PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BCAR3	5	IARS	5	affinity chromatography technology	Ewing RM (2007)	1
ERBB2	6	THRSP	0	two hybrid	Arroyo R (2015)	1
IRS1	7	APP	1	pull down	Olah J (2011)	1
BCAR3	5	GLCE	0	two hybrid	Arroyo R (2015)	1
NEDD9	3	BCAR1	6	affinity chromatography technology	Law SF (1999)	1
BCAR3	5	CASZ1	7	two hybrid	Arroyo R (2015)	1
BCAR3	5	ERRFI1	1	two hybrid	Arroyo R (2015)	1
PRDM14	1	BEX2	0	two hybrid	Rolland T (2014)	1
BCAR3	5	APP	1	pull down	Olah J (2011)	1
BCAR3	5	OSGIN1	1	two hybrid	Arroyo R (2015)	1
BCAR3	5	PDLIM2	0	two hybrid	Arroyo R (2015)	1
ERBB2	6	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Scaltriti M (2009), Graus-Porta D (1997), Le XF (2005), Chen TC (2014), Ritch PS (2005)	5
TRIM25	5	TARS	2	affinity chromatography technology	Choudhury NR (2017)	1
BCAR3	5	CCL5	1	two hybrid	Arroyo R (2015)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
ERBB2	6	GLCE	0	two hybrid	Arroyo R (2015)	1
IARS	5	APP	1	pull down	Olah J (2011)	1
BCAR3	5	PABPC1	5	affinity chromatography technology	Ewing RM (2007)	1
BCAR3	5	PRDM14	1	two hybrid	Arroyo R (2015)	1
BCAR3	5	EPSTI1	0	two hybrid	Arroyo R (2015)	1
BCAR3	5	HOXC6	0	two hybrid	Arroyo R (2015)	1
BCAR3	5	BAP1	4	two hybrid	Arroyo R (2015)	1
KPNA1	5	MTA3	3	affinity chromatography technology	Hein MY (2015)	1
CASZ1	7	APP	1	pull down	Olah J (2011)	1
BCAR3	5	CST6	1	two hybrid	Arroyo R (2015)	1
BCAR3	5	RPRD1A	2	two hybrid	Wang J (2011)	1
BCAR3	5	ATAD2	6	two hybrid	Arroyo R (2015)	1
BCAR3	5	NSD3	6	two hybrid	Arroyo R (2015)	1
TRIM25	5	ATAD2	6	affinity chromatography technology	Choudhury NR (2017)	1
BCAR3	5	GAST	0	affinity chromatography technology	Huttlin EL (2017)	1
ERBB2	6	PSMC3IP	0	two hybrid	Arroyo R (2015)	1
BCAR3	5	MTA3	3	two hybrid	Arroyo R (2015)	1
BCAR3	5	BEX2	0	two hybrid	Arroyo R (2015)	1
ERRFI1	1	ERBB2	6	affinity chromatography technology, two hybrid	Li J (2013), Arroyo R (2015)	2
TRIM25	5	PABPC1	5	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
ERBB2	6	PRDM14	1	two hybrid	Arroyo R (2015)	1
BCAR3	5	NEDD9	3	affinity chromatography technology, two hybrid, affinity chromatography technology	Cai D (2003), Rolland T (2014), Huttlin EL (2017)	3
TRIM25	5	CASZ1	7	affinity chromatography technology	Choudhury NR (2017)	1
BCAR3	5	KPNA1	5	two hybrid	Wang J (2011)	1
BCAR3	5	AGR3	2	two hybrid	Arroyo R (2015)	1
BCAR3	5	IMPDH2	3	affinity chromatography technology	Ewing RM (2007)	1
BCAR3	5	SERPINB5	0	two hybrid	Arroyo R (2015)	1
BCAR3	5	GREB1	8	two hybrid	Arroyo R (2015)	1
BCAR3	5	PSMC3IP	0	two hybrid	Arroyo R (2015)	1
BCAR1	6	ERBB2	6	affinity chromatography technology	Bisaro B (2016)	1
TRIM25	5	BCAR1	6	affinity chromatography technology	Choudhury NR (2017)	1
ERBB2	6	IARS	5	two hybrid	Arroyo R (2015)	1
HOXC6	0	APP	1	pull down	Olah J (2011)	1
NEDD9	3	APP	1	pull down	Olah J (2011)	1
TRIM25	5	BCAR3	5	affinity chromatography technology	Choudhury NR (2017)	1
ERBB2	6	IRS1	7	unspecified method	Jones RB (2006)	1
BCAR3	5	BEX1	0	two hybrid	Arroyo R (2015)	1
BCAR3	5	BCAR1	6	affinity chromatography technology, affinity chromatography technology	Cai D (2003), Huttlin EL (2017)	2
BCAR3	5	DEFA5	1	affinity chromatography technology	Huttlin EL (2017)	1
DEFA5	1	GLCE	0	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	IMPDH2	3	affinity chromatography technology	Choudhury NR (2017)	1
IRS1	7	BCAR3	5	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
TRIM25	5	IARS	5	affinity chromatography technology	Choudhury NR (2017)	1
BCAR3	5	VPS45	0	two hybrid	Arroyo R (2015)	1
BCAR3	5	DKK3	3	two hybrid	Arroyo R (2015)	1
ERBB2	6	BCAR3	5	unspecified method	Jones RB (2006)	1
BCAR3	5	THRSP	0	two hybrid	Arroyo R (2015)	1
TRIM25	5	PSMC3IP	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	GREB1	8	affinity chromatography technology	Choudhury NR (2017)	1
ERBB3	3	BCAR3	5	unspecified method	Jones RB (2006)	1
BCAR3	5	TARS	2	affinity chromatography technology	Ewing RM (2007)	1