Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
ARID5B	rs10994982	A	methotrexate	metabolism/PK	yes	A was associated with greater methotrexate polyglutamate accumulation in lymphoblasts from patients with B-hyperdiploid ALL.	Allele A is associated with decreased clearance of methotrexate in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to allele G.	19684603	981478035
ARID5B	rs4948496	CC	methotrexate	metabolism/PK	yes	Patients with the CC genotype were found to have higher serum methotrexate levels as compared to those with the CT or TT genotype.	Genotype CC is associated with increased concentrations of methotrexate in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotypes CT + TT.	24712521	1296666342