PPI network (data source: BioGrid)

Symbol A GeneA coding DNM count Symbol B GeneB coding DNM count Interaction detection method Publication Evidence
CASP7 1 CASP7 1 enzymatic study Walsh JG (2008) 1
CASP7 1 CLSPN 1 enzymatic study Clarke CA (2005) 1
CASP10 1 CASP2 1 enzymatic study Srinivasula SM (1996) 1
CASP3 0 CASP7 1 enzymatic study Walsh JG (2008) 1
BIRC5 1 CASP3 0 pull down, enzymatic study, pull down Tamm I (1998), Shin S (2001), Shin S (2001) 3
CASP8 1 CRYAB 0 affinity chromatography technology Lee JS (2012) 1
CCT2 1 CASP7 1 pull down, affinity chromatography technology Lin YF (2012), Lin YF (2012) 2
HSPA5 0 VIM 0 affinity chromatography technology Boldt K (2016) 1
CNDP2 3 RPS6KA1 3 biochemical Kristensen AR (2012) 1
BIRC2 1 XIAP 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017) 5
GBP2 0 MVD 2 biochemical Kristensen AR (2012) 1
XIAP 0 ARHGDIA 3 affinity chromatography technology, affinity chromatography technology Liu J (2011), Liu J (2012) 2
CASP8 1 RB1 2 enzymatic study Lemaire C (2005) 1
CASP7 1 RPS6KA1 3 biochemical Kristensen AR (2012) 1
BIRC3 1 CASP7 1 pull down, affinity chromatography technology Roy N (1997), Eckelman BP (2006) 2
BIRC3 1 XIAP 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Rajalingam K (2006), Rajalingam K (2006), Yang W (2014), Yang W (2014) 4
GNS 3 GBP2 0 biochemical Kristensen AR (2012) 1
SP1 0 VIM 0 affinity chromatography technology Chuang JY (2012) 1
CASP3 0 SP1 0 enzymatic study Rickers A (1999) 1
BAX 3 CASP3 0 biochemical Chandra D (2004) 1
BIRC2 1 CASP10 1 affinity chromatography technology McDonald ER (2004) 1
VCP 6 CASP9 6 affinity chromatography technology Yu CC (2013) 1
CASP3 0 DFFA 0 enzymatic study, imaging technique Walsh JG (2008), Chen TC (2014) 2
BIRC3 1 BIRC5 1 pull down Dohi T (2004) 1
CTSA 2 CASP7 1 biochemical Kristensen AR (2012) 1
BIRC3 1 CASP9 6 pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, imaging technique Deveraux QL (1998), Deveraux QL (1998), Eckelman BP (2006), Cheung HH (2006), Wang J (2011), McDonald ER (2004), Chen TC (2014) 7
SAT1 0 COPS6 0 two hybrid Stelzl U (2005) 1
CASP7 1 SP1 0 enzymatic study Rickers A (1999) 1
BIRC5 1 CASP9 6 affinity chromatography technology, imaging technique OConnor DS (2000), Chen TC (2014) 2
CAPN1 3 CASP7 1 biochemical Kristensen AR (2012) 1
XIAP 0 CASP7 1 pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Tenev T (2005), Paulsen M (2008), Huang Y (2001), Huang Y (2001), Chai J (2001), Chai J (2001), Huang Y (2003), Huang Y (2003), Sun M (2009), Takahashi R (1998), Lee JS (2012), Lin YF (2013), Lin YF (2013), Hou Y (2017) 20
MVD 2 RPS6KA1 3 biochemical Kristensen AR (2012) 1
GNS 3 MVD 2 biochemical Kristensen AR (2012) 1
CASP7 1 ARHGDIA 3 enzymatic study Walsh JG (2008) 1
EEF2 11 RPS6KA1 3 biochemical Kristensen AR (2012) 1
CASP3 0 FBXW11 2 affinity chromatography technology Tan M (2006) 1
CASP3 0 STAT1 1 enzymatic study Walsh JG (2008) 1
XIAP 0 CASP10 1 two hybrid, affinity chromatography technology Rolland T (2014), McDonald ER (2004) 2
GZMB 0 DFFA 0 enzymatic study Cullen SP (2007) 1
VCP 6 FBXW11 2 affinity chromatography technology Li JM (2013) 1
PEPD 5 GNS 3 biochemical Kristensen AR (2012) 1
TNFRSF1A 3 CASP2 1 affinity chromatography technology Duan H (1997) 1
CASP7 1 SPTAN1 9 enzymatic study Walsh JG (2008) 1
BIRC3 1 CASP3 0 pull down, affinity chromatography technology Roy N (1997), Rajalingam K (2006) 2
SP1 0 PARP1 3 affinity chromatography technology, affinity chromatography technology, enzymatic study Zaniolo K (2007), Zaniolo K (2007), Zaniolo K (2007) 3
CASP7 1 CRYAB 0 affinity chromatography technology, affinity chromatography technology Lee JS (2012), Jeong WJ (2012) 2
CASP3 0 PARP1 3 enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study Nicholson DW (1995), Lueschen S (1998), Walsh JG (2008), Boucher D (2012), Luo S (2010), Betin VM (2009) 6
PEPD 5 RPS6KA1 3 biochemical Kristensen AR (2012) 1
EEF2 11 CASP7 1 biochemical Kristensen AR (2012) 1
CNDP2 3 PEPD 5 biochemical Kristensen AR (2012) 1
CASP8 1 XIAP 0 genetic interference, affinity chromatography technology, affinity chromatography technology Guo Y (2002), Lee JS (2012), McDonald ER (2004) 3
CASP8 1 CASP7 1 enzymatic study, enzymatic study Guo Y (2002), Srinivasula SM (1996) 2
BIRC2 1 CASP3 0 pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology Roy N (1997), Choi YE (2009), Choi YE (2009), Clem RJ (2001), Rajalingam K (2006) 5
CASP3 0 SPTAN1 9 enzymatic study Walsh JG (2008) 1
CASP8 1 TNFRSF1A 3 biochemical Gajate C (2005) 1
GZMB 0 CASP7 1 enzymatic study Cullen SP (2007) 1
CASP7 1 PTGES3 0 enzymatic study, enzymatic study Walsh JG (2008), Boucher D (2012) 2
BIRC3 1 CASP8 1 affinity chromatography technology, affinity chromatography technology McDonald ER (2004), Zinngrebe J (2016) 2
CASP10 1 CASP8 1 biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Gajate C (2005), Micheau O (2003), Micheau O (2003), Guo Y (2002), Srinivasula SM (1996), Srinivasula SM (1996), Sinha SK (2004), Lee EW (2012), Feoktistova M (2011) 9
CASP7 1 GBP2 0 biochemical Kristensen AR (2012) 1
CASP7 1 DFFA 0 enzymatic study Walsh JG (2008) 1
CAPN1 3 EEF2 11 biochemical Kristensen AR (2012) 1
CNDP2 3 CAPN1 3 biochemical Kristensen AR (2012) 1
VCP 6 VIM 0 affinity chromatography technology Yu CC (2013) 1
GZMB 0 CASP3 0 enzymatic study, enzymatic study Zhao T (2007), Cullen SP (2007) 2
COPS6 0 EEF2 11 affinity chromatography technology Bennett EJ (2010) 1
BIRC6 15 CASP7 1 affinity chromatography technology, enzymatic study Bartke T (2004), Qiu XB (2005) 2
BAX 3 CASP8 1 biochemical Chandra D (2004) 1
PEPD 5 CASP7 1 biochemical Kristensen AR (2012) 1
CASP8 1 CASP9 6 enzymatic study, genetic interference, enzymatic study Guo Y (2002), Guo Y (2002), Srinivasula SM (1996) 3
CRYAB 0 BAX 3 pull down, affinity chromatography technology, affinity chromatography technology Mao YW (2004), Mao YW (2004), Mao YW (2004) 3
XIAP 0 BIRC5 1 affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology Arora V (2007), Dohi T (2004), Dohi T (2004), Pavlyukov MS (2011) 4
BIRC2 1 CASP9 6 pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology Deveraux QL (1998), Deveraux QL (1998), Eckelman BP (2006), Cheung HH (2006), Kulathila R (2009), Kulathila R (2009), Vucic D (2000), Rolland T (2014), McDonald ER (2004), Chen TC (2014), Vu NT (2016), Vu NT (2016) 12
VCP 6 BAX 3 affinity chromatography technology Yu CC (2013) 1
TNFRSF1A 3 BIRC2 1 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Shu HB (1996), Vince JE (2009), Vince JE (2007), Wang YB (2015) 4
SAT1 0 GBP2 0 two hybrid Stelzl U (2005) 1
VCP 6 SPTAN1 9 affinity chromatography technology Fogeron ML (2013) 1
GINS2 1 EIF4H 1 biochemical Kristensen AR (2012) 1
RPS6KA1 3 VCP 6 two hybrid Vinayagam A (2011) 1
GZMB 0 PTGES3 0 enzymatic study Cullen SP (2007) 1
CASP3 0 PTGES3 0 enzymatic study Boucher D (2012) 1
STAT1 1 SPTAN1 9 two hybrid Bandyopadhyay S (2010) 1
CTSA 2 MVD 2 biochemical Kristensen AR (2012) 1
BIRC7 0 BIRC2 1 two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology Dynek JN (2010), Oberoi-Khanuja TK (2012), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017) 5
CAPN1 3 GINS2 1 biochemical Kristensen AR (2012) 1
SP1 0 RB1 2 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Singh J (2002), Chang YC (2001), Opitz OG (2000) 3
VCP 6 STAT1 1 affinity chromatography technology Yu CC (2013) 1
BIRC7 0 CASP7 1 pull down Kasof GM (2001) 1
CASP7 1 ROCK1 6 enzymatic study Walsh JG (2008) 1
TERF1 1 CASP7 1 two hybrid Lee OH (2011) 1
CASP8 1 BIRC2 1 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Micheau O (2003), Feoktistova M (2012), McDonald ER (2004), Zinngrebe J (2016) 4
PEPD 5 GBP2 0 biochemical Kristensen AR (2012) 1
EEF2 11 GINS2 1 biochemical Kristensen AR (2012) 1
TNFRSF1A 3 STAT1 1 affinity chromatography technology Wang Y (2000) 1
CASP3 0 CASP2 1 enzymatic study, enzymatic study Paroni G (2001), Walsh JG (2008) 2
BIRC2 1 CASP2 1 pull down Cheung HH (2006) 1
CASP8 1 VIM 0 two hybrid Stelzl U (2005) 1
BAX 3 CASP7 1 biochemical Chandra D (2004) 1
CASP7 1 CASP9 6 enzymatic study Walsh JG (2008) 1
CASP7 1 GINS2 1 biochemical Kristensen AR (2012) 1
BIRC2 1 CASP7 1 pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Roy N (1997), Choi YE (2009), Choi YE (2009), Tenev T (2005), Eckelman BP (2006), Vucic D (2000) 6
CASP7 1 PLA2G4B 0 enzymatic study Lueschen S (1998) 1
HSPA5 0 CASP7 1 affinity chromatography technology Rao RV (2002) 1
CASP7 1 SAT1 0 two hybrid Rolland T (2014) 1
CASP7 1 EIF4H 1 biochemical Kristensen AR (2012) 1
CNDP2 3 GBP2 0 biochemical Kristensen AR (2012) 1
ARHGDIA 3 CASP8 1 biochemical Gajate C (2005) 1
TERF1 1 ARHGDIA 3 two hybrid Lee OH (2011) 1
CTSA 2 PEPD 5 biochemical Kristensen AR (2012) 1
CASP10 1 CASP9 6 enzymatic study Srinivasula SM (1996) 1
CASP7 1 CASP2 1 enzymatic study Paroni G (2001) 1
PEPD 5 CAPN1 3 biochemical Kristensen AR (2012) 1
CAPN1 3 GBP2 0 biochemical Kristensen AR (2012) 1
BIRC3 1 CASP10 1 affinity chromatography technology McDonald ER (2004) 1
CASP7 1 PARP1 3 enzymatic study, enzymatic study, enzymatic study Lueschen S (1998), Walsh JG (2008), Boucher D (2012) 3
BIRC5 1 CASP7 1 pull down, enzymatic study, pull down Tamm I (1998), Shin S (2001), Shin S (2001) 3
HSPA5 0 SPTAN1 9 biochemical Havugimana PC (2012) 1
COPS6 0 HSPA5 0 affinity chromatography technology Bennett EJ (2010) 1
CASP3 0 ROCK1 6 enzymatic study Walsh JG (2008) 1
MVD 2 GINS2 1 biochemical Kristensen AR (2012) 1
XIAP 0 CASP9 6 two hybrid, far western blotting, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique Rual JF (2005), Davoodi J (2004), Deveraux QL (1998), Deveraux QL (1998), Richter BW (2001), Morizane Y (2005), Fu J (2003), Fu J (2003), Hao Y (2004), Varfolomeev E (2007), Vucic D (2002), Qiu XB (2005), Srinivasula SM (2001), Cheung HH (2006), Kulathila R (2009), Shiozaki EN (2003), Davoodi J (2007), Checinska A (2007), Huang Y (2003), Sun M (2009), Martin SA (2005), Lee JS (2012), Rolland T (2014), McDonald ER (2004), Chen TC (2014) 25
BIRC2 1 BIRC3 1 affinity chromatography technology, affinity chromatography technology Rajalingam K (2006), Rajalingam K (2006) 2
BIRC6 15 CASP9 6 affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study Hao Y (2004), Bartke T (2004), Qiu XB (2005), Qiu XB (2005), Qiu XB (2005) 5
EEF2 11 EIF4H 1 biochemical Kristensen AR (2012) 1
FBXW11 2 CLSPN 1 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Peschiaroli A (2006), Gao D (2011), Bassermann F (2008), Kim TY (2014), Low TY (2014), Kee Y (2009) 6
CNDP2 3 MVD 2 biochemical Kristensen AR (2012) 1
CASP10 1 CASP7 1 enzymatic study Srinivasula SM (1996) 1
VIM 0 SPTAN1 9 affinity chromatography technology, affinity chromatography technology Brown MJ (2001), Brown MJ (2001) 2
CRYAB 0 CASP3 0 affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology Stegh AH (2008), Stegh AH (2008), Stegh AH (2008), Lee JS (2012), Jeong WJ (2012) 5
BIRC6 15 CASP3 0 affinity chromatography technology, pull down, enzymatic study Bartke T (2004), Qiu XB (2005), Qiu XB (2005) 3
CASP8 1 BIRC6 15 enzymatic study Qiu XB (2005) 1
CASP7 1 STAT1 1 enzymatic study Walsh JG (2008) 1
CASP8 1 CASP3 0 enzymatic study, enzymatic study, enzymatic study Guo Y (2002), Srinivasula SM (1996), Chandra D (2004) 3
CASP7 1 RB1 2 enzymatic study, enzymatic study Lemaire C (2005), Fattman CL (2001) 2
CASP10 1 RB1 2 enzymatic study Lemaire C (2005) 1
CASP10 1 CASP3 0 enzymatic study Srinivasula SM (1996) 1
CAPN1 3 VIM 0 two hybrid, affinity chromatography technology Jiang LQ (2002), Huttlin EL (2017) 2
CASP10 1 TNFRSF1A 3 biochemical, affinity chromatography technology Gajate C (2005), Vincenz C (1997) 2
CTSA 2 VIM 0 affinity chromatography technology Boldt K (2016) 1
CASP8 1 PLA2G4B 0 enzymatic study Lueschen S (1998) 1
CASP7 1 VIM 0 enzymatic study Walsh JG (2008) 1
BAX 3 XIAP 0 affinity chromatography technology Gogada R (2011) 1
CASP8 1 CASP2 1 enzymatic study, enzymatic study Guo Y (2002), Srinivasula SM (1996) 2
CASP7 1 COPS6 0 enzymatic study da Silva Correia J (2007) 1
ARHGDIA 3 TNFRSF1A 3 biochemical Gajate C (2005) 1
GNS 3 CNDP2 3 biochemical Kristensen AR (2012) 1
CASP9 6 CRYAB 0 affinity chromatography technology Lee JS (2012) 1
TERF1 1 SPTAN1 9 affinity chromatography technology Giannone RJ (2010) 1
CCT2 1 XIAP 0 pull down, affinity chromatography technology Lin YF (2012), Lin YF (2012) 2
PEPD 5 GINS2 1 biochemical Kristensen AR (2012) 1
RPS6KA1 3 GBP2 0 two hybrid, biochemical Vinayagam A (2011), Kristensen AR (2012) 2
BIRC2 1 BIRC5 1 pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down Dohi T (2004), Samuel T (2005), Samuel T (2005), Jung SA (2015), Jung SA (2015), Jung SA (2015) 6
CNDP2 3 GINS2 1 biochemical Kristensen AR (2012) 1
TERF1 1 PEPD 5 two hybrid Lee OH (2011) 1
VCP 6 HSPA5 0 affinity chromatography technology Yu CC (2013) 1
CASP7 1 MVD 2 biochemical Kristensen AR (2012) 1
VCP 6 CASP7 1 affinity chromatography technology Yu CC (2013) 1
CASP3 0 VIM 0 enzymatic study Walsh JG (2008) 1
VCP 6 PTGES3 0 biochemical Wan C (2015) 1
CASP3 0 COPS6 0 enzymatic study da Silva Correia J (2007) 1
FBXW11 2 CASP7 1 affinity chromatography technology Low TY (2014) 1
CAPN1 3 SPTAN1 9 enzymatic study Stabach PR (1997) 1
XIAP 0 CRYAB 0 affinity chromatography technology Lee JS (2012) 1
CASP3 0 EEF2 11 biochemical Wan C (2015) 1
XIAP 0 CASP3 0 affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down Suzuki Y (2001), Suzuki Y (2001), Silke J (2002), Riedl SJ (2001), Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Nakhaei P (2012), Qiu XB (2005), Nomura T (2003), Paulsen M (2008), Scott FL (2005), Mufti AR (2006), Rajalingam K (2006), Dudich E (2006), Chai J (2001), Checinska A (2007), Sun M (2009), Takahashi R (1998), Conde C (2012), Walsh JG (2008), Lee JS (2012), Lin YF (2013), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Hou Y (2017) 30
ARHGDIA 3 CASP10 1 biochemical Gajate C (2005) 1
RPS6KA1 3 EIF4H 1 biochemical Kristensen AR (2012) 1
CNDP2 3 CASP7 1 biochemical Kristensen AR (2012) 1
CASP3 0 CASP9 6 enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique Qiu XB (2005), Denault JB (2007), Srinivasula SM (2001), Walsh JG (2008), Chen TC (2014) 5
TNFRSF1A 3 BIRC3 1 affinity chromatography technology, affinity chromatography technology Blankenship JW (2009), Vince JE (2009) 2
GNS 3 RPS6KA1 3 biochemical Kristensen AR (2012) 1
CCT2 1 VCP 6 pull down, affinity chromatography technology, affinity chromatography technology Lin YF (2012), Lin YF (2012), Yu CC (2013) 3
BIRC7 0 XIAP 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Oberoi-Khanuja TK (2012), Oberoi-Khanuja TK (2012), Huttlin EL (2015), Huttlin EL (2017) 4
RPS6KA1 3 GINS2 1 biochemical Kristensen AR (2012) 1
GNS 3 CAPN1 3 biochemical Kristensen AR (2012) 1
CAPN1 3 MVD 2 biochemical Kristensen AR (2012) 1
CASP3 0 PLA2G4B 0 enzymatic study Lueschen S (1998) 1
GNS 3 CASP7 1 biochemical Kristensen AR (2012) 1
CASP3 0 ARHGDIA 3 enzymatic study Walsh JG (2008) 1
CASP7 1 TNFRSF1A 3 enzymatic study Ethell DW (2001) 1
CTSA 2 GINS2 1 biochemical Kristensen AR (2012) 1
CAPN1 3 RPS6KA1 3 biochemical Kristensen AR (2012) 1
BAX 3 CASP9 6 biochemical Chandra D (2004) 1
GZMB 0 CASP8 1 enzymatic study Cullen SP (2007) 1
BIRC7 0 CASP3 0 pull down, affinity chromatography technology Kasof GM (2001), Liu GH (2013) 2
CASP9 6 BIRC7 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid Kasof GM (2001), Vucic D (2002), Vucic D (2000), Rolland T (2014) 4
CASP8 1 COPS6 0 enzymatic study da Silva Correia J (2007) 1
CCT2 1 EEF2 11 pull down Lin YF (2012) 1
CASP3 0 RB1 2 enzymatic study, enzymatic study Lemaire C (2005), Fattman CL (2001) 2
CASP2 1 CRYAB 0 affinity chromatography technology Jeong WJ (2012) 1
CASP2 1 CASP9 6 genetic interference Guo Y (2002) 1
PEPD 5 MVD 2 biochemical Kristensen AR (2012) 1
CASP9 6 RB1 2 enzymatic study Lemaire C (2005) 1
CASP2 1 XIAP 0 genetic interference Guo Y (2002) 1
CASP8 1 PARP1 3 enzymatic study Betin VM (2009) 1