PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ARHGDIA	3	MSN	0	biochemical, biochemical	Gajate C (2005), Wan C (2015)	2
CASP8AP2	3	FADD	1	affinity chromatography technology	Imai Y (1999)	1
CFLAR	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
CASP6	0	CASP8	1	enzymatic study, enzymatic study, enzymatic study	Cowling V (2002), Guo Y (2002), Srinivasula SM (1996)	3
CASP10	1	ECE2	6	two hybrid	Wang J (2011)	1
EZR	8	TNFRSF1A	3	biochemical	Gajate C (2005)	1
CASP10	1	CASP2	1	enzymatic study	Srinivasula SM (1996)	1
CASP3	0	CASP7	1	enzymatic study	Walsh JG (2008)	1
BID	1	FASLG	0	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
CFLAR	1	TNFRSF1A	3	genetic interference	Ma Y (2017)	1
CASP10	1	RIPK1	2	affinity chromatography technology	Chaudhary PM (2000)	1
BID	1	TNFRSF1A	3	biochemical	Gajate C (2005)	1
CASP8	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (2000), Oshima S (2009), Bertrand MJ (2008), Knox PG (2011), Kim S (2010), Cheung HH (2009), Tenev T (2011), Tenev T (2011), Mahul-Mellier AL (2011), Legarda-Addison D (2009), Biton S (2011), Bellail AC (2012), Bellail AC (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Puliyappadamba VT (2013), Wu P (2014), Wu P (2014), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Moquin DM (2013), Ranjan K (2016), Zinngrebe J (2016), Nakazawa S (2016), Zheng M (2016)	27
TNFRSF10A	0	FADD	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (1997), Sinha SK (2004), Guo F (2005), Gonzalvez F (2012), Jeong M (2017), Huttlin EL (2017)	6
FAS	2	MAPK8	3	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
RIPK1	2	BIRC2	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Xu M (2009), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Fu J (2016), Vu NT (2016), Vu NT (2016)	12
RHOA	0	BID	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
XIAP	0	ARHGDIA	3	affinity chromatography technology, affinity chromatography technology	Liu J (2011), Liu J (2012)	2
BIRC3	1	TRAF1	0	pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Roy N (1997), Li X (2002), Goncharov T (2013), Chen TC (2014), Greenfeld H (2015)	5
CASP8	1	RB1	2	enzymatic study	Lemaire C (2005)	1
CASP10	1	RIOK3	2	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
BIRC3	1	CASP7	1	pull down, affinity chromatography technology	Roy N (1997), Eckelman BP (2006)	2
MAP3K14	1	TRAF1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Luftig MA (2001), Zheng C (2010), Song HY (1997), Liao G (2004), Choudhary S (2013), Choudhary S (2013)	6
CASP10	1	TNFRSF10B	1	biochemical, affinity chromatography technology	Gajate C (2005), MacFarlane M (1997)	2
ARHGDIA	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
23429	0	FADD	1	affinity chromatography technology	Zheng L (2001)	1
MSN	0	BID	1	biochemical	Gajate C (2005)	1
CASP10	1	FASLG	0	biochemical	Gajate C (2005)	1
CASP10	1	OIP5	1	two hybrid	Wang J (2011)	1
BIRC3	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006), Yang W (2014), Yang W (2014)	4
FAS	2	FADD	1	biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Gajate C (2005), MacFarlane M (1997), Pan G (1997), Huang B (1996), Huang B (1996), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Thomas LR (2002), Kumar A (2001), Lee EW (2012), Zhang M (2011), Huttlin EL (2015), Chen TC (2014), Jeong M (2017), Huttlin EL (2017), Kleber S (2008), Torii S (1999), Torii S (1999), Chang HY (1999)	20
CASP10	1	CASP4	1	enzymatic study	Srinivasula SM (1996)	1
CASP8	1	FADD	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Srinivasula SM (1997), Srinivasula SM (1997), Henshall DC (2003), Boldin MP (1996), Oshima S (2009), Thomas LR (2002), Ikner A (2011), Tenev T (2011), Ramakrishnan P (2011), Mahul-Mellier AL (2011), Won M (2010), Ryu SW (2003), Sinha SK (2004), Biton S (2011), Fu K (2012), Fu K (2012), Gonzalvez F (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Wang J (2011), Puliyappadamba VT (2013), Choi H (2011), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Saitoh Y (2016), Moquin DM (2013), Ranjan K (2016), Nakazawa S (2016), Jeong M (2017), Jeong M (2017), Pescatore A (2016)	35
CASP6	0	XIAP	0	affinity chromatography technology	Lee JS (2012)	1
FAS	2	ARHGDIA	3	biochemical	Gajate C (2005)	1
BIRC2	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
TNFRSF10A	0	CASP8	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kaunisto A (2009), Kaunisto A (2009), Sinha SK (2004), Guo F (2005), Jin Z (2009), Gonzalvez F (2012), Gonzalvez F (2012), Jeong M (2017), Huttlin EL (2017)	10
BIRC3	1	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, imaging technique	Deveraux QL (1998), Deveraux QL (1998), Eckelman BP (2006), Cheung HH (2006), Wang J (2011), McDonald ER (2004), Chen TC (2014)	7
RHOA	0	BIRC2	1	pull down	Marivin A (2013)	1
CASP10	1	DEDD2	1	affinity chromatography technology	Alcivar A (2003)	1
XIAP	0	CASP7	1	pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Tenev T (2005), Paulsen M (2008), Huang Y (2001), Huang Y (2001), Chai J (2001), Chai J (2001), Huang Y (2003), Huang Y (2003), Sun M (2009), Takahashi R (1998), Lee JS (2012), Lin YF (2013), Lin YF (2013), Hou Y (2017)	20
CASP7	1	ARHGDIA	3	enzymatic study	Walsh JG (2008)	1
XIAP	0	CASP10	1	two hybrid, affinity chromatography technology	Rolland T (2014), McDonald ER (2004)	2
CASP14	2	CASP10	1	affinity chromatography technology	Hu S (1998)	1
EZR	8	CASP8	1	biochemical	Gajate C (2005)	1
BID	1	TNFRSF10B	1	biochemical	Gajate C (2005)	1
CASP3	0	MAPK8	3	enzymatic study	Enomoto A (2003)	1
RIPK1	2	FADD	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen D (2002), Young JA (2011), Tenev T (2011), Ramakrishnan P (2011), Legarda-Addison D (2009), ODonnell MA (2012), Vanlangenakker N (2011), Biton S (2011), Biton S (2011), Lee EW (2012), Puliyappadamba VT (2013), Wu P (2014), Huttlin EL (2015), Baratchian M (2016), Moquin DM (2013), Ranjan K (2016), Pescatore A (2016), Zheng M (2016)	18
CASP14	2	CASP8	1	affinity chromatography technology	Hu S (1998)	1
TNFRSF1A	3	CASP2	1	affinity chromatography technology	Duan H (1997)	1
RHOA	0	FADD	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
CASP2	1	BID	1	enzymatic study, enzymatic study	Paroni G (2001), Guo Y (2002)	2
ARHGDIA	3	EZR	8	biochemical, biochemical	Gajate C (2005), Wan C (2015)	2
BIRC3	1	CASP3	0	pull down, affinity chromatography technology	Roy N (1997), Rajalingam K (2006)	2
CASP10	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
MAPK8	3	CASP10	1	biochemical	Gajate C (2005)	1
MAPK8	3	FASLG	0	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
MSN	0	FASLG	0	biochemical	Gajate C (2005)	1
PRDX6	0	RHOA	0	biochemical	Havugimana PC (2012)	1
CASP8	1	XIAP	0	genetic interference, affinity chromatography technology, affinity chromatography technology	Guo Y (2002), Lee JS (2012), McDonald ER (2004)	3
PRDX6	0	CASP8	1	pull down, affinity chromatography technology, affinity chromatography technology, protein complementation assay	Choi H (2011), Choi H (2011), Choi H (2011), Choi H (2011)	4
TNFRSF1A	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
CASP8	1	CASP7	1	enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996)	2
BIRC2	1	CASP3	0	pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology	Roy N (1997), Choi YE (2009), Choi YE (2009), Clem RJ (2001), Rajalingam K (2006)	5
CASP8	1	TNFRSF1A	3	biochemical	Gajate C (2005)	1
TNFRSF10A	0	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kaunisto A (2009), Gonzalvez F (2012), Jeong M (2017)	4
ARHGDIA	3	RHOA	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, biochemical, pull down, x-ray crystallography	Ewing RM (2007), Gajate C (2005), Michaelson D (2001), Gorvel JP (1998), Faure J (2001), Man JH (2010), Rolland T (2014), Wan C (2015), Jaffe AB (2004), Kuhlmann N (2016), Kuhlmann N (2016), Kuhlmann N (2016)	12
BIRC3	1	CASP8	1	affinity chromatography technology, affinity chromatography technology	McDonald ER (2004), Zinngrebe J (2016)	2
CASP10	1	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Micheau O (2003), Guo Y (2002), Srinivasula SM (1996), Srinivasula SM (1996), Sinha SK (2004), Lee EW (2012), Feoktistova M (2011)	9
DEDD	0	CASP8	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Zhan Y (2002), Alcivar A (2003), Stegh AH (1998), Stegh AH (1998)	4
CASP10	1	RNF34	1	two hybrid, affinity chromatography technology	McDonald ER (2004), McDonald ER (2004)	2
RB1	2	MAPK8	3	affinity chromatography technology	Li H (2001)	1
RIPK1	2	BIRC3	1	affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Wu CJ (2006)	8
BID	1	CASP10	1	biochemical	Gajate C (2005)	1
MAPK8	3	CASP8	1	biochemical	Gajate C (2005)	1
CASP14	2	CASP1	1	affinity chromatography technology	Hu S (1998)	1
FASLG	0	CFLAR	1	affinity chromatography technology	Tao RH (2011)	1
CASP8	1	CASP9	6	enzymatic study, genetic interference, enzymatic study	Guo Y (2002), Guo Y (2002), Srinivasula SM (1996)	3
BID	1	CASP8	1	biochemical, enzymatic study	Gajate C (2005), Guo Y (2002)	2
EZR	8	CASP10	1	biochemical	Gajate C (2005)	1
RHOA	0	CASP8	1	biochemical	Gajate C (2005)	1
EZR	8	MAPK8	3	biochemical	Gajate C (2005)	1
FAS	2	CASP10	1	biochemical, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Vincenz C (1997), MacFarlane M (1997)	3
BIRC2	1	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Deveraux QL (1998), Deveraux QL (1998), Eckelman BP (2006), Cheung HH (2006), Kulathila R (2009), Kulathila R (2009), Vucic D (2000), Rolland T (2014), McDonald ER (2004), Chen TC (2014), Vu NT (2016), Vu NT (2016)	12
SERPINB9	0	CASP1	1	pull down	Annand RR (1999)	1
TNFRSF1A	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1996), Vince JE (2009), Vince JE (2007), Wang YB (2015)	4
CASP8	1	FASLG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Legler DF (2003), Tao RH (2011)	4
RHOA	0	MAPK8	3	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
CASP8	1	CASP4	1	enzymatic study	Srinivasula SM (1996)	1
CASP10	1	CASP6	0	enzymatic study	Srinivasula SM (1996)	1
RHOA	0	CASP10	1	biochemical	Gajate C (2005)	1
FAS	2	EZR	8	biochemical	Gajate C (2005)	1
ARHGDIA	3	MAPK8	3	biochemical	Gajate C (2005)	1
CASP10	1	DEDD	0	affinity chromatography technology	Alcivar A (2003)	1
MSN	0	FADD	1	biochemical	Gajate C (2005)	1
CASP10	1	CASP8AP2	3	two hybrid	McDonald ER (2004)	1
CASP14	2	CASP4	1	affinity chromatography technology	Hu S (1998)	1
CFLAR	1	DEDD	0	affinity chromatography technology, pull down	Roth W (2002), Zhan Y (2002)	2
CASP8	1	CASP1	1	enzymatic study	Srinivasula SM (1996)	1
MSN	0	CASP8	1	biochemical	Gajate C (2005)	1
DEDD2	1	CFLAR	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Roth W (2002), Roth W (2002), Zhan Y (2002), Zhan Y (2002)	4
CASP10	1	CASP1	1	enzymatic study	Srinivasula SM (1996)	1
CFLAR	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kataoka T (2000), Chaudhary PM (2000), Rebe C (2007), Feoktistova M (2011), Ranjan K (2016), Ranjan K (2016)	6
CASP3	0	TRAF1	0	imaging technique	Chen TC (2014)	1
CASP6	0	RB1	2	enzymatic study	Lemaire C (2005)	1
BFAR	0	CASP10	1	affinity chromatography technology	Zhang H (2000)	1
TNFRSF1A	3	NFKBIL1	3	affinity chromatography technology	Huttlin EL (2017)	1
CASP8	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Feoktistova M (2012), McDonald ER (2004), Zinngrebe J (2016)	4
CASP10	1	TRAF1	0	enzymatic study	Leo E (2001)	1
BIRC2	1	TRAF1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Shu HB (1996), Li X (2002), Li S (2011), Mace PD (2010), Rothe M (1995), Varfolomeev E (2006), Goncharov T (2013), Wang J (2011), Greenfeld H (2015), Huttlin EL (2017)	11
CASP3	0	BID	1	enzymatic study, enzymatic study	Paroni G (2001), Walsh JG (2008)	2
CASP3	0	CASP2	1	enzymatic study, enzymatic study	Paroni G (2001), Walsh JG (2008)	2
BIRC2	1	CASP2	1	pull down	Cheung HH (2006)	1
MAP3K14	1	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
CASP7	1	CASP9	6	enzymatic study	Walsh JG (2008)	1
CASP8AP2	3	FAS	2	affinity chromatography technology	Imai Y (1999)	1
BIRC2	1	CASP7	1	pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Choi YE (2009), Choi YE (2009), Tenev T (2005), Eckelman BP (2006), Vucic D (2000)	6
CASP8	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Shu HB (1997), Goltsev YV (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Micheau O (2002), Han DK (1997), Han DK (1997), Han DK (1997), Roth W (2002), Zhang L (2009), Tenev T (2011), Kerr E (2012), Sinha SK (2004), Lee EW (2012), Rebe C (2007), Rebe C (2007), Kaunisto A (2009), Feoktistova M (2011), Feoktistova M (2011), Huttlin EL (2015), Huttlin EL (2017)	23
FAS	2	RIPK1	2	two hybrid	Stanger BZ (1995)	1
CASP10	1	FADD	1	biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, pull down, pull down	Gajate C (2005), Vincenz C (1997), Vincenz C (1997), Srinivasula SM (1997), Srinivasula SM (1997), Wang J (2001), McDonald ER (2004), Choi H (2011), Choi H (2011)	9
CFLAR	1	CASP3	0	affinity chromatography technology, pull down, two hybrid	Shu HB (1997), Han DK (1997), Han DK (1997)	3
ARHGDIA	3	CASP8	1	biochemical	Gajate C (2005)	1
BID	1	FADD	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
TNFRSF10B	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Chaudhary PM (1997), Bellail AC (2012)	2
CASP10	1	PRDX6	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, protein complementation assay	Choi H (2011), Choi H (2011), Choi H (2011), Choi H (2011), Choi H (2011), Choi H (2011)	6
FAS	2	MSN	0	biochemical	Gajate C (2005)	1
CASP8	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
ARHGDIA	3	BID	1	biochemical	Gajate C (2005)	1
CASP10	1	CASP9	6	enzymatic study	Srinivasula SM (1996)	1
RHOA	0	TNFRSF10B	1	biochemical	Gajate C (2005)	1
MAPK8	3	TNFRSF1A	3	biochemical	Gajate C (2005)	1
FADD	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Chaudhary PM (1997), Kim Y (2002), Guo F (2005), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017)	8
RHOA	0	TNFRSF1A	3	biochemical	Gajate C (2005)	1
EZR	8	FASLG	0	biochemical, affinity chromatography technology	Gajate C (2005), Parlato S (2000)	2
CASP7	1	CASP2	1	enzymatic study	Paroni G (2001)	1
BIRC3	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
CASP10	1	23429	0	affinity chromatography technology, affinity chromatography technology	Zheng L (2001), Zheng L (2001)	2
RHOA	0	FASLG	0	biochemical	Gajate C (2005)	1
SERPINB9	0	CASP10	1	affinity chromatography technology	Kummer JA (2007)	1
FAS	2	TNFRSF1A	3	biochemical	Gajate C (2005)	1
XIAP	0	CASP9	6	two hybrid, far western blotting, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Rual JF (2005), Davoodi J (2004), Deveraux QL (1998), Deveraux QL (1998), Richter BW (2001), Morizane Y (2005), Fu J (2003), Fu J (2003), Hao Y (2004), Varfolomeev E (2007), Vucic D (2002), Qiu XB (2005), Srinivasula SM (2001), Cheung HH (2006), Kulathila R (2009), Shiozaki EN (2003), Davoodi J (2007), Checinska A (2007), Huang Y (2003), Sun M (2009), Martin SA (2005), Lee JS (2012), Rolland T (2014), McDonald ER (2004), Chen TC (2014)	25
FAS	2	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Shu HB (1997), MacFarlane M (1997), Huttlin EL (2015), Jeong M (2017), Huttlin EL (2017), Kleber S (2008)	7
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
TNFRSF10A	0	CASP10	1	affinity chromatography technology	MacFarlane M (1997)	1
FAS	2	BID	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
CASP10	1	CASP10	1	enzymatic study	Srinivasula SM (1996)	1
DEDD2	1	CASP8	1	affinity chromatography technology, pull down, affinity chromatography technology	Zhan Y (2002), Zhan Y (2002), Alcivar A (2003)	3
CFLAR	1	FADD	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Han DK (1997), Kerr E (2012), Rebe C (2007), Choi H (2011), Feoktistova M (2011), Ranjan K (2016), Jeong M (2017)	13
MAP3K14	1	CASP3	0	imaging technique	Chen TC (2014)	1
MSN	0	TNFRSF1A	3	biochemical	Gajate C (2005)	1
CASP10	1	CASP7	1	enzymatic study	Srinivasula SM (1996)	1
TNFRSF10A	0	TNFRSF10B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guo F (2005), Jin Z (2009), Huttlin EL (2017)	3
CASP8	1	CASP3	0	enzymatic study, enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996), Chandra D (2004)	3
CASP6	0	TRAF1	0	enzymatic study	Leo E (2001)	1
CASP7	1	RB1	2	enzymatic study, enzymatic study	Lemaire C (2005), Fattman CL (2001)	2
FADD	1	FASLG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Gajate C (2005), Micheau O (2003), Legler DF (2003), Tao RH (2011), Chen TC (2014)	5
FASLG	0	TNFRSF10B	1	biochemical	Gajate C (2005)	1
CASP10	1	RB1	2	enzymatic study	Lemaire C (2005)	1
CASP10	1	CASP3	0	enzymatic study	Srinivasula SM (1996)	1
MSN	0	CASP10	1	biochemical	Gajate C (2005)	1
FAS	2	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), MacFarlane M (1997), Jeong M (2017)	3
CASP10	1	TNFRSF1A	3	biochemical, affinity chromatography technology	Gajate C (2005), Vincenz C (1997)	2
SERPINB9	0	CASP8	1	affinity chromatography technology	Kummer JA (2007)	1
BIRC3	1	CASP1	1	affinity chromatography technology, affinity chromatography technology	Labbe K (2011), Labbe K (2011)	2
RHOA	0	EZR	8	biochemical	Gajate C (2005)	1
MAPK8	3	FADD	1	biochemical	Gajate C (2005)	1
CASP8	1	CASP2	1	enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996)	2
ARHGDIA	3	TNFRSF1A	3	biochemical	Gajate C (2005)	1
CASP14	2	CASP2	1	affinity chromatography technology	Hu S (1998)	1
RHOA	0	MSN	0	biochemical	Gajate C (2005)	1
CASP8AP2	3	CASP8	1	affinity chromatography technology	Imai Y (1999)	1
CASP8	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Kaunisto A (2009), Guo F (2005), Gonzalvez F (2012), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017), Xu L (2017)	12
FADD	1	DEDD	0	affinity chromatography technology, pull down, affinity chromatography technology	Roth W (2002), Stegh AH (1998), Stegh AH (1998)	3
TNFRSF1A	3	TRAF1	0	affinity chromatography technology, pull down, affinity chromatography technology	Hsu H (1996), Mosialos G (1995), Wicovsky A (2009)	3
CASP3	0	CASP6	0	enzymatic study, enzymatic study, imaging technique	Srinivasula SM (1996), Walsh JG (2008), Chen TC (2014)	3
CASP8	1	TRAF1	0	affinity chromatography technology, enzymatic study	Micheau O (2003), Leo E (2001)	2
FAS	2	TNFRSF10B	1	biochemical	Gajate C (2005)	1
BFAR	0	CASP8	1	affinity chromatography technology	Zhang H (2000)	1
BID	1	MAPK8	3	biochemical	Gajate C (2005)	1
CASP8	1	RNF34	1	two hybrid, affinity chromatography technology	McDonald ER (2004), McDonald ER (2004)	2
RNF34	1	CASP9	6	affinity chromatography technology	McDonald ER (2004)	1
XIAP	0	RIPK1	2	pull down	Bertrand MJ (2011)	1
EZR	8	FADD	1	biochemical, affinity chromatography technology, imaging technique	Gajate C (2005), Young JA (2011), Chen TC (2014)	3
FADD	1	TNFRSF1A	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Hsu H (1996), Kumar A (2001), Zheng L (2006)	4
MAPK8	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
CASP10	1	PHF20L1	4	two hybrid	Wang J (2011)	1
XIAP	0	CASP3	0	affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Suzuki Y (2001), Suzuki Y (2001), Silke J (2002), Riedl SJ (2001), Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Nakhaei P (2012), Qiu XB (2005), Nomura T (2003), Paulsen M (2008), Scott FL (2005), Mufti AR (2006), Rajalingam K (2006), Dudich E (2006), Chai J (2001), Checinska A (2007), Sun M (2009), Takahashi R (1998), Conde C (2012), Walsh JG (2008), Lee JS (2012), Lin YF (2013), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Hou Y (2017)	30
TRAF1	0	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Shu HB (1997), Kataoka T (2000), Kataoka T (2000), Rolland T (2014)	4
ARHGDIA	3	CASP10	1	biochemical	Gajate C (2005)	1
FAS	2	RHOA	0	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
RIPK1	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim JW (2000), Duan H (1997), Hsu H (1996), Blankenship JW (2009), Newton K (2008), Varfolomeev E (2008), Fearns C (2006), Vince JE (2009), Dynek JN (2010), Kim S (2010), Cheung HH (2009), Tenev T (2011), Mahul-Mellier AL (2011), Won M (2010), Glowacka WK (2012), Fan YH (2011), Cusson-Hermance N (2005), ODonnell MA (2012), Zheng L (2006), Vince JE (2007), Mitsuhashi S (2008), Kim TW (2013), Wertz IE (2004), Liao W (2008), Wang YB (2015), Chang YL (2014), Zilberman-Rudenko J (2016), Zemirli N (2014), Moquin DM (2013), Nakazawa S (2016), Jeong M (2017), Huttlin EL (2017), Elliott PR (2016)	33
CASP3	0	CASP9	6	enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Qiu XB (2005), Denault JB (2007), Srinivasula SM (2001), Walsh JG (2008), Chen TC (2014)	5
TNFRSF1A	3	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Blankenship JW (2009), Vince JE (2009)	2
MSN	0	EZR	8	biochemical, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Gary R (1995), Gary R (1993), Gary R (1993), Hein MY (2015)	5
SERPINB9	0	CASP4	1	pull down	Annand RR (1999)	1
MAP3K14	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varfolomeev E (2007), Kanno Y (2010), Lee S (2014), Lee S (2014)	4
FAS	2	RB1	2	affinity chromatography technology	Huttlin EL (2015)	1
MSN	0	TNFRSF10B	1	biochemical	Gajate C (2005)	1
XIAP	0	CASP4	1	affinity chromatography technology	Silke J (2002)	1
EZR	8	ECE2	6	biochemical	Wan C (2015)	1
MSN	0	MAPK8	3	biochemical	Gajate C (2005)	1
CASP3	0	ARHGDIA	3	enzymatic study	Walsh JG (2008)	1
CASP7	1	TNFRSF1A	3	enzymatic study	Ethell DW (2001)	1
FASLG	0	TNFRSF1A	3	biochemical, affinity chromatography technology	Gajate C (2005), Legler DF (2003)	2
FAS	2	FASLG	0	biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Gajate C (2005), Micheau O (2003), Starling GC (1997), Schneider P (1997), Legler DF (2003), Tao RH (2011), Chen TC (2014)	7
TRAF1	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, two hybrid	Hsu H (1996), Wicovsky A (2009), Rolland T (2014)	3
23429	0	CASP8	1	affinity chromatography technology	Tan K (2017)	1
CASP3	0	RB1	2	enzymatic study, enzymatic study	Lemaire C (2005), Fattman CL (2001)	2
CASP10	1	NFKBIL1	3	two hybrid	Wang J (2011)	1
CASP10	1	CFLAR	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Micheau O (2003), Goltsev YV (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Feoktistova M (2011), Chen TC (2014)	7
TNFRSF10B	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Gonzalvez F (2012)	4
EZR	8	TNFRSF10B	1	biochemical	Gajate C (2005)	1
ARHGDIA	3	FASLG	0	biochemical	Gajate C (2005)	1
EZR	8	BID	1	biochemical	Gajate C (2005)	1
CASP2	1	CASP9	6	genetic interference	Guo Y (2002)	1
CASP9	6	RB1	2	enzymatic study	Lemaire C (2005)	1
DEDD2	1	DEDD	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Zhan Y (2002), Alcivar A (2003), Alcivar A (2003), Alcivar A (2003), Zhan Y (2002), Zhan Y (2002)	6
ARHGDIA	3	FADD	1	biochemical	Gajate C (2005)	1
CASP2	1	XIAP	0	genetic interference	Guo Y (2002)	1