PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MDC1	8	ABRAXAS1	0	affinity chromatography technology	Woods NT (2012)	1
ABRAXAS1	0	LAMC1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	ABRAXAS1	0	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Wang B (2009), Zhang X (2017)	3
BABAM2	2	BRCC3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Dong Y (2003), Dong Y (2003), Dong Y (2003), Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Cooper EM (2010), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009)	17
PAXIP1	1	ABRAXAS1	0	affinity chromatography technology	Woods NT (2012)	1
PAXIP1	1	BABAM1	1	affinity chromatography technology	Woods NT (2012)	1
BABAM2	2	ABRAXAS1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sowa ME (2009), Wang B (2009), Wang B (2009), Wang B (2009), Shao G (2009), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Zheng H (2013)	14
MDC1	8	BABAM2	2	affinity chromatography technology	Woods NT (2012)	1
MDC1	8	BABAM1	1	affinity chromatography technology	Woods NT (2012)	1
ABRAXAS1	0	WTAP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UIMC1	4	UBC	7	pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, unspecified method, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Sobhian B (2007), Sobhian B (2007), Wang B (2009), Hu X (2012), Sekiyama N (2012), Cho HJ (2009), Markin CJ (2010), Sekiyama N (2012), Sekiyama N (2012), Sato Y (2009), Sato Y (2009), Nikkilae J (2009), Nikkilae J (2009), Wu J (2009), Guzzo CM (2012), Nathan JA (2013), Anamika A (2014), Kensche T (2012), Yan J (2007), Castaneda CA (2013), Nakasone MA (2013), Thach TT (2015), Zhang X (2017), Li Y (2017), Kristariyanto YA (2017)	25
BABAM2	2	BRCA1	7	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Dong Y (2003), Dong Y (2003), Dong Y (2003), Woods NT (2012), Hill SJ (2014)	5
BABAM1	1	BRCA1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang B (2009), Shao G (2009), Shao G (2009), Shao G (2009), Bian C (2012), Hill SJ (2014)	6
UBC	7	PSMC5	4	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhu Q (2004), Zhang X (2017)	3
FANCG	3	UIMC1	4	affinity chromatography technology, pull down, fluorescent resonance energy transfe	Zhu B (2014), Zhu B (2014), Zhu B (2014)	3
BRCA1	7	PSMC5	4	affinity chromatography technology	Ertych N (2016)	1
BRCC3	0	ABRAXAS1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Wang B (2007), Wang B (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2010), Solyom S (2012), Zheng H (2013)	19
SUMO2	0	UIMC1	4	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography	Hu X (2012), Hu X (2012), Hu X (2012), Hu X (2012), Guzzo CM (2012), Guzzo CM (2012), Anamika (2016)	7
ABRAXAS1	0	BARD1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang B (2009), Feng L (2009), Hu Y (2014)	3
BARD1	4	UIMC1	4	affinity chromatography technology, affinity chromatography technology	Sobhian B (2007), Sowa ME (2009)	2
UIMC1	4	MDC1	8	imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, pull down, affinity chromatography technology	Strauss C (2011), Strauss C (2011), Strauss C (2011), Strauss C (2011), Strauss C (2011), Strauss C (2011), Woods NT (2012)	7
FANCG	3	BRCC3	0	affinity chromatography technology, enzymatic study	Zhu B (2014), Zhu B (2014)	2
UIMC1	4	HSPA4	3	affinity chromatography technology	Cho HJ (2013)	1
UIMC1	4	PARP1	3	affinity chromatography technology, affinity chromatography technology	Hu Y (2014), Hu Y (2014)	2
PAXIP1	1	UIMC1	4	affinity chromatography technology	Woods NT (2012)	1
PARP1	3	BRCA1	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference, genetic interference, affinity chromatography technology	Hu Y (2014), Hu Y (2014), Hu Y (2014), Shen JP (2017), Srivas R (2016), Ertych N (2016)	6
PAXIP1	1	MDC1	8	affinity chromatography technology	Woods NT (2012)	1
BRCA1	7	UIMC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Kim H (2007), Kim H (2007), Sobhian B (2007), Sobhian B (2007), Sowa ME (2009), Strauss C (2011), Strauss C (2011), Feng L (2009), Feng L (2009), Yan J (2007), Wang B (2007), Wang B (2007), Wang B (2007), Nikkilae J (2009), Nikkilae J (2009), Mok MT (2010), Johnson N (2013), Hill SJ (2014), Hu Y (2014), Hu Y (2014), Hu Y (2014), Renaud E (2016), Li Y (2017)	23
ABRAXAS1	0	ABRAXAS1	0	affinity chromatography technology	Wu Q (2016)	1
ABRAXAS1	0	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method	Wang B (2009), Shao G (2009), Hu X (2011), Feng L (2009), Wang B (2007), Wang B (2007), Liu Z (2007), Liu Z (2007), Nikkilae J (2009), Mok MT (2010), Kim H (2007), Kim H (2007), Kim H (2007), Solyom S (2012), Sevcik J (2013), Hill SJ (2014), Wu Q (2016), Wu Q (2016)	18
MDC1	8	BRCC3	0	affinity chromatography technology	Woods NT (2012)	1
ABRAXAS1	0	PSMC5	4	affinity chromatography technology	Huttlin EL (2017)	1
FANCG	3	ABRAXAS1	0	affinity chromatography technology	Zhu B (2014)	1
PARP1	3	ABRAXAS1	0	affinity chromatography technology	Hu Y (2014)	1
UIMC1	4	ABRAXAS1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Wang B (2007), Wang B (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2010), Wang B (2007), Wang B (2007), Liu Z (2007), Liu Z (2007), Nikkilae J (2009), Nikkilae J (2009), Wu J (2009), Kim H (2007), Kim H (2007), Kim H (2007), Solyom S (2012), Cho HJ (2013), Hu Y (2014), Li Y (2017), Zheng H (2013)	30
PSMC5	4	LAMC1	5	two hybrid	Albers M (2005)	1
BARD1	4	HSPA4	3	affinity chromatography technology	Tembe V (2015)	1
ABRAXAS1	0	ALDH6A1	2	affinity chromatography technology	Huttlin EL (2017)	1
SUMO2	0	MDC1	8	pull down	Ouyang J (2009)	1
UBC	7	BABAM2	2	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Wang B (2009), Zhang X (2017)	3
PAXIP1	1	BRCC3	0	affinity chromatography technology	Woods NT (2012)	1
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
TEKT4	1	ABRAXAS1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BABAM1	1	ABRAXAS1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Wang B (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Shao G (2009), Shao G (2009), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Bian C (2012), Solyom S (2012), Huttlin EL (2015), Huttlin EL (2017), Zheng H (2013)	20
UBC	7	LAMC1	5	pull down	Zhang X (2017)	1
UBC	7	SUMO2	0	affinity chromatography technology	Sahin U (2014)	1
MDC1	8	BARD1	4	affinity chromatography technology	Lou Z (2003)	1
SUMO2	0	BABAM2	2	affinity chromatography technology, pull down, affinity chromatography technology	Hu X (2012), Hu X (2012), Guzzo CM (2012)	3
BABAM2	2	BARD1	4	affinity chromatography technology, affinity chromatography technology	Dong Y (2003), Dong Y (2003)	2
SUMO2	0	BRCC3	0	pull down, affinity chromatography technology	Hu X (2012), Guzzo CM (2012)	2
UIMC1	4	BRCC3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sobhian B (2007), Sowa ME (2009), Sowa ME (2009), Wang B (2007), Wang B (2007), Wang B (2009), Shao G (2009), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Nikkilae J (2009), Wu J (2009), Shao G (2009), Cho HJ (2013)	17
BRCC3	0	BABAM1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Cooper EM (2010), Hu X (2011), Hu X (2011), Feng L (2009), Feng L (2009), Feng L (2009), Huttlin EL (2015), Huttlin EL (2017)	14
BABAM2	2	BABAM1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Hu X (2011), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	21
BRCA1	7	HSPA4	3	affinity chromatography technology	Ertych N (2016)	1
SUMO2	0	BRCA1	7	affinity chromatography technology	Hu X (2012)	1
BARD1	4	PARP1	3	affinity chromatography technology	Hu Y (2014)	1
UBC	7	BRCC3	0	pull down, enzymatic study, pull down	Wang B (2009), Shao G (2009), Zhang X (2017)	3
UIMC1	4	BABAM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sobhian B (2007), Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Wu J (2009)	14
SUMO2	0	ABRAXAS1	0	affinity chromatography technology, pull down, affinity chromatography technology	Hu X (2012), Hu X (2012), Guzzo CM (2012)	3
UIMC1	4	BABAM1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Hu X (2011), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Huttlin EL (2015), Huttlin EL (2017), Li Y (2017)	15
RABGGTB	1	ABRAXAS1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCC3	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dong Y (2003), Dong Y (2003), Dong Y (2003), Kumaraswamy E (2007), Nikkilae J (2009), Woods NT (2012), Hill SJ (2014), Hu Y (2014)	8
BRCA1	7	BARD1	4	two hybrid, two hybrid, pull down, pull down, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, two hybrid, pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, two hybrid, x-ray crystallography, imaging technique, imaging technique, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Wu LC (1996), Wang Q (2001), Wang Q (2001), Mallery DL (2002), Wu-Baer F (2003), Hashizume R (2001), Fabbro M (2002), Rodriguez JA (2004), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Dong Y (2003), Chiba N (2001), Kleiman FE (2001), Kleiman FE (2001), Kleiman FE (2001), Wu LC (1996), Morris JR (2002), Brzovic PS (2001), Xia Y (2003), Meza JE (1999), Kentsis A (2002), Hashizume R (2001), Fabbro M (2004), Brzovic PS (2001), Yu X (1998), Jin Y (1997), Scully R (1999), Fabbro M (2004), Kleiman FE (1999), Kleiman FE (1999), Tascou S (2003), Brzovic PS (2003), Benezra M (2003), Meza JE (1999), Cantor SB (2001), Wang Q (1998), Ryser S (2009), Ryser S (2009), Nishikawa H (2009), Nishikawa H (2009), Sobhian B (2007), Harte MT (2010), Simons AM (2006), Wei L (2008), Kumaraswamy E (2007), Kumaraswamy E (2007), Dizin E (2010), Dizin E (2010), Greenberg RA (2006), Greenberg RA (2006), Greenberg RA (2006), Zhu Q (2011), Chen A (2002), Chen A (2002), Sy SM (2009), Sy SM (2009), Nelson AC (2010), Nelson AC (2010), Morris JR (2006), Brzovic PS (2001), Mok MT (2010), Au WW (2005), Ayi TC (1998), Choudhury AD (2005), Sarkar M (2008), Sarkar M (2008), Thakar A (2010), Lu Y (2012), Kentsis A (2002), Christou CM (2014), Christou CM (2014), Sevcik J (2013), Johnson N (2013), Matsuzawa A (2014), Matsuzawa A (2014), Hill SJ (2014), Hill SJ (2014), Hill SJ (2014), Starita LM (2015), Hu Y (2014), Wu W (2015), Loke J (2015), Densham RM (2016), Boukerroucha M (2015), Huttlin EL (2017), Liang Y (2017), Liang Y (2017), Liang Y (2017), Ertych N (2016), Ertych N (2016)	91
BRCC3	0	BARD1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dong Y (2003), Dong Y (2003), Sobhian B (2007), Kumaraswamy E (2007), Kumaraswamy E (2007)	5
ABRAXAS1	0	HSPA4	3	affinity chromatography technology	Wang B (2009)	1
UBC	7	BABAM1	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
MDC1	8	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, imaging technique, imaging technique	Matsuoka S (2007), Strauss C (2011), Strauss C (2011), Stewart GS (2003), Lou Z (2003), Mok MT (2010), Au WW (2005)	7
PAXIP1	1	BABAM2	2	affinity chromatography technology	Woods NT (2012)	1