PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ASCC2	3	DEAF1	12	two hybrid	Stelzl U (2005)	1
ASCC2	3	FAF1	1	two hybrid	Stelzl U (2005)	1
ASCC2	3	RPA1	0	two hybrid	Stelzl U (2005)	1
NTRK1	1	IMMT	0	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	UBC	7	affinity chromatography technology	Emdal KB (2015)	1
ASCC2	3	RPLP1	0	two hybrid	Stelzl U (2005)	1
NTRK1	1	VCL	6	affinity chromatography technology	Emdal KB (2015)	1
ASCC2	3	URM1	0	two hybrid	Stelzl U (2005)	1
GFER	1	KDM1A	2	genetic interference	Horlbeck MA (2018)	1
CEP128	1	ASCC2	3	bioid	Gupta GD (2015)	1
ASCC2	3	ELAC2	3	two hybrid	Stelzl U (2005)	1
RPS19	1	ASCC2	3	biochemical	Wan C (2015)	1
TBC1D17	2	GTF3C1	11	two hybrid	Stelzl U (2005)	1
ASCC1	0	TRIP4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Knierim E (2016), Knierim E (2016), Huttlin EL (2017)	4
TEPSIN	1	ASCC2	3	affinity chromatography technology	Hein MY (2015)	1
SMURF1	4	UBC	7	affinity chromatography technology, enzymatic study, pull down	Xie Y (2013), Kristariyanto YA (2015), Zhang Y (2017)	3
TRIP4	2	CSRP1	0	affinity chromatography technology	Knierim E (2016)	1
UBC	7	ASCC2	3	pull down	Zhang X (2017)	1
ASCC2	3	MYH9	19	two hybrid	Stelzl U (2005)	1
BAG6	2	IMMT	0	two hybrid	Stelzl U (2005)	1
ASCC2	3	RADIL	3	two hybrid	Stelzl U (2005)	1
SNW1	0	PCBD2	0	two hybrid	Ravasi T (2010)	1
NTRK1	1	EMC2	3	affinity chromatography technology	Emdal KB (2015)	1
SMURF1	4	RPS19	1	affinity chromatography technology	Xie Y (2013)	1
RPLP1	0	RPS19	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
PIN4	0	RPS19	1	biochemical	Havugimana PC (2012)	1
SPC24	0	ASCC2	3	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	OLA1	2	affinity chromatography technology	Emdal KB (2015)	1
UBC	7	PJA1	1	affinity chromatography technology	Matsumoto M (2005)	1
ASCC2	3	KDM1A	2	two hybrid	Stelzl U (2005)	1
RPA1	0	KDM1A	2	affinity chromatography technology	Marechal A (2014)	1
ASCC2	3	TBC1D17	2	two hybrid	Stelzl U (2005)	1
BAG6	2	ASCC2	3	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	KDM1A	2	affinity chromatography technology	Emdal KB (2015)	1
EMC2	3	CKAP4	0	affinity chromatography technology	Hein MY (2015)	1
PCBD2	0	ASCC2	3	two hybrid	Ravasi T (2010)	1
ASCC1	0	CSRP1	0	affinity chromatography technology	Knierim E (2016)	1
NTRK1	1	GNL3	3	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	ASCC2	3	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	CKAP4	0	affinity chromatography technology	Emdal KB (2015)	1
ALKBH3	1	ASCC3	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Zhao Y (2015), Zhao Y (2015), Huttlin EL (2017)	4
MAP3K1	4	ASCC2	3	enzymatic study	Charlaftis N (2014)	1
RPA1	0	MYH9	19	affinity chromatography technology	Marechal A (2014)	1
CEP128	1	ASCC3	12	bioid	Gupta GD (2015)	1
NTRK1	1	RPA1	0	affinity chromatography technology	Emdal KB (2015)	1
HDAC1	4	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Hakimi MA (2003), You A (2001), You A (2001), Shi YJ (2005), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Humphrey GW (2001), Godmann M (2007), Godmann M (2007), Terhune SS (2010), Godmann M (2010), Godmann M (2010), Wang Y (2009), Nicholson TB (2011), Li Q (2011), Cui S (2011), Cui S (2011), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Wang Q (2016), Huttlin EL (2017)	26
NTRK1	1	GTF3C1	11	affinity chromatography technology	Emdal KB (2015)	1
EEF1D	3	BAG6	2	biochemical, biochemical	Kristensen AR (2012), Kristensen AR (2012)	2
ALKBH3	1	ASCC1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ASCC2	3	TRIP4	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wan C (2015), Knierim E (2016), Knierim E (2016), Huttlin EL (2017)	4
ASCC2	3	CSRP1	0	affinity chromatography technology	Knierim E (2016)	1
ASCC2	3	FBP1	2	two hybrid	Stelzl U (2005)	1
ASCC2	3	ASS1	0	two hybrid	Stelzl U (2005)	1
NTRK1	1	SNW1	0	affinity chromatography technology	Emdal KB (2015)	1
ASCC3	12	RPLP1	0	genetic interference	Horlbeck MA (2018)	1
SMURF1	4	EEF1D	3	affinity chromatography technology	Xie Y (2013)	1
NTRK1	1	MYH9	19	affinity chromatography technology	Emdal KB (2015)	1
SMURF1	4	SNRPB	0	affinity chromatography technology	Xie Y (2013)	1
ALKBH3	1	TRIP4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF11	0	SMURF1	4	two hybrid	Colland F (2004)	1
SNW1	0	MYH9	19	affinity chromatography technology	Lleres D (2010)	1
ASCC2	3	GADD45A	1	two hybrid	Wang J (2011)	1
HDAC1	4	ASCC2	3	affinity chromatography technology	Hein MY (2015)	1
ASCC2	3	GTF3C1	11	two hybrid	Stelzl U (2005)	1
VCL	6	ASCC2	3	affinity chromatography technology	Hein MY (2015)	1
ASCC2	3	LPL	3	two hybrid	Stelzl U (2005)	1
ASCC2	3	GFER	1	two hybrid	Stelzl U (2005)	1
URM1	0	VCL	6	biochemical	Havugimana PC (2012)	1
NTRK1	1	MAP3K1	4	affinity chromatography technology	Emdal KB (2015)	1
ASCC2	3	SNW1	0	two hybrid	Stelzl U (2005)	1
UBC	7	ASCC3	12	pull down	Zhang X (2017)	1
NTRK1	1	ASCC3	12	affinity chromatography technology	Emdal KB (2015)	1
ASCC1	0	ASCC3	12	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ALKBH3	1	ASCC2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ASCC2	3	MED31	0	two hybrid	Stelzl U (2005)	1
ASCC2	3	FUNDC2	0	two hybrid	Stelzl U (2005)	1
RNF11	0	ASCC2	3	two hybrid	Colland F (2004)	1
ASCC2	3	PJA1	1	two hybrid	Stelzl U (2005)	1
NTRK1	1	ELAC2	3	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	BAG6	2	affinity chromatography technology	Emdal KB (2015)	1
ASCC2	3	CKAP4	0	two hybrid	Stelzl U (2005)	1
EMC2	3	ASCC2	3	affinity chromatography technology	Hein MY (2015)	1
RPA1	0	UBC	7	affinity chromatography technology	Marechal A (2014)	1
FAF1	1	BAG6	2	affinity chromatography technology	Baron Y (2014)	1
UBC	7	TRIP4	2	pull down	Zhang X (2017)	1
NTRK1	1	NIPSNAP1	3	affinity chromatography technology	Emdal KB (2015)	1
FAF1	1	UBC	7	pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Song EJ (2005), Lee JJ (2012), Song J (2009), Song J (2009), Song J (2009), Lee JJ (2013), Lee JJ (2013), Nathan JA (2013), Baron Y (2014), Alexandru G (2008), Lee JJ (2012)	11
NTRK1	1	TRIP4	2	affinity chromatography technology	Emdal KB (2015)	1
RPA1	0	SNRPB	0	affinity chromatography technology	Marechal A (2014)	1
SNW1	0	RPA1	0	affinity chromatography technology	Lleres D (2010)	1
ASCC2	3	GPC4	0	biochemical	Wan C (2015)	1
KDM1A	2	IMMT	0	two hybrid, pull down	Stelzl U (2005), Stelzl U (2005)	2
NIPSNAP1	3	ASCC2	3	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	FAF1	1	affinity chromatography technology	Emdal KB (2015)	1
CC2D2A	3	ASCC2	3	bioid	Gupta GD (2015)	1
ASCC2	3	OLA1	2	two hybrid	Stelzl U (2005)	1
SMURF1	4	ASCC2	3	enzymatic study	Andrews PS (2010)	1
ASCC2	3	SNRPB	0	two hybrid	Stelzl U (2005)	1
NTRK1	1	EEF1D	3	affinity chromatography technology	Emdal KB (2015)	1
ASCC2	3	CUTC	0	two hybrid	Stelzl U (2005)	1
ASCC1	0	ASCC2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Knierim E (2016), Knierim E (2016), Huttlin EL (2017)	4
ASCC2	3	POLDIP2	1	two hybrid	Stelzl U (2005)	1
ASCC2	3	PIK3CD	4	two hybrid	Stelzl U (2005)	1
ASCC2	3	IMMT	0	two hybrid	Stelzl U (2005)	1
ASCC2	3	EEF1D	3	two hybrid	Stelzl U (2005)	1
ASCC2	3	GNL3	3	two hybrid	Stelzl U (2005)	1
SNW1	0	OLA1	2	affinity chromatography technology	Lleres D (2010)	1
MYH9	19	IMMT	0	affinity chromatography technology	Hein MY (2015)	1
TEPSIN	1	MED31	0	affinity chromatography technology	Hein MY (2015)	1
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
ASCC2	3	IGSF9	2	two hybrid	Stelzl U (2005)	1
ASCC2	3	PIN4	0	two hybrid	Stelzl U (2005)	1
ASCC2	3	POLA2	2	two hybrid	Stelzl U (2005)	1
GADD45A	1	BAG6	2	two hybrid	Vinayagam A (2011)	1
CC2D2A	3	ASCC3	12	bioid	Gupta GD (2015)	1
ASCC2	3	ASCC3	12	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
PAPD5	3	ASCC2	3	affinity chromatography technology	Hein MY (2015)	1