PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CALCOCO2	0	ENKD1	3	two hybrid	Rual JF (2005)	1
ZBTB14	2	ENKD1	3	two hybrid	Rolland T (2014)	1
DGCR6	0	TRAF2	1	two hybrid	Corominas R (2014)	1
ENKD1	3	SPERT	0	two hybrid	Rolland T (2014)	1
DVL2	5	TRAF2	1	two hybrid	Rual JF (2005)	1
PLSCR1	0	APP	1	pull down	Olah J (2011)	1
PDLIM7	0	ENKD1	3	two hybrid	Rual JF (2005)	1
SPAG5	1	ENKD1	3	two hybrid	Yu H (2011)	1
PPP1CC	2	APP	1	pull down	Olah J (2011)	1
TRAF2	1	UBXN11	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
EGLN3	0	RAD54B	3	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	ENKD1	3	affinity chromatography technology	Rodriguez J (2016)	1
ENKD1	3	MIPOL1	1	two hybrid	Rolland T (2014)	1
MKRN3	2	ENKD1	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
PPP1CC	2	NEFL	1	affinity chromatography technology	Cid C (2007)	1
EGLN3	0	YWHAE	0	affinity chromatography technology	Rodriguez J (2016)	1
YWHAE	0	ENKD1	3	two hybrid	Bandyopadhyay S (2010)	1
CCDC136	1	CCDC85B	0	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	DVL3	7	affinity chromatography technology	Rodriguez J (2016)	1
WDR62	6	ENKD1	3	affinity chromatography technology	Hein MY (2015)	1
PLSCR1	0	ENKD1	3	two hybrid	Rual JF (2005)	1
MDFI	1	ENKD1	3	two hybrid, two hybrid, two hybrid	Rual JF (2005), Xin X (2009), Rolland T (2014)	3
EGLN3	0	WDR62	6	affinity chromatography technology	Rodriguez J (2016)	1
BEGAIN	3	ENKD1	3	two hybrid	Rual JF (2005)	1
PPP1CC	2	ENKD1	3	two hybrid	Fardilha M (2011)	1
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
CCDC136	1	ENKD1	3	two hybrid	Rolland T (2014)	1
PHC2	3	ENKD1	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
CEP70	1	ENKD1	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ENKD1	3	KRTAP10-5	2	two hybrid	Rolland T (2014)	1
PDLIM7	0	TRAF2	1	protein complementation assay, protein complementation assay	Talaty P (2011), Talaty P (2011)	2
ENKD1	3	FAM102A	5	two hybrid	Rolland T (2014)	1
TRAF2	1	ENKD1	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
STAC3	1	ENKD1	3	two hybrid	Yu H (2011)	1
XPO1	8	DVL3	7	affinity chromatography technology	Kirli K (2015)	1
TRIM54	1	ENKD1	3	two hybrid	Rolland T (2014)	1
SUV39H1	0	ENKD1	3	affinity chromatography technology	Huttlin EL (2017)	1
NEFL	1	ENKD1	3	two hybrid	Rolland T (2014)	1
PNMA1	0	ENKD1	3	two hybrid	Rolland T (2014)	1
ENKD1	3	DVL3	7	two hybrid	Xin X (2009)	1
CCDC85B	0	ENKD1	3	two hybrid	Rual JF (2005)	1
DVL2	5	RBPMS	0	two hybrid	Rual JF (2005)	1
DGCR6	0	SPERT	0	two hybrid	Corominas R (2014)	1
ENKD1	3	6981	0	two hybrid	Xin X (2009)	1
TSC22D4	1	ENKD1	3	two hybrid	Rual JF (2005)	1
XPO1	8	ENKD1	3	affinity chromatography technology	Kirli K (2015)	1
ENKD1	3	SPSB3	1	two hybrid	Rolland T (2014)	1
BEGAIN	3	APP	1	pull down	Olah J (2011)	1
CDR2	1	ENKD1	3	two hybrid	Rolland T (2014)	1
PNMA2	0	ENKD1	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
XPO1	8	PDLIM7	0	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	DVL2	5	affinity chromatography technology	Kirli K (2015)	1
RAD54B	3	ENKD1	3	two hybrid	Rolland T (2014)	1
NEFL	1	APP	1	imaging technique	Chen TC (2014)	1
EGLN3	0	PDLIM7	0	affinity chromatography technology	Rodriguez J (2016)	1
CCDC85B	0	CEP70	1	two hybrid	Rual JF (2005)	1
XPO1	8	BEGAIN	3	affinity chromatography technology	Kirli K (2015)	1
TRIM54	1	CCDC102B	0	two hybrid	Rolland T (2014)	1
PNMA1	0	PNMA2	0	affinity chromatography technology	Brajenovic M (2004)	1
EGLN3	0	DVL2	5	affinity chromatography technology	Rodriguez J (2016)	1
ENKD1	3	UBXN11	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
DVL2	5	ENKD1	3	two hybrid	Rual JF (2005)	1
ENKD1	3	285622	0	two hybrid	Rolland T (2014)	1
DGCR6	0	ENKD1	3	two hybrid	Corominas R (2014)	1
PPP1CC	2	CCDC85B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), Huttlin EL (2017), Yadav L (2017), Yadav L (2017)	4
YWHAE	0	XPO1	8	biochemical	Kristensen AR (2012)	1
RBPMS	0	ENKD1	3	two hybrid	Rual JF (2005)	1
SUV39H1	0	CEP70	1	two hybrid	Rolland T (2014)	1
TRAF2	1	CALCOCO2	0	two hybrid	Rual JF (2005)	1
DVL2	5	DVL3	7	affinity chromatography technology, affinity chromatography technology	de Groot RE (2014), Huttlin EL (2017)	2
DGCR6	0	MIPOL1	1	two hybrid	Corominas R (2014)	1
DGCR6	0	PDLIM7	0	two hybrid	Corominas R (2014)	1
CCDC102B	0	ENKD1	3	two hybrid	Rolland T (2014)	1
EGLN3	0	PPP1CC	2	affinity chromatography technology	Rodriguez J (2016)	1
ENKD1	3	APP	1	pull down	Olah J (2011)	1
DGCR6	0	APP	1	pull down	Olah J (2011)	1