PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CFTR	5	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vij N (2006), Ballar P (2010), Goldstein RF (2007), Goldstein RF (2007), Sun F (2006), Sun F (2006), Wang X (2006), Morito D (2008), Pankow S (2015)	9
PIBF1	2	PTPRQ	5	affinity chromatography technology	Boldt K (2016)	1
RAB5C	2	EEA1	3	pull down	Merithew E (2003)	1
PPP1R3C	3	EEA1	3	affinity chromatography technology	Huttlin EL (2015)	1
CFTR	5	MARS	1	affinity chromatography technology	Pankow S (2015)	1
EEA1	3	PDCD6IP	3	biochemical	Zhou X (2010)	1
EEA1	3	NSF	3	biochemical	McBride HM (1999)	1
BMI1	0	TP53	0	affinity chromatography technology, affinity chromatography technology	Calao M (2012), Yin J (2013)	2
USP47	4	EEA1	3	affinity chromatography technology	Huttlin EL (2017)	1
RAB5A	0	EEA1	3	fluorescent resonance energy transfe, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down	Galperin E (2003), Valsdottir R (2001), Raiborg C (2001), Miaczynska M (2004), Christoforidis S (2000), Schnatwinkel C (2004), Mishra A (2010), Mishra A (2010)	8
VCP	6	RNF2	1	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Cao Q (2014)	2
MLLT6	2	EEA1	3	affinity chromatography technology	Huttlin EL (2017)	1
SNRNP27	0	EEA1	3	affinity chromatography technology	Huttlin EL (2017)	1
VCP	6	NSF	3	biochemical	Wan C (2015)	1
VCP	6	NUP58	0	affinity chromatography technology	Yu CC (2013)	1
EEA1	3	STX12	2	pull down	McBride HM (1999)	1
CCDC8	1	PDCD6IP	3	affinity chromatography technology	Hanson D (2014)	1
CCDC8	1	NSF	3	affinity chromatography technology	Hanson D (2014)	1
RAB31	1	EEA1	3	pull down	Ng EL (2009)	1
CCDC8	1	VCP	6	affinity chromatography technology	Hanson D (2014)	1
TP53	0	TNK2	7	affinity chromatography technology	Ding G (2013)	1
RAB31	1	RAB22A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FUOM	1	EEA1	3	affinity chromatography technology	Huttlin EL (2017)	1
RABGEF1	1	RAB5A	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhu H (2009), Christoforidis S (2000), Aikawa Y (2012), Aikawa Y (2012)	4
VCP	6	EEA1	3	affinity chromatography technology	Ramanathan HN (2012)	1
VCP	6	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Yu CC (2013), Fogeron ML (2013)	3
TP53	0	BMP1	5	two hybrid	Wang J (2008)	1
PCNA	0	EEA1	3	affinity chromatography technology	Hein MY (2015)	1
IGF1R	5	TP53	0	affinity chromatography technology	Broussas M (2009)	1
BMI1	0	RNF2	1	biochemical, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Cao R (2005), Cao R (2005), Ben-Saadon R (2006), Li Z (2006), Maertens GN (2009), Wei J (2006), Gao Z (2012), Gao Z (2012), Gao Z (2012), Gao Z (2012), Pan MR (2011), Pan MR (2011), Voncken JW (2005), Woodsmith J (2012), Voncken JW (2003), Woodsmith J (2012), Li Z (2006), Li Z (2006), McGinty RK (2014), Cao Q (2014), Cao Q (2014), Hein MY (2015), Balasubramanian S (2015), Taherbhoy AM (2015), Taherbhoy AM (2015), Abdouh M (2016), Sanchez A (2016), Wheaton K (2017), Hauri S (2016), Hauri S (2016)	30
RAB22A	0	RAB5A	0	affinity chromatography technology	Zhu H (2009)	1
RAB31	1	RAB5A	0	affinity chromatography technology	Huttlin EL (2015)	1
EEA1	3	PIBF1	2	affinity chromatography technology	Boldt K (2016)	1
TP53	0	EEA1	3	affinity chromatography technology	Kikuchi J (2003)	1
RNF2	1	EEA1	3	affinity chromatography technology	Cao Q (2014)	1
IGF1R	5	EEA1	3	affinity chromatography technology	Sehat B (2008)	1
RABGEF1	1	RABEP1	4	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kalesnikoff J (2007), Christoforidis S (2000), Lippe R (2001), Horiuchi H (1997), Zhang Z (2014), Zhang Z (2014), Kaelin S (2015), Kaelin S (2015), Huttlin EL (2017)	9
FCGR2A	0	EEA1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RRAD	2	EEA1	3	pull down	Yeom SY (2014)	1
RABGEF1	1	RAB22A	0	affinity chromatography technology, affinity chromatography technology	Zhu H (2009), Zhu H (2009)	2
CFTR	5	TP53	0	affinity chromatography technology	Pankow S (2015)	1
TP53	0	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CFTR	5	RAB5A	0	affinity chromatography technology, affinity chromatography technology	Bomberger JM (2009), Pankow S (2015)	2
BMP1	5	EEA1	3	affinity chromatography technology	Huttlin EL (2017)	1
RAB5A	0	RAB5C	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
PXK	1	EEA1	3	imaging technique	Takeuchi H (2010)	1
ERBB2	6	EEA1	3	affinity chromatography technology	Giri DK (2005)	1
EEA1	3	TNK2	7	imaging technique	Grovdal LM (2008)	1
EEA1	3	SNX27	5	affinity chromatography technology	Boldt K (2016)	1
TMA16	0	EEA1	3	affinity chromatography technology	Huttlin EL (2017)	1
EEA1	3	RAB22A	0	two hybrid, pull down	Kauppi M (2002), Kauppi M (2002)	2
NSF	3	STX12	2	affinity chromatography technology	Behrends C (2010)	1
MARS	1	EEA1	3	biochemical	Wan C (2015)	1
PIBF1	2	SNX27	5	affinity chromatography technology	Boldt K (2016)	1
TP53	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Banks D (2006), Banks D (2006), Hampp S (2016), Hampp S (2016)	4
EEA1	3	RABEP1	4	biochemical, affinity chromatography technology, affinity chromatography technology	McBride HM (1999), Christoforidis S (2000), Christoforidis S (2000)	3
RNF2	1	NSF	3	affinity chromatography technology	Cao Q (2014)	1
CCDC8	1	RAB5C	2	affinity chromatography technology	Hanson D (2014)	1
CCDC8	1	MARS	1	affinity chromatography technology	Hanson D (2014)	1
RNF2	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Calao M (2012), Wen W (2013), Wen W (2013)	3
IGF1R	5	ERBB2	6	affinity chromatography technology	Riedemann J (2007)	1
TP53	0	CCDC8	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dai C (2011), Dai C (2011), Dai C (2011), Dai C (2011), Fogeron ML (2013), Hanson D (2014), Hanson D (2014)	7
CCDC8	1	EEA1	3	affinity chromatography technology	Hanson D (2014)	1
EEA1	3	EEA1	3	x-ray crystallography, two hybrid, pull down, affinity chromatography technology	Dumas JJ (2001), Callaghan J (1999), Callaghan J (1999), Ramanathan HN (2012)	4
CFTR	5	RAB5C	2	affinity chromatography technology	Pankow S (2015)	1
RNF2	1	MARS	1	affinity chromatography technology	Cao Q (2014)	1
CFTR	5	EEA1	3	biochemical	Villella VR (2013)	1
BMI1	0	EEA1	3	affinity chromatography technology	Cao Q (2014)	1
NUP58	0	EEA1	3	affinity chromatography technology	Huttlin EL (2017)	1
EEA1	3	PTPRQ	5	affinity chromatography technology	Boldt K (2016)	1
CFTR	5	SNX27	5	affinity chromatography technology	Pankow S (2015)	1
SERPINB2	0	EEA1	3	affinity chromatography technology	Huttlin EL (2017)	1
PTPRQ	5	SNX27	5	affinity chromatography technology	Boldt K (2016)	1
EEA1	3	RABGEF1	1	affinity chromatography technology	Christoforidis S (2000)	1
RABEP1	4	RAB5A	0	two hybrid, two hybrid, two hybrid, biochemical, pull down, pull down, pull down, affinity chromatography technology, pull down	Xiao GH (1997), Vitale G (1998), Vitale G (1998), Vitale G (1998), Stenmark H (1995), Valsdottir R (2001), Christoforidis S (2000), Schnatwinkel C (2004), Kaelin S (2015)	9