PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELOF1	2	SUV39H1	0	two hybrid	Weimann M (2013)	1
SUV39H1	0	KDM1A	2	two hybrid	Weimann M (2013)	1
SMURF1	4	ELOF1	2	enzymatic study	Andrews PS (2010)	1
C5orf22	1	ELOF1	2	two hybrid	Rual JF (2005)	1
AURKA	1	MAPK6	1	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Rodriguez J (2016)	2
MAPK6	1	ELOF1	2	two hybrid	Vinayagam A (2011)	1
AURKA	1	ELOF1	2	affinity chromatography technology	Hein MY (2015)	1
ATP5C1	0	ELOF1	2	two hybrid	Stelzl U (2005)	1
MAPK6	1	ATP5C1	0	affinity chromatography technology	Rodriguez J (2016)	1
CHMP6	0	ELOF1	2	two hybrid	Tsang HT (2006)	1
ELOF1	2	KDM1A	2	two hybrid	Weimann M (2013)	1