PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ATR	6	RPA2	0	enzymatic study, affinity chromatography technology	Olson E (2006), Marechal A (2014)	2
MSH2	4	ATM	9	biochemical	Wang Y (2000)	1
ATM	9	MCM2	3	enzymatic study	Cortez D (2004)	1
ATM	9	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wu ZH (2006), Wu ZH (2006), Rosato RR (2010), Wu ZH (2008), Wu ZH (2008), Mohanty S (2014)	6
ATRIP	1	ATR	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Wang Y (2003), Wang Y (2003), Cortez D (2004), Cortez D (2001), Cortez D (2001), Cortez D (2001), Cortez D (2001), Rendtlew Danielsen JM (2009), Kulkarni A (2008), Sivasubramaniam S (2008), Sivasubramaniam S (2008), Itakura E (2004), Itakura E (2004), Itakura E (2004), Pabla N (2008), Pabla N (2011), Collis SJ (2007), Collis SJ (2007), Warmerdam DO (2010), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Bomgarden RD (2004), Choi JH (2007), Lovejoy CA (2009), Huttlin EL (2017)	27
CDC6	0	ATRIP	1	pull down	Yoshida K (2010)	1
PRKDC	12	ATM	9	unspecified method, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Suzuki K (1999), Suzuki K (1999)	3
ATR	6	RPA1	0	unspecified method, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Pabla N (2008), Marechal A (2014)	3
CDK9	3	ATR	6	affinity chromatography technology	Yu DS (2010)	1
RPA3	2	RPA2	0	biochemical, x-ray crystallography, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Havugimana PC (2012), Du Y (2009), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
MOS	1	ATRIP	1	two hybrid	Rolland T (2014)	1
ATRIP	1	MUL1	1	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPUL1	1	ATM	9	affinity chromatography technology	Blackford AN (2008)	1
TIMELESS	8	ATRIP	1	affinity chromatography technology	Unsal-Kacmaz K (2005)	1
MCM2	3	MCM7	5	pull down, pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Drissi R (2015), Boldt K (2016)	14
MCM2	3	PRKDC	12	affinity chromatography technology	Drissi R (2015)	1
CINP	0	ATRIP	1	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Lovejoy CA (2009), Lovejoy CA (2009), Lovejoy CA (2009), Rolland T (2014)	4
KIR3DL2	1	ATRIP	1	affinity chromatography technology	Huttlin EL (2017)	1
ATRIP	1	MCM7	5	affinity chromatography technology	Cortez D (2004)	1
PRKDC	12	RPA2	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Shao RG (1999), Shao RG (1999), Shao RG (1999), Wu X (2006), Zernik-Kobak M (1997), Chan DW (2000), Marechal A (2014), Fried LM (1996)	8
IKBKG	0	ATR	6	affinity chromatography technology	Wu ZH (2008)	1
RPA1	0	RPA2	0	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shao RG (1999), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Kristensen AR (2012), Ghospurkar PL (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Elia AE (2015), Elia AE (2015), Huttlin EL (2017), Feeney L (2017)	13
FAAP24	1	FANCL	0	affinity chromatography technology	Ciccia A (2007)	1
ATRIP	1	TELO2	6	affinity chromatography technology	Collis SJ (2007)	1
BRCA1	7	TOPBP1	5	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenberg RA (2006), Mok MT (2010), Tian F (2013), Hill SJ (2014), Sakasai R (2012)	5
ATR	6	NBN	1	unspecified method, pull down, affinity chromatography technology	Kim ST (1999), Falck J (2005), Falck J (2005)	3
POLR1C	2	FAM208B	4	two hybrid	Rolland T (2014)	1
RPA3	2	HNRNPUL1	1	affinity chromatography technology	Marechal A (2014)	1
MID2	1	ATRIP	1	two hybrid	Rolland T (2014)	1
MCM2	3	GDA	1	affinity chromatography technology	Drissi R (2015)	1
ATRIP	1	PEX14	2	affinity chromatography technology	Huttlin EL (2017)	1
FAM156A	0	ATRIP	1	two hybrid	Rolland T (2014)	1
HERC2	9	RPA1	0	affinity chromatography technology, affinity chromatography technology	Al-Hakim AK (2012), Elia AE (2015)	2
BRCA1	7	HERC2	9	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wu W (2010), Wu W (2010), Wu W (2010), Peng Y (2015)	4
ATRIP	1	LNX1	7	two hybrid	Rolland T (2014)	1
RPA1	0	MSH2	4	affinity chromatography technology, biochemical	Marechal A (2014), Wan C (2015)	2
TELO2	6	ATM	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kaizuka T (2010), Takai H (2010), Takai H (2007), Takai H (2007)	4
HNRNPUL1	1	RPA2	0	pull down, affinity chromatography technology	Blackford AN (2008), Marechal A (2014)	2
CDK9	3	MSH2	4	affinity chromatography technology	Mak AB (2010)	1
LNX1	7	PRKDC	12	affinity chromatography technology	Lenihan JA (2017)	1
CEP164	6	ATRIP	1	affinity chromatography technology, affinity chromatography technology, pull down	Sivasubramaniam S (2008), Sivasubramaniam S (2008), Sivasubramaniam S (2008)	3
ATM	9	TOPBP1	5	affinity chromatography technology	Perfettini JL (2009)	1
TOPBP1	5	ATRIP	1	affinity chromatography technology	Venere M (2007)	1
IKBKG	0	MCM7	5	pull down	Fenner BJ (2010)	1
ATR	6	TOPBP1	5	affinity chromatography technology	Rendtlew Danielsen JM (2009)	1
ATRIP	1	NPEPL1	0	biochemical	Wan C (2015)	1
MSH2	4	ATR	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Wang Y (2003), Wang Y (2003), Wang Y (2003), Wang Y (2003), Pabla N (2011), Pabla N (2011), Pabla N (2011)	7
HERC2	9	RPA3	2	affinity chromatography technology	Al-Hakim AK (2012)	1
PRKDC	12	BRCA1	7	unspecified method	Kim ST (1999)	1
TELO2	6	PRKDC	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaizuka T (2010), Takai H (2010), Takai H (2010), Takai H (2007), Takai H (2007)	5
BRCA1	7	RPA1	0	affinity chromatography technology, imaging technique, affinity chromatography technology	Suhasini AN (2011), Mok MT (2010), Tian F (2013)	3
FAM208B	4	ATRIP	1	two hybrid	Rolland T (2014)	1
TOPBP1	5	RPA1	0	imaging technique	Gong Z (2010)	1
ATRIP	1	ATRIP	1	two hybrid	Tomida J (2013)	1
BRCA1	7	MSH2	4	two hybrid, pull down, biochemical, affinity chromatography technology, genetic interference	Wang Q (2001), Wang Q (2001), Wang Y (2000), Wada-Hiraike O (2005), Peng M (2014)	5
ATR	6	MCM2	3	enzymatic study	Cortez D (2004)	1
FANCL	0	FAAP100	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Singh TR (2010), Ling C (2007), Ling C (2007), Ling C (2007), Huang Y (2014), Huang Y (2014), Ali AM (2012), Ali AM (2012), Ali AM (2012)	9
ATRIP	1	FANCL	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Tomida J (2013), Tomida J (2013), Tomida J (2013)	3
SCG2	1	ATRIP	1	two hybrid	Rolland T (2014)	1
CD70	0	TIMELESS	8	affinity chromatography technology	Huttlin EL (2017)	1
POLR1C	2	ATRIP	1	two hybrid	Rolland T (2014)	1
NBN	1	PRKDC	12	pull down, affinity chromatography technology	Falck J (2005), Falck J (2005)	2
LNX1	7	METTL21A	0	two hybrid	Rolland T (2014)	1
CCDC28B	1	ATRIP	1	two hybrid	Rolland T (2014)	1
ATM	9	BRCA1	7	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Gatei M (2000), Gatei M (2000), Kim ST (1999), Cortez D (1999), Cortez D (1999), Tibbetts RS (2000), Wang Y (2000), Mu JJ (2007), Tsai WB (2008), Gatei M (2000), Gatei M (2000), Gatei M (2000)	12
MID2	1	BRCA1	7	two hybrid	Hill SJ (2014)	1
MCM7	5	ATR	6	affinity chromatography technology	Cortez D (2004)	1
RPA3	2	NBN	1	affinity chromatography technology	Marechal A (2014)	1
RPA2	0	MSH2	4	affinity chromatography technology	Marechal A (2014)	1
FZD10	5	ATRIP	1	affinity chromatography technology	Huttlin EL (2017)	1
MCM7	5	TIMELESS	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	MCM2	3	affinity chromatography technology	Ertych N (2016)	1
FAAP24	1	ATRIP	1	biochemical	Collis SJ (2008)	1
SPRY2	4	ATRIP	1	two hybrid	Rolland T (2014)	1
BRCA1	7	CDK16	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Yu X (1998), Woods NT (2012), Hill SJ (2014), Huttlin EL (2015)	4
RPA3	2	PRKDC	12	affinity chromatography technology	Marechal A (2014)	1
MX2	5	ATRIP	1	two hybrid	Rolland T (2014)	1
CD70	0	ATM	9	affinity chromatography technology	Huttlin EL (2017)	1
ATM	9	CDK9	3	imaging technique	Fang L (2014)	1
ATRIP	1	C1orf94	1	two hybrid	Rolland T (2014)	1
RPA3	2	ATRIP	1	affinity chromatography technology, pull down	Marechal A (2014), Tomida J (2013)	2
CDK16	0	ATRIP	1	two hybrid	Rolland T (2014)	1
HNRNPUL1	1	RPA1	0	affinity chromatography technology, pull down, affinity chromatography technology	Blackford AN (2008), Blackford AN (2008), Marechal A (2014)	3
RPA1	0	MCM2	3	two hybrid, two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Drissi R (2015)	3
BRCA1	7	CDK9	3	two hybrid	Woods NT (2012)	1
ATRIP	1	MSH2	4	affinity chromatography technology, affinity chromatography technology	Wang Y (2003), Wang Y (2003)	2
BRCA1	7	NBN	1	biochemical, biochemical, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Chiba N (2001), Zhong Q (1999), Shimada M (2009), Chen L (2008), Hill SJ (2014), Goldstein M (2015), Goldstein M (2015), Parameswaran B (2015)	9
BRCA1	7	ATRIP	1	affinity chromatography technology, pull down, x-ray crystallography	Venere M (2007), Liu X (2013), Liu X (2013)	3
ATR	6	CINP	0	affinity chromatography technology	Lovejoy CA (2009)	1
TELO2	6	TOPBP1	5	affinity chromatography technology	Rendtlew Danielsen JM (2009)	1
NBN	1	MSH2	4	biochemical	Wang Y (2000)	1
SPRY2	4	MID2	1	two hybrid	Rolland T (2014)	1
RPA3	2	ATR	6	affinity chromatography technology	Marechal A (2014)	1
CDK9	3	ATRIP	1	affinity chromatography technology	Yu DS (2010)	1
ATRIP	1	PRKDC	12	pull down	Falck J (2005)	1
ATRIP	1	HERC2	9	affinity chromatography technology	Izawa N (2011)	1
CDC6	0	ATM	9	pull down	Yoshida K (2010)	1
RPA2	0	ATRIP	1	affinity chromatography technology, pull down	Marechal A (2014), Tomida J (2013)	2
RPA3	2	RPA1	0	biochemical, x-ray crystallography, affinity chromatography technology, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Du Y (2009), Wan C (2015), Hein MY (2015), Elia AE (2015)	8
ATRIP	1	MCM2	3	affinity chromatography technology	Izawa N (2011)	1
ATRIP	1	ATM	9	pull down, affinity chromatography technology	Falck J (2005), Falck J (2005)	2
ATRIP	1	FAAP100	1	two hybrid	Tomida J (2013)	1
IKBKG	0	ATRIP	1	affinity chromatography technology	Wu ZH (2008)	1
ATR	6	CEP164	6	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Sivasubramaniam S (2008), Sivasubramaniam S (2008), Sivasubramaniam S (2008), Sivasubramaniam S (2008)	4
RPA3	2	MSH2	4	affinity chromatography technology	Marechal A (2014)	1
BRCA1	7	HNRNPUL1	1	affinity chromatography technology	Ertych N (2016)	1
FAAP24	1	TELO2	6	biochemical, affinity chromatography technology, affinity chromatography technology	Collis SJ (2008), Collis SJ (2008), Collis SJ (2008)	3
PNKD	2	ATRIP	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPA1	0	NBN	1	affinity chromatography technology	Marechal A (2014)	1
CDC6	0	MCM7	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1999), Fujita M (1999), Sugimoto N (2015), Hubbi ME (2013)	7
ATM	9	RPA2	0	enzymatic study	Chan DW (2000)	1
ATRIP	1	NBN	1	affinity chromatography technology	Falck J (2005)	1
ATR	6	ATM	9	unspecified method, enzymatic study	Kim ST (1999), Stiff T (2006)	2
PRKDC	12	RPA1	0	pull down, affinity chromatography technology, affinity chromatography technology	Shao RG (1999), Gong Z (2011), Marechal A (2014)	3
GDA	1	ATRIP	1	biochemical	Wan C (2015)	1
MOS	1	MID2	1	two hybrid	Rolland T (2014)	1
ATM	9	NBN	1	unspecified method, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Wang Y (2000), Cariveau MJ (2007), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Wu J (2012), Wu J (2012), Wei F (2015)	12
TELO2	6	ATR	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaizuka T (2010), Takai H (2010), Takai H (2010), Takai H (2007), Takai H (2007), Collis SJ (2007), Collis SJ (2007), Collis SJ (2007), Rendtlew Danielsen JM (2009), Rendtlew Danielsen JM (2009)	10
RPA3	2	MCM2	3	two hybrid	Kneissl M (2003)	1
FAAP100	1	FAAP24	1	affinity chromatography technology	Ali AM (2012)	1
CD70	0	ATRIP	1	affinity chromatography technology	Huttlin EL (2017)	1
CDK9	3	PRKDC	12	genetic interference	Shen JP (2017)	1
RPA2	0	MCM2	3	two hybrid	Kneissl M (2003)	1
GDA	1	NPEPL1	0	biochemical	Wan C (2015)	1
CDC6	0	MCM2	3	pull down, affinity chromatography technology	Ramachandran N (2004), Hubbi ME (2013)	2
HNRNPUL1	1	ATRIP	1	affinity chromatography technology	Blackford AN (2008)	1
CDC6	0	ATR	6	pull down, affinity chromatography technology	Yoshida K (2010), Yoshida K (2010)	2
MCM2	3	HNRNPUL1	1	affinity chromatography technology	Drissi R (2015)	1
ATM	9	RPA1	0	enzymatic study	Chan DW (2000)	1
CDC23	3	ATRIP	1	two hybrid	Rolland T (2014)	1
LNX1	7	MID2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lenihan JA (2017), Lenihan JA (2017), Lenihan JA (2017)	3
TOPBP1	5	NBN	1	affinity chromatography technology, affinity chromatography technology	Morishima K (2007), Morishima K (2007)	2
ATRIP	1	METTL21A	0	two hybrid	Rolland T (2014)	1
MCM7	5	RPA1	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
ATRIP	1	RPA1	0	imaging technique, pull down, affinity chromatography technology, pull down, pull down	Zou L (2003), Liu Y (2011), Marechal A (2014), Tomida J (2013), Shigechi T (2012)	5
ATR	6	BRCA1	7	pull down, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Tibbetts RS (2000), Kim ST (1999), Mu JJ (2007), Chen J (2000), Chen J (2000), Tibbetts RS (2000), Gatei M (2001), Gatei M (2001), Gatei M (2001), Tian F (2013)	10
RPA2	0	NBN	1	affinity chromatography technology	Marechal A (2014)	1
ST6GAL1	0	ATRIP	1	affinity chromatography technology	Huttlin EL (2017)	1
FAAP24	1	ATR	6	biochemical	Collis SJ (2008)	1