (2005)	1
ATN1	2	RBPMS	0	two hybrid	Lim J (2006)	1
MAGED1	0	RHOXF2	0	two hybrid	Rolland T (2014)	1
DAZAP2	1	RBPMS	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ATN1	2	DVL2	5	two hybrid	Lim J (2006)	1
MAGED1	0	CCDC33	3	two hybrid	Rolland T (2014)	1
EWSR1	2	SUMO1	0	bioid	Elzi DJ (2014)	1
HYPK	2	RHOXF2	0	affinity chromatography technology	Choudhury KR (2012)	1
DAB1	1	KRTAP19-7	0	two hybrid	Rolland T (2014)	1
DAZAP2	1	CLASRP	1	two hybrid	Rolland T (2014)	1
MVP	1	VAC14	5	two hybrid	Corominas R (2014)	1
DAZAP2	1	ARID5A	4	two hybrid	Rolland T (2014)	1
RHOXF2	0	HNRNPLL	1	two hybrid	Rolland T (2014)	1
MVP	1	FAM46C	3	two hybrid	Corominas R (2014)	1
PITX1	2	LZTS2	4	two hybrid	Corominas R (2014)	1
TMCC2	1	HNRNPLL	1	affinity chromatography technology	Huttlin EL (2017)	1
RBFOX1	1	RBFOX2	5	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
RBFOX1	1	DVL2	5	two hybrid	Lim J (2006)	1
SERF2	0	RHOXF2	0	two hybrid	Rual JF (2005)	1
SUMO1	0	RHOXF2	0	two hybrid	Rolland T (2014)	1
DAZAP2	1	RBFOX2	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	4
CCNK	1	LZTS2	4	two hybrid	Rolland T (2014)	1
AES	2	TMCC2	1	two hybrid	Rolland T (2014)	1
PSMF1	0	RBFOX2	5	two hybrid	Venkatesan K (2009)	1
RHOXF2	0	NEU4	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Xin X (2009), Rolland T (2014)	3
RBFOX1	1	RBPMS	0	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
POU2AF1	1	RHOXF2	0	two hybrid	Ravasi T (2010)	1
FAM46C	3	RHOXF2	0	two hybrid	Rolland T (2014)	1
RHOXF2	0	FAM46D	0	two hybrid	Rual JF (2005)	1
RADIL	3	RHOXF2	0	two hybrid	Rual JF (2005)	1
ATXN1	2	DAZAP2	1	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
MAGED1	0	KRTAP19-5	0	two hybrid	Rolland T (2014)	1
DAZAP2	1	FAM46C	3	two hybrid	Rual JF (2005)	1
DAB1	1	DAZAP2	1	two hybrid	Rolland T (2014)	1
CHAC1	1	RHOXF2	0	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
ATXN1	2	FAM46B	2	two hybrid, two hybrid	Lim J (2006), Suter B (2013)	2
UBE2I	0	HNRNPLL	1	two hybrid	Rolland T (2014)	1
SNAPC1	0	RHOXF2	0	two hybrid	Ravasi T (2010)	1
MVP	1	ZBTB32	0	two hybrid	Corominas R (2014)	1
ATXN1	2	RBFOX2	5	two hybrid, affinity chromatography technology, two hybrid, two hybrid	Lim J (2006), Lim J (2006), Suter B (2013), Rolland T (2014)	4
MAGED1	0	RBFOX2	5	two hybrid	Rolland T (2014)	1
ATXN1	2	ZBTB32	0	two hybrid	Lim J (2006)	1
DVL2	5	RBPMS	0	two hybrid	Rual JF (2005)	1
PITX1	2	RHOXF2	0	two hybrid	Rual JF (2005)	1
RBFOX1	1	RHOXF2	0	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Corominas R (2014)	3
ATN1	2	RHOXF2	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
ATXN1	2	HNRNPLL	1	two hybrid	Suter B (2013)	1
CRYBA1	0	RHOXF2	0	two hybrid	Rolland T (2014)	1
ATXN1	2	SUMO1	0	two hybrid	Kang S (2010)	1
SERF2	0	RBPMS	0	two hybrid	Rual JF (2005)	1
HYPK	2	RBPMS	0	affinity chromatography technology	Choudhury KR (2012)	1
FAM46B	2	DAZAP2	1	two hybrid	Venkatesan K (2009)	1
RHOXF2	0	RHOXF2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ARID5A	4	RHOXF2	0	two hybrid	Rolland T (2014)	1
TOLLIP	3	RHOXF2	0	two hybrid, two hybrid	Rual JF (2005), Xin X (2009)	2
ARID5A	4	RBPMS	0	two hybrid	Rolland T (2014)	1
ATXN1	2	CCNK	1	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
UBE2I	0	RHOXF2	0	two hybrid	Yu H (2011)	1
CLDN7	0	RHOXF2	0	two hybrid	Rual JF (2005)	1
PSMF1	0	RHOXF2	0	two hybrid, two hybrid	Rual JF (2005), Xin X (2009)	2
RHOXF2	0	DTX2	3	two hybrid	Rual JF (2005)	1
LASP1	1	RHOXF2	0	two hybrid	Rolland T (2014)	1
RBPMS	0	TOLLIP	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
RBFOX1	1	ATN1	2	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
EWSR1	2	PITX1	2	bioid	Elzi DJ (2014)	1
ATN1	2	RBFOX2	5	two hybrid	Lim J (2006)	1
TMCC2	1	CCDC33	3	two hybrid	Rolland T (2014)	1
MVP	1	RBPMS	0	two hybrid	Corominas R (2014)	1
RHOXF2	0	FAM46B	2	two hybrid	Rual JF (2005)	1
RHOXF2	0	KRTAP19-7	0	two hybrid	Rolland T (2014)	1
MED7	1	RHOXF2	0	two hybrid	Ravasi T (2010)	1
POLR3D	0	RBFOX2	5	two hybrid	Ravasi T (2010)	1
DAB1	1	ZBTB32	0	two hybrid	Rolland T (2014)	1
PITX1	2	MAGED1	0	two hybrid	Corominas R (2014)	1
DAB1	1	KRTAP19-5	0	two hybrid	Rolland T (2014)	1
RHOXF2	0	KRTAP19-5	0	two hybrid	Rolland T (2014)	1
ATXN1	2	LASP1	1	two hybrid	Suter B (2013)	1
ZBTB32	0	RHOXF2	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Xin X (2009), Rolland T (2014)	3
NANOG	0	MAGED1	0	affinity chromatography technology	Oliviero G (2015)	1
RBPMS	0	KRTAP19-7	0	two hybrid	Rolland T (2014)	1
AES	2	CCNK	1	two hybrid	Rolland T (2014)	1
EFEMP2	0	RHOXF2	0	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
MVP	1	RHOXF2	0	two hybrid	Corominas R (2014)	1
MVP	1	TRIP13	0	two hybrid	Corominas R (2014)	1
ATXN1	2	CLASRP	1	two hybrid, affinity chromatography technology	Lim J (2006), Huttlin EL (2017)	2
RBFOX2	5	RHOXF2	0	two hybrid	Rual JF (2005)	1
RBFOX2	5	VAC14	5	two hybrid	Rolland T (2014)	1
UTP6	2	RHOXF2	0	two hybrid	Rual JF (2005)	1
RBPMS	0	ZBTB32	0	two hybrid	Rolland T (2014)	1
LASP1	1	DAZAP2	1	two hybrid	Venkatesan K (2009)	1
DAZAP2	1	KRTAP19-5	0	two hybrid	Rolland T (2014)	1
PITX1	2	RBPMS	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Corominas R (2014), Rolland T (2014)	3
RBFOX2	5	DEDD2	1	two hybrid	Ravasi T (2010)	1
CCNK	1	RBPMS	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
RBPMS	0	KRTAP19-5	0	two hybrid	Rolland T (2014)	1
UBE2I	0	TRIP13	0	two hybrid	Yu H (2011)	1
LASP1	1	TRIP13	0	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014), Yu H (2011)	4
DAB1	1	CLASRP	1	two hybrid	Rolland T (2014)	1
VAC14	5	KRTAP19-5	0	two hybrid	Rolland T (2014)	1
EWSR1	2	RBPMS	0	two hybrid	Rual JF (2005)	1
DAB1	1	FAM103A1	0	two hybrid	Rolland T (2014)	1
EFEMP2	0	CCDC33	3	two hybrid	Rolland T (2014)	1
POLR3D	0	RHOXF2	0	two hybrid	Ravasi T (2010)	1
LSM4	1	VAC14	5	biochemical	Havugimana PC (2012)	1
DVL2	5	RHOXF2	0	two hybrid	Rual JF (2005)	1
DAZAP2	1	TOLLIP	3	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
RBPMS	0	DTX2	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
RBFOX1	1	DAZAP2	1	two hybrid	Corominas R (2014)	1
RBPMS	0	LZTS2	4	two hybrid	Rual JF (2005)	1
PITX1	2	ZBTB32	0	two hybrid	Corominas R (2014)	1
ATXN1	2	EFEMP2	0	two hybrid	Lim J (2006)	1
VAC14	5	RHOXF2	0	two hybrid	Rolland T (2014)	1
RBFOX1	1	PSMF1	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
AES	2	FBF1	2	two hybrid	Rolland T (2014)	1
EWSR1	2	UPF1	8	bioid	Elzi DJ (2014)	1
TMCC2	1	RHOXF2	0	two hybrid	Rolland T (2014)	1
RBM11	0	DAZAP2	1	two hybrid	Yu H (2011)	1
LZTS2	4	FBF1	2	two hybrid, bioid	Rolland T (2014), Gupta GD (2015)	2
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
RBPMS	0	HNRNPLL	1	two hybrid	Rolland T (2014)	1
HYPK	2	LENG8	2	affinity chromatography technology	Choudhury KR (2012)	1
CCNK	1	RHOXF2	0	two hybrid	Rual JF (2005)	1
VPS25	1	RHOXF2	0	two hybrid	Rual JF (2005)	1
TOLLIP	3	MAGED1	0	affinity chromatography technology	Li S (2011)	1
EWSR1	2	RHOXF2	0	two hybrid	Rual JF (2005)	1
RBFOX1	1	LZTS2	4	two hybrid	Lim J (2006)	1
RHOXF2	0	TRIP13	0	two hybrid, two hybrid	Venkatesan K (2009), Rolland T (2014)	2